JP2006514931A - 化粧用及び医薬用活性化合物としてのアントラニル酸アミド類及びそれらの誘導体 - Google Patents
化粧用及び医薬用活性化合物としてのアントラニル酸アミド類及びそれらの誘導体 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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- Veterinary Medicine (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| DE10254872A DE10254872A1 (de) | 2002-11-25 | 2002-11-25 | Anthranilsäureamide und deren Derivate als kosmetische und pharmazeutische Wirkstoffe |
| PCT/EP2003/012990 WO2004047833A2 (de) | 2002-11-25 | 2003-11-20 | Anthranilsäureamide und deren derivate als kosmetische und pharmazeutische wirkstoffe |
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| JP2010176413A Division JP5467014B2 (ja) | 2002-11-25 | 2010-08-05 | 化粧用及び医薬用活性化合物としてのアントラニル酸アミド類及びそれらの誘導体 |
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| JP2010176413A Expired - Lifetime JP5467014B2 (ja) | 2002-11-25 | 2010-08-05 | 化粧用及び医薬用活性化合物としてのアントラニル酸アミド類及びそれらの誘導体 |
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| JP2010176413A Expired - Lifetime JP5467014B2 (ja) | 2002-11-25 | 2010-08-05 | 化粧用及び医薬用活性化合物としてのアントラニル酸アミド類及びそれらの誘導体 |
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| US (2) | US8203016B2 (enExample) |
| EP (1) | EP1567143B1 (enExample) |
| JP (2) | JP2006514931A (enExample) |
| KR (1) | KR20050085127A (enExample) |
| CN (2) | CN101683310B (enExample) |
| AU (1) | AU2003288126A1 (enExample) |
| BR (1) | BRPI0307117B8 (enExample) |
| DE (1) | DE10254872A1 (enExample) |
| WO (1) | WO2004047833A2 (enExample) |
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Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4993335A (enExample) * | 1973-01-18 | 1974-09-05 | ||
| JPS5736905B2 (enExample) * | 1974-04-17 | 1982-08-06 | ||
| JPS5838244A (ja) * | 1981-09-01 | 1983-03-05 | Kissei Pharmaceut Co Ltd | 核置換シンナモイルアントラニル酸塩およびその製造方法 |
| JPS60116657A (ja) * | 1983-11-30 | 1985-06-24 | Ono Pharmaceut Co Ltd | アニリン誘導体 |
| JPH02264716A (ja) * | 1989-04-04 | 1990-10-29 | Kissei Pharmaceut Co Ltd | トラニラスト水溶液製剤 |
| JPH09104607A (ja) * | 1995-07-31 | 1997-04-22 | L'oreal Sa | 化粧品的、薬学的、または皮膚病学的組成物におけるブラジキニンアンタゴニストの使用およびその組成物 |
| JP2000507269A (ja) * | 1996-03-15 | 2000-06-13 | イーライ・リリー・アンド・カンパニー | 一般かぜまたはアレルギー性鼻炎の処置方法 |
| WO2000067626A2 (en) * | 1999-05-06 | 2000-11-16 | Ceapro Inc. | Oat extracts: refining, compositions and methods of use |
| JP2001097865A (ja) * | 1999-09-29 | 2001-04-10 | Lion Corp | 眼科用組成物 |
| JP2001122730A (ja) * | 1999-10-26 | 2001-05-08 | Ichimaru Pharcos Co Ltd | 保湿性植物抽出物を含有する化粧料組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5126839B1 (enExample) | 1970-01-16 | 1976-08-09 | ||
| US4070484A (en) | 1973-01-18 | 1978-01-24 | Kissei Pharmaceutical Co., Ltd. | Antiallergic composition containing aromatic carboxylic amide derivatives and method of using the same |
| JPS5126839A (ja) * | 1974-08-21 | 1976-03-05 | Dainippon Pharmaceutical Co | Benzuaniridojudotaino seizoho |
| US4347188A (en) * | 1977-01-06 | 1982-08-31 | Sumitomo Chemical Company, Limited | N-Benzoylanthranilate derivatives |
| US4337270A (en) * | 1980-05-21 | 1982-06-29 | Hisamitsu Pharmaceutical Co., Inc. | Novel anthranilic acid derivatives |
| JPS5736905A (ja) | 1980-08-12 | 1982-02-27 | Iseki Agricult Mach | Naeishokuki |
| JPS5817186B2 (ja) * | 1981-01-23 | 1983-04-05 | キツセイ薬品工業株式会社 | 新規芳香族カルボン酸誘導体の製造方法 |
| JPS5838444A (ja) | 1981-08-29 | 1983-03-05 | Shimadzu Corp | クロマトグラフ質量分析計 |
| US4587356A (en) * | 1981-09-01 | 1986-05-06 | Kissei Pharmaceutical Co., Ltd. | Process for the production of nuclear substituted cinnamoylanthranilic acid derivatives |
| JPS60146856A (ja) | 1983-12-30 | 1985-08-02 | Kissei Pharmaceut Co Ltd | α−ハロ芳香族アミドカルボン酸誘導体及びこの化合物より成る抗アレルギ−剤 |
| JPH0733357B2 (ja) | 1986-09-30 | 1995-04-12 | 日本レダリ−株式会社 | ケイ皮酸誘導体 |
| CA2017287A1 (en) * | 1989-05-23 | 1990-11-23 | Shunji Naruto | Substituted phenol derivatives and their use |
| JPH08143525A (ja) * | 1994-11-21 | 1996-06-04 | Banyu Pharmaceut Co Ltd | ヒドロキシ安息香酸アミド誘導体を有効成分とする骨疾患の予防・治療剤 |
| JP3621483B2 (ja) * | 1995-12-01 | 2005-02-16 | 花王株式会社 | ヒスタミン遊離抑制剤 |
| ES2462925T3 (es) * | 2006-06-14 | 2014-05-26 | Symrise Ag | Compuestos con efecto antimicrobiano para el tratamiento de fetidez oral |
-
2002
- 2002-11-25 DE DE10254872A patent/DE10254872A1/de not_active Withdrawn
-
2003
- 2003-11-20 BR BRPI0307117A patent/BRPI0307117B8/pt not_active IP Right Cessation
- 2003-11-20 KR KR1020057009267A patent/KR20050085127A/ko not_active Ceased
- 2003-11-20 JP JP2004554400A patent/JP2006514931A/ja active Pending
- 2003-11-20 CN CN200910173877XA patent/CN101683310B/zh not_active Expired - Lifetime
- 2003-11-20 EP EP03780002.6A patent/EP1567143B1/de not_active Expired - Lifetime
- 2003-11-20 CN CNB2003801040167A patent/CN100548289C/zh not_active Expired - Lifetime
- 2003-11-20 AU AU2003288126A patent/AU2003288126A1/en not_active Abandoned
- 2003-11-20 US US10/535,985 patent/US8203016B2/en active Active
- 2003-11-20 WO PCT/EP2003/012990 patent/WO2004047833A2/de not_active Ceased
-
2010
- 2010-08-05 JP JP2010176413A patent/JP5467014B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-15 US US13/524,374 patent/US8409552B2/en not_active Expired - Lifetime
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4993335A (enExample) * | 1973-01-18 | 1974-09-05 | ||
| JPS5736905B2 (enExample) * | 1974-04-17 | 1982-08-06 | ||
| JPS5838244A (ja) * | 1981-09-01 | 1983-03-05 | Kissei Pharmaceut Co Ltd | 核置換シンナモイルアントラニル酸塩およびその製造方法 |
| JPS60116657A (ja) * | 1983-11-30 | 1985-06-24 | Ono Pharmaceut Co Ltd | アニリン誘導体 |
| JPH02264716A (ja) * | 1989-04-04 | 1990-10-29 | Kissei Pharmaceut Co Ltd | トラニラスト水溶液製剤 |
| JPH09104607A (ja) * | 1995-07-31 | 1997-04-22 | L'oreal Sa | 化粧品的、薬学的、または皮膚病学的組成物におけるブラジキニンアンタゴニストの使用およびその組成物 |
| JP2000507269A (ja) * | 1996-03-15 | 2000-06-13 | イーライ・リリー・アンド・カンパニー | 一般かぜまたはアレルギー性鼻炎の処置方法 |
| WO2000067626A2 (en) * | 1999-05-06 | 2000-11-16 | Ceapro Inc. | Oat extracts: refining, compositions and methods of use |
| JP2002544145A (ja) * | 1999-05-06 | 2002-12-24 | シープロ・インコーポレイテッド | オート麦抽出物：精製、組成物および使用方法 |
| JP2001097865A (ja) * | 1999-09-29 | 2001-04-10 | Lion Corp | 眼科用組成物 |
| JP2001122730A (ja) * | 1999-10-26 | 2001-05-08 | Ichimaru Pharcos Co Ltd | 保湿性植物抽出物を含有する化粧料組成物 |
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| JP2021518370A (ja) * | 2018-03-23 | 2021-08-02 | シムライズ アーゲー | 皮膚状態改善剤 |
| JP2023516451A (ja) * | 2020-03-06 | 2023-04-19 | シムライズ アーゲー | アベナンスラミドｌの化粧品または医薬品としての使用 |
| JP2023516452A (ja) * | 2020-03-06 | 2023-04-19 | シムライズ アーゲー | アベナンスラミドおよびβ－グルカンを含む組成物またはエンバク抽出物 |
| JP2023516453A (ja) * | 2020-03-06 | 2023-04-19 | シムライズ アーゲー | 改善された安定性を有するアベナンスラミドまたはその類似体を含む組成物 |
| JP2023517314A (ja) * | 2020-03-06 | 2023-04-25 | シムライズ アーゲー | 改善された皮膚浸透性を有する、アベナンスラミドを含む組成物 |
| JP2025004109A (ja) * | 2020-03-06 | 2025-01-14 | シムライズ アーゲー | 改善された皮膚浸透性を有する、アベナンスラミドを含む組成物 |
| JP7652789B2 (ja) | 2020-03-06 | 2025-03-27 | シムライズ アーゲー | アベナンスラミドおよびβ－グルカンを含む組成物またはエンバク抽出物 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0307117A (pt) | 2004-12-28 |
| DE10254872A1 (de) | 2004-06-03 |
| CN101683310A (zh) | 2010-03-31 |
| AU2003288126A1 (en) | 2004-06-18 |
| EP1567143A2 (de) | 2005-08-31 |
| US20060089413A1 (en) | 2006-04-27 |
| JP2010248268A (ja) | 2010-11-04 |
| US20120315233A1 (en) | 2012-12-13 |
| CN1713904A (zh) | 2005-12-28 |
| WO2004047833A2 (de) | 2004-06-10 |
| CN100548289C (zh) | 2009-10-14 |
| WO2004047833A3 (de) | 2005-01-13 |
| BRPI0307117B8 (pt) | 2021-05-25 |
| US8409552B2 (en) | 2013-04-02 |
| JP5467014B2 (ja) | 2014-04-09 |
| EP1567143B1 (de) | 2013-08-14 |
| BRPI0307117B1 (pt) | 2017-07-18 |
| CN101683310B (zh) | 2012-12-12 |
| US8203016B2 (en) | 2012-06-19 |
| KR20050085127A (ko) | 2005-08-29 |
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