JP2006525359A5 - - Google Patents
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- JP2006525359A5 JP2006525359A5 JP2006514216A JP2006514216A JP2006525359A5 JP 2006525359 A5 JP2006525359 A5 JP 2006525359A5 JP 2006514216 A JP2006514216 A JP 2006514216A JP 2006514216 A JP2006514216 A JP 2006514216A JP 2006525359 A5 JP2006525359 A5 JP 2006525359A5
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- JP
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- Prior art keywords
- alkyl
- formula
- substituted
- compound according
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- -1 N-morpholinyl Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 206010018634 Gouty Arthritis Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010048873 Traumatic arthritis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- WASQWSOJHCZDFK-UHFFFAOYSA-N diketene Chemical compound C=C1CC(=O)O1 WASQWSOJHCZDFK-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 claims 1
- REPVNSJSTLRQEQ-UHFFFAOYSA-N n,n-dimethylacetamide;n,n-dimethylformamide Chemical compound CN(C)C=O.CN(C)C(C)=O REPVNSJSTLRQEQ-UHFFFAOYSA-N 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 claims 1
- 229940067157 phenylhydrazine Drugs 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000005404 rubella Diseases 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46702903P | 2003-05-01 | 2003-05-01 | |
| PCT/US2004/013604 WO2004099156A1 (en) | 2003-05-01 | 2004-05-03 | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006525359A JP2006525359A (ja) | 2006-11-09 |
| JP2006525359A5 true JP2006525359A5 (enExample) | 2007-04-26 |
| JP4601611B2 JP4601611B2 (ja) | 2010-12-22 |
Family
ID=33435012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006514216A Expired - Fee Related JP4601611B2 (ja) | 2003-05-01 | 2004-05-03 | キナーゼインヒビターとして有用なアリール置換ピラゾール−アミド化合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (8) | US7151113B2 (enExample) |
| EP (5) | EP2385041B1 (enExample) |
| JP (1) | JP4601611B2 (enExample) |
| KR (1) | KR20060022649A (enExample) |
| CN (1) | CN1816529A (enExample) |
| AT (2) | ATE482200T1 (enExample) |
| AU (1) | AU2004236240C1 (enExample) |
| BR (1) | BRPI0409949A (enExample) |
| CA (1) | CA2524321A1 (enExample) |
| CO (1) | CO5640039A2 (enExample) |
| DE (1) | DE602004029242D1 (enExample) |
| DK (1) | DK1618092T3 (enExample) |
| ES (3) | ES2370463T3 (enExample) |
| GE (1) | GEP20074236B (enExample) |
| HR (1) | HRP20100670T1 (enExample) |
| IS (1) | IS8101A (enExample) |
| MX (1) | MXPA05011666A (enExample) |
| NO (1) | NO20054970L (enExample) |
| NZ (1) | NZ543375A (enExample) |
| PL (1) | PL1618092T3 (enExample) |
| PT (1) | PT1618092E (enExample) |
| RS (1) | RS20050789A (enExample) |
| RU (1) | RU2342365C2 (enExample) |
| SI (1) | SI1618092T1 (enExample) |
| UA (1) | UA81668C2 (enExample) |
| WO (3) | WO2004099156A1 (enExample) |
| ZA (1) | ZA200508830B (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US7078419B2 (en) * | 2003-03-10 | 2006-07-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
| WO2004099156A1 (en) * | 2003-05-01 | 2004-11-18 | Bristol-Myers Squibb Company | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors |
| NZ544756A (en) | 2003-07-22 | 2009-09-25 | Astex Therapeutics Ltd | 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
| EP1692116B1 (en) * | 2003-12-03 | 2011-03-09 | Boehringer Ingelheim Pharmaceuticals Inc. | 1,2,3-triazole amide derivatives as inhibitors of cytokine production |
| JP2007514759A (ja) | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| CA2557856C (en) * | 2004-03-09 | 2010-06-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | 3-'4-heterocyclyl-1,2,3,-triazol-1-yl!-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases |
| WO2005105788A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
| WO2005108387A2 (en) * | 2004-05-03 | 2005-11-17 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
| US7485657B2 (en) * | 2004-05-12 | 2009-02-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| JP2008510734A (ja) | 2004-08-18 | 2008-04-10 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| WO2006040520A1 (en) | 2004-10-12 | 2006-04-20 | Astrazeneca Ab | Quinazoline derivatives |
| DE602005023333D1 (de) | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
| US7531560B2 (en) * | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
| RU2425677C2 (ru) * | 2005-01-21 | 2011-08-10 | Астекс Терапьютикс Лимитед | Соединения, предназначенные для использования в фармацевтике |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| CA2612976C (en) | 2005-06-21 | 2012-04-10 | Mitsui Chemicals, Inc. | Amide derivative and insecticide containing the same |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| WO2007052843A1 (ja) * | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| BRPI0620362A2 (pt) * | 2005-12-22 | 2012-07-03 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável do mesmo, uso do mesmo, métodos para produzir um efeito inibidor de csf-1r quinase em um animal de sangue quente, para produzir um efeito anti-cáncer em um animal de sangue quente e para tratar doença, e, composição farmacêutica |
| UY30183A1 (es) | 2006-03-02 | 2007-10-31 | Astrazeneca Ab | Derivados de quinolina |
| ES2548002T3 (es) | 2006-03-22 | 2015-10-13 | F. Hoffmann-La Roche Ag | Pirazoles como 11beta-SD1 |
| EP2223925A1 (en) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| BRPI0719883A2 (pt) | 2006-10-09 | 2015-05-05 | Takeda Pharmaceutical | Inibidores de quinase |
| ES2430821T3 (es) | 2006-10-10 | 2013-11-21 | Amgen Inc. | Compuestos de N-arilpirazol para usar contra la diabetes |
| EP2083816A2 (en) * | 2006-10-27 | 2009-08-05 | Brystol-Myers Squibb Company | Heterocyclic amide compounds useful as kinase inhibitors |
| MX2009004625A (es) * | 2006-10-30 | 2009-05-15 | Novartis Ag | Derivados de 3-amino-pirazol-4-carboxamida utiles como inhibidores de proteina cinasas. |
| EP2099779A1 (en) * | 2006-12-20 | 2009-09-16 | Brystol-Myers Squibb Company | Crystalline forms of aryl-substituted pyrazole-amide compounds |
| US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| JP5361857B2 (ja) | 2007-03-23 | 2013-12-04 | ファイザー・リミテッド | イオンチャネルの阻害剤 |
| WO2008121786A1 (en) * | 2007-03-29 | 2008-10-09 | Smithkline Beecham Corporation | Inhibitors of akt activity |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| BRPI0812163A2 (pt) | 2007-05-25 | 2014-12-16 | Abbott Gmbh & Co Kg | Compostos heterocíclicos como moduladores positivos do receptor metabotrópico de glutamato 2 (receptor mglu2) |
| CN101743226B (zh) | 2007-07-17 | 2012-10-10 | 霍夫曼-拉罗奇有限公司 | 11β-羟基类固醇脱氢酶抑制剂 |
| CN101754962B (zh) | 2007-07-19 | 2013-12-25 | 赛马拜制药公司 | 作为rup3或gpr119受体的激动剂治疗糖尿病和代谢性病症的n-氮杂环状经取代吡咯、吡唑、咪唑、三唑和四唑衍生物 |
| TW201446748A (zh) | 2007-08-22 | 2014-12-16 | Astrazeneca Ab | 環丙基醯胺衍生物 |
| WO2009055033A1 (en) | 2007-10-26 | 2009-04-30 | Amgen Inc. | Pyrazolo-pyridinone derivatives and methods of use |
| US8309580B2 (en) | 2007-11-01 | 2012-11-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| NZ588011A (en) | 2008-03-05 | 2012-06-29 | Takeda Pharmaceutical | Heterocyclic compounds having glucagon antagonistic action useful for treating diabetes |
| WO2009140342A1 (en) * | 2008-05-16 | 2009-11-19 | Schering Corporation | Glucagon receptor antagonists, compositions, and methods for their use |
| EP2151434A1 (en) | 2008-08-05 | 2010-02-10 | Institut Pasteur | Alkoxypyrazoles and the process for their preparation |
| MX2011001601A (es) | 2008-08-14 | 2011-03-29 | Bayer Cropscience Ag | 4-fenil-1h-pirazoles insecticidas. |
| EP2184273A1 (de) * | 2008-11-05 | 2010-05-12 | Bayer CropScience AG | Halogen-substituierte Verbindungen als Pestizide |
| US8969350B2 (en) | 2008-12-18 | 2015-03-03 | Astrazeneca Ab | Pharmaceutical product comprising a p38 kinase inhibitor and a second active ingredient |
| UY32088A (es) * | 2009-02-06 | 2010-08-31 | Takeda Pharmaceutical | Compuesto heterociclico |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| ES2497566T3 (es) | 2009-10-01 | 2014-09-23 | Cymabay Therapeutics, Inc. | Sales de tetrazol-1-il-fenoximetil-tiazol-2-il-piperidinil-pirimidina sustituida |
| NZ602110A (en) | 2010-02-18 | 2014-09-26 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
| RU2639876C2 (ru) | 2010-03-30 | 2017-12-25 | Версеон Корпорейшн | Мультизамещенные ароматические соединения в качестве ингибиторов тромбина |
| CA2794801C (en) | 2010-04-07 | 2019-01-15 | F. Hoffmann-La Roche Ag | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| US8293738B2 (en) | 2010-05-12 | 2012-10-23 | Abbott Laboratories | Indazole inhibitors of kinase |
| WO2012138809A1 (en) * | 2011-04-05 | 2012-10-11 | Dawei Zhang | Heterocyclic compounds as kinase inhibitors |
| US9630976B2 (en) | 2012-07-03 | 2017-04-25 | Ono Pharmaceutical Co., Ltd. | Compound having agonistic activity on somatostatin receptor, and use thereof for medical purposes |
| RU2666730C2 (ru) | 2012-12-07 | 2018-09-12 | Кемосентрикс, Инк. | Диазольные лактамы |
| US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
| CN104918921B (zh) | 2012-12-21 | 2017-09-22 | 凯莫森特里克斯股份有限公司 | 二唑酰胺 |
| MX373964B (es) | 2013-03-15 | 2020-07-13 | Verseon Corp | Compuestos aromaticos multisustituidos como inhibidores de serina proteasa. |
| US9951025B2 (en) * | 2013-03-15 | 2018-04-24 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
| MX379228B (es) | 2013-03-15 | 2025-03-10 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulación de la hemoglobina. |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| EP3076789A4 (en) * | 2013-12-04 | 2017-11-22 | The Scripps Research Institute | Novel compounds as jnk kinase inhibitors |
| WO2015104662A1 (en) | 2014-01-10 | 2015-07-16 | Aurigene Discovery Technologies Limited | Indazole compounds as irak4 inhibitors |
| NZ722019A (en) | 2014-01-13 | 2022-07-01 | Aurigene Discovery Tech Ltd | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
| WO2015143654A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| WO2015143652A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| WO2015143653A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| JP6434048B2 (ja) * | 2014-04-02 | 2018-12-05 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 農薬としてのヘテロ環式化合物 |
| WO2015170218A1 (en) * | 2014-05-07 | 2015-11-12 | Pfizer Inc. | Tropomyosin-related kinase inhibitors |
| US10356904B2 (en) * | 2014-05-14 | 2019-07-16 | AT&S Austria Technologie & Systemtechnik Aktiengesellshaft | Conductor track with enlargement-free transition between conductor path and contact structure |
| RU2583158C2 (ru) * | 2014-06-06 | 2016-05-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" | Метил 5-(арилкарбамоил)-1-(бензил и фенил)-4-циннамоил-1н-пиразол-3-карбоксилаты, проявляющие анальгетическую активность, и способ их получения |
| MX2016017147A (es) * | 2014-06-20 | 2017-06-07 | Aurigene Discovery Tech Ltd | Compuestos de indazole substituidos como inhibidores de irak4. |
| US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| SI3261639T1 (sl) | 2015-02-27 | 2023-01-31 | Verseon International Corporation | Substituirane pirazolne spojine kot zaviralci serinskih proteaz |
| WO2016161572A1 (en) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| WO2016202935A1 (en) | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| PT3395801T (pt) | 2015-12-16 | 2021-05-24 | Nippon Soda Co | Composto de arilazol e agente de controlo de pragas |
| BR112018070361A2 (pt) | 2016-04-07 | 2019-01-29 | Chemocentryx Inc | redução da carga tumoral através da administração de antagonistas do ccr1 em combinação com inibidores de pd-1 ou inibidores de pd-l1 |
| CN109862896A (zh) | 2016-08-03 | 2019-06-07 | 西玛贝医药公司 | 用于治疗炎症性胃肠疾病或胃肠病症的氧亚甲基芳基化合物 |
| NZ750416A (en) | 2016-09-15 | 2022-04-29 | Boehringer Ingelheim Int | Heteroaryl carboxamide compounds as inhibitors of ripk2 |
| US10414753B2 (en) * | 2016-10-26 | 2019-09-17 | Rigel Pharmaceuticals, Inc. | Amide compounds and method for making and using |
| ES2902527T3 (es) * | 2016-11-03 | 2022-03-28 | Bristol Myers Squibb Co | Derivados biciclo heterocíclicos sustituidos, útiles como inhibidores del canal ROMK |
| TWI795381B (zh) * | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| IL305150B2 (en) | 2017-03-31 | 2025-03-01 | Aurigene Oncology Ltd | Compounds and preparations for the treatment of hematological disorders |
| PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| SI3704108T1 (sl) | 2017-10-31 | 2024-07-31 | Curis, Inc. | Inhibitor irak4 v kombinaciji z inhibitorjem bcl-2 za uporabo pri zdravljenju raka |
| CN110028450A (zh) * | 2018-01-12 | 2019-07-19 | 沈阳中化农药化工研发有限公司 | 一种吡唑酰胺类化合物的制备方法 |
| JP7476167B2 (ja) | 2018-04-06 | 2024-04-30 | アルトス ラブス，インコーポレーテッド | Ａｔｆ６阻害剤およびその使用 |
| JP7296408B2 (ja) | 2018-06-18 | 2023-06-22 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤としてのピラゾール誘導体 |
| JP7296407B2 (ja) | 2018-06-18 | 2023-06-22 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤としてのピラゾール誘導体 |
| MA53096A (fr) * | 2018-07-03 | 2021-05-12 | Ifm Due Inc | Composés et compositions destinés au traitement d'états pathologiques associés à une activité de sting |
| MA55593A (fr) | 2019-04-11 | 2022-02-16 | Janssen Pharmaceutica Nv | Cycles pyridine contenant des dérivés servant d'inhibiteurs de malt1 |
| US11427558B1 (en) | 2019-07-11 | 2022-08-30 | ESCAPE Bio, Inc. | Indazoles and azaindazoles as LRRK2 inhibitors |
| EP4319750A4 (en) | 2021-04-08 | 2025-02-26 | Curis, Inc. | COMBINATION THERAPIES FOR THE TREATMENT OF CANCER |
| WO2024226603A1 (en) * | 2023-04-24 | 2024-10-31 | Regents Of The University Of Minnesota | Therapeutic compounds |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4134987A (en) * | 1976-01-14 | 1979-01-16 | Huppatz John L | Compounds and compositions |
| US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
| JPH04316559A (ja) | 1990-11-28 | 1992-11-06 | Nissan Chem Ind Ltd | ピラゾールカルボキサニリド誘導体及び殺菌剤 |
| GB9816837D0 (en) | 1998-08-04 | 1998-09-30 | Zeneca Ltd | Amide derivatives |
| KR100214732B1 (ko) * | 1992-12-14 | 1999-08-02 | 세야 히로미치 | 유리제품의 성형 방법 및 장치 |
| US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
| US6147080A (en) | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US6020357A (en) * | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| AUPO622597A0 (en) * | 1997-04-15 | 1997-05-08 | Fujisawa Pharmaceutical Co., Ltd. | New heterocyclic compounds |
| US5998424A (en) * | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
| CN1271279A (zh) * | 1997-09-23 | 2000-10-25 | 普尼卡有限公司 | 用于治疗细胞因子介导性疾病的酰胺类衍生物 |
| US6316466B1 (en) * | 1998-05-05 | 2001-11-13 | Syntex (U.S.A.) Llc | Pyrazole derivatives P-38 MAP kinase inhibitors |
| WO1999058523A1 (en) | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| US6200968B1 (en) | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| IL141979A0 (en) * | 1998-09-25 | 2002-03-10 | Astrazeneca Ab | Benzamide derivatives and their use as cytokine inhibitors |
| RU2240998C2 (ru) | 1998-12-04 | 2004-11-27 | Бристол-Маерс Сквибб Компани | Производные 3-замещенного 4-арилхинолин-2-она в качестве модуляторов калиевых каналов |
| AU2460600A (en) * | 1999-02-10 | 2000-08-29 | Mitsubishi Pharma Corporation | Amide compounds and medicinal use thereof |
| US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
| JP4627944B2 (ja) | 1999-06-03 | 2011-02-09 | あすか製薬株式会社 | 置換ピラゾール化合物 |
| FR2795726A1 (fr) * | 1999-06-30 | 2001-01-05 | Aventis Cropscience Sa | Nouveaux pyrazoles fongicides |
| WO2001036376A1 (en) | 1999-11-18 | 2001-05-25 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| US6569885B1 (en) | 1999-12-23 | 2003-05-27 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US6194132B1 (en) * | 1999-12-28 | 2001-02-27 | Eastman Kodak Company | Photographic element, compound, and process |
| US6197492B1 (en) * | 1999-12-28 | 2001-03-06 | Eastman Kodak Company | Photographic element, compound, and process |
| US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| US6906067B2 (en) | 1999-12-28 | 2005-06-14 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of TNF-α expression |
| HN2001000008A (es) | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
| MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| MXPA03000923A (es) * | 2000-07-31 | 2003-06-09 | Smithkline Beecham Plc | Compuestos de carboxamida y su uso como antagonistas de un receptor 11cby humano. |
| AU2001280099A1 (en) * | 2000-08-25 | 2002-04-02 | Sankyo Company Limited | 4-acylaminopyrazole derivatives |
| GB2384776C (en) | 2000-10-30 | 2006-02-03 | Kudos Pharm Ltd | Phthalazinone derivatives |
| GB0102687D0 (en) | 2001-02-02 | 2001-03-21 | Pharmacia & Upjohn Spa | Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them |
| CA2445357A1 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Pyrazole derived kinase inhibitors |
| DE60214703T2 (de) | 2001-06-01 | 2007-09-13 | Vertex Pharmaceuticals Inc., Cambridge | Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen |
| HUP0401711A3 (en) | 2001-06-26 | 2009-07-28 | Bristol Myers Squibb Co | N-heterocyclic inhibitors of tnf-alpha and pharmaceutical compositions containing them |
| WO2003037274A2 (en) | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Pyrazole-amides and-sulfonamides |
| AU2002357137A1 (en) | 2001-12-10 | 2003-06-23 | Bristol-Myers Squibb Company | (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase |
| US6521395B1 (en) * | 2002-01-30 | 2003-02-18 | Eastman Kodak Company | Infrared couplers for incorporating and recovering metadata |
| WO2003064389A1 (en) | 2002-01-31 | 2003-08-07 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient |
| US7541477B2 (en) * | 2002-07-30 | 2009-06-02 | Banyu Pharmaceutical Co., Ltd. | Antagonists to melanin-concentrating hormone receptor comprising benzimidazole derivative as active ingredient |
| CN1703395A (zh) | 2002-08-09 | 2005-11-30 | 特兰斯泰克制药公司 | 芳基和杂芳基化合物以及调节凝血的方法 |
| AU2003301443A1 (en) | 2002-10-18 | 2004-05-04 | E.I. Du Pont De Nemours And Company | Azolecarboxamide herbicides |
| AU2003296404A1 (en) * | 2003-01-06 | 2004-08-10 | Eli Lilly And Company | Heterocyclic ppar modulators |
| DE602004028907D1 (de) | 2003-02-06 | 2010-10-14 | Bristol Myers Squibb Co | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis |
| WO2004099156A1 (en) * | 2003-05-01 | 2004-11-18 | Bristol-Myers Squibb Company | Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors |
| WO2004106324A1 (en) | 2003-05-27 | 2004-12-09 | E.I. Dupont De Nemours And Company | Azolecarboxamide herbicides |
| US7419978B2 (en) | 2003-10-22 | 2008-09-02 | Bristol-Myers Squibb Company | Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors |
| GB0329572D0 (en) | 2003-12-20 | 2004-01-28 | Astrazeneca Ab | Amide derivatives |
| US7491725B2 (en) | 2004-02-06 | 2009-02-17 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
| TWI338004B (en) | 2004-02-06 | 2011-03-01 | Bristol Myers Squibb Co | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
| US7652146B2 (en) | 2004-02-06 | 2010-01-26 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors |
| US20060069132A1 (en) | 2004-04-07 | 2006-03-30 | Armel Gregory R | Azolecarboxamide herbicides |
| WO2007002742A1 (en) | 2005-06-28 | 2007-01-04 | Pharmacopeia, Inc. | Substituted [1,4]-diazepanes as cxcr3 antagonists and their use in the treatment of inflammatory disorders |
-
2004
- 2004-05-03 WO PCT/US2004/013604 patent/WO2004099156A1/en not_active Ceased
- 2004-05-03 AT AT04751133T patent/ATE482200T1/de active
- 2004-05-03 CN CNA2004800188458A patent/CN1816529A/zh active Pending
- 2004-05-03 MX MXPA05011666A patent/MXPA05011666A/es active IP Right Grant
- 2004-05-03 BR BRPI0409949-4A patent/BRPI0409949A/pt not_active IP Right Cessation
- 2004-05-03 ES ES09010209T patent/ES2370463T3/es not_active Expired - Lifetime
- 2004-05-03 US US10/838,006 patent/US7151113B2/en not_active Expired - Lifetime
- 2004-05-03 UA UAA200511373A patent/UA81668C2/ru unknown
- 2004-05-03 EP EP11005867.4A patent/EP2385041B1/en not_active Expired - Lifetime
- 2004-05-03 EP EP04760705A patent/EP1620108B1/en not_active Expired - Lifetime
- 2004-05-03 KR KR1020057020642A patent/KR20060022649A/ko not_active Ceased
- 2004-05-03 DE DE602004029242T patent/DE602004029242D1/de not_active Expired - Lifetime
- 2004-05-03 DK DK04751133.2T patent/DK1618092T3/da active
- 2004-05-03 PT PT04751133T patent/PT1618092E/pt unknown
- 2004-05-03 EP EP04760683A patent/EP1617840A4/en not_active Withdrawn
- 2004-05-03 US US10/838,129 patent/US7396935B2/en not_active Expired - Lifetime
- 2004-05-03 ES ES04751133T patent/ES2350837T3/es not_active Expired - Lifetime
- 2004-05-03 RS YUP-2005/0789A patent/RS20050789A/sr unknown
- 2004-05-03 RU RU2005135162/04A patent/RU2342365C2/ru not_active IP Right Cessation
- 2004-05-03 SI SI200431517T patent/SI1618092T1/sl unknown
- 2004-05-03 JP JP2006514216A patent/JP4601611B2/ja not_active Expired - Fee Related
- 2004-05-03 CA CA002524321A patent/CA2524321A1/en not_active Abandoned
- 2004-05-03 HR HR20100670T patent/HRP20100670T1/hr unknown
- 2004-05-03 PL PL04751133T patent/PL1618092T3/pl unknown
- 2004-05-03 EP EP04751133A patent/EP1618092B1/en not_active Expired - Lifetime
- 2004-05-03 AT AT09010209T patent/ATE522525T1/de not_active IP Right Cessation
- 2004-05-03 US US10/837,778 patent/US7414056B2/en not_active Expired - Lifetime
- 2004-05-03 AU AU2004236240A patent/AU2004236240C1/en not_active Ceased
- 2004-05-03 NZ NZ543375A patent/NZ543375A/en unknown
- 2004-05-03 EP EP09010209A patent/EP2133348B1/en not_active Expired - Lifetime
- 2004-05-03 WO PCT/US2004/013594 patent/WO2004098518A2/en not_active Ceased
- 2004-05-03 WO PCT/US2004/013786 patent/WO2004098528A2/en not_active Ceased
- 2004-05-03 ES ES04760705T patent/ES2386784T3/es not_active Expired - Lifetime
- 2004-05-03 GE GEAP20049086A patent/GEP20074236B/en unknown
-
2005
- 2005-10-26 NO NO20054970A patent/NO20054970L/no not_active Application Discontinuation
- 2005-10-28 IS IS8101A patent/IS8101A/is unknown
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- 2005-11-01 CO CO05111218A patent/CO5640039A2/es not_active Application Discontinuation
-
2006
- 2006-06-28 US US11/477,010 patent/US7253170B2/en not_active Expired - Lifetime
-
2007
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- 2007-10-31 US US11/931,309 patent/US7390810B2/en not_active Expired - Lifetime
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2008
- 2008-05-12 US US12/118,794 patent/US7605273B2/en not_active Expired - Lifetime
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2009
- 2009-09-18 US US12/562,383 patent/US20100016320A1/en not_active Abandoned
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