|
US7087229B2
(en)
*
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7122189B2
(en)
*
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7413738B2
(en)
*
|
2002-08-13 |
2008-08-19 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on biodegradable linkers
|
|
US7332164B2
(en)
*
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
|
NZ542687A
(en)
*
|
2003-04-13 |
2010-02-26 |
Enzon Pharmaceuticals Inc |
Polymeric oligonucleotide prodrugs
|
|
US7919118B2
(en)
*
|
2003-05-12 |
2011-04-05 |
Affymax, Inc. |
Spacer moiety for poly (ethylene glycol) modified peptide based compounds
|
|
ATE428727T1
(de)
|
2003-05-12 |
2009-05-15 |
Affymax Inc |
Neue, an den erythropoietinrezeptor bindende peptide
|
|
AU2004238868B2
(en)
|
2003-05-12 |
2010-01-21 |
Affymax, Inc. |
Peptides that bind to the erythropoietin receptor
|
|
CZ294996B6
(cs)
*
|
2003-07-16 |
2005-04-13 |
Ústav Makromolekulární Chemie Av Čr |
Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
|
|
US8394365B2
(en)
|
2003-09-17 |
2013-03-12 |
Nektar Therapeutics |
Multi-arm polymer prodrugs
|
|
CA2537336C
(en)
*
|
2003-09-17 |
2013-02-26 |
Nektar Therapeutics Al, Corporation |
Multi-arm polymer prodrugs
|
|
CA2940803A1
(en)
*
|
2004-03-23 |
2005-10-27 |
Ascendis Pharma Gmbh |
Prodrug linker
|
|
US7365127B2
(en)
*
|
2005-02-04 |
2008-04-29 |
Enzon Pharmaceuticals, Inc. |
Process for the preparation of polymer conjugates
|
|
US7550433B2
(en)
|
2005-06-03 |
2009-06-23 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|
|
GB2427360A
(en)
*
|
2005-06-22 |
2006-12-27 |
Complex Biosystems Gmbh |
Aliphatic prodrug linker
|
|
EP2089052A4
(en)
*
|
2006-05-24 |
2011-02-16 |
Peg Biosciences |
POLYETHYLENE GLYCOL-BASED LINK COMPOUNDS AND BIOLOGICALLY ACTIVE CONJUGATES BASED ON SAID COMPOUNDS
|
|
AU2007267798A1
(en)
*
|
2006-05-26 |
2007-12-06 |
Ipsen Pharma S.A.S. |
Methods for site-specific pegylation
|
|
JP2009539879A
(ja)
*
|
2006-06-09 |
2009-11-19 |
エンゾン ファーマスーティカルズ インコーポレイテッド |
インデノイソキノリン放出性ポリマー複合体
|
|
JP5308333B2
(ja)
*
|
2006-06-30 |
2013-10-09 |
シグマ−タウ レア ディジージズ エスィアー |
L−アスパラギナーゼiiを産生する組換え宿主
|
|
JP2010503708A
(ja)
*
|
2006-09-15 |
2010-02-04 |
エンゾン ファーマスーティカルズ インコーポレイテッド |
多官能性リンカーを含む標的化ポリマープロドラッグ
|
|
BRPI0716808A2
(pt)
*
|
2006-09-15 |
2013-11-05 |
Enzon Pharmaceuticals Inc |
Ligantes poliméricos baseados em lisina
|
|
CA2664271A1
(en)
*
|
2006-11-27 |
2008-06-12 |
Enzon Pharmaceuticals, Inc. |
Polymeric short interfering rna conjugates
|
|
CN101583380B
(zh)
*
|
2006-11-30 |
2013-07-10 |
尼克塔治疗公司 |
用于制备聚合物轭合物的方法
|
|
PT2101821E
(pt)
|
2006-12-15 |
2014-10-03 |
Baxter Int |
Fator conjugado viia-ácido (poli)siálico com prolongamento do tempo de meia vida in vivo
|
|
US20080159964A1
(en)
*
|
2006-12-29 |
2008-07-03 |
Enzon Pharmaceuticals, Inc. |
Use of adenosine deaminase for treating pulmonary disease
|
|
EP2118127A4
(en)
*
|
2007-01-31 |
2010-12-01 |
Affymax Inc |
NICKET-BASED LINKER FOR BONDING MODIFYING GROUPS OF POLYPEPTIDES AND OTHER MACROMOLECULES
|
|
TWI486169B
(zh)
*
|
2007-04-20 |
2015-06-01 |
Sigma Tau Rare Diseases S A |
酵素性抗癌療法
|
|
WO2008131208A1
(en)
*
|
2007-04-20 |
2008-10-30 |
Enzon Pharmaceuticals, Inc. |
Stable recombinant adenosine deaminase
|
|
US7714147B2
(en)
*
|
2007-06-26 |
2010-05-11 |
Baxter International Inc. |
Method for preparing Fmoc-based hydrolysable linkers
|
|
US20100203066A1
(en)
*
|
2007-08-20 |
2010-08-12 |
Enzon Pharmaceuticals, Inc. |
Polymeric linkers containing pyridyl disulfide moieties
|
|
AU2009282413B2
(en)
|
2008-08-11 |
2014-07-17 |
Nektar Therapeutics |
Multi-arm polymeric alkanoate conjugates
|
|
LT2349346T
(lt)
|
2008-09-23 |
2019-09-25 |
Nektar Therapeutics |
Kamptotecino provaistų (pvz., peg-irinotekano) metronominio dozavimo būdas
|
|
PL2431741T3
(pl)
|
2008-10-21 |
2014-01-31 |
Baxalta Inc |
Sposoby określania ilości aktywnych składników w prolekach, będących koniugatami PEG-białko, za pomocą reagentów uwalniających PEG (depegylacja in vitro)
|
|
ES2597954T3
(es)
|
2009-07-27 |
2017-01-24 |
Baxalta GmbH |
Conjugados de proteína de la coagulación sanguínea
|
|
US8642737B2
(en)
|
2010-07-26 |
2014-02-04 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
JP5909755B2
(ja)
|
2009-07-27 |
2016-04-27 |
リポクセン テクノロジーズ リミテッド |
非血液凝固タンパク質の糖ポリシアル酸化
|
|
EP3093029A1
(en)
|
2009-07-27 |
2016-11-16 |
Baxalta GmbH |
Blood coagulation protein conjugates
|
|
US8809501B2
(en)
|
2009-07-27 |
2014-08-19 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
US8927190B2
(en)
*
|
2010-01-25 |
2015-01-06 |
Rohm And Haas Electronic Materials Llc |
Photoresist comprising nitrogen-containing compound
|
|
WO2012088445A1
(en)
|
2010-12-22 |
2012-06-28 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
|
|
BR112013015898A2
(pt)
|
2010-12-22 |
2018-06-26 |
Baxter International Inc. |
derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada.
|
|
WO2012088422A1
(en)
|
2010-12-22 |
2012-06-28 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of taxane-based compounds
|
|
BR112014001274A2
(pt)
|
2011-07-18 |
2017-04-18 |
Arts Biologics As |
composto de hormônio luteinizante, e, composição farmacêutica
|
|
US8962577B2
(en)
*
|
2012-03-16 |
2015-02-24 |
The Johns Hopkins University |
Controlled release formulations for the delivery of HIF-1 inhibitors
|
|
JP6138904B2
(ja)
*
|
2012-03-16 |
2017-05-31 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート
|
|
US20150133383A1
(en)
|
2012-05-11 |
2015-05-14 |
Prorec Bio Ab |
Method for diagnosis and treatment of prolactin associated disorders
|
|
CN103881083A
(zh)
*
|
2012-12-21 |
2014-06-25 |
张雅珍 |
含有蒽环类抗生素结构的新化合物以及制备方法和用途
|
|
CN103897176B
(zh)
*
|
2012-12-24 |
2018-08-17 |
张雅珍 |
蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用
|
|
CN103897178A
(zh)
*
|
2012-12-24 |
2014-07-02 |
张雅珍 |
含有蒽环类抗生素结构的新化合物以及制备方法和用途
|
|
CN103910871A
(zh)
*
|
2012-12-28 |
2014-07-09 |
张雅珍 |
蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用
|
|
CN103910870B
(zh)
*
|
2012-12-28 |
2018-08-17 |
张雅珍 |
蒽环类抗生素偶联非线性多嵌段共聚物及其制备方法和应用
|
|
CN103910866B
(zh)
*
|
2012-12-31 |
2018-08-17 |
张雅珍 |
含有蒽环类抗生素结构的新化合物以及制备方法和用途
|
|
HK1220626A1
(zh)
|
2013-03-15 |
2017-05-12 |
The Centre For Drug Research And Development |
具细胞毒性和抗有丝分裂的化合物以及其使用方法
|
|
WO2015095953A1
(en)
|
2013-12-27 |
2015-07-02 |
The Centre For Drug Research And Development |
Sulfonamide-containing linkage systems for drug conjugates
|
|
MX370138B
(es)
|
2014-02-26 |
2019-12-03 |
Univ Texas |
Liberación de protones de nitrobenzaldehído para la manipulación de la acidosis celular.
|
|
ES2905569T3
(es)
|
2014-09-17 |
2022-04-11 |
Zymeworks Inc |
Compuestos citotóxicos y antimitóticos y métodos para utilizarlos
|
|
BR112017007765B1
(pt)
|
2014-10-14 |
2023-10-03 |
Halozyme, Inc |
Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo
|
|
AU2016252864B2
(en)
|
2015-04-24 |
2021-10-14 |
Duke University |
Metal complexes with bisphosphonate or pyrophosphate useful as imaging agents
|
|
DK3400019T3
(da)
|
2016-01-08 |
2022-10-24 |
Ascendis Pharma Growth Disorders As |
CNP-prodrugs med bærerbinding ved ringenheden
|
|
IL259827B2
(en)
|
2016-01-08 |
2025-07-01 |
Ascendis Pharma Growth Disorders As |
Controlled-release CNP agonists with low initial NPR-B activity
|
|
ES3064816T3
(en)
|
2016-01-08 |
2026-04-29 |
Ascendis Pharma Growth Disorders As |
Controlled-release cnp agonists with reduced side-effects
|
|
CA3007976C
(en)
|
2016-01-08 |
2023-09-26 |
Ascendis Pharma Growth Disorders A/S |
Cnp prodrugs with large carrier moieties
|
|
WO2017118700A1
(en)
|
2016-01-08 |
2017-07-13 |
Ascendis Pharma Growth Disorders A/S |
Controlled-release cnp agonists with increased nep stability
|
|
EP3400021A1
(en)
|
2016-01-08 |
2018-11-14 |
Ascendis Pharma Growth Disorders A/S |
Controlled-release cnp agonists with low npr-c binding
|
|
MY208384A
(en)
|
2016-03-01 |
2025-05-05 |
Ascendis Pharma Bone Diseases As |
Pth prodrugs
|
|
HRP20230383T1
(hr)
|
2016-09-29 |
2023-07-07 |
Ascendis Pharma Bone Diseases A/S |
Pth spojevi s malim omjerima maksimalne prema minimalnoj koncentraciji
|
|
KR102627405B1
(ko)
|
2016-09-29 |
2024-01-18 |
아센디스 파마 본 디지즈 에이/에스 |
조절 방출 pth 화합물을 위한 투여 용법
|
|
US11564974B2
(en)
|
2016-09-29 |
2023-01-31 |
Ascendis Pharma Growth Disorders A/S |
Combination therapy with controlled-release CNP agonists
|
|
US12453778B2
(en)
|
2016-09-29 |
2025-10-28 |
Ascendis Pharma Bone Diseases A/S |
Incremental dose finding in controlled-release PTH compounds
|
|
CN108530637B
(zh)
*
|
2017-03-05 |
2021-03-30 |
厦门赛诺邦格生物科技股份有限公司 |
一种单一功能化支化聚乙二醇的制备方法
|
|
US10391154B2
(en)
|
2017-07-19 |
2019-08-27 |
Leadiant Biosciences Ltd. |
Compositions and methods for treating or ameliorating fibrosis, systemic sclerosis and scleroderma
|
|
CN111918665B
(zh)
|
2018-03-28 |
2024-11-26 |
阿森迪斯药物肿瘤股份有限公司 |
Il-2缀合物
|
|
WO2020064847A1
(en)
|
2018-09-26 |
2020-04-02 |
Ascendis Pharma A/S |
Degradable hyaluronic acid hydrogels
|
|
MX2021008708A
(es)
|
2019-02-11 |
2021-09-21 |
Ascendis Pharma Growth Disorders As |
Formulaciones farmaceuticas secas de conjugados de peptido natriuretico tipo c (cnp).
|
|
MY209748A
(en)
|
2019-02-11 |
2025-07-31 |
Ascendis Pharma Bone Diseases As |
Liquid pharmaceutical formulations of pth conjugates
|
|
KR20230019889A
(ko)
|
2020-06-03 |
2023-02-09 |
아센디스 파마 온콜로지 디비전 에이/에스 |
Il-2 서열 및 이의 용도
|