JPS5576868A - Novel 3,1-bezoxazine derivative - Google Patents
Novel 3,1-bezoxazine derivativeInfo
- Publication number
- JPS5576868A JPS5576868A JP14920178A JP14920178A JPS5576868A JP S5576868 A JPS5576868 A JP S5576868A JP 14920178 A JP14920178 A JP 14920178A JP 14920178 A JP14920178 A JP 14920178A JP S5576868 A JPS5576868 A JP S5576868A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- benzoxazine
- bezoxazine
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- 230000003266 anti-allergic effect Effects 0.000 abstract 2
- -1 2-(3,4-Dimethoxystyryl)-6-iodo-4H-3,1-benzoxazin-4-one Chemical compound 0.000 abstract 1
- WMQSKECCMQRJRX-UHFFFAOYSA-N 2-methyl-3,1-benzoxazin-4-one Chemical class C1=CC=C2C(=O)OC(C)=NC2=C1 WMQSKECCMQRJRX-UHFFFAOYSA-N 0.000 abstract 1
- GTYZDORKFFSTLS-UHFFFAOYSA-N 2h-3,1-benzoxazine Chemical class C1=CC=CC2=NCOC=C21 GTYZDORKFFSTLS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000005504 styryl group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 3,1-benzoxazine derivative of formula I: (X is halogen, lower alkyl, or nitro group; R is phenyl or styryl group which may be substituted by 1W3 hydroxyl or methoxy groups).
EXAMPLE: 2-(3,4-Dimethoxystyryl)-6-iodo-4H-3,1-benzoxazin-4-one.
USE: Useful as medicines having antiallergic, anti-inflammatory, and analgesic actions, and an intermediate for the synthesis of anthranilic acid derivatives having an antiallergic action.
PROCESS: An anthranilic derivative of formula II is heated in acetic anhydride to give the compound of formula I. Alternatively, a 2-methyl-4H-3,1-benzoxazine-4-one derivative of formula III is reacted with an aldehyde of formula IV in the absence of a solvent.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14920178A JPS5576868A (en) | 1978-12-01 | 1978-12-01 | Novel 3,1-bezoxazine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14920178A JPS5576868A (en) | 1978-12-01 | 1978-12-01 | Novel 3,1-bezoxazine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5576868A true JPS5576868A (en) | 1980-06-10 |
Family
ID=15470024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14920178A Pending JPS5576868A (en) | 1978-12-01 | 1978-12-01 | Novel 3,1-bezoxazine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5576868A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657893A (en) * | 1984-05-09 | 1987-04-14 | Syntex (U.S.A.) Inc. | 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors |
| WO2004108139A2 (en) | 2003-06-06 | 2004-12-16 | Arexis Ab | Use of fused heterocyclic compounds as scce inhibitors for the treatment of skin conditions or cancer |
-
1978
- 1978-12-01 JP JP14920178A patent/JPS5576868A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657893A (en) * | 1984-05-09 | 1987-04-14 | Syntex (U.S.A.) Inc. | 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors |
| WO2004108139A2 (en) | 2003-06-06 | 2004-12-16 | Arexis Ab | Use of fused heterocyclic compounds as scce inhibitors for the treatment of skin conditions or cancer |
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