KR100988733B1 - 개질된 생체 관련 물질, 이의 제조방법 및 중간체 - Google Patents

개질된 생체 관련 물질, 이의 제조방법 및 중간체 Download PDF

Info

Publication number
KR100988733B1
KR100988733B1 KR1020057009090A KR20057009090A KR100988733B1 KR 100988733 B1 KR100988733 B1 KR 100988733B1 KR 1020057009090 A KR1020057009090 A KR 1020057009090A KR 20057009090 A KR20057009090 A KR 20057009090A KR 100988733 B1 KR100988733 B1 KR 100988733B1
Authority
KR
South Korea
Prior art keywords
formula
group
compound
reaction
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020057009090A
Other languages
English (en)
Korean (ko)
Other versions
KR20050083923A (ko
Inventor
겐이치로 나카모토
šœ스케 오하시
유지 야마모토
겐지 사카노우에
치카 이토
도루 야스코치
Original Assignee
니치유 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 니치유 가부시키가이샤 filed Critical 니치유 가부시키가이샤
Publication of KR20050083923A publication Critical patent/KR20050083923A/ko
Application granted granted Critical
Publication of KR100988733B1 publication Critical patent/KR100988733B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
    • C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
KR1020057009090A 2002-11-20 2003-11-20 개질된 생체 관련 물질, 이의 제조방법 및 중간체 Expired - Lifetime KR100988733B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JPJP-P-2002-00337113 2002-11-20
JP2002337113 2002-11-20

Publications (2)

Publication Number Publication Date
KR20050083923A KR20050083923A (ko) 2005-08-26
KR100988733B1 true KR100988733B1 (ko) 2010-10-20

Family

ID=32321831

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057009090A Expired - Lifetime KR100988733B1 (ko) 2002-11-20 2003-11-20 개질된 생체 관련 물질, 이의 제조방법 및 중간체

Country Status (11)

Country Link
US (4) US20050058620A1 (https=)
EP (3) EP1911789B1 (https=)
JP (2) JP4412461B2 (https=)
KR (1) KR100988733B1 (https=)
CN (1) CN100402580C (https=)
AT (1) ATE388186T1 (https=)
AU (1) AU2003302031A1 (https=)
CA (1) CA2502948C (https=)
DE (1) DE60319568T2 (https=)
IL (2) IL168238A (https=)
WO (1) WO2004046222A1 (https=)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179617B2 (en) * 2001-10-10 2007-02-20 Neose Technologies, Inc. Factor IX: remolding and glycoconjugation of Factor IX
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
MXPA04012496A (es) 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
JP4412461B2 (ja) * 2002-11-20 2010-02-10 日油株式会社 修飾された生体関連物質、その製造方法および中間体
US8828373B2 (en) * 2002-11-20 2014-09-09 Nof Corporation Polyalkylene glycol derivative and modified bio-related substance
US8003117B2 (en) * 2002-11-20 2011-08-23 Nof Corporation Polyalkylene glycol derivative and modified bio-related substance
EA008866B1 (ru) 2002-12-26 2007-08-31 Маунтин Вью Фамэсьютикэлс, Инк. ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ
NZ541122A (en) * 2002-12-26 2008-09-26 Mountain View Pharmaceuticals Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
US7432331B2 (en) 2002-12-31 2008-10-07 Nektar Therapeutics Al, Corporation Hydrolytically stable maleimide-terminated polymers
KR20060003862A (ko) 2003-03-14 2006-01-11 네오스 테크놀로지스, 인크. 수용성분기폴리머 및 그 접합체
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
EP2055189A1 (en) 2003-04-09 2009-05-06 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
AU2004240553A1 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
NZ592039A (en) * 2003-08-27 2013-03-28 Ophthotech Corp Combination therapy for the treatment of ocular neovascular disorders
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7338933B2 (en) 2004-01-08 2008-03-04 Neose Technologies, Inc. O-linked glycosylation of peptides
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
JP2008511610A (ja) * 2004-08-31 2008-04-17 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー グリセロール分岐のポリエチレングリコール−ヒト成長ホルモン結合体、それらの製造方法及び使用方法
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
KR101468345B1 (ko) * 2004-11-12 2014-12-03 바이엘 헬스케어 엘엘씨 Ｆｖｉｉｉ의 부위 지향 변형
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1857462B9 (en) * 2005-02-18 2013-02-13 Nof Corporation Polyoxyalkylene derivative
US20070154992A1 (en) 2005-04-08 2007-07-05 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP1891231A4 (en) 2005-05-25 2011-06-22 Novo Nordisk As GLYCOPEGYLATED FACTOR IX
KR100735784B1 (ko) * 2005-07-20 2007-07-06 재단법인 목암생명공학연구소 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
EP1787660A1 (en) * 2005-11-22 2007-05-23 GBF Gesellschaft für Biotechnologische Forschung mbH New adjuvants on the basis of bisacyloxypropylcysteine conjugates and their uses in pharmaceutical compositions
MX2008014358A (es) * 2006-05-12 2008-11-24 Dong A Pharm Co Ltd Conjugado de polietilenglicol-interferon alfa.
ES2516694T3 (es) 2006-07-21 2014-10-31 Ratiopharm Gmbh Glicosilación de péptidos a través de secuencias de glicosilación con unión en O
JP5277599B2 (ja) * 2006-09-29 2013-08-28 日油株式会社 生分解性ポリオキシアルキレン誘導体の製造方法
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
US20100041872A1 (en) * 2006-10-04 2010-02-18 Defrees Shawn Glycerol linked pegylated sugars and glycopeptides
KR101079993B1 (ko) * 2006-11-17 2011-11-04 동아제약주식회사 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체
JP5515224B2 (ja) * 2007-02-28 2014-06-11 日油株式会社 多分岐鎖ポリオキシアルキレン誘導体
KR20100016160A (ko) 2007-04-03 2010-02-12 바이오제너릭스 에이지 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
KR101582841B1 (ko) 2008-02-27 2016-01-11 노보 노르디스크 에이/에스 콘쥬게이트된 인자 ｖｉｉｉ 분자
US20090246430A1 (en) 2008-03-28 2009-10-01 The Coca-Cola Company Bio-based polyethylene terephthalate polymer and method of making same
ES2589385T3 (es) 2009-03-03 2016-11-14 The Coca-Cola Company Envase de poli(tereftalato de etileno) de base biológica y método para su fabricación
US8067526B2 (en) * 2009-03-27 2011-11-29 Nof Corporation Method for producing polyoxalkylene derivative
JP5569787B2 (ja) * 2009-03-31 2014-08-13 日油株式会社 高分子量ポリエチレングリコール化合物の精製方法
DK2415800T3 (da) * 2009-03-31 2013-12-02 Nof Corp Hyperforgrenet polyoxyalkylenforbindelse og fremgangsmåde til deres fremstilling
US8816099B2 (en) * 2010-03-31 2014-08-26 Nof Corporation Polyfunctional polyoxyalkylene compound, and producing method and intermediate thereof
EP2569331A1 (en) 2010-05-10 2013-03-20 Perseid Therapeutics LLC Polypeptide inhibitors of vla4
CA2798518A1 (en) 2010-05-17 2011-11-24 Cebix, Inc. Pegylated c-peptide
US10040761B2 (en) 2010-06-25 2018-08-07 Nof Corporation Branched hetero polyethylene glycol and intermediate
US8933070B2 (en) 2010-07-02 2015-01-13 University Health Network Methods of targeting PTEN mutant diseases and compositions therefor
JP5949037B2 (ja) 2011-03-30 2016-07-06 日油株式会社 末端に複数の水酸基を有するポリオキシエチレン誘導体
WO2014157150A1 (ja) 2013-03-25 2014-10-02 日油株式会社 ベンジリデンアセタールリンカーを有する親水性ポリマー誘導体
EP2980115B1 (en) 2013-03-27 2019-03-06 NOF Corporation Purification method for polyethylene glycol having a single amino group
AU2014286996A1 (en) 2013-07-12 2016-01-07 Iveric Bio, Inc. Methods for treating or preventing ophthalmological conditions
CN103881084B (zh) * 2014-03-14 2016-09-28 厦门赛诺邦格生物科技股份有限公司 一种支化聚乙二醇的磷脂类衍生物及其组成的脂质膜结构体
WO2017043653A1 (ja) * 2015-09-11 2017-03-16 国立大学法人 東京大学 タンパク質を安定化するための化合物
JP6860827B2 (ja) * 2016-04-28 2021-04-21 日油株式会社 分岐型ポリオキシエチレン化合物およびコンタクトレンズ
WO2018066692A1 (ja) 2016-10-07 2018-04-12 国立大学法人東京工業大学 分岐型ヘテロ単分散ポリエチレングリコール、その製造方法、及びその結合体
JP6935059B2 (ja) 2017-03-30 2021-09-15 日油株式会社 カルボキシル基を一つ有するポリエチレングリコールの精製方法
US11905367B2 (en) 2018-03-20 2024-02-20 Nof Corporation Branched monodispersed polyethylene glycol, intermediate and methods for producing same
US12441776B2 (en) 2018-11-30 2025-10-14 Eirgen Pharma Ltd. Oxyntomodulin peptide analog formulations
US12378356B2 (en) 2019-12-27 2025-08-05 Nof Corporation Method for purifying branched polyethylene glycol
EP4083108A4 (en) 2019-12-27 2024-02-14 NOF Corporation IMPROVEMENT METHOD FOR POLYETHYLENE GLYCOL COMPOUND
CN118871503A (zh) 2022-03-09 2024-10-29 日油株式会社 聚氧乙烯衍生物的制备方法、聚氧乙烯化合物的定量方法和分析用标记试剂
KR20240161641A (ko) 2022-03-17 2024-11-12 니치유 가부시키가이샤 폴리에틸렌글리콜 유도체의 제조 방법
WO2025070508A1 (ja) 2023-09-27 2025-04-03 日油株式会社 末端にカルボキシル基を有するポリエチレングリコール誘導体の製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0859818A (ja) * 1994-08-23 1996-03-05 Nippon Oil & Fats Co Ltd グリセリンポリアルキレングリコールエーテル誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3025807A1 (de) * 1980-07-08 1982-02-04 Th. Goldschmidt Ag, 4300 Essen Verfahren zur herstellung von polyaethern unter erhalt von mindestens zwei freien hydroxylgruppen am startalkohol
JPH02242823A (ja) * 1989-03-02 1990-09-27 Kiyouseki Seihin Gijutsu Kenkyusho:Kk シアノエチル化ポリエーテルポリオール及び該化合物を有効成分として含有する冷凍機油
US5118448A (en) * 1990-10-19 1992-06-02 Arco Chemical Technology, L.P. Process for producing esterified alkoxylated polyols
JP3218755B2 (ja) * 1992-11-12 2001-10-15 日本油脂株式会社 グリセリンエーテルエステル
JP3921781B2 (ja) * 1998-02-12 2007-05-30 日本油脂株式会社 カルボキシル基含有ポリオキシアルキレン化合物
JP4055250B2 (ja) * 1998-06-15 2008-03-05 日油株式会社 アミノ基含有ポリオキシアルキレン化合物
JP2000230000A (ja) * 1999-02-08 2000-08-22 Hokkaido Univ 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体
JP4123856B2 (ja) * 2001-07-31 2008-07-23 日油株式会社 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法
JP4412461B2 (ja) * 2002-11-20 2010-02-10 日油株式会社 修飾された生体関連物質、その製造方法および中間体
US8003117B2 (en) * 2002-11-20 2011-08-23 Nof Corporation Polyalkylene glycol derivative and modified bio-related substance

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0859818A (ja) * 1994-08-23 1996-03-05 Nippon Oil & Fats Co Ltd グリセリンポリアルキレングリコールエーテル誘導体

Also Published As

Publication number Publication date
US20050288490A1 (en) 2005-12-29
EP1564236A1 (en) 2005-08-17
EP1911788A1 (en) 2008-04-16
JP5273589B2 (ja) 2013-08-28
JP4412461B2 (ja) 2010-02-10
DE60319568T2 (de) 2009-04-02
EP1564236B1 (en) 2008-03-05
US7524875B2 (en) 2009-04-28
US20110082277A1 (en) 2011-04-07
IL194501A (en) 2011-11-30
JP2004197077A (ja) 2004-07-15
US20090192320A1 (en) 2009-07-30
CN1714116A (zh) 2005-12-28
US8034981B2 (en) 2011-10-11
DE60319568D1 (de) 2008-04-17
ATE388186T1 (de) 2008-03-15
AU2003302031A1 (en) 2004-06-15
EP1564236A4 (en) 2006-01-25
KR20050083923A (ko) 2005-08-26
US7851491B2 (en) 2010-12-14
EP1911789A1 (en) 2008-04-16
US20050058620A1 (en) 2005-03-17
CN100402580C (zh) 2008-07-16
WO2004046222A1 (ja) 2004-06-03
CA2502948C (en) 2013-04-02
EP1911789B1 (en) 2016-04-27
IL168238A (en) 2009-09-22
JP2009102649A (ja) 2009-05-14
CA2502948A1 (en) 2004-06-03
EP1911788B1 (en) 2019-03-27

Similar Documents

Publication Publication Date Title
KR100988733B1 (ko) 개질된 생체 관련 물질, 이의 제조방법 및 중간체
CN101622295B (zh) 多支链聚氧化亚烷基衍生物
JP5825507B2 (ja) 分岐型ヘテロポリエチレングリコール
EP1283233B1 (en) Polyoxyalkylene derivative and process of producing the same
JP5951496B2 (ja) ポリマー−薬物コンジュゲートの酸性塩形態及びアルコキシル化方法
US8003117B2 (en) Polyalkylene glycol derivative and modified bio-related substance
KR102498068B1 (ko) 분기형 헤테로 단분산 폴리에틸렌 글리콜, 그 제조 방법, 및 그 결합체
CN103044676A (zh) 一种聚乙二醇修饰的生物相关物质
JP2015157946A (ja) 分岐型ヘテロポリエチレングリコールおよび中間体
JP2004323691A (ja) ポリオキシアルキレン誘導体およびその製造方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20050519

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20080731

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20091214

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20100809

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20101013

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20101014

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20130924

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20130924

Start annual number: 4

End annual number: 4

FPAY Annual fee payment

Payment date: 20141001

Year of fee payment: 5

PR1001 Payment of annual fee

Payment date: 20141001

Start annual number: 5

End annual number: 5

FPAY Annual fee payment

Payment date: 20150917

Year of fee payment: 6

PR1001 Payment of annual fee

Payment date: 20150917

Start annual number: 6

End annual number: 6

FPAY Annual fee payment

Payment date: 20160701

Year of fee payment: 7

PR1001 Payment of annual fee

Payment date: 20160701

Start annual number: 7

End annual number: 7

FPAY Annual fee payment

Payment date: 20170703

Year of fee payment: 8

PR1001 Payment of annual fee

Payment date: 20170703

Start annual number: 8

End annual number: 8

FPAY Annual fee payment

Payment date: 20180702

Year of fee payment: 9

PR1001 Payment of annual fee

Payment date: 20180702

Start annual number: 9

End annual number: 9

FPAY Annual fee payment

Payment date: 20190701

Year of fee payment: 10

PR1001 Payment of annual fee

Payment date: 20190701

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20200701

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20210701

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20220701

Start annual number: 13

End annual number: 13

PR1001 Payment of annual fee

Payment date: 20230703

Start annual number: 14

End annual number: 14

PC1801 Expiration of term

Termination date: 20240520

Termination category: Expiration of duration