JP2005504747A5 - - Google Patents
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- Publication number
- JP2005504747A5 JP2005504747A5 JP2003515497A JP2003515497A JP2005504747A5 JP 2005504747 A5 JP2005504747 A5 JP 2005504747A5 JP 2003515497 A JP2003515497 A JP 2003515497A JP 2003515497 A JP2003515497 A JP 2003515497A JP 2005504747 A5 JP2005504747 A5 JP 2005504747A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydroxy
- alkenyl
- methoxy
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 82
- -1 amino, piperidyl Chemical group 0.000 claims 28
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 23
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 21
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 19
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 19
- 125000003277 amino group Chemical group 0.000 claims 18
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 17
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 17
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 11
- 229910005965 SO 2 Inorganic materials 0.000 claims 10
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 125000004429 atom Chemical group 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 8
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 8
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 3
- VUHCPMIDSUGHNO-UHFFFAOYSA-N 6-methoxy-1,5-naphthyridin-4-amine Chemical compound N1=CC=C(N)C2=NC(OC)=CC=C21 VUHCPMIDSUGHNO-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 125000005035 acylthio group Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims 2
- XVSNWPMYYVNDKC-FZYLFJGDSA-N (2R)-2-methoxy-N-(6-methoxy-1,5-naphthyridin-4-yl)-1-[2-(3-oxo-4H-1,4-benzothiazin-6-yl)ethyl]piperidine-4-carboxamide Chemical compound COC=1N=C2C(=CC=NC2=CC=1)NC(=O)C1C[C@H](N(CC1)CCC=1C=CC2=C(NC(CS2)=O)C=1)OC XVSNWPMYYVNDKC-FZYLFJGDSA-N 0.000 claims 1
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000001414 1,2,4-triazol-5-yl group Chemical group [H]N1N=C([H])N=C1[*] 0.000 claims 1
- QRZHDCJDCYMKAK-UHFFFAOYSA-N 1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-hydroxy-n-(6-methoxy-1,5-naphthyridin-4-yl)piperidine-4-carboxamide Chemical compound C1=C2OCOC2=CC(CCN2CCC(CC2)(O)C(=O)NC2=CC=NC3=CC=C(N=C32)OC)=C1 QRZHDCJDCYMKAK-UHFFFAOYSA-N 0.000 claims 1
- NKUGCHGBXABNQR-UHFFFAOYSA-N 1-[2-(1,3-benzodioxol-5-yl)ethyl]-n-(6-methoxy-1,5-naphthyridin-4-yl)-4-methylpiperidine-4-carboxamide Chemical compound C1=C2OCOC2=CC(CCN2CCC(CC2)(C)C(=O)NC2=CC=NC3=CC=C(N=C32)OC)=C1 NKUGCHGBXABNQR-UHFFFAOYSA-N 0.000 claims 1
- PXPHCHQEAHKWPI-UHFFFAOYSA-N 1-[2-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)ethyl]-4-hydroxy-n-(6-methoxy-1,5-naphthyridin-4-yl)piperidine-4-carboxamide Chemical compound O1CCOC(C=N2)=C1C=C2CCN(CC1)CCC1(O)C(=O)NC1=CC=NC2=CC=C(OC)N=C21 PXPHCHQEAHKWPI-UHFFFAOYSA-N 0.000 claims 1
- BNGJCINCSDUEAL-UHFFFAOYSA-N 1-[2-(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)ethyl]-n-(8-fluoro-6-methoxyquinolin-4-yl)-4-hydroxypiperidine-4-carboxamide;hydrochloride Chemical compound Cl.O1CCOC(C=N2)=C1C=C2CCN(CC1)CCC1(O)C(=O)NC1=CC=NC2=C(F)C=C(OC)C=C21 BNGJCINCSDUEAL-UHFFFAOYSA-N 0.000 claims 1
- OARVAZMJJMPTEM-UHFFFAOYSA-N 4-(hydroxymethyl)-n-(6-methoxy-1,5-naphthyridin-4-yl)-1-[2-(3-oxo-4h-1,4-benzothiazin-6-yl)ethyl]piperidine-4-carboxamide Chemical compound S1CC(=O)NC2=CC(CCN3CCC(CC3)(CO)C(=O)NC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 OARVAZMJJMPTEM-UHFFFAOYSA-N 0.000 claims 1
- IQIOELVNILZQJR-UHFFFAOYSA-N 4-[(6-methoxy-1,5-naphthyridin-4-yl)carbamoyl]-1-[2-(3-oxo-4h-1,4-benzothiazin-6-yl)ethyl]piperidine-4-carboxylic acid Chemical compound S1CC(=O)NC2=CC(CCN3CCC(CC3)(C(=O)NC3=CC=NC4=CC=C(N=C43)OC)C(O)=O)=CC=C21 IQIOELVNILZQJR-UHFFFAOYSA-N 0.000 claims 1
- SKJILIRDRXLNKR-UHFFFAOYSA-N 4-amino-n-(6-methoxy-1,5-naphthyridin-4-yl)-1-[2-(3-oxo-4h-1,4-benzothiazin-6-yl)ethyl]piperidine-4-carboxamide Chemical compound S1CC(=O)NC2=CC(CCN3CCC(CC3)(N)C(=O)NC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 SKJILIRDRXLNKR-UHFFFAOYSA-N 0.000 claims 1
- PBIHPDRFBYEZGZ-UHFFFAOYSA-N 4-cyano-n-(6-methoxy-1,5-naphthyridin-4-yl)-1-[2-(3-oxo-4h-1,4-benzothiazin-6-yl)ethyl]piperidine-4-carboxamide Chemical compound S1CC(=O)NC2=CC(CCN3CCC(CC3)(C(=O)NC3=CC=NC4=CC=C(N=C43)OC)C#N)=CC=C21 PBIHPDRFBYEZGZ-UHFFFAOYSA-N 0.000 claims 1
- LMQHDESYTYKPGK-IBGZPJMESA-N 4-hydroxy-1-[(2r)-2-hydroxy-2-(3-oxo-4h-1,4-benzothiazin-6-yl)ethyl]-n-(6-methoxy-1,5-naphthyridin-4-yl)piperidine-4-carboxamide Chemical compound S1CC(=O)NC2=CC([C@@H](O)CN3CCC(CC3)(O)C(=O)NC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 LMQHDESYTYKPGK-IBGZPJMESA-N 0.000 claims 1
- BMQOZNLUBCOQBR-UHFFFAOYSA-N 4-hydroxy-n-(6-methoxy-1,5-naphthyridin-4-yl)-1-[2-(3-oxo-4h-1,4-benzothiazin-6-yl)ethyl]piperidine-4-carboxamide Chemical compound S1CC(=O)NC2=CC(CCN3CCC(CC3)(O)C(=O)NC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 BMQOZNLUBCOQBR-UHFFFAOYSA-N 0.000 claims 1
- FIMGZXMBDCMXPT-UHFFFAOYSA-N 4-hydroxy-n-(6-methoxy-1,5-naphthyridin-4-yl)-1-[2-oxo-2-(3-oxo-4h-1,4-benzothiazin-6-yl)ethyl]piperidine-4-carboxamide Chemical compound S1CC(=O)NC2=CC(C(=O)CN3CCC(CC3)(O)C(=O)NC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 FIMGZXMBDCMXPT-UHFFFAOYSA-N 0.000 claims 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 claims 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 1
- XZOFUFUOKSMJHL-UHFFFAOYSA-N 6-[2-[4-fluoro-4-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperidin-1-yl]ethyl]-4h-1,4-benzothiazin-3-one Chemical compound S1CC(=O)NC2=CC(CCN3CCC(CC3)(F)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 XZOFUFUOKSMJHL-UHFFFAOYSA-N 0.000 claims 1
- DYJVGEYZDNXUTF-UHFFFAOYSA-N 6-[2-[4-hydroxy-4-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperidin-1-yl]ethyl]-4h-1,4-benzothiazin-3-one Chemical compound S1CC(=O)NC2=CC(CCN3CCC(CC3)(O)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 DYJVGEYZDNXUTF-UHFFFAOYSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 239000005973 Carvone Substances 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000003302 alkenyloxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000005361 aryl sulfoxide group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 150000003950 cyclic amides Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 1
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 125000004468 heterocyclylthio group Chemical group 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- LDUXXRURVFSEKO-UHFFFAOYSA-N n-(6-methoxy-1,5-naphthyridin-4-yl)-1-[2-(6-oxo-5h-pyridazino[3,4-b][1,4]thiazin-3-yl)ethyl]-4-(trifluoromethyl)piperidine-4-carboxamide Chemical compound N1C(=O)CSC(N=N2)=C1C=C2CCN(CC1)CCC1(C(F)(F)F)C(=O)NC1=CC=NC2=CC=C(OC)N=C21 LDUXXRURVFSEKO-UHFFFAOYSA-N 0.000 claims 1
- VPBDSFQBBRTQBO-UHFFFAOYSA-N n-(6-methoxy-1,5-naphthyridin-4-yl)-4-methyl-1-[2-(3-oxo-4h-1,4-benzothiazin-6-yl)ethyl]piperidine-4-carboxamide Chemical compound S1CC(=O)NC2=CC(CCN3CCC(CC3)(C)C(=O)NC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 VPBDSFQBBRTQBO-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0118238.5A GB0118238D0 (en) | 2001-07-26 | 2001-07-26 | Medicaments |
| PCT/EP2002/008319 WO2003010138A2 (en) | 2001-07-26 | 2002-07-25 | Piperidine derivatives as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504747A JP2005504747A (ja) | 2005-02-17 |
| JP2005504747A5 true JP2005504747A5 (enExample) | 2006-01-05 |
Family
ID=9919236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003515497A Pending JP2005504747A (ja) | 2001-07-26 | 2002-07-25 | 薬物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040198756A1 (enExample) |
| EP (1) | EP1419155B1 (enExample) |
| JP (1) | JP2005504747A (enExample) |
| AT (1) | ATE344799T1 (enExample) |
| AU (1) | AU2002328972A1 (enExample) |
| DE (1) | DE60215951T2 (enExample) |
| ES (1) | ES2274999T3 (enExample) |
| GB (1) | GB0118238D0 (enExample) |
| WO (1) | WO2003010138A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6803369B1 (en) | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
| EP1719770A3 (en) * | 2000-09-21 | 2008-03-05 | Smithkline Beecham Plc | Quinoline derivatives as antibacterials |
| GB0031088D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| WO2003064431A2 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| WO2003064421A1 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine derivatives |
| TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| AR040335A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
| AU2003301414B8 (en) | 2002-10-10 | 2010-06-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Novel compounds with antibacterial activity |
| AU2003291227A1 (en) | 2002-11-05 | 2004-06-07 | Smithkline Beecham Corporation | Antibacterial agents |
| DE60331849D1 (de) | 2002-11-05 | 2010-05-06 | Glaxosmithkline Llc | Antibakterielle wirkstoffe |
| TW200427688A (en) * | 2002-12-18 | 2004-12-16 | Glaxo Group Ltd | Antibacterial agents |
| JP4762155B2 (ja) * | 2004-01-08 | 2011-08-31 | エフ．ホフマン−ラ ロシュ アーゲー | ジアザ−スピロピペリジン誘導体 |
| FR2867472B1 (fr) * | 2004-03-12 | 2008-07-18 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| WO2006002361A2 (en) | 2004-06-24 | 2006-01-05 | Incyte Corporation | 2-methylpropanamides and their use as pharmaceuticals |
| EP1773343A4 (en) * | 2004-07-13 | 2009-05-13 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
| PT1650186E (pt) * | 2004-10-22 | 2008-09-16 | Bioprojet Soc Civ | Novos derivados de ácidos dicarboxílicos |
| WO2006081179A1 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| WO2006081182A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| WO2006081178A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| US7605169B2 (en) | 2005-01-25 | 2009-10-20 | Glaxo Group Limited | Antibacterial agents |
| WO2006081289A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| KR101415861B1 (ko) | 2005-12-05 | 2014-07-04 | 인사이트 코포레이션 | 락탐 화합물 및 이를 사용하는 방법 |
| EP1991540A1 (en) * | 2006-02-21 | 2008-11-19 | Amgen Inc. | Cinnoline derivatives as phosphodiesterase 10 inhibitors |
| EP1991531A1 (en) * | 2006-02-28 | 2008-11-19 | Amgen Inc. | Cinnoline and quinoxaline derivates as phosphodiesterase 10 inhibitors |
| CA2644850A1 (en) * | 2006-03-08 | 2007-09-13 | Amgen Inc. | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors |
| EP2001887B1 (en) | 2006-04-06 | 2010-09-15 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
| EP2007377A4 (en) | 2006-04-06 | 2011-08-17 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| CL2007002958A1 (es) * | 2006-10-12 | 2008-05-09 | Epix Delaware Inc | Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr |
| CA2684659C (en) * | 2007-04-20 | 2015-11-24 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
| KR20090130347A (ko) | 2007-05-09 | 2009-12-22 | 화이자 인코포레이티드 | 치환된 헤테로사이클릭 유도체 및 조성물 및 항균제로서의 이의 약학적 용도 |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
| CA2708364A1 (en) | 2007-12-11 | 2009-06-18 | Efrat Ben-Zeev | Carboxamide compounds and their use as chemokine receptor agonists |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| JP2011523658A (ja) * | 2008-06-02 | 2011-08-18 | シプラ・リミテッド | アルホルモテロールの合成方法 |
| WO2010043714A1 (en) | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
| JP5653935B2 (ja) | 2009-01-15 | 2015-01-14 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物 |
| JP5685589B2 (ja) * | 2010-05-25 | 2015-03-18 | 大正製薬株式会社 | 新規な複素環化合物又はその塩 |
| CN102267995A (zh) * | 2010-06-04 | 2011-12-07 | 艾琪康医药科技（上海）有限公司 | 一种制备二氮杂螺环化合物的方法 |
| CA2817365A1 (en) * | 2010-12-14 | 2012-06-21 | Merck Sharp & Dohme Corp. | Process and intermediates for preparing macrolactams |
| AR089929A1 (es) | 2012-02-10 | 2014-10-01 | Actelion Pharmaceuticals Ltd | Proceso para manufacturar un derivado de naftiridina |
| US9133167B2 (en) * | 2012-04-27 | 2015-09-15 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| WO2013160431A1 (en) * | 2012-04-27 | 2013-10-31 | Janssen Pharmaceutica Nv | Antibacterial quinoline derivatives |
| WO2016027249A1 (en) | 2014-08-22 | 2016-02-25 | Glaxosmithkline Intellectual Property Development Limited | Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection |
| TW201722965A (zh) | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| US11884647B2 (en) | 2019-10-18 | 2024-01-30 | The Regents Of The University Of California | Compounds and methods for targeting pathogenic blood vessels |
| CN116102537B (zh) * | 2021-11-10 | 2024-10-01 | 四川大学 | 一种喹啉酮类衍生物及其制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7908031A (nl) * | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen. |
| EP0541486A1 (de) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclische Konjugate |
| US5977134A (en) * | 1996-12-05 | 1999-11-02 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| GB9822450D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| GB9822440D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| JP2002535323A (ja) * | 1999-01-20 | 2002-10-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | プロテインキナーゼ阻害剤としてのピペリジニルキノリン |
| GB9914486D0 (en) * | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
| GB9917408D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| GB9917406D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| US6403610B1 (en) * | 1999-09-17 | 2002-06-11 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them |
| US6803369B1 (en) * | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
| DE60125373T2 (de) * | 2000-07-26 | 2007-10-18 | Smithkline Beecham P.L.C., Brentford | Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung |
| EP1719770A3 (en) * | 2000-09-21 | 2008-03-05 | Smithkline Beecham Plc | Quinoline derivatives as antibacterials |
| US6603005B2 (en) * | 2000-11-15 | 2003-08-05 | Aventis Pharma S.A. | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them |
| FR2816618B1 (fr) * | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
| GB0031088D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| US6602884B2 (en) * | 2001-03-13 | 2003-08-05 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them |
| GB0112834D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112836D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| US20030203917A1 (en) * | 2001-07-25 | 2003-10-30 | Smithkline Beecham Corporation And Smithkline Beecham P.L.C. | Compounds and methods for the treatment of neoplastic disease |
| WO2003064431A2 (en) * | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| WO2003064421A1 (en) * | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine derivatives |
| GB0217294D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
-
2001
- 2001-07-26 GB GBGB0118238.5A patent/GB0118238D0/en not_active Ceased
-
2002
- 2002-07-25 US US10/484,563 patent/US20040198756A1/en not_active Abandoned
- 2002-07-25 WO PCT/EP2002/008319 patent/WO2003010138A2/en not_active Ceased
- 2002-07-25 EP EP02764786A patent/EP1419155B1/en not_active Expired - Lifetime
- 2002-07-25 AU AU2002328972A patent/AU2002328972A1/en not_active Abandoned
- 2002-07-25 ES ES02764786T patent/ES2274999T3/es not_active Expired - Lifetime
- 2002-07-25 AT AT02764786T patent/ATE344799T1/de not_active IP Right Cessation
- 2002-07-25 DE DE60215951T patent/DE60215951T2/de not_active Expired - Fee Related
- 2002-07-25 JP JP2003515497A patent/JP2005504747A/ja active Pending
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