RS39704A - Novi 1,2,4-tiadiazolijum derivati kao modulatori melanokortinskog receptora - Google Patents

Novi 1,2,4-tiadiazolijum derivati kao modulatori melanokortinskog receptora

Info

Publication number
RS39704A
RS39704A YU39704A YUP39704A RS39704A RS 39704 A RS39704 A RS 39704A YU 39704 A YU39704 A YU 39704A YU P39704 A YUP39704 A YU P39704A RS 39704 A RS39704 A RS 39704A
Authority
RS
Serbia
Prior art keywords
new
receptor modulators
melanocortine
derivatives
thiadiazolium derivatives
Prior art date
Application number
YU39704A
Other languages
English (en)
Inventor
Magdalena Eisinger
Louis Fitzpatrick
Daniel Lee
Kevin Pan
Carlos Plata-Salaman
Allen Reitz
Virginia Smith-Swintosky
Boyu Zhao
Original Assignee
Ortho-Mcneil Pharmaceutical Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical Corporation filed Critical Ortho-Mcneil Pharmaceutical Corporation
Publication of RS39704A publication Critical patent/RS39704A/sr
Publication of RS51530B publication Critical patent/RS51530B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Ovaj pronalazak je usmeren na nove derivate 1,2,4-tiadiazola formule (II): gde su R1, R2 i R4 radikali koje sadrži prsten, koji sukorisni kao agonisti ili antagonisti receptora melankortina. Odredenije, jedinjenja iz ovog pronalaska su korisna za tretman metaboličkih, CNS i dermatoloških poremećaja.
YUP-397/04A 2001-11-08 2002-11-04 Novi 1,2,4-tiadiazolijum derivati kao modulatori melanokortinskog receptora RS51530B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33792701P 2001-11-08 2001-11-08
PCT/US2002/035340 WO2003040117A1 (en) 2001-11-08 2002-11-04 Novel 1,2,4-thiadiazole derivatives as melanocortin receptor modulators

Publications (2)

Publication Number Publication Date
RS39704A true RS39704A (sr) 2006-10-27
RS51530B RS51530B (sr) 2011-06-30

Family

ID=23322615

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-397/04A RS51530B (sr) 2001-11-08 2002-11-04 Novi 1,2,4-tiadiazolijum derivati kao modulatori melanokortinskog receptora

Country Status (26)

Country Link
US (2) US7049331B2 (sr)
EP (1) EP1446394B1 (sr)
JP (1) JP4436676B2 (sr)
CN (1) CN1312139C (sr)
AR (1) AR037331A1 (sr)
AT (1) ATE344254T1 (sr)
AU (1) AU2009201842B2 (sr)
BR (1) BR0214024A (sr)
CA (1) CA2466140C (sr)
CY (1) CY1105907T1 (sr)
DE (1) DE60215848T2 (sr)
DK (1) DK1446394T3 (sr)
ES (1) ES2275918T3 (sr)
IL (1) IL161829A (sr)
MX (1) MXPA04004458A (sr)
MY (1) MY134993A (sr)
NO (1) NO328195B1 (sr)
NZ (1) NZ532883A (sr)
PT (1) PT1446394E (sr)
RS (1) RS51530B (sr)
RU (1) RU2317292C2 (sr)
SG (1) SG176310A1 (sr)
SI (1) SI1446394T1 (sr)
TW (1) TWI328586B (sr)
WO (1) WO2003040117A1 (sr)
ZA (1) ZA200404484B (sr)

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AU2002331064B2 (en) 2001-08-10 2007-08-23 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7319107B2 (en) * 2001-11-08 2008-01-15 Johnson & Johnson Consumer Companies, Inc. 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators
PT1446394E (pt) * 2001-11-08 2007-01-31 Ortho Mcneil Pharm Inc Novos derivados de 1,2,4-tiadiazole como moduladores do receptor da melanocortina
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7968548B2 (en) * 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
WO2005054849A2 (en) * 2003-12-06 2005-06-16 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor mc5 (mc5r)
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7820704B2 (en) 2004-04-20 2010-10-26 Transtech Pharma, Inc. Substituted heteroaryl derivatives, compositions, and methods of use
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
EP2127676A3 (en) 2004-11-01 2013-09-04 Amylin Pharmaceuticals, LLC Treatment of obesity and related disorders
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
CA2617649A1 (en) 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
BRPI0614649A2 (pt) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc polipeptìdeos hìbridos com propriedades selecionáveis
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
US7704533B2 (en) * 2006-12-13 2010-04-27 J&J Consumer Companies, Inc. Compositions and methods of inducing hair growth utilizing Continus coggygria
WO2008071438A2 (en) * 2006-12-14 2008-06-19 Neuronova Ab Treatment of disease or injury of the nervous system using agents that decrease the activity of the melanocortin 4 receptor
ES2453640T3 (es) 2008-02-21 2014-04-08 Janssen Pharmaceutica N.V. Métodos para el tratamiento de desordenes dermatológicos
US8377925B2 (en) 2008-02-29 2013-02-19 Mimetica Pty Ltd Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor
US8008291B2 (en) 2008-02-29 2011-08-30 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists
US8343958B2 (en) 2008-02-29 2013-01-01 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5-receptor antagonists
US8563742B2 (en) 2008-08-29 2013-10-22 High Point Pharmaceuticals, Llc Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use
CA2743489A1 (en) 2008-11-17 2010-05-20 Merck Sharp & Dohme Corp. Substituted bicyclic amines for the treatment of diabetes
BRPI1013853A2 (pt) * 2009-04-24 2019-09-24 Janssen Pharmaceuticals Inc composições tópicas estáveis de derivados de 1,2,4-tiadiazol
WO2011011506A1 (en) 2009-07-23 2011-01-27 Schering Corporation Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
WO2011011508A1 (en) 2009-07-23 2011-01-27 Schering Corporation Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
ES2360783B1 (es) * 2009-10-02 2012-07-04 Consejo Superior De Investigaciones Científicas (Csic) 1,2,4-tiadiazoles-5-imino sustituidos utiles en el tratamiento de enfermedades neurodegenerativas
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Also Published As

Publication number Publication date
EP1446394A1 (en) 2004-08-18
EP1446394B1 (en) 2006-11-02
CA2466140C (en) 2011-02-01
ES2275918T3 (es) 2007-06-16
NO20042372L (no) 2004-06-07
AU2009201842B2 (en) 2011-06-16
NO328195B1 (no) 2010-01-04
WO2003040117A1 (en) 2003-05-15
JP4436676B2 (ja) 2010-03-24
US20060128772A1 (en) 2006-06-15
CN1617862A (zh) 2005-05-18
NZ532883A (en) 2007-09-28
RS51530B (sr) 2011-06-30
AR037331A1 (es) 2004-11-03
PT1446394E (pt) 2007-01-31
TW200303311A (en) 2003-09-01
AU2009201842A1 (en) 2009-06-04
ZA200404484B (en) 2005-12-28
SG176310A1 (en) 2011-12-29
CA2466140A1 (en) 2003-05-15
ATE344254T1 (de) 2006-11-15
US7375123B2 (en) 2008-05-20
MY134993A (en) 2008-01-31
DE60215848T2 (de) 2007-04-19
CN1312139C (zh) 2007-04-25
RU2317292C2 (ru) 2008-02-20
US20030176425A1 (en) 2003-09-18
TWI328586B (en) 2010-08-11
JP2005511605A (ja) 2005-04-28
IL161829A0 (en) 2005-11-20
US7049331B2 (en) 2006-05-23
IL161829A (en) 2010-11-30
RU2004114214A (ru) 2005-10-27
DE60215848D1 (de) 2006-12-14
BR0214024A (pt) 2004-12-07
MXPA04004458A (es) 2005-06-08
DK1446394T3 (da) 2007-03-12
CY1105907T1 (el) 2011-02-02
SI1446394T1 (sl) 2007-04-30

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