CN101683310B - 作为化妆品和药物活性化合物的邻氨基苯甲酰胺及其衍生物 - Google Patents
作为化妆品和药物活性化合物的邻氨基苯甲酰胺及其衍生物 Download PDFInfo
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- CN101683310B CN101683310B CN200910173877XA CN200910173877A CN101683310B CN 101683310 B CN101683310 B CN 101683310B CN 200910173877X A CN200910173877X A CN 200910173877XA CN 200910173877 A CN200910173877 A CN 200910173877A CN 101683310 B CN101683310 B CN 101683310B
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- chemical compound
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- acyloxy
- polyethylene glycol
- mixture
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- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
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- 229940035936 ubiquinone Drugs 0.000 description 1
- GAAKLDANOSASAM-UHFFFAOYSA-N undec-10-enoic acid;zinc Chemical compound [Zn].OC(=O)CCCCCCCCC=C GAAKLDANOSASAM-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 230000002568 urticarial effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
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- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
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- 229940118257 zinc undecylenate Drugs 0.000 description 1
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10254872.2 | 2002-11-25 | ||
| DE10254872A DE10254872A1 (de) | 2002-11-25 | 2002-11-25 | Anthranilsäureamide und deren Derivate als kosmetische und pharmazeutische Wirkstoffe |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003801040167A Division CN100548289C (zh) | 2002-11-25 | 2003-11-20 | 作为化妆品和药物活性化合物的邻氨基苯甲酰胺及其衍生物 |
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| CN101683310A CN101683310A (zh) | 2010-03-31 |
| CN101683310B true CN101683310B (zh) | 2012-12-12 |
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| CN200910173877XA Expired - Lifetime CN101683310B (zh) | 2002-11-25 | 2003-11-20 | 作为化妆品和药物活性化合物的邻氨基苯甲酰胺及其衍生物 |
| CNB2003801040167A Expired - Lifetime CN100548289C (zh) | 2002-11-25 | 2003-11-20 | 作为化妆品和药物活性化合物的邻氨基苯甲酰胺及其衍生物 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2003801040167A Expired - Lifetime CN100548289C (zh) | 2002-11-25 | 2003-11-20 | 作为化妆品和药物活性化合物的邻氨基苯甲酰胺及其衍生物 |
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| Country | Link |
|---|---|
| US (2) | US8203016B2 (enExample) |
| EP (1) | EP1567143B1 (enExample) |
| JP (2) | JP2006514931A (enExample) |
| KR (1) | KR20050085127A (enExample) |
| CN (2) | CN101683310B (enExample) |
| AU (1) | AU2003288126A1 (enExample) |
| BR (1) | BRPI0307117B8 (enExample) |
| DE (1) | DE10254872A1 (enExample) |
| WO (1) | WO2004047833A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104418764A (zh) * | 2013-09-11 | 2015-03-18 | 上海伊明化学科技有限公司 | 一种二氢燕麦酰基邻氨基苯甲酸d合成方法 |
Families Citing this family (170)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20060100274A1 (en) * | 2004-11-05 | 2006-05-11 | Trustees Of Tufts College | Therapeutic avenanthramide compounds |
| SE0400234D0 (sv) | 2004-02-06 | 2004-02-06 | Active Biotech Ab | New compounds, methods for their preparation and use thereof |
| ITMI20050674A1 (it) * | 2005-04-15 | 2006-10-16 | Univ Degli Studi Milano | Uso di derivati ammidici come agenti modificatori del gusto composizioni aromatizzanti e prodotti che li contengono |
| WO2006134013A1 (en) * | 2005-06-14 | 2006-12-21 | Symrise Gmbh & Co. Kg | Mixtures comprising anthranilic acid amides and cooling agents as cosmetic and pharmaceutical compositions for alleviating itching |
| US20070059268A1 (en) * | 2005-09-09 | 2007-03-15 | Laura Magee | Compositions, methods and kits for treating allergic dermatitis of skin |
| US20070059679A1 (en) * | 2005-09-09 | 2007-03-15 | Michelle Garay | Method for demonstrating efficacy of a topically applied active ingredient |
| US20070059390A1 (en) * | 2005-09-09 | 2007-03-15 | Laura Magee | Compositions for inhibiting or reducing inflammation of skin |
| WO2007041548A2 (en) * | 2005-09-30 | 2007-04-12 | The Procter & Gamble Company | Composition for regulation of mammalian keratinous tissue |
| US8911795B2 (en) * | 2005-11-30 | 2014-12-16 | Symrise Ag | Compositions comprising dihydroavenanthramide D and climbazole as cosmetic and pharmaceutical compositions for alleviating itching |
| EP1886662B1 (de) | 2006-06-14 | 2014-04-09 | Symrise AG | Antimikrobiell wirksame Verbindungen zur Behandlung von Mundgeruch |
| ES2462925T3 (es) * | 2006-06-14 | 2014-05-26 | Symrise Ag | Compuestos con efecto antimicrobiano para el tratamiento de fetidez oral |
| PT2799427T (pt) * | 2006-07-05 | 2018-10-16 | Fibrotech Therapeutics Pty Ltd | Compostos terapêuticos |
| CA2677457A1 (en) * | 2007-02-06 | 2008-08-14 | Helen Tuvesson Andersson | New compounds, methods for their preparation and use thereof |
| KR101527829B1 (ko) | 2007-04-19 | 2015-06-12 | 마리 케이 인코포레이티드 | 마그놀리아 추출물 함유 조성물 |
| WO2008131481A1 (en) * | 2007-04-26 | 2008-11-06 | Fibrotech Therapeutics Pty Ltd | Treatment of mesangioproliferative diseases |
| AU2008324692A1 (en) * | 2007-11-08 | 2009-05-14 | Ceapro Inc. | Avenanthramide-containing compositions |
| KR101593708B1 (ko) | 2007-12-21 | 2016-02-12 | 피브로테크 세라퓨틱 피티와이 엘티디 | 항섬유증 제제의 할로겐화 유사체 |
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| EP3090726B1 (en) | 2015-12-21 | 2019-05-29 | Thiocyn GmbH | Cosmetic composition comprising a combination of active substances |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940422A (en) * | 1973-01-18 | 1976-02-24 | Kissei Yakuhin Kogyo Kabushiki Kaisha | Aromatic carboxylic amide derivatives |
| US4337270A (en) * | 1980-05-21 | 1982-06-29 | Hisamitsu Pharmaceutical Co., Inc. | Novel anthranilic acid derivatives |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5126839B1 (enExample) | 1970-01-16 | 1976-08-09 | ||
| US4070484A (en) | 1973-01-18 | 1978-01-24 | Kissei Pharmaceutical Co., Ltd. | Antiallergic composition containing aromatic carboxylic amide derivatives and method of using the same |
| JPS5736905B2 (enExample) * | 1974-04-17 | 1982-08-06 | ||
| JPS5126839A (ja) * | 1974-08-21 | 1976-03-05 | Dainippon Pharmaceutical Co | Benzuaniridojudotaino seizoho |
| US4347188A (en) * | 1977-01-06 | 1982-08-31 | Sumitomo Chemical Company, Limited | N-Benzoylanthranilate derivatives |
| JPS5736905A (ja) | 1980-08-12 | 1982-02-27 | Iseki Agricult Mach | Naeishokuki |
| JPS5817186B2 (ja) * | 1981-01-23 | 1983-04-05 | キツセイ薬品工業株式会社 | 新規芳香族カルボン酸誘導体の製造方法 |
| JPS5838444A (ja) | 1981-08-29 | 1983-03-05 | Shimadzu Corp | クロマトグラフ質量分析計 |
| US4587356A (en) * | 1981-09-01 | 1986-05-06 | Kissei Pharmaceutical Co., Ltd. | Process for the production of nuclear substituted cinnamoylanthranilic acid derivatives |
| JPS5838244A (ja) * | 1981-09-01 | 1983-03-05 | Kissei Pharmaceut Co Ltd | 核置換シンナモイルアントラニル酸塩およびその製造方法 |
| JPS60116657A (ja) * | 1983-11-30 | 1985-06-24 | Ono Pharmaceut Co Ltd | アニリン誘導体 |
| JPS60146856A (ja) | 1983-12-30 | 1985-08-02 | Kissei Pharmaceut Co Ltd | α−ハロ芳香族アミドカルボン酸誘導体及びこの化合物より成る抗アレルギ−剤 |
| JPH0733357B2 (ja) | 1986-09-30 | 1995-04-12 | 日本レダリ−株式会社 | ケイ皮酸誘導体 |
| JPH07116029B2 (ja) | 1989-04-04 | 1995-12-13 | キッセイ薬品工業株式会社 | トラニラスト水溶液製剤 |
| CA2017287A1 (en) * | 1989-05-23 | 1990-11-23 | Shunji Naruto | Substituted phenol derivatives and their use |
| JPH08143525A (ja) * | 1994-11-21 | 1996-06-04 | Banyu Pharmaceut Co Ltd | ヒドロキシ安息香酸アミド誘導体を有効成分とする骨疾患の予防・治療剤 |
| FR2737408B1 (fr) | 1995-07-31 | 1997-09-05 | Oreal | Utilisation d'un antagoniste de bradykinine dans une composition cosmetique, pharmaceutique ou dermatologique et composition obtenue |
| JP3621483B2 (ja) * | 1995-12-01 | 2005-02-16 | 花王株式会社 | ヒスタミン遊離抑制剤 |
| BR9708146A (pt) | 1996-03-15 | 1999-07-27 | Lilly Co Eli | Processo de tratamento de resfriado comum ou de rinite alérgica |
| ES2233394T3 (es) * | 1999-05-06 | 2005-06-16 | Ceapro Inc. | Composiciones que contienen avenantramida de extractos de avena. |
| JP4687837B2 (ja) | 1999-09-29 | 2011-05-25 | ライオン株式会社 | 眼科用組成物 |
| JP4488560B2 (ja) * | 1999-10-26 | 2010-06-23 | 一丸ファルコス株式会社 | 保湿性植物抽出物を含有する化粧料組成物 |
| ES2462925T3 (es) * | 2006-06-14 | 2014-05-26 | Symrise Ag | Compuestos con efecto antimicrobiano para el tratamiento de fetidez oral |
-
2002
- 2002-11-25 DE DE10254872A patent/DE10254872A1/de not_active Withdrawn
-
2003
- 2003-11-20 BR BRPI0307117A patent/BRPI0307117B8/pt not_active IP Right Cessation
- 2003-11-20 KR KR1020057009267A patent/KR20050085127A/ko not_active Ceased
- 2003-11-20 JP JP2004554400A patent/JP2006514931A/ja active Pending
- 2003-11-20 CN CN200910173877XA patent/CN101683310B/zh not_active Expired - Lifetime
- 2003-11-20 EP EP03780002.6A patent/EP1567143B1/de not_active Expired - Lifetime
- 2003-11-20 CN CNB2003801040167A patent/CN100548289C/zh not_active Expired - Lifetime
- 2003-11-20 AU AU2003288126A patent/AU2003288126A1/en not_active Abandoned
- 2003-11-20 US US10/535,985 patent/US8203016B2/en active Active
- 2003-11-20 WO PCT/EP2003/012990 patent/WO2004047833A2/de not_active Ceased
-
2010
- 2010-08-05 JP JP2010176413A patent/JP5467014B2/ja not_active Expired - Lifetime
-
2012
- 2012-06-15 US US13/524,374 patent/US8409552B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940422A (en) * | 1973-01-18 | 1976-02-24 | Kissei Yakuhin Kogyo Kabushiki Kaisha | Aromatic carboxylic amide derivatives |
| US4337270A (en) * | 1980-05-21 | 1982-06-29 | Hisamitsu Pharmaceutical Co., Inc. | Novel anthranilic acid derivatives |
Non-Patent Citations (2)
| Title |
|---|
| JP昭57－38759A 1982.03.03 |
| 杜敏琼.过敏反应中肥大细胞的脱颗粒和微量组胺释放的测试.《医药工业》.1985,第16卷(第8期),25－28. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104418764A (zh) * | 2013-09-11 | 2015-03-18 | 上海伊明化学科技有限公司 | 一种二氢燕麦酰基邻氨基苯甲酸d合成方法 |
| CN104418764B (zh) * | 2013-09-11 | 2017-02-01 | 上海伊明化学科技有限公司 | 一种二氢燕麦酰基邻氨基苯甲酸d合成方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0307117A (pt) | 2004-12-28 |
| DE10254872A1 (de) | 2004-06-03 |
| CN101683310A (zh) | 2010-03-31 |
| AU2003288126A1 (en) | 2004-06-18 |
| JP2006514931A (ja) | 2006-05-18 |
| EP1567143A2 (de) | 2005-08-31 |
| US20060089413A1 (en) | 2006-04-27 |
| JP2010248268A (ja) | 2010-11-04 |
| US20120315233A1 (en) | 2012-12-13 |
| CN1713904A (zh) | 2005-12-28 |
| WO2004047833A2 (de) | 2004-06-10 |
| CN100548289C (zh) | 2009-10-14 |
| WO2004047833A3 (de) | 2005-01-13 |
| BRPI0307117B8 (pt) | 2021-05-25 |
| US8409552B2 (en) | 2013-04-02 |
| JP5467014B2 (ja) | 2014-04-09 |
| EP1567143B1 (de) | 2013-08-14 |
| BRPI0307117B1 (pt) | 2017-07-18 |
| US8203016B2 (en) | 2012-06-19 |
| KR20050085127A (ko) | 2005-08-29 |
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