JP2006511582A5 - - Google Patents
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- Publication number
- JP2006511582A5 JP2006511582A5 JP2004563920A JP2004563920A JP2006511582A5 JP 2006511582 A5 JP2006511582 A5 JP 2006511582A5 JP 2004563920 A JP2004563920 A JP 2004563920A JP 2004563920 A JP2004563920 A JP 2004563920A JP 2006511582 A5 JP2006511582 A5 JP 2006511582A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- needle
- skin
- therapeutic agent
- injection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 40
- 238000009472 formulation Methods 0.000 claims 38
- 239000003814 drug Substances 0.000 claims 16
- 229940124597 therapeutic agent Drugs 0.000 claims 16
- 238000002347 injection Methods 0.000 claims 15
- 239000007924 injection Substances 0.000 claims 15
- 210000003491 skin Anatomy 0.000 claims 15
- 241001465754 Metazoa Species 0.000 claims 11
- 239000002245 particle Substances 0.000 claims 9
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 5
- 210000002615 epidermis Anatomy 0.000 claims 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
- 210000004207 dermis Anatomy 0.000 claims 4
- 239000000499 gel Substances 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 4
- -1 alkyl benzoates Chemical class 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 244000208734 Pisonia aculeata Species 0.000 claims 2
- 239000012190 activator Substances 0.000 claims 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 2
- 239000001087 glyceryl triacetate Substances 0.000 claims 2
- 238000010348 incorporation Methods 0.000 claims 2
- 239000007972 injectable composition Substances 0.000 claims 2
- 239000002002 slurry Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 230000009974 thixotropic effect Effects 0.000 claims 2
- 229960002622 triacetin Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 229960002903 benzyl benzoate Drugs 0.000 claims 1
- 230000006652 catabolic pathway Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000013583 drug formulation Substances 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 230000009477 glass transition Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43546602P | 2002-12-20 | 2002-12-20 | |
| US60/435,466 | 2002-12-20 | ||
| PCT/US2003/040876 WO2004057959A2 (en) | 2002-12-20 | 2003-12-22 | Intracutaneous injection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012021596A Division JP5964602B2 (ja) | 2002-12-20 | 2012-02-03 | 皮内注射方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006511582A JP2006511582A (ja) | 2006-04-06 |
| JP2006511582A5 true JP2006511582A5 (https=) | 2007-02-22 |
| JP5591434B2 JP5591434B2 (ja) | 2014-09-17 |
Family
ID=32682245
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004563920A Expired - Lifetime JP5591434B2 (ja) | 2002-12-20 | 2003-12-22 | 皮内注射方法 |
| JP2012021596A Expired - Lifetime JP5964602B2 (ja) | 2002-12-20 | 2012-02-03 | 皮内注射方法 |
| JP2014226796A Withdrawn JP2015061848A (ja) | 2002-12-20 | 2014-11-07 | 皮内注射方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012021596A Expired - Lifetime JP5964602B2 (ja) | 2002-12-20 | 2012-02-03 | 皮内注射方法 |
| JP2014226796A Withdrawn JP2015061848A (ja) | 2002-12-20 | 2014-11-07 | 皮内注射方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8110209B2 (https=) |
| EP (3) | EP1589901A4 (https=) |
| JP (3) | JP5591434B2 (https=) |
| AU (2) | AU2003299795A1 (https=) |
| CA (1) | CA2510196C (https=) |
| DK (1) | DK2526996T3 (https=) |
| WO (1) | WO2004057959A2 (https=) |
Families Citing this family (129)
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2003
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- 2003-12-22 US US10/539,931 patent/US8110209B2/en active Active
- 2003-12-22 WO PCT/US2003/040876 patent/WO2004057959A2/en not_active Ceased
- 2003-12-22 DK DK12180169T patent/DK2526996T3/da active
- 2003-12-22 EP EP03800068A patent/EP1589901A4/en not_active Withdrawn
- 2003-12-22 JP JP2004563920A patent/JP5591434B2/ja not_active Expired - Lifetime
- 2003-12-22 EP EP12180169.0A patent/EP2526996B1/en not_active Expired - Lifetime
- 2003-12-22 AU AU2003299795A patent/AU2003299795A1/en not_active Abandoned
- 2003-12-22 EP EP19196481.6A patent/EP3597262B1/en not_active Expired - Lifetime
-
2010
- 2010-02-09 AU AU2010200469A patent/AU2010200469A1/en not_active Abandoned
- 2010-11-16 US US12/946,994 patent/US8790679B2/en not_active Expired - Lifetime
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2012
- 2012-02-03 JP JP2012021596A patent/JP5964602B2/ja not_active Expired - Lifetime
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2014
- 2014-05-28 US US14/289,448 patent/US9314424B2/en not_active Expired - Lifetime
- 2014-11-07 JP JP2014226796A patent/JP2015061848A/ja not_active Withdrawn
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