DK1367886T3 - SCCE-transgene mus og deres anvendelse som modeller for humane sygdomme - Google Patents
SCCE-transgene mus og deres anvendelse som modeller for humane sygdommeInfo
- Publication number
- DK1367886T3 DK1367886T3 DK02720389.2T DK02720389T DK1367886T3 DK 1367886 T3 DK1367886 T3 DK 1367886T3 DK 02720389 T DK02720389 T DK 02720389T DK 1367886 T3 DK1367886 T3 DK 1367886T3
- Authority
- DK
- Denmark
- Prior art keywords
- scce
- increased
- transgenic mice
- expression
- models
- Prior art date
Links
- 101001091388 Homo sapiens Kallikrein-7 Proteins 0.000 title abstract 6
- 102100034867 Kallikrein-7 Human genes 0.000 title abstract 5
- 241000699660 Mus musculus Species 0.000 title abstract 2
- 238000011830 transgenic mouse model Methods 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010020649 Hyperkeratosis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 102000055383 human KLK7 Human genes 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/20—Dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Environmental Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100218 | 2001-02-09 | ||
| CA2332655A CA2332655C (en) | 2001-02-09 | 2001-02-09 | Scce modified transgenic mammals and their use as models of human diseases |
| PCT/IB2002/001300 WO2002062135A2 (en) | 2001-02-09 | 2002-02-08 | Scce modified transgenic mammals and their use as models of human disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1367886T3 true DK1367886T3 (da) | 2011-10-24 |
Family
ID=25682362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02720389.2T DK1367886T3 (da) | 2001-02-09 | 2002-02-08 | SCCE-transgene mus og deres anvendelse som modeller for humane sygdomme |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1367886B1 (da) |
| JP (1) | JP4262479B2 (da) |
| AT (1) | ATE515940T1 (da) |
| AU (1) | AU2002251429B2 (da) |
| CY (1) | CY1111935T1 (da) |
| DK (1) | DK1367886T3 (da) |
| PT (1) | PT1367886E (da) |
| WO (1) | WO2002062135A2 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1631295T3 (da) | 2003-06-06 | 2010-06-21 | Arexis Ab | Anvendelse af kondenserede heterocykliske forbindelser som SCCE-inhibitorer ved behandling af hudsygdomme |
| US7247767B2 (en) | 2004-01-21 | 2007-07-24 | Boehringer Ingelheim International Gmbh | Mouse model for psoriasis and psoriatic arthritis |
| EP1557085A1 (en) * | 2004-01-21 | 2005-07-27 | Boehringer Ingelheim International GmbH | Mouse model for human psoriasis |
| WO2005075667A1 (en) * | 2004-02-03 | 2005-08-18 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7) |
| EP1743022A4 (en) * | 2004-02-27 | 2008-02-06 | Gen Hospital Corp | METHODS AND COMPOSITIONS FOR CAPILLARY GROWTH |
| US20200040103A1 (en) | 2018-03-14 | 2020-02-06 | Genentech, Inc. | Anti-klk5 antibodies and methods of use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK72593D0 (da) * | 1993-06-18 | 1993-06-18 | Symbicom Ab | Rekombinant protein |
| WO1996002254A1 (en) * | 1994-07-15 | 1996-02-01 | Michel Cohen | SYNERGISTIC PHARMACEUTICAL COMPOSITONS CONTAINING 16'alpha',17'alpha'-ISOPROPYLIDENEDIOXY SUBSTITUTED PREGNANES |
| WO1998041656A1 (en) * | 1997-03-19 | 1998-09-24 | The Board Of Trustees Of The University Of Arkansas | Compositions and method for the early diagnosis of ovarian cancer |
| AU3418499A (en) * | 1999-03-29 | 2000-10-16 | Harry Frank Abts | Nucleic acid encoding a serine protease inhibitor |
| AU2085502A (en) * | 2000-11-30 | 2002-06-11 | Molecular Skincare Ltd | Diagnosis and treatment of disease |
-
2002
- 2002-02-08 EP EP02720389A patent/EP1367886B1/en not_active Expired - Lifetime
- 2002-02-08 PT PT02720389T patent/PT1367886E/pt unknown
- 2002-02-08 JP JP2002562148A patent/JP4262479B2/ja not_active Expired - Fee Related
- 2002-02-08 WO PCT/IB2002/001300 patent/WO2002062135A2/en active Application Filing
- 2002-02-08 AT AT02720389T patent/ATE515940T1/de active
- 2002-02-08 AU AU2002251429A patent/AU2002251429B2/en not_active Ceased
- 2002-02-08 DK DK02720389.2T patent/DK1367886T3/da active
-
2011
- 2011-10-07 CY CY20111100962T patent/CY1111935T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4262479B2 (ja) | 2009-05-13 |
| EP1367886B1 (en) | 2011-07-13 |
| EP1367886A2 (en) | 2003-12-10 |
| CY1111935T1 (el) | 2015-11-04 |
| JP2004523234A (ja) | 2004-08-05 |
| WO2002062135A2 (en) | 2002-08-15 |
| ATE515940T1 (de) | 2011-07-15 |
| AU2002251429B2 (en) | 2007-01-18 |
| PT1367886E (pt) | 2011-10-03 |
| WO2002062135A3 (en) | 2003-09-25 |
| WO2002062135A8 (en) | 2004-03-11 |
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