JP2006525359A5 - - Google Patents
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- JP2006525359A5 JP2006525359A5 JP2006514216A JP2006514216A JP2006525359A5 JP 2006525359 A5 JP2006525359 A5 JP 2006525359A5 JP 2006514216 A JP2006514216 A JP 2006514216A JP 2006514216 A JP2006514216 A JP 2006514216A JP 2006525359 A5 JP2006525359 A5 JP 2006525359A5
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- JP
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- Prior art keywords
- alkyl
- formula
- substituted
- compound according
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- -1 N-morpholinyl Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010048873 Traumatic arthritis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- WASQWSOJHCZDFK-UHFFFAOYSA-N diketene Chemical compound C=C1CC(=O)O1 WASQWSOJHCZDFK-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 claims 1
- REPVNSJSTLRQEQ-UHFFFAOYSA-N n,n-dimethylacetamide;n,n-dimethylformamide Chemical compound CN(C)C=O.CN(C)C(C)=O REPVNSJSTLRQEQ-UHFFFAOYSA-N 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 claims 1
- 229940067157 phenylhydrazine Drugs 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000005404 rubella Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46702903P | 2003-05-01 | 2003-05-01 | |
| PCT/US2004/013604 WO2004099156A1 (en) | 2003-05-01 | 2004-05-03 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006525359A JP2006525359A (ja) | 2006-11-09 |
| JP2006525359A5 true JP2006525359A5 (enExample) | 2007-04-26 |
| JP4601611B2 JP4601611B2 (ja) | 2010-12-22 |
Family
ID=33435012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006514216A Expired - Fee Related JP4601611B2 (ja) | 2003-05-01 | 2004-05-03 | キナーゼインヒビターとして有用なアリール置換ピラゾール−アミド化合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (8) | US7151113B2 (enExample) |
| EP (5) | EP1617840A4 (enExample) |
| JP (1) | JP4601611B2 (enExample) |
| KR (1) | KR20060022649A (enExample) |
| CN (1) | CN1816529A (enExample) |
| AT (2) | ATE522525T1 (enExample) |
| AU (1) | AU2004236240C1 (enExample) |
| BR (1) | BRPI0409949A (enExample) |
| CA (1) | CA2524321A1 (enExample) |
| CO (1) | CO5640039A2 (enExample) |
| DE (1) | DE602004029242D1 (enExample) |
| DK (1) | DK1618092T3 (enExample) |
| ES (3) | ES2386784T3 (enExample) |
| GE (1) | GEP20074236B (enExample) |
| HR (1) | HRP20100670T1 (enExample) |
| IS (1) | IS8101A (enExample) |
| MX (1) | MXPA05011666A (enExample) |
| NO (1) | NO20054970L (enExample) |
| NZ (1) | NZ543375A (enExample) |
| PL (1) | PL1618092T3 (enExample) |
| PT (1) | PT1618092E (enExample) |
| RS (1) | RS20050789A (enExample) |
| RU (1) | RU2342365C2 (enExample) |
| SI (1) | SI1618092T1 (enExample) |
| UA (1) | UA81668C2 (enExample) |
| WO (3) | WO2004098528A2 (enExample) |
| ZA (1) | ZA200508830B (enExample) |
Families Citing this family (97)
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| US7285545B2 (en) * | 2004-05-03 | 2007-10-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
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| US7531560B2 (en) * | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
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| BRPI0611596A2 (pt) | 2005-06-21 | 2010-09-21 | Mitsui Chemicals Inc | derivado de amina e inseticida contendo o mesmo |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
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| CN101405270B (zh) | 2006-03-22 | 2013-01-16 | 霍夫曼-拉罗奇有限公司 | 作为11-β-HSD-1的吡唑类 |
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2004
- 2004-05-03 EP EP04760683A patent/EP1617840A4/en not_active Withdrawn
- 2004-05-03 CN CNA2004800188458A patent/CN1816529A/zh active Pending
- 2004-05-03 ES ES04760705T patent/ES2386784T3/es not_active Expired - Lifetime
- 2004-05-03 JP JP2006514216A patent/JP4601611B2/ja not_active Expired - Fee Related
- 2004-05-03 CA CA002524321A patent/CA2524321A1/en not_active Abandoned
- 2004-05-03 NZ NZ543375A patent/NZ543375A/en unknown
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- 2004-05-03 MX MXPA05011666A patent/MXPA05011666A/es active IP Right Grant
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- 2004-05-03 EP EP11005867.4A patent/EP2385041B1/en not_active Expired - Lifetime
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- 2004-05-03 WO PCT/US2004/013786 patent/WO2004098528A2/en not_active Ceased
- 2004-05-03 AU AU2004236240A patent/AU2004236240C1/en not_active Ceased
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- 2004-05-03 RU RU2005135162/04A patent/RU2342365C2/ru not_active IP Right Cessation
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- 2004-05-03 DE DE602004029242T patent/DE602004029242D1/de not_active Expired - Lifetime
- 2004-05-03 DK DK04751133.2T patent/DK1618092T3/da active
- 2004-05-03 UA UAA200511373A patent/UA81668C2/ru unknown
- 2004-05-03 KR KR1020057020642A patent/KR20060022649A/ko not_active Ceased
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2005
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2006
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2007
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2008
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2009
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