JP4412461B2 - 修飾された生体関連物質、その製造方法および中間体 - Google Patents

修飾された生体関連物質、その製造方法および中間体 Download PDF

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JP4412461B2
JP4412461B2 JP2003388886A JP2003388886A JP4412461B2 JP 4412461 B2 JP4412461 B2 JP 4412461B2 JP 2003388886 A JP2003388886 A JP 2003388886A JP 2003388886 A JP2003388886 A JP 2003388886A JP 4412461 B2 JP4412461 B2 JP 4412461B2
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formula
group
compound
reaction
molecular weight
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JP2004197077A (ja
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憲一郎 中本
俊輔 大橋
裕二 山本
研二 坂上
智佳 伊藤
徹 安河内
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NOF Corp
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
    • C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
    • C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
JP2003388886A 2002-11-20 2003-11-19 修飾された生体関連物質、その製造方法および中間体 Expired - Lifetime JP4412461B2 (ja)

Priority Applications (1)

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JP2003388886A JP4412461B2 (ja) 2002-11-20 2003-11-19 修飾された生体関連物質、その製造方法および中間体

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JP2002337113 2002-11-20
JP2003388886A JP4412461B2 (ja) 2002-11-20 2003-11-19 修飾された生体関連物質、その製造方法および中間体

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JP2009003472A Division JP5273589B2 (ja) 2002-11-20 2009-01-09 生体関連物質、その製造方法およびその中間体

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JP2004197077A JP2004197077A (ja) 2004-07-15
JP4412461B2 true JP4412461B2 (ja) 2010-02-10

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US (4) US20050058620A1 (https=)
EP (3) EP1911789B1 (https=)
JP (2) JP4412461B2 (https=)
KR (1) KR100988733B1 (https=)
CN (1) CN100402580C (https=)
AT (1) ATE388186T1 (https=)
AU (1) AU2003302031A1 (https=)
CA (1) CA2502948C (https=)
DE (1) DE60319568T2 (https=)
IL (2) IL168238A (https=)
WO (1) WO2004046222A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2023171608A1 (ja) 2022-03-09 2023-09-14 日油株式会社 ポリオキシエチレン誘導体の製造方法、ポリオキシエチレン化合物の定量方法及び分析用ラベル化試薬

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US20050288490A1 (en) 2005-12-29
EP1564236A1 (en) 2005-08-17
EP1911788A1 (en) 2008-04-16
JP5273589B2 (ja) 2013-08-28
DE60319568T2 (de) 2009-04-02
EP1564236B1 (en) 2008-03-05
US7524875B2 (en) 2009-04-28
US20110082277A1 (en) 2011-04-07
IL194501A (en) 2011-11-30
JP2004197077A (ja) 2004-07-15
US20090192320A1 (en) 2009-07-30
CN1714116A (zh) 2005-12-28
US8034981B2 (en) 2011-10-11
DE60319568D1 (de) 2008-04-17
ATE388186T1 (de) 2008-03-15
AU2003302031A1 (en) 2004-06-15
KR100988733B1 (ko) 2010-10-20
EP1564236A4 (en) 2006-01-25
KR20050083923A (ko) 2005-08-26
US7851491B2 (en) 2010-12-14
EP1911789A1 (en) 2008-04-16
US20050058620A1 (en) 2005-03-17
CN100402580C (zh) 2008-07-16
WO2004046222A1 (ja) 2004-06-03
CA2502948C (en) 2013-04-02
EP1911789B1 (en) 2016-04-27
IL168238A (en) 2009-09-22
JP2009102649A (ja) 2009-05-14
CA2502948A1 (en) 2004-06-03
EP1911788B1 (en) 2019-03-27

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