SG10201506526QA - Halogenated analogues of anti-fibrotic agents - Google Patents
Halogenated analogues of anti-fibrotic agentsInfo
- Publication number
- SG10201506526QA SG10201506526QA SG10201506526QA SG10201506526QA SG10201506526QA SG 10201506526Q A SG10201506526Q A SG 10201506526QA SG 10201506526Q A SG10201506526Q A SG 10201506526QA SG 10201506526Q A SG10201506526Q A SG 10201506526QA SG 10201506526Q A SG10201506526Q A SG 10201506526QA
- Authority
- SG
- Singapore
- Prior art keywords
- fibrotic agents
- halogenated analogues
- analogues
- halogenated
- fibrotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1613407P | 2007-12-21 | 2007-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201506526QA true SG10201506526QA (en) | 2015-09-29 |
Family
ID=40800565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201506526QA SG10201506526QA (en) | 2007-12-21 | 2008-12-19 | Halogenated analogues of anti-fibrotic agents |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8624056B2 (en) |
| EP (2) | EP2220028B1 (en) |
| JP (2) | JP5730578B2 (en) |
| KR (2) | KR20160017139A (en) |
| CN (2) | CN102164887A (en) |
| AU (1) | AU2008341010B2 (en) |
| CA (1) | CA2709937C (en) |
| MX (1) | MX337320B (en) |
| NZ (1) | NZ584613A (en) |
| SG (1) | SG10201506526QA (en) |
| WO (1) | WO2009079692A1 (en) |
| ZA (1) | ZA201003376B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2799427T3 (en) | 2006-07-05 | 2018-10-22 | Fibrotech Therapeutics Pty Ltd | Therapeutic compounds |
| US8624056B2 (en) | 2007-12-21 | 2014-01-07 | Fibrotech Therapeutics Pty Ltd | Halogenated analogues of anti-fibrotic agents |
| US9062076B2 (en) | 2009-10-22 | 2015-06-23 | Fibrotech Therapeutics Pty Ltd | Fused ring analogues of anti-fibrotic agents |
| NZ609144A (en) | 2010-11-24 | 2014-08-29 | Occurx Pty Ltd | Methods of treating eye diseases associated with inflammation and vascular proliferation |
| DK2970383T3 (en) * | 2013-03-15 | 2021-07-05 | Univ Texas | Method for treating fibrosis |
| US9908915B2 (en) * | 2013-11-26 | 2018-03-06 | Yale University | Cell-penetrating compositions and methods using same |
| JP6533997B2 (en) * | 2014-12-26 | 2019-06-26 | 株式会社ヤクルト本社 | Compound having ZNF143 inhibitory activity and use thereof |
| US11014873B2 (en) | 2017-02-03 | 2021-05-25 | Certa Therapeutics Pty Ltd. | Anti-fibrotic compounds |
| CN110357789B (en) * | 2018-04-11 | 2022-09-30 | 华东理工大学 | N-substituted acrylamide derivative as DHODH inhibitor and preparation and application thereof |
| AU2022238294A1 (en) * | 2021-03-17 | 2023-10-05 | Occurx Pty Ltd | Compounds for the treatment of disorders and salts and polymorphs thereof |
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| JPS5640710B2 (en) | 1973-01-18 | 1981-09-22 | ||
| JPS5830302B2 (en) * | 1974-04-16 | 1983-06-28 | キツセイヤクヒンコウギヨウ カブシキガイシヤ | Shinki Hōkōzoku Carbon Sanamide Yudōtai no Seizō Hōhō |
| JPS511440A (en) * | 1974-04-18 | 1976-01-08 | Kissei Pharmaceutical | SHINKIHOKOZOKUKARUBONSANJUDOTAI NO SEIZOHOHO |
| JPS5848545B2 (en) | 1974-04-18 | 1983-10-28 | キツセイヤクヒンコウギヨウ カブシキガイシヤ | Shinki Hōkōzoku Carbon Sanamide Yudōtai no Seizō Hōhō |
| GB1484413A (en) | 1974-04-18 | 1977-09-01 | Kissei Pharmaceutical | Aromatic amidocarboxylic acid derivatives |
| JPS5576852A (en) | 1978-12-01 | 1980-06-10 | Hisamitsu Pharmaceut Co Inc | Novel derivative of anthranilic acid |
| JPS5817186B2 (en) | 1981-01-23 | 1983-04-05 | キツセイ薬品工業株式会社 | Method for producing novel aromatic carboxylic acid derivatives |
| US4587356A (en) | 1981-09-01 | 1986-05-06 | Kissei Pharmaceutical Co., Ltd. | Process for the production of nuclear substituted cinnamoylanthranilic acid derivatives |
| JPS5838244A (en) * | 1981-09-01 | 1983-03-05 | Kissei Pharmaceut Co Ltd | Nuclear substituted cinnamoylanthranilate and its preparation |
| JPS6019754A (en) | 1983-07-14 | 1985-01-31 | Kissei Pharmaceut Co Ltd | Production of aromatic carboxylic acid amide derivative |
| JPS60152454A (en) | 1984-01-18 | 1985-08-10 | Terumo Corp | Amide derivative and 5-lipoxigenase inhibitor containing said derivative as active component |
| JPH07116029B2 (en) | 1989-04-04 | 1995-12-13 | キッセイ薬品工業株式会社 | Tranilast aqueous solution formulation |
| ES2100943T3 (en) | 1990-02-08 | 1997-07-01 | Eisai Co Ltd | DERIVATIVE OF BENZENE SULFONAMIDE. |
| US5248825A (en) | 1990-09-20 | 1993-09-28 | Merrell Dow Pharmaceuticals Inc. | Calcium uptake inhibitors |
| DE69410956T2 (en) | 1993-12-09 | 1999-03-25 | Ono Pharmaceutical Co | Naphthylacetic acid derivatives as PGEZ agonists and antagonists |
| CN1211182A (en) | 1996-02-15 | 1999-03-17 | 橘生药品工业株式会社 | Neovascularization inhibitor |
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| JPH10259129A (en) | 1997-01-16 | 1998-09-29 | Kissei Pharmaceut Co Ltd | Arterialization inhibitor |
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| JPH10306024A (en) * | 1997-03-07 | 1998-11-17 | Kissei Pharmaceut Co Ltd | Preventive and therapeutic agent against glomerular disease |
| JPH10330254A (en) | 1997-04-01 | 1998-12-15 | Kissei Pharmaceut Co Ltd | Suppressant for progress of pterygium and postoperative relapse |
| US6127392A (en) | 1997-08-05 | 2000-10-03 | American Home Products Corporation | Anthranilic acid analogs |
| DE19935219A1 (en) | 1999-07-27 | 2001-02-01 | Boehringer Ingelheim Pharma | Carboxamides, medicines containing these compounds, their use and manufacture |
| US6646009B2 (en) | 2001-02-28 | 2003-11-11 | Temple University — Of Commonwealth System of Higher Education | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
| US7429593B2 (en) | 2001-09-14 | 2008-09-30 | Shionogi & Co., Ltd. | Utilities of amide compounds |
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| WO2007015744A1 (en) | 2005-07-21 | 2007-02-08 | Incyte Corporation | Disubstituted thienyl compounds and their use as pharmaceuticals |
| EP1959915B1 (en) | 2005-11-30 | 2015-05-13 | Symrise AG | Mixtures comprising anthranilic acid amides and antidandruff agents as cosmetic and pharmaceutical compositions for alleviating itching |
| US20070286892A1 (en) | 2006-06-13 | 2007-12-13 | Uri Herzberg | Compositions and methods for preventing or reducing postoperative ileus and gastric stasis in mammals |
| ES2462925T3 (en) | 2006-06-14 | 2014-05-26 | Symrise Ag | Compounds with antimicrobial effect for the treatment of oral fetidity |
| DK2799427T3 (en) * | 2006-07-05 | 2018-10-22 | Fibrotech Therapeutics Pty Ltd | Therapeutic compounds |
| KR100832747B1 (en) | 2006-10-27 | 2008-05-27 | 한국화학연구원 | Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating an ischemic disease containing the same |
| WO2008057862A2 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
| EP2030617A1 (en) | 2007-08-17 | 2009-03-04 | Sygnis Bioscience GmbH & Co. KG | Use of tranilast and derivatives thereof for the therapy of neurological conditions |
| EP2225214A1 (en) | 2007-11-28 | 2010-09-08 | NeuroSearch AS | Novel phenyl-acetamide and phenyl-propionamide derivatives useful as potassium channel modulators |
| US20090163586A1 (en) | 2007-12-20 | 2009-06-25 | Astrazeneca Ab | Bis-(Sulfonylamino) Derivatives in Therapy 205 |
| US8624056B2 (en) | 2007-12-21 | 2014-01-07 | Fibrotech Therapeutics Pty Ltd | Halogenated analogues of anti-fibrotic agents |
| EP2179984A1 (en) | 2008-10-27 | 2010-04-28 | Congenia S.r.l. | Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition |
-
2008
- 2008-12-19 US US12/809,751 patent/US8624056B2/en active Active
- 2008-12-19 NZ NZ584613A patent/NZ584613A/en unknown
- 2008-12-19 CN CN2008801221536A patent/CN102164887A/en active Pending
- 2008-12-19 CN CN201710172053.5A patent/CN107162928B/en active Active
- 2008-12-19 JP JP2010538278A patent/JP5730578B2/en active Active
- 2008-12-19 CA CA2709937A patent/CA2709937C/en active Active
- 2008-12-19 WO PCT/AU2008/001868 patent/WO2009079692A1/en active Application Filing
- 2008-12-19 EP EP08865709.3A patent/EP2220028B1/en active Active
- 2008-12-19 MX MX2010006787A patent/MX337320B/en active IP Right Grant
- 2008-12-19 KR KR1020167002802A patent/KR20160017139A/en not_active Application Discontinuation
- 2008-12-19 AU AU2008341010A patent/AU2008341010B2/en active Active
- 2008-12-19 KR KR1020107011284A patent/KR101593708B1/en active IP Right Grant
- 2008-12-19 EP EP16156167.5A patent/EP3045170B1/en active Active
- 2008-12-19 SG SG10201506526QA patent/SG10201506526QA/en unknown
-
2010
- 2010-05-13 ZA ZA2010/03376A patent/ZA201003376B/en unknown
-
2015
- 2015-04-08 JP JP2015079433A patent/JP6063985B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5730578B2 (en) | 2015-06-10 |
| JP6063985B2 (en) | 2017-01-18 |
| EP3045170B1 (en) | 2018-07-04 |
| KR20160017139A (en) | 2016-02-15 |
| EP3045170A1 (en) | 2016-07-20 |
| NZ584613A (en) | 2011-07-29 |
| US20120059188A9 (en) | 2012-03-08 |
| EP2220028A4 (en) | 2011-02-16 |
| CN107162928B (en) | 2022-03-11 |
| US8624056B2 (en) | 2014-01-07 |
| JP2011506490A (en) | 2011-03-03 |
| AU2008341010A1 (en) | 2009-07-02 |
| MX2010006787A (en) | 2010-10-04 |
| CN107162928A (en) | 2017-09-15 |
| EP2220028B1 (en) | 2016-03-09 |
| JP2015180624A (en) | 2015-10-15 |
| MX337320B (en) | 2016-01-06 |
| CN102164887A (en) | 2011-08-24 |
| WO2009079692A1 (en) | 2009-07-02 |
| ZA201003376B (en) | 2011-02-23 |
| AU2008341010B2 (en) | 2013-04-18 |
| KR101593708B1 (en) | 2016-02-12 |
| CA2709937A1 (en) | 2009-07-02 |
| US20110021815A1 (en) | 2011-01-27 |
| CA2709937C (en) | 2016-03-22 |
| KR20100099134A (en) | 2010-09-10 |
| EP2220028A1 (en) | 2010-08-25 |
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