JP2009102649A5 - - Google Patents

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Publication number
JP2009102649A5
JP2009102649A5 JP2009003472A JP2009003472A JP2009102649A5 JP 2009102649 A5 JP2009102649 A5 JP 2009102649A5 JP 2009003472 A JP2009003472 A JP 2009003472A JP 2009003472 A JP2009003472 A JP 2009003472A JP 2009102649 A5 JP2009102649 A5 JP 2009102649A5
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Japan
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group
formula
carbon atoms
molecule
oxyalkylene
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JP2009003472A
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English (en)
Japanese (ja)
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JP5273589B2 (ja
JP2009102649A (ja
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Priority to JP2009003472A priority Critical patent/JP5273589B2/ja
Priority claimed from JP2009003472A external-priority patent/JP5273589B2/ja
Publication of JP2009102649A publication Critical patent/JP2009102649A/ja
Publication of JP2009102649A5 publication Critical patent/JP2009102649A5/ja
Application granted granted Critical
Publication of JP5273589B2 publication Critical patent/JP5273589B2/ja
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Expired - Lifetime legal-status Critical Current

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JP2009003472A 2002-11-20 2009-01-09 生体関連物質、その製造方法およびその中間体 Expired - Lifetime JP5273589B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009003472A JP5273589B2 (ja) 2002-11-20 2009-01-09 生体関連物質、その製造方法およびその中間体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002337113 2002-11-20
JP2002337113 2002-11-20
JP2009003472A JP5273589B2 (ja) 2002-11-20 2009-01-09 生体関連物質、その製造方法およびその中間体

Related Parent Applications (1)

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JP2003388886A Division JP4412461B2 (ja) 2002-11-20 2003-11-19 修飾された生体関連物質、その製造方法および中間体

Publications (3)

Publication Number Publication Date
JP2009102649A JP2009102649A (ja) 2009-05-14
JP2009102649A5 true JP2009102649A5 (https=) 2010-09-16
JP5273589B2 JP5273589B2 (ja) 2013-08-28

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JP2003388886A Expired - Lifetime JP4412461B2 (ja) 2002-11-20 2003-11-19 修飾された生体関連物質、その製造方法および中間体
JP2009003472A Expired - Lifetime JP5273589B2 (ja) 2002-11-20 2009-01-09 生体関連物質、その製造方法およびその中間体

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JP2003388886A Expired - Lifetime JP4412461B2 (ja) 2002-11-20 2003-11-19 修飾された生体関連物質、その製造方法および中間体

Country Status (11)

Country Link
US (4) US20050058620A1 (https=)
EP (3) EP1911789B1 (https=)
JP (2) JP4412461B2 (https=)
KR (1) KR100988733B1 (https=)
CN (1) CN100402580C (https=)
AT (1) ATE388186T1 (https=)
AU (1) AU2003302031A1 (https=)
CA (1) CA2502948C (https=)
DE (1) DE60319568T2 (https=)
IL (2) IL168238A (https=)
WO (1) WO2004046222A1 (https=)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179617B2 (en) * 2001-10-10 2007-02-20 Neose Technologies, Inc. Factor IX: remolding and glycoconjugation of Factor IX
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
MXPA04012496A (es) 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
JP4412461B2 (ja) * 2002-11-20 2010-02-10 日油株式会社 修飾された生体関連物質、その製造方法および中間体
US8828373B2 (en) * 2002-11-20 2014-09-09 Nof Corporation Polyalkylene glycol derivative and modified bio-related substance
US8003117B2 (en) * 2002-11-20 2011-08-23 Nof Corporation Polyalkylene glycol derivative and modified bio-related substance
EA008866B1 (ru) 2002-12-26 2007-08-31 Маунтин Вью Фамэсьютикэлс, Инк. ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ
NZ541122A (en) * 2002-12-26 2008-09-26 Mountain View Pharmaceuticals Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
KR20060003862A (ko) 2003-03-14 2006-01-11 네오스 테크놀로지스, 인크. 수용성분기폴리머 및 그 접합체
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
EP2055189A1 (en) 2003-04-09 2009-05-06 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
AU2004240553A1 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
NZ592039A (en) * 2003-08-27 2013-03-28 Ophthotech Corp Combination therapy for the treatment of ocular neovascular disorders
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7338933B2 (en) 2004-01-08 2008-03-04 Neose Technologies, Inc. O-linked glycosylation of peptides
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
JP2008511610A (ja) * 2004-08-31 2008-04-17 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー グリセロール分岐のポリエチレングリコール−ヒト成長ホルモン結合体、それらの製造方法及び使用方法
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
KR101468345B1 (ko) * 2004-11-12 2014-12-03 바이엘 헬스케어 엘엘씨 Fviii의 부위 지향 변형
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1857462B9 (en) * 2005-02-18 2013-02-13 Nof Corporation Polyoxyalkylene derivative
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP1891231A4 (en) 2005-05-25 2011-06-22 Novo Nordisk As GLYCOPEGYLATED FACTOR IX
KR100735784B1 (ko) * 2005-07-20 2007-07-06 재단법인 목암생명공학연구소 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
EP1787660A1 (en) * 2005-11-22 2007-05-23 GBF Gesellschaft für Biotechnologische Forschung mbH New adjuvants on the basis of bisacyloxypropylcysteine conjugates and their uses in pharmaceutical compositions
MX2008014358A (es) * 2006-05-12 2008-11-24 Dong A Pharm Co Ltd Conjugado de polietilenglicol-interferon alfa.
ES2516694T3 (es) 2006-07-21 2014-10-31 Ratiopharm Gmbh Glicosilación de péptidos a través de secuencias de glicosilación con unión en O
JP5277599B2 (ja) * 2006-09-29 2013-08-28 日油株式会社 生分解性ポリオキシアルキレン誘導体の製造方法
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
US20100041872A1 (en) * 2006-10-04 2010-02-18 Defrees Shawn Glycerol linked pegylated sugars and glycopeptides
KR101079993B1 (ko) * 2006-11-17 2011-11-04 동아제약주식회사 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체
JP5515224B2 (ja) * 2007-02-28 2014-06-11 日油株式会社 多分岐鎖ポリオキシアルキレン誘導体
KR20100016160A (ko) 2007-04-03 2010-02-12 바이오제너릭스 에이지 글리코페길화 g―csf를 이용하는 치료 방법
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
KR101582841B1 (ko) 2008-02-27 2016-01-11 노보 노르디스크 에이/에스 콘쥬게이트된 인자 viii 분자
US20090246430A1 (en) 2008-03-28 2009-10-01 The Coca-Cola Company Bio-based polyethylene terephthalate polymer and method of making same
ES2589385T3 (es) 2009-03-03 2016-11-14 The Coca-Cola Company Envase de poli(tereftalato de etileno) de base biológica y método para su fabricación
US8067526B2 (en) * 2009-03-27 2011-11-29 Nof Corporation Method for producing polyoxalkylene derivative
JP5569787B2 (ja) * 2009-03-31 2014-08-13 日油株式会社 高分子量ポリエチレングリコール化合物の精製方法
DK2415800T3 (da) * 2009-03-31 2013-12-02 Nof Corp Hyperforgrenet polyoxyalkylenforbindelse og fremgangsmåde til deres fremstilling
US8816099B2 (en) * 2010-03-31 2014-08-26 Nof Corporation Polyfunctional polyoxyalkylene compound, and producing method and intermediate thereof
EP2569331A1 (en) 2010-05-10 2013-03-20 Perseid Therapeutics LLC Polypeptide inhibitors of vla4
CA2798518A1 (en) 2010-05-17 2011-11-24 Cebix, Inc. Pegylated c-peptide
US10040761B2 (en) 2010-06-25 2018-08-07 Nof Corporation Branched hetero polyethylene glycol and intermediate
US8933070B2 (en) 2010-07-02 2015-01-13 University Health Network Methods of targeting PTEN mutant diseases and compositions therefor
JP5949037B2 (ja) 2011-03-30 2016-07-06 日油株式会社 末端に複数の水酸基を有するポリオキシエチレン誘導体
WO2014157150A1 (ja) 2013-03-25 2014-10-02 日油株式会社 ベンジリデンアセタールリンカーを有する親水性ポリマー誘導体
EP2980115B1 (en) 2013-03-27 2019-03-06 NOF Corporation Purification method for polyethylene glycol having a single amino group
AU2014286996A1 (en) 2013-07-12 2016-01-07 Iveric Bio, Inc. Methods for treating or preventing ophthalmological conditions
CN103881084B (zh) * 2014-03-14 2016-09-28 厦门赛诺邦格生物科技股份有限公司 一种支化聚乙二醇的磷脂类衍生物及其组成的脂质膜结构体
WO2017043653A1 (ja) * 2015-09-11 2017-03-16 国立大学法人 東京大学 タンパク質を安定化するための化合物
JP6860827B2 (ja) * 2016-04-28 2021-04-21 日油株式会社 分岐型ポリオキシエチレン化合物およびコンタクトレンズ
WO2018066692A1 (ja) 2016-10-07 2018-04-12 国立大学法人東京工業大学 分岐型ヘテロ単分散ポリエチレングリコール、その製造方法、及びその結合体
JP6935059B2 (ja) 2017-03-30 2021-09-15 日油株式会社 カルボキシル基を一つ有するポリエチレングリコールの精製方法
US11905367B2 (en) 2018-03-20 2024-02-20 Nof Corporation Branched monodispersed polyethylene glycol, intermediate and methods for producing same
US12441776B2 (en) 2018-11-30 2025-10-14 Eirgen Pharma Ltd. Oxyntomodulin peptide analog formulations
US12378356B2 (en) 2019-12-27 2025-08-05 Nof Corporation Method for purifying branched polyethylene glycol
EP4083108A4 (en) 2019-12-27 2024-02-14 NOF Corporation IMPROVEMENT METHOD FOR POLYETHYLENE GLYCOL COMPOUND
CN118871503A (zh) 2022-03-09 2024-10-29 日油株式会社 聚氧乙烯衍生物的制备方法、聚氧乙烯化合物的定量方法和分析用标记试剂
KR20240161641A (ko) 2022-03-17 2024-11-12 니치유 가부시키가이샤 폴리에틸렌글리콜 유도체의 제조 방법
WO2025070508A1 (ja) 2023-09-27 2025-04-03 日油株式会社 末端にカルボキシル基を有するポリエチレングリコール誘導体の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3025807A1 (de) * 1980-07-08 1982-02-04 Th. Goldschmidt Ag, 4300 Essen Verfahren zur herstellung von polyaethern unter erhalt von mindestens zwei freien hydroxylgruppen am startalkohol
JPH02242823A (ja) * 1989-03-02 1990-09-27 Kiyouseki Seihin Gijutsu Kenkyusho:Kk シアノエチル化ポリエーテルポリオール及び該化合物を有効成分として含有する冷凍機油
US5118448A (en) * 1990-10-19 1992-06-02 Arco Chemical Technology, L.P. Process for producing esterified alkoxylated polyols
JP3218755B2 (ja) * 1992-11-12 2001-10-15 日本油脂株式会社 グリセリンエーテルエステル
JP3067541B2 (ja) 1994-08-23 2000-07-17 日本油脂株式会社 グリセリンポリアルキレングリコールエーテル誘導体及びその製造方法
JP3921781B2 (ja) * 1998-02-12 2007-05-30 日本油脂株式会社 カルボキシル基含有ポリオキシアルキレン化合物
JP4055250B2 (ja) * 1998-06-15 2008-03-05 日油株式会社 アミノ基含有ポリオキシアルキレン化合物
JP2000230000A (ja) * 1999-02-08 2000-08-22 Hokkaido Univ 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体
JP4123856B2 (ja) * 2001-07-31 2008-07-23 日油株式会社 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法
JP4412461B2 (ja) * 2002-11-20 2010-02-10 日油株式会社 修飾された生体関連物質、その製造方法および中間体
US8003117B2 (en) * 2002-11-20 2011-08-23 Nof Corporation Polyalkylene glycol derivative and modified bio-related substance

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