JP2006526581A5 - - Google Patents
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- Publication number
- JP2006526581A5 JP2006526581A5 JP2006508134A JP2006508134A JP2006526581A5 JP 2006526581 A5 JP2006526581 A5 JP 2006526581A5 JP 2006508134 A JP2006508134 A JP 2006508134A JP 2006508134 A JP2006508134 A JP 2006508134A JP 2006526581 A5 JP2006526581 A5 JP 2006526581A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- nhr
- oxazin
- alkoxy
- thia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300840 | 2003-06-06 | ||
| DKPA200300844 | 2003-06-06 | ||
| DKPA200300844 | 2003-06-06 | ||
| DKPA200300842 | 2003-06-06 | ||
| DKPA200300842 | 2003-06-06 | ||
| DKPA200300840 | 2003-06-06 | ||
| DKPA200300843 | 2003-06-06 | ||
| DKPA200300843 | 2003-06-06 | ||
| PCT/DK2004/000388 WO2004108139A2 (en) | 2003-06-06 | 2004-06-07 | Use of fused heterocyclic compounds as scce inhibitors for the treatment of skin conditions or cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006526581A JP2006526581A (ja) | 2006-11-24 |
| JP2006526581A5 true JP2006526581A5 (https=) | 2011-05-26 |
| JP5044214B2 JP5044214B2 (ja) | 2012-10-10 |
Family
ID=33514772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508134A Expired - Fee Related JP5044214B2 (ja) | 2003-06-06 | 2004-06-07 | 皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7872052B2 (https=) |
| EP (1) | EP1631295B1 (https=) |
| JP (1) | JP5044214B2 (https=) |
| KR (2) | KR101205257B1 (https=) |
| CN (1) | CN101152185B (https=) |
| AT (1) | ATE459359T1 (https=) |
| CA (1) | CA2525383C (https=) |
| CY (1) | CY1110084T1 (https=) |
| DE (1) | DE602004025803D1 (https=) |
| DK (1) | DK1631295T3 (https=) |
| ES (1) | ES2341545T3 (https=) |
| NO (1) | NO20060091L (https=) |
| NZ (1) | NZ543636A (https=) |
| PL (1) | PL1631295T3 (https=) |
| PT (1) | PT1631295E (https=) |
| SI (1) | SI1631295T1 (https=) |
| WO (1) | WO2004108139A2 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
| DE10320785A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
| DE102004001873A1 (de) | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
| CA2617213C (en) * | 2005-07-29 | 2014-01-28 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| PL2066662T3 (pl) | 2006-09-21 | 2013-05-31 | Kyorin Seiyaku Kk | Inhibitory hydrolaz serynowych |
| WO2008041118A2 (en) | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| WO2008092231A1 (en) | 2007-02-01 | 2008-08-07 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
| WO2009024528A1 (en) | 2007-08-17 | 2009-02-26 | Novartis Ag | Use of cyclic depsipeptides to inhibit kallikrein 7 |
| MY151973A (en) | 2007-08-17 | 2014-07-31 | Novartis Ag | Cyclic depsipeptides |
| JP5498392B2 (ja) | 2007-11-30 | 2014-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用 |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| JP5453431B2 (ja) | 2008-09-08 | 2014-03-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピラゾロピリミジン及びｃｎｓ障害の治療のためのそれらの使用 |
| AU2010204106B2 (en) | 2009-01-08 | 2014-05-08 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
| EP2403857B1 (en) * | 2009-03-05 | 2013-12-04 | Takeda Pharmaceutical Company Limited | Thienopyrimidine as cdc7 kinase inhibitors |
| NZ755378A (en) | 2009-03-18 | 2022-07-29 | Resverlogix Corp | Novel quinazolinones and related compounds for use as anti-inflammatory agents |
| PE20120505A1 (es) | 2009-03-31 | 2012-05-09 | Boehringer Ingelheim Int | Derivados de 1-heterociclil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona como moduladores de pde9a |
| KR20190091564A (ko) | 2009-04-22 | 2019-08-06 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| TWI419884B (zh) * | 2010-06-24 | 2013-12-21 | Univ Chang Gung | 苯并雜氧嗪酮衍生物，其製備方法以及包含有此等衍生物的藥學組成物 |
| AP2012006631A0 (en) | 2010-08-12 | 2012-12-31 | Boehringer Ingelheim Int | 6-Cycloalkyl-1, 5-dihydro-pyrazolo[3,4-D] pyrimidin-4-one derivatives and their use as PDE9A inhibitors |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| US8614289B2 (en) | 2011-04-20 | 2013-12-24 | Novartis Ag | Processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| RU2640115C2 (ru) | 2011-11-01 | 2017-12-26 | Ресверлоджикс Корп. | Фармацевтические композиции замещенных хиназолинонов |
| KR20140138293A (ko) | 2012-03-16 | 2014-12-03 | 액시킨 파마수티컬스 인코포레이티드 | 3,5-다이아미노피라졸 키나아제 억제제 |
| ES2704744T3 (es) | 2012-06-13 | 2019-03-19 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US8987413B2 (en) | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
| EA035095B1 (ru) | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| PT3097084T (pt) | 2014-01-23 | 2020-12-09 | Sixera Pharma Ab | Novos inibidores de calicreína 7 |
| DK3097085T3 (da) | 2014-01-23 | 2020-10-26 | Sixera Pharma Ab | Benzoxazinonderivater til behandling af hudsygdomme |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US9546163B2 (en) | 2014-12-23 | 2017-01-17 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MX373169B (es) | 2015-02-20 | 2020-04-24 | Incyte Holdings Corp | Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr). |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| JO3789B1 (ar) | 2015-03-13 | 2021-01-31 | Resverlogix Corp | التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| WO2019074979A1 (en) | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| US10807994B2 (en) | 2017-10-09 | 2020-10-20 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| CN108421034A (zh) * | 2018-04-24 | 2018-08-21 | 济南磐升生物技术有限公司 | 激肽释放酶7在皮肤创伤愈合中的应用 |
| CR20200590A (es) | 2018-05-04 | 2021-04-26 | Incyte Corp | Formas sólidas de un inhibidor de fgfr y procesos para prepararlas |
| MA52493A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Sels d'un inhibiteur de fgfr |
| TWI803696B (zh) | 2018-09-14 | 2023-06-01 | 日商橘生藥品工業股份有限公司 | 次黃嘌呤化合物 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| CN113939296A (zh) | 2019-04-09 | 2022-01-14 | 诺维逊生物股份有限公司 | 杂环化合物及其用途 |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| US11643420B2 (en) | 2019-10-01 | 2023-05-09 | Molecular Skin Therapeutics, Inc. | Benzoxazinone compounds as KLK5/7 dual inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| TWI891666B (zh) | 2019-10-14 | 2025-08-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| BR112022010664A2 (pt) | 2019-12-04 | 2022-08-16 | Incyte Corp | Derivados de um inibidor de fgfr |
| EP4069696A1 (en) | 2019-12-04 | 2022-10-12 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP7502945B2 (ja) * | 2020-09-08 | 2024-06-19 | 花王株式会社 | デリケートエリアのかぶれの検査方法 |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| JP2024520154A (ja) | 2021-06-01 | 2024-05-21 | シクセラ・ファーマ・アーベー | ６－エトキシ－７－メトキシ－２－（２－メチルスルファニルフェニル）－３，１－ベンゾオキサジン－４－オンの水中油型乳剤 |
| EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US20250388573A1 (en) * | 2022-06-21 | 2025-12-25 | Dana-Farber Cancer Institute, Inc. | Fused bicyclic egfr inhibitors and methods of use thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1153994A (en) * | 1965-07-21 | 1969-06-04 | Aspro Nicholas Ltd | Hydroxyphenyl Anthranilic Acid Derivatives Capable of Absorbing 'Ultra-Violet Light and Compositions containing them |
| FR2121341A1 (en) * | 1971-01-04 | 1972-08-25 | Ferlux | 2-substd-3,1-benzoxazin-4-ones - antiinflammatories, analgesics sedatives and diuretics |
| IT1050750B (it) * | 1975-12-05 | 1981-03-20 | Erba Carlo Spa | Derivati della 3.4 di idro chinazolina |
| JPS5576868A (en) | 1978-12-01 | 1980-06-10 | Hisamitsu Pharmaceut Co Inc | Novel 3,1-bezoxazine derivative |
| GB8817651D0 (en) * | 1988-07-25 | 1988-09-01 | Smith Kline French Lab | Chemical compounds |
| WO1990006921A1 (en) * | 1988-12-21 | 1990-06-28 | The Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| JPH07316056A (ja) * | 1990-02-15 | 1995-12-05 | Teijin Ltd | エラスターゼ阻害用医薬組成物 |
| AU635403B2 (en) * | 1990-02-15 | 1993-03-18 | Teijin Limited | 4h-3,1-benzoxazin-4-one compound and elastase inhibitor composition containing the same |
| JPH05509302A (ja) * | 1990-06-20 | 1993-12-22 | ジ・アップジョン・カンパニー | 抗アテローム性動脈硬化性および抗血栓性１―ベンゾピラン―４―オン類および２―アミノ―１，３―ベンゾオキサジン―４―オン類 |
| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US5409930A (en) | 1991-05-10 | 1995-04-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| US5346886A (en) * | 1993-11-15 | 1994-09-13 | John Lezdey | Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin |
| AU1375000A (en) * | 1998-11-26 | 2000-06-13 | Novo Nordisk A/S | Heterocyclic compounds regulating clotting |
| EP1212097B1 (en) * | 1999-09-10 | 2005-11-16 | The Procter & Gamble Company | Enzyme inhibitors |
| ATE515940T1 (de) | 2001-02-09 | 2011-07-15 | Torbjoern Egelrud | Scce transgene mäuse und deren verwendung als modell für menschliche krankheiten |
| WO2003007955A2 (en) * | 2001-07-20 | 2003-01-30 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
| CA2503674A1 (en) * | 2002-10-03 | 2004-04-15 | Institute Of Medicinal Molecular Design, Inc. | Quinazolin-4-one derivatives |
| CA2502302A1 (en) * | 2002-11-04 | 2004-05-21 | Nps Pharmaceuticals, Inc. | Quinazolinone compounds as calcilytics |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
-
2004
- 2004-06-07 KR KR1020117022051A patent/KR101205257B1/ko not_active Expired - Fee Related
- 2004-06-07 PT PT04736195T patent/PT1631295E/pt unknown
- 2004-06-07 WO PCT/DK2004/000388 patent/WO2004108139A2/en not_active Ceased
- 2004-06-07 SI SI200431406T patent/SI1631295T1/sl unknown
- 2004-06-07 DE DE602004025803T patent/DE602004025803D1/de not_active Expired - Lifetime
- 2004-06-07 KR KR1020057023349A patent/KR101099409B1/ko not_active Expired - Fee Related
- 2004-06-07 PL PL04736195T patent/PL1631295T3/pl unknown
- 2004-06-07 AT AT04736195T patent/ATE459359T1/de active
- 2004-06-07 NZ NZ543636A patent/NZ543636A/en not_active IP Right Cessation
- 2004-06-07 DK DK04736195.1T patent/DK1631295T3/da active
- 2004-06-07 JP JP2006508134A patent/JP5044214B2/ja not_active Expired - Fee Related
- 2004-06-07 CA CA2525383A patent/CA2525383C/en not_active Expired - Fee Related
- 2004-06-07 ES ES04736195T patent/ES2341545T3/es not_active Expired - Lifetime
- 2004-06-07 CN CN2007101613027A patent/CN101152185B/zh not_active Expired - Fee Related
- 2004-06-07 US US10/559,322 patent/US7872052B2/en not_active Expired - Lifetime
- 2004-06-07 EP EP04736195A patent/EP1631295B1/en not_active Expired - Lifetime
-
2006
- 2006-01-06 NO NO20060091A patent/NO20060091L/no not_active Application Discontinuation
-
2010
- 2010-05-21 CY CY20101100450T patent/CY1110084T1/el unknown
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