RU2305680C2 - Ненуклеозидные ингибиторы обратной транскриптазы, их применение, фармацевтическая композиция для ингибирования вич - Google Patents

Ненуклеозидные ингибиторы обратной транскриптазы, их применение, фармацевтическая композиция для ингибирования вич Download PDF

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Publication number
RU2305680C2
RU2305680C2 RU2005128832/04A RU2005128832A RU2305680C2 RU 2305680 C2 RU2305680 C2 RU 2305680C2 RU 2005128832/04 A RU2005128832/04 A RU 2005128832/04A RU 2005128832 A RU2005128832 A RU 2005128832A RU 2305680 C2 RU2305680 C2 RU 2305680C2
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Russia
Prior art keywords
alkyl
alkoxy
phenyl
optionally substituted
substituted
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RU2005128832/04A
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English (en)
Russian (ru)
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RU2005128832A (ru
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Джеймс Патрик ДАНН (US)
Джеймс Патрик ДАНН
Джоан Хедер ХОГГ (US)
Джоан Хедер ХОГГ
Таранех МИРЗАДЕГАН (US)
Таранех МИРЗАДЕГАН
Стивен СВОЛОУ (US)
Стивен СВОЛОУ
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Ф.Хоффманн-Ля Рош Аг
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Publication of RU2005128832A publication Critical patent/RU2005128832A/ru
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Publication of RU2305680C2 publication Critical patent/RU2305680C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2005128832/04A 2003-02-18 2004-02-17 Ненуклеозидные ингибиторы обратной транскриптазы, их применение, фармацевтическая композиция для ингибирования вич RU2305680C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44797403P 2003-02-18 2003-02-18
US60/447,974 2003-02-18

Publications (2)

Publication Number Publication Date
RU2005128832A RU2005128832A (ru) 2006-04-27
RU2305680C2 true RU2305680C2 (ru) 2007-09-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2005128832/04A RU2305680C2 (ru) 2003-02-18 2004-02-17 Ненуклеозидные ингибиторы обратной транскриптазы, их применение, фармацевтическая композиция для ингибирования вич

Country Status (17)

Country Link
US (1) US7241794B2 (enExample)
EP (1) EP1597235B1 (enExample)
JP (1) JP4608480B2 (enExample)
KR (1) KR100776093B1 (enExample)
CN (1) CN100389109C (enExample)
AR (1) AR043195A1 (enExample)
AT (1) ATE370124T1 (enExample)
BR (1) BRPI0407591A (enExample)
CA (1) CA2515151C (enExample)
CL (1) CL2004000270A1 (enExample)
DE (1) DE602004008227T2 (enExample)
ES (1) ES2291854T3 (enExample)
MX (1) MXPA05008748A (enExample)
PL (1) PL378556A1 (enExample)
RU (1) RU2305680C2 (enExample)
TW (1) TW200423930A (enExample)
WO (1) WO2004074257A1 (enExample)

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WO2004099157A1 (en) * 2003-05-07 2004-11-18 Pfizer Products Inc. Cannabinoid receptor ligands and uses thereof
RU2383536C2 (ru) 2004-08-04 2010-03-10 Тайсо Фармасьютикал Ко., Лтд. Производное триазола
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
EP1988083B1 (en) 2006-02-03 2014-04-02 Taisho Pharmaceutical Co., Ltd. Triazole derivative
US7994204B2 (en) 2006-02-06 2011-08-09 Taisho Pharmaceutical Co., Ltd Binding inhibitor of sphingosine-1-phosphate
ES2381695T3 (es) * 2006-02-14 2012-05-30 Ihara Chemical Industry Co., Ltd. Procedimiento para producir un compuesto 5-alcoxi-4-hidroximetilpirazol
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
AU2007286345B2 (en) 2006-08-16 2012-03-08 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
CA2682637A1 (en) * 2007-03-29 2008-10-09 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
SI2177512T1 (sl) 2007-08-01 2012-06-29 Taisho Pharmaceutical Co Ltd Inhibitor vezave S1P1
JP5411160B2 (ja) * 2007-12-21 2014-02-12 エフ．ホフマン−ラ ロシュ アーゲー 複素環式抗ウイルス性化合物
DE102008015033A1 (de) * 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
MA34170B1 (fr) 2010-03-30 2013-04-03 Merck Canada Inc Inhibiteurs de transcriptase inverse non nucléosidiques
JP5722891B2 (ja) 2010-07-15 2015-05-27 大日本住友製薬株式会社 ピラゾール化合物
EP2508511A1 (en) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2822931B1 (en) 2012-03-09 2017-05-03 Inception 2, Inc. Triazolone compounds and uses thereof
KR20150023822A (ko) 2012-06-20 2015-03-05 벤더르빌트 유니버시티 Mglur5 수용체의 알로스테릭 조절물질로서 치환된 바이사이클릭 알콕시 피라졸 유사체
WO2013192346A1 (en) 2012-06-20 2013-12-27 Vanderbilt University Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mglur5 receptors
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
JP6404230B2 (ja) 2012-12-20 2018-10-10 インセプション ２、 インコーポレイテッド トリアゾロン化合物およびその使用
CA2921420A1 (en) 2013-09-06 2015-03-12 Inception 2, Inc. Triazolone compounds and uses thereof
CN106456639B (zh) 2014-04-01 2019-05-10 默沙东公司 Hiv逆转录酶抑制剂的前药
AU2015317823A1 (en) 2014-09-17 2017-03-23 Ironwood Pharmaceuticals, Inc. sGC stimulators
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
EP3271336A1 (en) * 2015-03-19 2018-01-24 E. I. du Pont de Nemours and Company Fungicidal pyrazoles
EP3478665A1 (en) * 2016-06-29 2019-05-08 Esteve Pharmaceuticals, S.A. Pyrazole derivatives having activity against pain
CN110818636A (zh) * 2019-11-29 2020-02-21 河北科技大学 一种化合物或其盐及其应用和合成方法
CN115677585B (zh) * 2022-10-31 2024-03-19 上海群力化工有限公司 一种甲醛吡唑衍生物的合成工艺

Citations (5)

* Cited by examiner, † Cited by third party
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WO1999007698A1 (de) * 1997-08-11 1999-02-18 Bayer Aktiengesellschaft (hetero)aryloxypyrazole als herbizide
RU99109971A (ru) * 1996-10-14 2001-03-20 Байер Акциенгезелльшафт Новые гетероциклилметилзамещенные производные пиразола
WO2002004424A1 (en) * 2000-07-07 2002-01-17 Pfizer Limited Pyrazole derivatives
WO2002030907A1 (en) * 2000-10-10 2002-04-18 F. Hoffmann-La Roche Ag Pyrazole derivatives for the treatment of viral diseases
WO2002100853A1 (en) * 2001-06-04 2002-12-19 F. Hoffmann-La Roche Ag Pyrazole derivatives as hiv reverse transcriptase inhibitors

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EP0786455B1 (en) 1994-09-26 2003-12-03 Shionogi & Co., Ltd. Imidazole derivative
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
GB0028484D0 (en) * 2000-11-22 2001-01-10 Hoffmann La Roche Imidazolone derivatives for the treatment of viral diseases
EE05400B1 (et) * 2001-04-10 2011-04-15 Pfizer Inc. Prasoolderivaadid, neid v?i nende farmatseutiliselt vastuv?etavaid sooli, solvaate v?i derivaate sisaldavad farmatseutilised kompositsioonid, nende kasutamine ning meetodid nende valmistamiseks

Patent Citations (5)

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RU99109971A (ru) * 1996-10-14 2001-03-20 Байер Акциенгезелльшафт Новые гетероциклилметилзамещенные производные пиразола
WO1999007698A1 (de) * 1997-08-11 1999-02-18 Bayer Aktiengesellschaft (hetero)aryloxypyrazole als herbizide
WO2002004424A1 (en) * 2000-07-07 2002-01-17 Pfizer Limited Pyrazole derivatives
WO2002030907A1 (en) * 2000-10-10 2002-04-18 F. Hoffmann-La Roche Ag Pyrazole derivatives for the treatment of viral diseases
WO2002100853A1 (en) * 2001-06-04 2002-12-19 F. Hoffmann-La Roche Ag Pyrazole derivatives as hiv reverse transcriptase inhibitors

Also Published As

Publication number Publication date
ATE370124T1 (de) 2007-09-15
CL2004000270A1 (es) 2005-02-04
PL378556A1 (pl) 2006-05-02
EP1597235B1 (en) 2007-08-15
JP4608480B2 (ja) 2011-01-12
EP1597235A1 (en) 2005-11-23
KR100776093B1 (ko) 2007-11-15
WO2004074257A1 (en) 2004-09-02
ES2291854T3 (es) 2008-03-01
CN100389109C (zh) 2008-05-21
JP2006515339A (ja) 2006-05-25
US20040192666A1 (en) 2004-09-30
AU2004213134A1 (en) 2004-09-02
DE602004008227D1 (de) 2007-09-27
BRPI0407591A (pt) 2006-02-14
TW200423930A (en) 2004-11-16
DE602004008227T2 (de) 2008-05-15
CA2515151C (en) 2010-11-30
AR043195A1 (es) 2005-07-20
KR20050105471A (ko) 2005-11-04
MXPA05008748A (es) 2005-09-20
RU2005128832A (ru) 2006-04-27
US7241794B2 (en) 2007-07-10
CA2515151A1 (en) 2004-09-02
CN1751028A (zh) 2006-03-22

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