HUP0302966A2 - Karboxamid-vegyületek és alkalmazásuk humán 11CBY receptor antagonistákként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Karboxamid-vegyületek és alkalmazásuk humán 11CBY receptor antagonistákként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0302966A2 HUP0302966A2 HU0302966A HUP0302966A HUP0302966A2 HU P0302966 A2 HUP0302966 A2 HU P0302966A2 HU 0302966 A HU0302966 A HU 0302966A HU P0302966 A HUP0302966 A HU P0302966A HU P0302966 A2 HUP0302966 A2 HU P0302966A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- heterocyclic ring
- general formula
- antagonists
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 Carboxamide compounds Chemical class 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000028683 bipolar I disease Diseases 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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Abstract
A találmány (I) általános képletű humán 11CBy receptor antagonistákalkalmazására vonatkozik cukorbetegség, major depresszió, mániásdepresszió, szorongás, skizofrénia és alvási rendellenességekkezelésére szánt gyógyászati készítmény előállítására. A találmánytárgyát képezik az (I) általános képletű vegyületeken belül maguk azúj vegyületek is, valamint eljárás ezek előállítására. Az (I)általános képletben: mindegyik A jelentése egymástól függetlenülhidrogénatom, alkilcsoport, alkoxi-, alkenil- vagy acilcsoport, vagyhalogénatom vagy hidroxilcsoport, CN vagy CF3 képletű csoport; R3jelentése hidrogénatom, metil- vagy etilcsoport, R4 jelentése aromáskarbociklusos vagy heterociklusos gyűrű, Z jelentése oxigén- vagykénatom, vagy egy NH vagy CH2 csoport, vagy egyes kötés, az R4 3- vagy4-helyzetében a karbonilcsoporthoz képest, R5 jelentése aromáskarbociklusos vagy heterociklusos gyűrű, vagy egy telített vagytelítetlen, karbociklusos vagy heterociklusos gyűrű, Q jelentése -X-Y-NR1R2 általános képletű csoport. Ó
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GBGB0018758.3A GB0018758D0 (en) | 2000-07-31 | 2000-07-31 | Novel use and compunds |
GB0112544A GB0112544D0 (en) | 2001-05-23 | 2001-05-23 | Novel use and compounds |
PCT/EP2001/008637 WO2002010146A1 (en) | 2000-07-31 | 2001-07-26 | Carboxamide compounds and their use as antagonists of a human 11cby receptor |
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HUP0302966A2 true HUP0302966A2 (hu) | 2003-12-29 |
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HU0302966A HUP0302966A2 (hu) | 2000-07-31 | 2001-07-26 | Karboxamid-vegyületek és alkalmazásuk humán 11CBY receptor antagonistákként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
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EP (1) | EP1305304A1 (hu) |
JP (1) | JP2004505070A (hu) |
KR (1) | KR20030059084A (hu) |
CN (1) | CN1444573A (hu) |
AP (1) | AP2003002720A0 (hu) |
AU (1) | AU2001278508A1 (hu) |
BG (1) | BG107510A (hu) |
BR (1) | BR0112856A (hu) |
CA (1) | CA2417638A1 (hu) |
CZ (1) | CZ2003297A3 (hu) |
EA (1) | EA200300064A1 (hu) |
HU (1) | HUP0302966A2 (hu) |
IL (1) | IL153645A0 (hu) |
MA (1) | MA25829A1 (hu) |
MX (1) | MXPA03000923A (hu) |
NO (1) | NO20030471L (hu) |
OA (1) | OA12346A (hu) |
PL (1) | PL365183A1 (hu) |
SK (1) | SK1142003A3 (hu) |
WO (1) | WO2002010146A1 (hu) |
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AU2003222648A1 (en) * | 2002-05-13 | 2003-12-02 | Eli Lilly And Company | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes |
US7141561B2 (en) | 2002-07-25 | 2006-11-28 | Sanofi-Aventis Deutschland Gmbh | Substituted diaryl heterocycles, process for their preparation and their use as medicaments |
DE10233817A1 (de) * | 2002-07-25 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
BRPI0409949A (pt) * | 2003-05-01 | 2006-04-25 | Bristol Myers Squibb Co | compostos de pirazol amida aril-substituìda úteis como inibidores de cinase |
EP2256106B1 (en) | 2003-07-22 | 2015-05-06 | Astex Therapeutics Limited | 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
US7037927B2 (en) | 2003-10-16 | 2006-05-02 | Abbott Laboratories | Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
US7241787B2 (en) | 2004-01-25 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments |
EP1720826A4 (en) * | 2004-03-02 | 2007-10-31 | Neurogen Corp | HETEROALKYL SUBSTITUTED BIPHENYL-4-CARBOXYL ACRYLAMIDE ANALOG |
US7605176B2 (en) | 2004-03-06 | 2009-10-20 | Boehringer Ingelheim International Gmbh | β-ketoamide compounds with MCH antagonistic activity |
DE102004010893A1 (de) * | 2004-03-06 | 2005-09-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue ß-Ketoamid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
DE102004039789A1 (de) | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
US7807706B2 (en) | 2005-08-12 | 2010-10-05 | Astrazeneca Ab | Metabotropic glutamate-receptor-potentiating isoindolones |
US8618115B2 (en) | 2005-10-26 | 2013-12-31 | Bristol-Myers Squibb Company | Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them |
US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
MY149854A (en) | 2006-02-15 | 2013-10-31 | Sanofi Aventis | Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
GB0625523D0 (en) * | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
TWI417100B (zh) | 2007-06-07 | 2013-12-01 | Astrazeneca Ab | 二唑衍生物及其作為代謝型麩胺酸受體增效劑-842之用途 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
PE20091928A1 (es) | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
US7790760B2 (en) | 2008-06-06 | 2010-09-07 | Astrazeneca Ab | Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286 |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
US8338367B2 (en) | 2008-10-15 | 2012-12-25 | Boehringer Ingelheim International Gmbh | Fused heteroaryl diamide compounds useful as MMP-13 inhibitors |
CA2738929A1 (en) | 2008-10-17 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as mmp-13 inhibitors |
AR075402A1 (es) | 2009-02-13 | 2011-03-30 | Sanofi Aventis | Derivados heterociclicos oxigenados y/o nitrogenados de tetrahidronaftaleno, medicamentos que los contienen y uso de los mismos en el tratamiento de trastornos metabolicos, tales como obesidad,entre otros. |
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WO2013130968A1 (en) * | 2012-03-01 | 2013-09-06 | University Of Cincinnati | Ros-activated compounds as selective anti-cancer therapeutics |
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ZA985542B (en) * | 1997-07-03 | 1999-04-07 | Smithkline Beecham Corp | Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents |
EP1100485A4 (en) * | 1998-07-28 | 2004-06-09 | Smithkline Beecham Corp | SUBSTITUTED ANILIDE COMPOUNDS AND RELATED METHODS |
NZ514095A (en) * | 1999-02-10 | 2001-09-28 | Welfide Corp | Amide compounds and medicinal use thereof |
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- 2001-07-26 HU HU0302966A patent/HUP0302966A2/hu unknown
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- 2001-07-26 AU AU2001278508A patent/AU2001278508A1/en not_active Abandoned
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CA2417638A1 (en) | 2002-02-07 |
MXPA03000923A (es) | 2003-06-09 |
CN1444573A (zh) | 2003-09-24 |
KR20030059084A (ko) | 2003-07-07 |
PL365183A1 (en) | 2004-12-27 |
MA25829A1 (fr) | 2003-07-01 |
BR0112856A (pt) | 2003-07-01 |
IL153645A0 (en) | 2003-07-06 |
AP2003002720A0 (en) | 2003-06-30 |
NO20030471D0 (no) | 2003-01-30 |
CZ2003297A3 (cs) | 2003-05-14 |
SK1142003A3 (en) | 2003-06-03 |
EA200300064A1 (ru) | 2003-06-26 |
WO2002010146A1 (en) | 2002-02-07 |
EP1305304A1 (en) | 2003-05-02 |
JP2004505070A (ja) | 2004-02-19 |
OA12346A (en) | 2004-04-13 |
NO20030471L (no) | 2003-03-28 |
AU2001278508A1 (en) | 2002-02-13 |
BG107510A (bg) | 2003-09-30 |
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