ATE388186T1 - Polyalkylenglykol derivat - Google Patents
Polyalkylenglykol derivatInfo
- Publication number
- ATE388186T1 ATE388186T1 AT03811545T AT03811545T ATE388186T1 AT E388186 T1 ATE388186 T1 AT E388186T1 AT 03811545 T AT03811545 T AT 03811545T AT 03811545 T AT03811545 T AT 03811545T AT E388186 T1 ATE388186 T1 AT E388186T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- polyalkylene glycol
- derivative
- glycol derivative
- hrd
- Prior art date
Links
- 229920001515 polyalkylene glycol Polymers 0.000 title abstract 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical class OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002334 glycols Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000005702 oxyalkylene group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000005227 gel permeation chromatography Methods 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
- C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002337113 | 2002-11-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE388186T1 true ATE388186T1 (de) | 2008-03-15 |
Family
ID=32321831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03811545T ATE388186T1 (de) | 2002-11-20 | 2003-11-20 | Polyalkylenglykol derivat |
Country Status (11)
Country | Link |
---|---|
US (4) | US20050058620A1 (de) |
EP (3) | EP1911789B1 (de) |
JP (2) | JP4412461B2 (de) |
KR (1) | KR100988733B1 (de) |
CN (1) | CN100402580C (de) |
AT (1) | ATE388186T1 (de) |
AU (1) | AU2003302031A1 (de) |
CA (1) | CA2502948C (de) |
DE (1) | DE60319568T2 (de) |
IL (2) | IL168238A (de) |
WO (1) | WO2004046222A1 (de) |
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US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
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US8828373B2 (en) * | 2002-11-20 | 2014-09-09 | Nof Corporation | Polyalkylene glycol derivative and modified bio-related substance |
WO2004060300A2 (en) * | 2002-12-26 | 2004-07-22 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
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US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
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WO2004103275A2 (en) | 2003-05-09 | 2004-12-02 | Neose Technologies, Inc. | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
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US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
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WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
BRPI0515118A (pt) * | 2004-08-31 | 2008-07-01 | Pharmacia & Upjohn Co Llc | conjugados de hormÈnio do crescimento humano com polietileno glicol |
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ES2566670T3 (es) | 2004-10-29 | 2016-04-14 | Ratiopharm Gmbh | Remodelación y glucopegilación del factor de crecimiento de fibroblastos (FGF) |
MX2007005466A (es) | 2004-11-12 | 2007-10-19 | Bayer Healthcare Llc | Modificacion dirigida al sitio del factor viii. |
AU2006203792B2 (en) | 2005-01-10 | 2011-11-03 | Ratiopharm Gmbh | Glycopegylated Granulocyte Colony Stimulating Factor |
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KR102546103B1 (ko) | 2018-03-20 | 2023-06-21 | 니치유 가부시키가이샤 | 분기형 단분산 폴리에틸렌 글리콜, 중간체 및 그 제조 방법 |
US20200262887A1 (en) | 2018-11-30 | 2020-08-20 | Opko Ireland Global Holdings, Ltd. | Oxyntomodulin peptide analog formulations |
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DE3025807A1 (de) * | 1980-07-08 | 1982-02-04 | Th. Goldschmidt Ag, 4300 Essen | Verfahren zur herstellung von polyaethern unter erhalt von mindestens zwei freien hydroxylgruppen am startalkohol |
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US5118448A (en) * | 1990-10-19 | 1992-06-02 | Arco Chemical Technology, L.P. | Process for producing esterified alkoxylated polyols |
JP3218755B2 (ja) * | 1992-11-12 | 2001-10-15 | 日本油脂株式会社 | グリセリンエーテルエステル |
JP3067541B2 (ja) * | 1994-08-23 | 2000-07-17 | 日本油脂株式会社 | グリセリンポリアルキレングリコールエーテル誘導体及びその製造方法 |
JP3921781B2 (ja) * | 1998-02-12 | 2007-05-30 | 日本油脂株式会社 | カルボキシル基含有ポリオキシアルキレン化合物 |
JP4055250B2 (ja) * | 1998-06-15 | 2008-03-05 | 日油株式会社 | アミノ基含有ポリオキシアルキレン化合物 |
JP2000230000A (ja) * | 1999-02-08 | 2000-08-22 | Hokkaido Univ | 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体 |
JP4123856B2 (ja) * | 2001-07-31 | 2008-07-23 | 日油株式会社 | 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法 |
JP4412461B2 (ja) * | 2002-11-20 | 2010-02-10 | 日油株式会社 | 修飾された生体関連物質、その製造方法および中間体 |
US8003117B2 (en) * | 2002-11-20 | 2011-08-23 | Nof Corporation | Polyalkylene glycol derivative and modified bio-related substance |
-
2003
- 2003-11-19 JP JP2003388886A patent/JP4412461B2/ja not_active Expired - Lifetime
- 2003-11-20 DE DE60319568T patent/DE60319568T2/de not_active Expired - Lifetime
- 2003-11-20 EP EP07024378.7A patent/EP1911789B1/de not_active Expired - Lifetime
- 2003-11-20 WO PCT/JP2003/014844 patent/WO2004046222A1/ja active Application Filing
- 2003-11-20 CN CNB2003801037963A patent/CN100402580C/zh not_active Expired - Lifetime
- 2003-11-20 EP EP07024377.9A patent/EP1911788B1/de not_active Expired - Lifetime
- 2003-11-20 US US10/716,432 patent/US20050058620A1/en not_active Abandoned
- 2003-11-20 CA CA2502948A patent/CA2502948C/en not_active Expired - Lifetime
- 2003-11-20 AT AT03811545T patent/ATE388186T1/de not_active IP Right Cessation
- 2003-11-20 EP EP03811545A patent/EP1564236B1/de not_active Expired - Lifetime
- 2003-11-20 KR KR1020057009090A patent/KR100988733B1/ko active IP Right Grant
- 2003-11-20 AU AU2003302031A patent/AU2003302031A1/en not_active Abandoned
-
2005
- 2005-04-26 IL IL168238A patent/IL168238A/en active IP Right Grant
- 2005-06-02 US US11/142,255 patent/US7524875B2/en active Active
-
2008
- 2008-10-02 IL IL194501A patent/IL194501A/en active IP Right Grant
-
2009
- 2009-01-09 JP JP2009003472A patent/JP5273589B2/ja not_active Expired - Lifetime
- 2009-03-06 US US12/399,249 patent/US7851491B2/en not_active Expired - Lifetime
-
2010
- 2010-11-09 US US12/942,554 patent/US8034981B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1911789B1 (de) | 2016-04-27 |
EP1911788B1 (de) | 2019-03-27 |
KR20050083923A (ko) | 2005-08-26 |
DE60319568D1 (de) | 2008-04-17 |
WO2004046222A1 (ja) | 2004-06-03 |
CA2502948A1 (en) | 2004-06-03 |
EP1911788A1 (de) | 2008-04-16 |
EP1911789A1 (de) | 2008-04-16 |
US20110082277A1 (en) | 2011-04-07 |
US20050288490A1 (en) | 2005-12-29 |
CN1714116A (zh) | 2005-12-28 |
US20050058620A1 (en) | 2005-03-17 |
AU2003302031A1 (en) | 2004-06-15 |
IL168238A (en) | 2009-09-22 |
DE60319568T2 (de) | 2009-04-02 |
JP2009102649A (ja) | 2009-05-14 |
KR100988733B1 (ko) | 2010-10-20 |
EP1564236A1 (de) | 2005-08-17 |
CA2502948C (en) | 2013-04-02 |
EP1564236A4 (de) | 2006-01-25 |
CN100402580C (zh) | 2008-07-16 |
JP4412461B2 (ja) | 2010-02-10 |
US8034981B2 (en) | 2011-10-11 |
US20090192320A1 (en) | 2009-07-30 |
US7851491B2 (en) | 2010-12-14 |
EP1564236B1 (de) | 2008-03-05 |
JP5273589B2 (ja) | 2013-08-28 |
IL194501A (en) | 2011-11-30 |
US7524875B2 (en) | 2009-04-28 |
JP2004197077A (ja) | 2004-07-15 |
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