JP2005539087A5 - - Google Patents
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- Publication number
- JP2005539087A5 JP2005539087A5 JP2004548887A JP2004548887A JP2005539087A5 JP 2005539087 A5 JP2005539087 A5 JP 2005539087A5 JP 2004548887 A JP2004548887 A JP 2004548887A JP 2004548887 A JP2004548887 A JP 2004548887A JP 2005539087 A5 JP2005539087 A5 JP 2005539087A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydroxy
- amino
- dihydro
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 77
- -1 amino, piperidyl Chemical group 0.000 claims 58
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 24
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 20
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 19
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 18
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 18
- 125000003277 amino group Chemical group 0.000 claims 18
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 16
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 12
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 11
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 11
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 11
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
- 229910005965 SO 2 Inorganic materials 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 9
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 9
- 125000004414 alkyl thio group Chemical group 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- QURAWDWTNZXEDT-UHFFFAOYSA-N 2-methoxyquinolin-8-amine Chemical compound C1=CC=C(N)C2=NC(OC)=CC=C21 QURAWDWTNZXEDT-UHFFFAOYSA-N 0.000 claims 4
- JHIAOWGCGNMQKA-UHFFFAOYSA-N 2-methyl-8-quinolinamine Chemical compound C1=CC=C(N)C2=NC(C)=CC=C21 JHIAOWGCGNMQKA-UHFFFAOYSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- MLHSEJGZQHDJSS-MIRXNBLZSA-N (1R,3R,4R)-1-[(2-cyanoquinolin-8-yl)carbamoyl]-3-hydroxy-4-[(3-oxo-4H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino]cyclohexane-1-carboxylic acid Chemical compound C1C[C@@](C[C@H]([C@@H]1NCC2=NC3=C(C=C2)SCC(=O)N3)O)(C(=O)NC4=CC=CC5=C4N=C(C=C5)C#N)C(=O)O MLHSEJGZQHDJSS-MIRXNBLZSA-N 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000001414 1,2,4-triazol-5-yl group Chemical group [H]N1N=C([H])N=C1[*] 0.000 claims 2
- RPBQBSWZBRIJSO-UHFFFAOYSA-N 3-methoxyquinoxalin-5-amine Chemical compound C1=CC=C(N)C2=NC(OC)=CN=C21 RPBQBSWZBRIJSO-UHFFFAOYSA-N 0.000 claims 2
- DMBFCTCQROWGDZ-UHFFFAOYSA-N 8-aminoquinoline-2-carbonitrile Chemical compound C1=C(C#N)N=C2C(N)=CC=CC2=C1 DMBFCTCQROWGDZ-UHFFFAOYSA-N 0.000 claims 2
- 101100240517 Caenorhabditis elegans nhr-11 gene Proteins 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- 125000005035 acylthio group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- ODGSTKZGPNVNKR-QKSGUBBWSA-N (1R,3S,4R)-1-[(2-cyanoquinolin-8-yl)carbamoyl]-3-hydroxy-4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]cyclohexane-1-carboxylic acid Chemical compound C1C[C@@](C[C@@H]([C@@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)O)(C(=O)NC4=CC=CC5=C4N=C(C=C5)C#N)C(=O)O ODGSTKZGPNVNKR-QKSGUBBWSA-N 0.000 claims 1
- MLHSEJGZQHDJSS-QKSGUBBWSA-N (1R,3S,4R)-1-[(2-cyanoquinolin-8-yl)carbamoyl]-3-hydroxy-4-[(3-oxo-4H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino]cyclohexane-1-carboxylic acid Chemical compound C1C[C@@](C[C@@H]([C@@H]1NCC2=NC3=C(C=C2)SCC(=O)N3)O)(C(=O)NC4=CC=CC5=C4N=C(C=C5)C#N)C(=O)O MLHSEJGZQHDJSS-QKSGUBBWSA-N 0.000 claims 1
- ODGSTKZGPNVNKR-RYGBOPQRSA-N (1S,3R,4S)-1-[(2-cyanoquinolin-8-yl)carbamoyl]-3-hydroxy-4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]cyclohexane-1-carboxylic acid Chemical compound C1C[C@](C[C@H]([C@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)O)(C(=O)NC4=CC=CC5=C4N=C(C=C5)C#N)C(=O)O ODGSTKZGPNVNKR-RYGBOPQRSA-N 0.000 claims 1
- MLHSEJGZQHDJSS-RYGBOPQRSA-N (1S,3R,4S)-1-[(2-cyanoquinolin-8-yl)carbamoyl]-3-hydroxy-4-[(3-oxo-4H-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino]cyclohexane-1-carboxylic acid Chemical compound C1C[C@](C[C@H]([C@H]1NCC2=NC3=C(C=C2)SCC(=O)N3)O)(C(=O)NC4=CC=CC5=C4N=C(C=C5)C#N)C(=O)O MLHSEJGZQHDJSS-RYGBOPQRSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- XQOHGKZCTXPHMB-UHFFFAOYSA-N 1,6-naphthyridin-4-amine Chemical compound C1=NC=C2C(N)=CC=NC2=C1 XQOHGKZCTXPHMB-UHFFFAOYSA-N 0.000 claims 1
- RRWFGHIMZGJJKU-UHFFFAOYSA-N 1-methoxyisoquinolin-8-amine Chemical compound C1=CC(N)=C2C(OC)=NC=CC2=C1 RRWFGHIMZGJJKU-UHFFFAOYSA-N 0.000 claims 1
- JTNBYFVUXPHZIJ-UHFFFAOYSA-N 2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-8-amine Chemical compound O1CCOC2=C1N=CC=C2N JTNBYFVUXPHZIJ-UHFFFAOYSA-N 0.000 claims 1
- CJIIYERJYXPGHA-UHFFFAOYSA-N 2-methylquinoxalin-5-amine Chemical compound NC1=CC=CC2=NC(C)=CN=C21 CJIIYERJYXPGHA-UHFFFAOYSA-N 0.000 claims 1
- AFCUWHBCKMZWOR-UHFFFAOYSA-N 3-methyl-1,2,3,4-tetrahydroquinoxalin-5-amine Chemical compound C1=CC(N)=C2NC(C)CNC2=C1 AFCUWHBCKMZWOR-UHFFFAOYSA-N 0.000 claims 1
- TXZGIJQANGIGSE-UHFFFAOYSA-N 3-methylquinoxalin-5-amine Chemical compound C1=CC=C(N)C2=NC(C)=CN=C21 TXZGIJQANGIGSE-UHFFFAOYSA-N 0.000 claims 1
- FQYRLEXKXQRZDH-UHFFFAOYSA-N 4-aminoquinoline Chemical compound C1=CC=C2C(N)=CC=NC2=C1 FQYRLEXKXQRZDH-UHFFFAOYSA-N 0.000 claims 1
- ANDGDEKVTJNURV-UHFFFAOYSA-N 4-aminoquinoline-6-carbonitrile Chemical compound C1=C(C#N)C=C2C(N)=CC=NC2=C1 ANDGDEKVTJNURV-UHFFFAOYSA-N 0.000 claims 1
- DTVYNUOOZIKEEX-UHFFFAOYSA-N 5-aminoisoquinoline Chemical compound N1=CC=C2C(N)=CC=CC2=C1 DTVYNUOOZIKEEX-UHFFFAOYSA-N 0.000 claims 1
- PJDFSPWLDZBWIX-UHFFFAOYSA-N 5-methoxyquinolin-4-amine Chemical compound C1=CC(N)=C2C(OC)=CC=CC2=N1 PJDFSPWLDZBWIX-UHFFFAOYSA-N 0.000 claims 1
- VUHCPMIDSUGHNO-UHFFFAOYSA-N 6-methoxy-1,5-naphthyridin-4-amine Chemical compound N1=CC=C(N)C2=NC(OC)=CC=C21 VUHCPMIDSUGHNO-UHFFFAOYSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- KAVBUDPNQPEDNY-UHFFFAOYSA-N OC1(CCC(CC1)NCC=1C=CC=2SCC(NC2N1)=O)CCC=1C=CC=C2C=CC(=NC12)OC.O1NC(CC=C1)=O Chemical compound OC1(CCC(CC1)NCC=1C=CC=2SCC(NC2N1)=O)CCC=1C=CC=C2C=CC(=NC12)OC.O1NC(CC=C1)=O KAVBUDPNQPEDNY-UHFFFAOYSA-N 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 125000005360 alkyl sulfoxide group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000005361 aryl sulfoxide group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 150000003950 cyclic amides Chemical class 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 125000004468 heterocyclylthio group Chemical group 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004546 quinazolin-4-yl group Chemical group N1=CN=C(C2=CC=CC=C12)* 0.000 claims 1
- 125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 claims 1
- 125000004553 quinoxalin-5-yl group Chemical group N1=CC=NC2=C(C=CC=C12)* 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- CWXZEXZFHGYYCD-UHFFFAOYSA-N thieno[3,2-b]pyridin-7-amine Chemical compound NC1=CC=NC2=C1SC=C2 CWXZEXZFHGYYCD-UHFFFAOYSA-N 0.000 claims 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39170002P | 2002-06-26 | 2002-06-26 | |
| US46096103P | 2003-04-07 | 2003-04-07 | |
| PCT/EP2003/006756 WO2004002992A1 (en) | 2002-06-26 | 2003-06-25 | Compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005539087A JP2005539087A (ja) | 2005-12-22 |
| JP2005539087A5 true JP2005539087A5 (enExample) | 2006-06-15 |
| JP4522262B2 JP4522262B2 (ja) | 2010-08-11 |
Family
ID=30003201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004548887A Expired - Fee Related JP4522262B2 (ja) | 2002-06-26 | 2003-06-25 | 化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7622481B2 (enExample) |
| EP (1) | EP1537123B1 (enExample) |
| JP (1) | JP4522262B2 (enExample) |
| AR (1) | AR040335A1 (enExample) |
| AT (1) | ATE430154T1 (enExample) |
| AU (1) | AU2003266949A1 (enExample) |
| DE (1) | DE60327438D1 (enExample) |
| ES (1) | ES2325831T3 (enExample) |
| TW (1) | TW200406413A (enExample) |
| WO (1) | WO2004002992A1 (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0112834D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| JP4445753B2 (ja) | 2002-01-29 | 2010-04-07 | グラクソ グループ リミテッド | アミノピペリジン誘導体 |
| WO2003064431A2 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| ES2340484T3 (es) | 2002-11-05 | 2010-06-04 | Glaxo Group Limited | Agentes antibacterianos. |
| EP1560488B1 (en) | 2002-11-05 | 2010-09-01 | Glaxo Group Limited | Antibacterial agents |
| WO2004050036A2 (en) * | 2002-12-04 | 2004-06-17 | Glaxo Group Limited | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents |
| AR042486A1 (es) * | 2002-12-18 | 2005-06-22 | Glaxo Group Ltd | Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . |
| US7691850B2 (en) * | 2004-06-15 | 2010-04-06 | Glaxo Group Limited | Antibacterial agents |
| DE102004041163A1 (de) * | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| CA2580621A1 (en) * | 2004-09-24 | 2006-03-30 | Actelion Pharmaceuticals Ltd | New bicyclic antibiotics |
| ES2343127T3 (es) * | 2004-10-05 | 2010-07-23 | Actelion Pharmaceuticals Ltd. | Nuevos antibioticos de piperidina. |
| WO2006046552A1 (ja) * | 2004-10-27 | 2006-05-04 | Toyama Chemical Co., Ltd. | 新規な含窒素複素環化合物およびその塩 |
| WO2006081264A1 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| JP2008528586A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
| US7592334B2 (en) | 2005-01-25 | 2009-09-22 | Glaxo Group Limited | Antibacterial agents |
| WO2006081179A1 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| WO2006081289A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| EP2468743A1 (en) | 2005-06-24 | 2012-06-27 | Toyama Chemical Co., Ltd. | Nitrogen-containing bicyclic compounds useful as antibacterial agents |
| WO2007016610A2 (en) * | 2005-08-02 | 2007-02-08 | Glaxo Group Limited | Antibacterial agents |
| WO2007086016A1 (en) | 2006-01-26 | 2007-08-02 | Actelion Pharmaceuticals Ltd | Tetrahydropyrane antibiotics |
| CA2635205C (en) | 2006-02-15 | 2014-06-10 | Actelion Pharmaceuticals Ltd | Ethanol or 1,2-ethanediol cyclohexyl antibiotic derivatives |
| DE602007009205D1 (de) | 2006-04-06 | 2010-10-28 | Glaxo Group Ltd | Pyrrolochinoxalinonderivate als antibakterielle mittel |
| EP2007377A4 (en) * | 2006-04-06 | 2011-08-17 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
| AU2007268749B2 (en) | 2006-05-26 | 2012-07-26 | Taisho Pharmaceutical Co., Ltd. | Novel heterocyclic compound or salt thereof and intermediate thereof |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| WO2008071962A1 (en) * | 2006-12-15 | 2008-06-19 | Astrazeneca Ab | Pteridines and pyrimidinopyridines as antibacterial agents |
| CL2007003693A1 (es) * | 2006-12-22 | 2008-06-27 | Actelion Pharmaceuticals Ltd | Compuestos derivados de pirido [3,2-b] [1,4] tiazina; composicion farmaceutica que contiene dichos compuestos; y su uso en el tratamiento de infecciones bacterianas. |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| WO2008128942A1 (en) * | 2007-04-20 | 2008-10-30 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
| PL2221309T3 (pl) | 2007-11-26 | 2013-12-31 | Toyama Chemical Co Ltd | Monohydrat pochodnej naftyrydyny i sposób jego wytwarzania |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| CN102046603B (zh) * | 2008-06-03 | 2014-08-13 | 埃科特莱茵药品有限公司 | 作为抗细菌剂的[4-(1-氨基-乙基)-环己基]-甲基-胺及[6-(1-氨基-乙基)-四氢-吡喃-3-基]-甲基-胺衍生物 |
| JP2012505866A (ja) | 2008-10-17 | 2012-03-08 | グラクソ グループ リミテッド | 抗菌剤として使用される三環式窒素化合物 |
| WO2010045987A1 (en) * | 2008-10-23 | 2010-04-29 | Glaxo Group Limited | Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials |
| PE20110703A1 (es) | 2008-11-17 | 2011-10-13 | Hoffmann La Roche | Acidos naftilaceticos |
| JP5653935B2 (ja) | 2009-01-15 | 2015-01-14 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物 |
| CN102361863B (zh) | 2009-01-21 | 2014-12-03 | 巴斯利尔药物股份公司 | 新的二环抗生素 |
| AR076222A1 (es) * | 2009-04-09 | 2011-05-26 | Actelion Pharmaceuticals Ltd | Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen |
| US8394858B2 (en) | 2009-12-03 | 2013-03-12 | Novartis Ag | Cyclohexane derivatives and uses thereof |
| EP2513115B1 (en) | 2009-12-18 | 2013-10-09 | Basilea Pharmaceutica AG | Tricyclic antibiotics |
| JPWO2012108376A1 (ja) | 2011-02-07 | 2014-07-03 | 第一三共株式会社 | アミノ基含有ピロリジノン誘導体 |
| US9321788B2 (en) | 2011-06-17 | 2016-04-26 | Basilea Pharmaceutica Ag | Tricyclic antibiotics |
| US8470884B2 (en) | 2011-11-09 | 2013-06-25 | Hoffmann-La Roche Inc. | Alkenyl naphthylacetic acids |
| US9359275B2 (en) * | 2012-02-23 | 2016-06-07 | Children's Medical Center Corporation | Natural product antibiotics and analogs thereof |
| CA2896338A1 (en) * | 2013-03-29 | 2014-10-02 | Daiichi Sankyo Company, Limited | Method for producing (1s,4s,5s)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one |
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| EA202091325A1 (ru) | 2017-11-30 | 2020-08-28 | Лэндос Байофарма, Инк. | Способы лечения с помощью лигандов лантионин c-подобного белка 2 и подготовленных с их помощью клеток |
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-
2003
- 2003-06-24 TW TW092117044A patent/TW200406413A/zh unknown
- 2003-06-24 AR ARP030102248A patent/AR040335A1/es not_active Application Discontinuation
- 2003-06-25 DE DE60327438T patent/DE60327438D1/de not_active Expired - Lifetime
- 2003-06-25 JP JP2004548887A patent/JP4522262B2/ja not_active Expired - Fee Related
- 2003-06-25 AU AU2003266949A patent/AU2003266949A1/en not_active Abandoned
- 2003-06-25 US US10/518,653 patent/US7622481B2/en not_active Expired - Fee Related
- 2003-06-25 ES ES03747857T patent/ES2325831T3/es not_active Expired - Lifetime
- 2003-06-25 EP EP03747857A patent/EP1537123B1/en not_active Expired - Lifetime
- 2003-06-25 AT AT03747857T patent/ATE430154T1/de not_active IP Right Cessation
- 2003-06-25 WO PCT/EP2003/006756 patent/WO2004002992A1/en not_active Ceased
-
2009
- 2009-11-17 US US12/620,129 patent/US20100081650A1/en not_active Abandoned
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