JP2005504006A5 - - Google Patents

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Publication number
JP2005504006A5
JP2005504006A5 JP2002580872A JP2002580872A JP2005504006A5 JP 2005504006 A5 JP2005504006 A5 JP 2005504006A5 JP 2002580872 A JP2002580872 A JP 2002580872A JP 2002580872 A JP2002580872 A JP 2002580872A JP 2005504006 A5 JP2005504006 A5 JP 2005504006A5
Authority
JP
Japan
Prior art keywords
group
alkyl
compound
compound according
heteroalkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002580872A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005504006A (ja
Filing date
Publication date
Priority claimed from US10/066,306 external-priority patent/US6774116B2/en
Application filed filed Critical
Publication of JP2005504006A publication Critical patent/JP2005504006A/ja
Publication of JP2005504006A5 publication Critical patent/JP2005504006A5/ja
Pending legal-status Critical Current

Links

JP2002580872A 2001-04-17 2002-04-12 シンナメートとのアシル化によるプロドラッグ結合 Pending JP2005504006A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28430401P 2001-04-17 2001-04-17
US31578201P 2001-08-28 2001-08-28
US10/066,306 US6774116B2 (en) 2001-04-17 2002-01-31 Prodrugs via acylation with cinnamate
PCT/US2002/011330 WO2002083067A2 (en) 2001-04-17 2002-04-12 Prodrugs via acylation with cinnamate

Publications (2)

Publication Number Publication Date
JP2005504006A JP2005504006A (ja) 2005-02-10
JP2005504006A5 true JP2005504006A5 (https=) 2005-12-22

Family

ID=27370948

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002580872A Pending JP2005504006A (ja) 2001-04-17 2002-04-12 シンナメートとのアシル化によるプロドラッグ結合

Country Status (5)

Country Link
US (1) US6774116B2 (https=)
EP (1) EP1395256A4 (https=)
JP (1) JP2005504006A (https=)
CA (1) CA2444264A1 (https=)
WO (1) WO2002083067A2 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157458B2 (en) * 2001-04-17 2007-01-02 Cryolife, Inc. Bifunctional energy-reversible acyl-compositions
AU2002953533A0 (en) 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
MXPA05007151A (es) 2002-12-31 2005-09-21 Nektar Therapeutics Al Corp Polimeros terminados en maleimida hidroliticamente estables.
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
WO2005042539A1 (en) 2003-10-29 2005-05-12 Sonus Pharmaceuticals, Inc. Tocopherol-modified therapeutic drug compounds
US20080119421A1 (en) * 2003-10-31 2008-05-22 Jack Tuszynski Process for treating a biological organism
US6887952B1 (en) * 2004-02-12 2005-05-03 Biosite, Inc. N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use
US20080177220A1 (en) * 2006-01-06 2008-07-24 The Curators Of The University Of Missouri Ultrasound-Mediated Transcleral Drug Delivery
FR2902792A1 (fr) * 2006-06-21 2007-12-28 Servier Lab Nouveaux derives cinnamates de tetrahydro-7h-pyrano(2,3-c)acridin-7-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2176404A4 (en) * 2007-07-11 2014-11-19 Belrose Pharma Inc POLYMERIC DRUG DELIVERY SYSTEMS WITH AN AROMATIC ALLYLIC ACID
CN101970012A (zh) * 2007-09-14 2011-02-09 日东电工株式会社 药物载体
US20100068266A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo-modifiable multiple-release state final dosage form
US20100069821A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-sites final dosage form
US20100068233A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Modifiable dosage form
US20100068254A1 (en) * 2008-09-16 2010-03-18 Mahalaxmi Gita Bangera Modifying a medicament availability state of a final dosage form
US20100068153A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo activatable final dosage form
US20100068275A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Personalizable dosage form
US20100068235A1 (en) * 2008-09-16 2010-03-18 Searete LLC, a limited liability corporation of Deleware Individualizable dosage form
US20100068152A1 (en) * 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable particle or polymeric based final dosage form
DK2806897T3 (en) * 2012-01-27 2017-10-16 Hoffmann La Roche INTEGRIN ANAGONIST CONJUGATES FOR TARGETED RELEASE TO LFA-1 EXPRESSING CELLS
GB2528643A (en) * 2014-07-08 2016-02-03 Adc Biotechnology Ltd Method of synthesising ADCs
CN117982673A (zh) 2017-02-28 2024-05-07 第一三共株式会社 抗her3抗体-药物偶联物的应用
CN107365283B (zh) * 2017-08-07 2020-12-08 无锡紫杉药业有限公司 一种紫杉醇光降解获得杂质的方法
WO2020059772A1 (ja) 2018-09-20 2020-03-26 第一三共株式会社 抗ｈｅｒ３抗体－薬物コンジュゲート投与によるｈｅｒ３変異がんの治療
CN113101372B (zh) * 2019-12-24 2025-02-14 北京大学 具有辐射响应基团的缀合物及其用途
EP4721766A1 (en) 2023-06-02 2026-04-08 Daiichi Sankyo Company, Limited Combination of (anti-her3 antibody)-drug conjugate and rasg12c inhibitor
CN121464130A (zh) * 2023-06-26 2026-02-03 北京大学 可通过辐射激活的化合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5218136A (en) * 1987-12-28 1993-06-08 Sumitomo Chemical Company, Limited Styryl compounds, process for preparing the same and photoresist compositions comprising the same
US5114851A (en) * 1989-08-29 1992-05-19 Duke University Light activated acyl-enzymes
US5218137A (en) * 1989-08-29 1993-06-08 Duke University Light activated acyl-enzymes
EP0936211B1 (en) * 1998-02-13 2010-07-07 Givaudan SA Aryl-acrylic acid esters useful as precursors for organoleptic compounds
JP2000264868A (ja) * 1999-01-12 2000-09-26 Bunshi Biophotonics Kenkyusho:Kk 新規ケージドアミノ酸
JP2000319202A (ja) * 1999-01-12 2000-11-21 Bunshi Biophotonics Kenkyusho:Kk 新規ケージド化合物調製用試薬、及びケージド化方法

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