JP2019137674A5 - - Google Patents
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- Publication number
- JP2019137674A5 JP2019137674A5 JP2019011014A JP2019011014A JP2019137674A5 JP 2019137674 A5 JP2019137674 A5 JP 2019137674A5 JP 2019011014 A JP2019011014 A JP 2019011014A JP 2019011014 A JP2019011014 A JP 2019011014A JP 2019137674 A5 JP2019137674 A5 JP 2019137674A5
- Authority
- JP
- Japan
- Prior art keywords
- magnetic material
- iron oxide
- organic acid
- acid nanoparticles
- biocompatible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 21
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 14
- 229910052742 iron Inorganic materials 0.000 claims 12
- 239000000696 magnetic material Substances 0.000 claims 11
- 239000002105 nanoparticle Substances 0.000 claims 11
- 239000000243 solution Substances 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 229920000249 biocompatible polymer Polymers 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 150000002500 ions Chemical class 0.000 claims 3
- -1 iron ions Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 229910052786 argon Inorganic materials 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000011261 inert gas Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000011259 mixed solution Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- PXXSHCAEZBHGII-UHFFFAOYSA-N [O-2].[Fe+2].C(CCCCCCCC=C/CCCCCCCC)(=O)O Chemical compound [O-2].[Fe+2].C(CCCCCCCC=C/CCCCCCCC)(=O)O PXXSHCAEZBHGII-UHFFFAOYSA-N 0.000 claims 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810145800.0A CN110157000B (zh) | 2018-02-12 | 2018-02-12 | 生物相容性磁性材料 |
| CN201810145800.0 | 2018-02-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019137674A JP2019137674A (ja) | 2019-08-22 |
| JP2019137674A5 true JP2019137674A5 (https=) | 2022-01-27 |
| JP7335472B2 JP7335472B2 (ja) | 2023-08-30 |
Family
ID=65529243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019011014A Active JP7335472B2 (ja) | 2018-02-12 | 2019-01-25 | 生体適合性磁性材料 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20190247522A1 (https=) |
| EP (1) | EP3524276B1 (https=) |
| JP (1) | JP7335472B2 (https=) |
| KR (1) | KR102782693B1 (https=) |
| CN (1) | CN110157000B (https=) |
| AU (1) | AU2019200753B2 (https=) |
| CA (1) | CA3032985A1 (https=) |
| DK (1) | DK3524276T3 (https=) |
| ES (1) | ES2903387T3 (https=) |
| TW (1) | TWI811297B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107999037B (zh) * | 2017-12-18 | 2020-07-31 | 南京大学 | 一种磁性高分子吸附材料、制备方法和应用 |
| JP7788100B2 (ja) * | 2020-09-11 | 2025-12-18 | Jsr株式会社 | 複合体及び光免疫療法 |
| CN115520907A (zh) * | 2022-04-14 | 2022-12-27 | 西安超磁纳米生物科技有限公司 | 一种具有活性基团的超小铁氧体纳米颗粒及其制备与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5031979B2 (ja) | 2004-07-12 | 2012-09-26 | 戸田工業株式会社 | 磁性粒子含有医薬用原薬 |
| WO2007099289A1 (en) | 2006-02-28 | 2007-09-07 | Medical Research Council | Targeted iron oxide nanoparticles |
| JP4894332B2 (ja) | 2006-04-05 | 2012-03-14 | 三洋化成工業株式会社 | 磁気共鳴画像用造影剤 |
| ES2787502T3 (es) * | 2008-04-22 | 2020-10-16 | Megapro Biomedical Co Ltd | Polímero biocompatible y nanopartícula magnética con biocompatibilidad |
| GB0808086D0 (en) | 2008-05-02 | 2008-06-11 | Iti Scotland Ltd | Magnetic proteins for in vivo imaging |
| CA2781329A1 (en) | 2009-11-20 | 2011-05-26 | Toda Kogyo Corporation | Magnetic iron oxide fine particles, and magnetic particle-containing water dispersion and process for producing the same |
| CN102552945B (zh) * | 2012-01-19 | 2013-09-11 | 青岛科技大学 | 一种磁性四氧化三铁纳米粒子的表面修饰方法 |
| CN103405789B (zh) * | 2013-08-06 | 2015-02-11 | 哈尔滨工业大学 | 生物膜修饰的四氧化三铁纳米粒子的制备方法 |
| TWI689310B (zh) * | 2014-07-11 | 2020-04-01 | 巨生生醫股份有限公司 | 治療鐵缺乏症之方法 |
| TWI745272B (zh) | 2014-07-14 | 2021-11-11 | 巨生生醫股份有限公司 | 免疫細胞追蹤方法 |
| US20180280545A1 (en) * | 2014-11-04 | 2018-10-04 | University Of Washington | Iron oxide nanoparticles and their synthesis by controlled oxidation |
-
2018
- 2018-02-12 CN CN201810145800.0A patent/CN110157000B/zh active Active
- 2018-11-29 US US16/204,510 patent/US20190247522A1/en not_active Abandoned
-
2019
- 2019-01-25 JP JP2019011014A patent/JP7335472B2/ja active Active
- 2019-02-01 TW TW108104248A patent/TWI811297B/zh active
- 2019-02-05 AU AU2019200753A patent/AU2019200753B2/en active Active
- 2019-02-07 CA CA3032985A patent/CA3032985A1/en active Pending
- 2019-02-11 ES ES19156555T patent/ES2903387T3/es active Active
- 2019-02-11 EP EP19156555.5A patent/EP3524276B1/en active Active
- 2019-02-11 KR KR1020190015657A patent/KR102782693B1/ko active Active
- 2019-02-11 DK DK19156555.5T patent/DK3524276T3/da active
-
2021
- 2021-11-24 US US17/535,168 patent/US12268756B2/en active Active
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