ATE515940T1 - Scce transgene mäuse und deren verwendung als modell für menschliche krankheiten - Google Patents

Scce transgene mäuse und deren verwendung als modell für menschliche krankheiten

Info

Publication number
ATE515940T1
ATE515940T1 AT02720389T AT02720389T ATE515940T1 AT E515940 T1 ATE515940 T1 AT E515940T1 AT 02720389 T AT02720389 T AT 02720389T AT 02720389 T AT02720389 T AT 02720389T AT E515940 T1 ATE515940 T1 AT E515940T1
Authority
AT
Austria
Prior art keywords
scce
increased
transgenic mice
expression
model
Prior art date
Application number
AT02720389T
Other languages
English (en)
Inventor
Torbjoern Egelrud
Lennart Hansson
Original Assignee
Torbjoern Egelrud
Lennart Hansson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA2332655A external-priority patent/CA2332655C/en
Application filed by Torbjoern Egelrud, Lennart Hansson filed Critical Torbjoern Egelrud
Application granted granted Critical
Publication of ATE515940T1 publication Critical patent/ATE515940T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/20—Dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
AT02720389T 2001-02-09 2002-02-08 Scce transgene mäuse und deren verwendung als modell für menschliche krankheiten ATE515940T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200100218 2001-02-09
CA2332655A CA2332655C (en) 2001-02-09 2001-02-09 Scce modified transgenic mammals and their use as models of human diseases
PCT/IB2002/001300 WO2002062135A2 (en) 2001-02-09 2002-02-08 Scce modified transgenic mammals and their use as models of human disease

Publications (1)

Publication Number Publication Date
ATE515940T1 true ATE515940T1 (de) 2011-07-15

Family

ID=25682362

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02720389T ATE515940T1 (de) 2001-02-09 2002-02-08 Scce transgene mäuse und deren verwendung als modell für menschliche krankheiten

Country Status (8)

Country Link
EP (1) EP1367886B1 (de)
JP (1) JP4262479B2 (de)
AT (1) ATE515940T1 (de)
AU (1) AU2002251429B2 (de)
CY (1) CY1111935T1 (de)
DK (1) DK1367886T3 (de)
PT (1) PT1367886E (de)
WO (1) WO2002062135A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1631295T3 (da) 2003-06-06 2010-06-21 Arexis Ab Anvendelse af kondenserede heterocykliske forbindelser som SCCE-inhibitorer ved behandling af hudsygdomme
US7247767B2 (en) 2004-01-21 2007-07-24 Boehringer Ingelheim International Gmbh Mouse model for psoriasis and psoriatic arthritis
EP1557085A1 (de) * 2004-01-21 2005-07-27 Boehringer Ingelheim International GmbH Mausmodell für menschliche Psoriasis
WO2005075667A1 (en) * 2004-02-03 2005-08-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7)
EP1743022A4 (de) * 2004-02-27 2008-02-06 Gen Hospital Corp Verfahren und zusammensetzungen für haarwachstum
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK72593D0 (da) * 1993-06-18 1993-06-18 Symbicom Ab Rekombinant protein
WO1996002254A1 (en) * 1994-07-15 1996-02-01 Michel Cohen SYNERGISTIC PHARMACEUTICAL COMPOSITONS CONTAINING 16'alpha',17'alpha'-ISOPROPYLIDENEDIOXY SUBSTITUTED PREGNANES
WO1998041656A1 (en) * 1997-03-19 1998-09-24 The Board Of Trustees Of The University Of Arkansas Compositions and method for the early diagnosis of ovarian cancer
AU3418499A (en) * 1999-03-29 2000-10-16 Harry Frank Abts Nucleic acid encoding a serine protease inhibitor
AU2085502A (en) * 2000-11-30 2002-06-11 Molecular Skincare Ltd Diagnosis and treatment of disease

Also Published As

Publication number Publication date
DK1367886T3 (da) 2011-10-24
JP4262479B2 (ja) 2009-05-13
EP1367886B1 (de) 2011-07-13
EP1367886A2 (de) 2003-12-10
CY1111935T1 (el) 2015-11-04
JP2004523234A (ja) 2004-08-05
WO2002062135A2 (en) 2002-08-15
AU2002251429B2 (en) 2007-01-18
PT1367886E (pt) 2011-10-03
WO2002062135A3 (en) 2003-09-25
WO2002062135A8 (en) 2004-03-11

Similar Documents

Publication Publication Date Title
CY1111935T1 (el) Διαγονιδιακα ποντικια scce και η χρηση τους ως προτυπα ανθρωπινης ασθενειας
Ishida-Yamamoto et al. The biology and regulation of corneodesmosomes
Freitas-Rodriguez et al. The role of matrix metalloproteinases in aging: Tissue remodeling and beyond
Takeuchi et al. Neutrophil elastase contributes to extracellular matrix damage induced by chronic low-dose UV irradiation in a hairless mouse photoaging model
Kishibe Physiological and pathological roles of kallikrein-related peptidases in the epidermis
Nauroy et al. Kallikreins: Essential epidermal messengers for regulation of the skin microenvironment during homeostasis, repair and disease
Iba et al. Possible involvement of mast cells in collagen remodeling in the late phase of cutaneous wound healing in mice
Onoue et al. Induction of matrix metalloproteinase-9 secretion from human keratinocytes in culture by ultraviolet B irradiation
Yokose et al. The endogenous protease inhibitor TIMP-1 mediates protection and recovery from cutaneous photodamage
Iddamalgoda et al. Mast cell tryptase and photoaging: possible involvement in the degradation of extra cellular matrix and basement membrane proteins
Angel et al. Function and regulation of AP-1 subunits in skin physiology and pathology
Salo et al. Expression of matrix metalloproteinase-2 and-9 during early human wound healing.
Ferreira et al. Diminished induction of skin fibrosis in mice with MCP-1 deficiency
Gillespie et al. Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variation in MMP-1 and MMP-13
Park et al. Green tea polyphenol (−)-epigallocatechin gallate reduces matrix metalloproteinase-9 activity following transient focal cerebral ischemia
Roelandt et al. Proteolytically active allergens cause barrier breakdown
MX2010009767A (es) Uso de celulas madre mesenquimales para tratar trastornos y enfermedades geneticas.
WO2008042174A3 (en) Mesenchymal stem cells and uses therefor
Lee et al. The effects of epigallocatechin-3-gallate on extracellular matrix metabolism
Di Paolo et al. The role of kallikreins in inflammatory skin disorders and their potential as therapeutic targets
Ke et al. Homocysteine modulates the proteolytic potential of human arterial smooth muscle cells through a reactive oxygen species dependant mechanism
ATE394491T1 (de) Regulierung einer humanen transmembran- serinprotease
Del Rosso Application of protease technology in dermatology: rationale for incorporation into skin care with initial observations on formulations designed for skin cleansing, maintenance of hydration, and restoration of the epidermal permeability barrier
Kolaczkowska et al. Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis
Jain et al. Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1367886

Country of ref document: EP