JP2006515339A5 - - Google Patents
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- Publication number
- JP2006515339A5 JP2006515339A5 JP2006500034A JP2006500034A JP2006515339A5 JP 2006515339 A5 JP2006515339 A5 JP 2006515339A5 JP 2006500034 A JP2006500034 A JP 2006500034A JP 2006500034 A JP2006500034 A JP 2006500034A JP 2006515339 A5 JP2006515339 A5 JP 2006515339A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- group
- phenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 127
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 46
- 125000003545 alkoxy group Chemical group 0.000 claims description 42
- 229910052736 halogen Inorganic materials 0.000 claims description 23
- 150000002367 halogens Chemical group 0.000 claims description 23
- 229910052739 hydrogen Inorganic materials 0.000 claims description 23
- 239000001257 hydrogen Substances 0.000 claims description 23
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 18
- 125000003342 alkenyl group Chemical group 0.000 claims description 17
- 125000001072 heteroaryl group Chemical group 0.000 claims description 17
- 150000002431 hydrogen Chemical class 0.000 claims description 17
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Chemical group C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 13
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims description 10
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 10
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 10
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 10
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical group C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 10
- 125000000304 alkynyl group Chemical group 0.000 claims description 9
- 125000004076 pyridyl group Chemical group 0.000 claims description 9
- 125000001424 substituent group Chemical group 0.000 claims description 9
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 8
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims description 5
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 5
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 5
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims description 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 5
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical group C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 5
- DZJXKISLUDYJSV-UHFFFAOYSA-N [N].C1CCNC1 Chemical compound [N].C1CCNC1 DZJXKISLUDYJSV-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 5
- 150000004677 hydrates Chemical class 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000012453 solvate Substances 0.000 claims description 5
- 241000725303 Human immunodeficiency virus Species 0.000 claims description 4
- 229930192474 thiophene Chemical group 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 230000001404 mediated effect Effects 0.000 claims description 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 8
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 8
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- -1 substituted Chemical class 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 0 CC1OCC*C1 Chemical compound CC1OCC*C1 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44797403P | 2003-02-18 | 2003-02-18 | |
| PCT/EP2004/001477 WO2004074257A1 (en) | 2003-02-18 | 2004-02-17 | Non-nucleoside reverse transcriptase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006515339A JP2006515339A (ja) | 2006-05-25 |
| JP2006515339A5 true JP2006515339A5 (enExample) | 2009-12-10 |
| JP4608480B2 JP4608480B2 (ja) | 2011-01-12 |
Family
ID=32908518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006500034A Expired - Fee Related JP4608480B2 (ja) | 2003-02-18 | 2004-02-17 | 非ヌクレオシド逆転写酵素インヒビター |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7241794B2 (enExample) |
| EP (1) | EP1597235B1 (enExample) |
| JP (1) | JP4608480B2 (enExample) |
| KR (1) | KR100776093B1 (enExample) |
| CN (1) | CN100389109C (enExample) |
| AR (1) | AR043195A1 (enExample) |
| AT (1) | ATE370124T1 (enExample) |
| BR (1) | BRPI0407591A (enExample) |
| CA (1) | CA2515151C (enExample) |
| CL (1) | CL2004000270A1 (enExample) |
| DE (1) | DE602004008227T2 (enExample) |
| ES (1) | ES2291854T3 (enExample) |
| MX (1) | MXPA05008748A (enExample) |
| PL (1) | PL378556A1 (enExample) |
| RU (1) | RU2305680C2 (enExample) |
| TW (1) | TW200423930A (enExample) |
| WO (1) | WO2004074257A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2524397A1 (en) * | 2003-05-07 | 2004-11-18 | Pfizer Products Inc. | Cannabinoid receptor ligands and uses thereof |
| JP4993407B2 (ja) | 2004-08-04 | 2012-08-08 | 大正製薬株式会社 | トリアゾール誘導体 |
| UA87884C2 (uk) * | 2004-12-03 | 2009-08-25 | Мерк Энд Ко., Инк. | Безводна кристалічна калієва сіль інгібітора віл-інтегрази |
| PL1988083T3 (pl) | 2006-02-03 | 2014-08-29 | Taisho Pharmaceutical Co Ltd | Pochodna triazolowa |
| RU2395499C2 (ru) | 2006-02-06 | 2010-07-27 | Тайсо Фармасьютикал Ко., Лтд. | Ингибитор связывания сфингозин-1-фосфата |
| KR101401139B1 (ko) * | 2006-02-14 | 2014-05-29 | 이하라케미칼 고교가부시키가이샤 | 5-알콕시-4-히드록시메틸피라졸 화합물의 제조방법 |
| CL2007002105A1 (es) * | 2006-07-21 | 2008-02-22 | Hoffmann La Roche | Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u |
| DE602007013573D1 (de) * | 2006-08-16 | 2011-05-12 | Hoffmann La Roche | Nicht-nukleosidische reverse-transkriptase-hemmer |
| MX2009009920A (es) | 2007-03-29 | 2009-10-19 | Hoffmann La Roche | Inhibidores no nucleosidos de transcriptasa inversa. |
| ATE554070T1 (de) | 2007-08-01 | 2012-05-15 | Taisho Pharmaceutical Co Ltd | Hemmer der s1p1-bindung |
| AU2008340422B2 (en) * | 2007-12-21 | 2014-06-19 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| DE102008015033A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| MX2012011379A (es) * | 2010-03-30 | 2012-11-30 | Merck Canada Inc | Inhibidores no nucleosidicos de la transcriptasa inversa. |
| ES2565193T3 (es) | 2010-07-15 | 2016-04-01 | Sumitomo Dainippon Pharma Co., Ltd. | Compuesto de pirazol |
| EP2508511A1 (en) * | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
| WO2013134562A1 (en) | 2012-03-09 | 2013-09-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| CA2876969A1 (en) | 2012-06-20 | 2013-12-27 | Vanderbilt University | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mglur5 receptors |
| BR112014031896A2 (pt) | 2012-06-20 | 2017-06-27 | Univ Vanderbilt | composto, composição farmacêutica, e, método para o tratamento de um distúrbio |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| MX376108B (es) | 2012-12-20 | 2025-03-07 | Tempest Therapeutics Inc | Compuestos de triazolona y usos de los mismos. |
| AU2014315151A1 (en) | 2013-09-06 | 2016-03-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| SI3125894T1 (sl) | 2014-04-01 | 2020-12-31 | Merck Sharp & Dohme Corp. | Predzdravila inhibitorjev reverzne transkriptaze HIV |
| WO2016044445A2 (en) | 2014-09-17 | 2016-03-24 | Ironwood Pharmaceuticals, Inc. | sGC STIMULATORS |
| US10844064B2 (en) | 2014-09-17 | 2020-11-24 | Cyclerion Therapeutics, Inc. | sGC stimulators |
| US20180042234A1 (en) * | 2015-03-19 | 2018-02-15 | E I Du Pont De Nemours And Company | Fungicidal pyrazoles |
| US20200002283A1 (en) * | 2016-06-29 | 2020-01-02 | Esteve Pharmaceuticals, S.A. | Pyrazole derivatives having activity against pain |
| CN110818636A (zh) * | 2019-11-29 | 2020-02-21 | 河北科技大学 | 一种化合物或其盐及其应用和合成方法 |
| CN115677585B (zh) * | 2022-10-31 | 2024-03-19 | 上海群力化工有限公司 | 一种甲醛吡唑衍生物的合成工艺 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9509024A (pt) | 1994-09-26 | 1997-09-30 | Shionogi & Co | Derivados de imidazol |
| DE19734664A1 (de) * | 1997-08-11 | 1999-02-18 | Bayer Ag | (Hetero)Aryloxypyrazole |
| GB0016787D0 (en) * | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| US20030008841A1 (en) * | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| GB0024795D0 (en) * | 2000-10-10 | 2000-11-22 | Hoffmann La Roche | Pyrazole derivatives for the treatment of viral diseases |
| GB0028484D0 (en) * | 2000-11-22 | 2001-01-10 | Hoffmann La Roche | Imidazolone derivatives for the treatment of viral diseases |
| SI1762567T1 (sl) * | 2001-04-10 | 2012-08-31 | Pfizer | Derivati pirazola za zdravljenje HIV-a |
| GB0113524D0 (en) * | 2001-06-04 | 2001-07-25 | Hoffmann La Roche | Pyrazole derivatives |
-
2004
- 2004-02-12 TW TW093103358A patent/TW200423930A/zh unknown
- 2004-02-16 CL CL200400270A patent/CL2004000270A1/es unknown
- 2004-02-17 PL PL378556A patent/PL378556A1/pl not_active Application Discontinuation
- 2004-02-17 AR ARP040100477A patent/AR043195A1/es not_active Application Discontinuation
- 2004-02-17 BR BRPI0407591-9A patent/BRPI0407591A/pt not_active IP Right Cessation
- 2004-02-17 RU RU2005128832/04A patent/RU2305680C2/ru active
- 2004-02-17 CA CA2515151A patent/CA2515151C/en not_active Expired - Fee Related
- 2004-02-17 MX MXPA05008748A patent/MXPA05008748A/es active IP Right Grant
- 2004-02-17 EP EP04711607A patent/EP1597235B1/en not_active Expired - Lifetime
- 2004-02-17 CN CNB2004800044061A patent/CN100389109C/zh not_active Expired - Fee Related
- 2004-02-17 DE DE602004008227T patent/DE602004008227T2/de not_active Expired - Lifetime
- 2004-02-17 AT AT04711607T patent/ATE370124T1/de not_active IP Right Cessation
- 2004-02-17 JP JP2006500034A patent/JP4608480B2/ja not_active Expired - Fee Related
- 2004-02-17 ES ES04711607T patent/ES2291854T3/es not_active Expired - Lifetime
- 2004-02-17 KR KR1020057015085A patent/KR100776093B1/ko not_active Expired - Fee Related
- 2004-02-17 WO PCT/EP2004/001477 patent/WO2004074257A1/en not_active Ceased
- 2004-02-18 US US10/781,373 patent/US7241794B2/en not_active Expired - Fee Related
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