JP2008505920A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008505920A5 JP2008505920A5 JP2007520525A JP2007520525A JP2008505920A5 JP 2008505920 A5 JP2008505920 A5 JP 2008505920A5 JP 2007520525 A JP2007520525 A JP 2007520525A JP 2007520525 A JP2007520525 A JP 2007520525A JP 2008505920 A5 JP2008505920 A5 JP 2008505920A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- methyloxy
- pyrido
- amino
- naphthyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 18
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 14
- -1 hydroxy, amino, piperidyl Chemical group 0.000 claims 11
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000004423 acyloxy group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 2
- WCOPEZIWYVDOGJ-NNJIEVJOSA-N 6-[[[(2r)-4-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-2-hydroxyethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC[C@H]3OCCN(C3)CC(O)C3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 WCOPEZIWYVDOGJ-NNJIEVJOSA-N 0.000 claims 2
- WCOPEZIWYVDOGJ-BUSXIPJBSA-N 6-[[[(2s)-4-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-2-hydroxyethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC[C@@H]3OCCN(C3)CC(O)C3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 WCOPEZIWYVDOGJ-BUSXIPJBSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000005035 acylthio group Chemical group 0.000 claims 2
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
- MDPIIKLBVPRYLK-HNNXBMFYSA-N (2s)-n-(6-methoxy-1,5-naphthyridin-4-yl)-2-[[(3-oxo-4h-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino]methyl]morpholine-4-carboxamide Chemical compound S1CC(=O)NC2=NC(CNC[C@@H]3OCCN(C3)C(=O)NC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 MDPIIKLBVPRYLK-HNNXBMFYSA-N 0.000 claims 1
- BEJKRDDWNPMACI-UHFFFAOYSA-N 4-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]-n-methyl-n-[(3-oxo-4h-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]morpholine-2-carboxamide Chemical compound S1CC(=O)NC2=NC(CN(C)C(=O)C3OCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 BEJKRDDWNPMACI-UHFFFAOYSA-N 0.000 claims 1
- NZJRODSXVMZZDT-UHFFFAOYSA-N 6-[[7-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CN3CC4N(C3=O)CCN(C4)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 NZJRODSXVMZZDT-UHFFFAOYSA-N 0.000 claims 1
- XRAJCWSBLKBNDM-UHFFFAOYSA-N 6-[[8-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-3-oxo-1,4,6,7,9,9a-hexahydropyrazino[1,2-a]pyrazin-2-yl]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CN3C(=O)CN4CCN(CC4C3)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 XRAJCWSBLKBNDM-UHFFFAOYSA-N 0.000 claims 1
- HPYOIEYJFIOJFT-UHFFFAOYSA-N 6-[[8-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-4-oxo-1,3,6,7,9,9a-hexahydropyrazino[1,2-a]pyrazin-2-yl]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CN3CC4N(C(C3)=O)CCN(C4)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 HPYOIEYJFIOJFT-UHFFFAOYSA-N 0.000 claims 1
- DNJYXXMLVYYZID-APWZRJJASA-N 6-[[[(2r)-4-[(2r)-2-hydroxy-2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC[C@H]3OCCN(C3)C[C@H](O)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 DNJYXXMLVYYZID-APWZRJJASA-N 0.000 claims 1
- OAJYFQBGENGKHJ-GOSISDBHSA-N 6-[[[(2r)-4-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC[C@H]3OCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 OAJYFQBGENGKHJ-GOSISDBHSA-N 0.000 claims 1
- DNJYXXMLVYYZID-LPHOPBHVSA-N 6-[[[(2s)-4-[(2r)-2-hydroxy-2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC[C@@H]3OCCN(C3)C[C@H](O)C3=CC=NC4=CC=C(N=C43)OC)=CC=C21 DNJYXXMLVYYZID-LPHOPBHVSA-N 0.000 claims 1
- OLLLXPOAZSYQDY-INIZCTEOSA-N 6-[[[(2s)-4-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC[C@@H]3OCCN(C3)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 OLLLXPOAZSYQDY-INIZCTEOSA-N 0.000 claims 1
- NXBSBBMUDZDBMP-SFHVURJKSA-N 6-[[[(2s)-4-[2-(3-fluoro-6-methoxyquinolin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound O1CC(=O)NC2=NC(CNC[C@@H]3OCCN(C3)CCC3=C(F)C=NC4=CC=C(C=C43)OC)=CC=C21 NXBSBBMUDZDBMP-SFHVURJKSA-N 0.000 claims 1
- QGYGRBYHGOAPRP-SFHVURJKSA-N 6-[[[(2s)-4-[2-(3-fluoro-6-methoxyquinolin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC[C@@H]3OCCN(C3)CCC3=C(F)C=NC4=CC=C(C=C43)OC)=CC=C21 QGYGRBYHGOAPRP-SFHVURJKSA-N 0.000 claims 1
- DJIJBENPXOOCBF-UHFFFAOYSA-N 6-[[[1-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperidin-3-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNCC3CCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 DJIJBENPXOOCBF-UHFFFAOYSA-N 0.000 claims 1
- UGOBYQRYYQCZRB-UHFFFAOYSA-N 6-[[[4-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperazin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNCC3NCCN(C3)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 UGOBYQRYYQCZRB-UHFFFAOYSA-N 0.000 claims 1
- OAJYFQBGENGKHJ-UHFFFAOYSA-N 6-[[[4-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNCC3OCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 OAJYFQBGENGKHJ-UHFFFAOYSA-N 0.000 claims 1
- NWWLLPDMCNFPOA-UHFFFAOYSA-N 6-[[[4-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperazin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNCC3NCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 NWWLLPDMCNFPOA-UHFFFAOYSA-N 0.000 claims 1
- OXEITQIJQHGVNK-SFHVURJKSA-N 6-methoxy-4-[2-[(2s)-2-[[(3-oxo-4h-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]methyl]morpholin-4-yl]ethyl]-1,5-naphthyridine-3-carbonitrile Chemical compound O1CC(=O)NC2=NC(CNC[C@@H]3OCCN(C3)CCC3=C(C#N)C=NC4=CC=C(N=C43)OC)=CC=C21 OXEITQIJQHGVNK-SFHVURJKSA-N 0.000 claims 1
- CTRVZTOAQIFNGS-SFHVURJKSA-N 6-methoxy-4-[2-[(2s)-2-[[(3-oxo-4h-pyrido[3,2-b][1,4]thiazin-6-yl)methylamino]methyl]morpholin-4-yl]ethyl]-1,5-naphthyridine-3-carbonitrile Chemical compound S1CC(=O)NC2=NC(CNC[C@@H]3OCCN(C3)CCC3=C(C#N)C=NC4=CC=C(N=C43)OC)=CC=C21 CTRVZTOAQIFNGS-SFHVURJKSA-N 0.000 claims 1
- INCQTOLYCXVNOH-AWEZNQCLSA-N 7-chloro-6-[[[(2s)-4-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]oxazin-3-one Chemical compound N1C(=O)COC(C=C2Cl)=C1N=C2CNC[C@@H](C1)OCCN1CCC1=C(F)C=NC2=CC=C(OC)N=C21 INCQTOLYCXVNOH-AWEZNQCLSA-N 0.000 claims 1
- NITQQTGQNJQKIJ-INIZCTEOSA-N 8-fluoro-6-[[[(2s)-4-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methylamino]methyl]-4h-1,4-benzoxazin-3-one Chemical compound O1CC(=O)NC2=CC(CNC[C@@H]3OCCN(C3)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC(F)=C21 NITQQTGQNJQKIJ-INIZCTEOSA-N 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000790917 Dioxys <bee> Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- PSDYQSWHANEKRV-UHFFFAOYSA-N [S]N Chemical group [S]N PSDYQSWHANEKRV-UHFFFAOYSA-N 0.000 claims 1
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 1
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 125000005360 alkyl sulfoxide group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
- 125000005361 aryl sulfoxide group Chemical group 0.000 claims 1
- 125000005110 aryl thio group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 1
- 125000004468 heterocyclylthio group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- QVXLXJYKKAKILO-UHFFFAOYSA-N n-[[1-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperidin-3-yl]methyl]-3-oxo-4h-1,4-benzothiazine-6-sulfonamide Chemical compound S1CC(=O)NC2=CC(S(=O)(=O)NCC3CCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 QVXLXJYKKAKILO-UHFFFAOYSA-N 0.000 claims 1
- LMJJOAJSFFEASA-UHFFFAOYSA-N n-[[1-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]piperidin-3-yl]methyl]-3-oxo-4h-pyrido[3,2-b][1,4]thiazine-6-carboxamide Chemical compound S1CC(=O)NC2=NC(C(=O)NCC3CCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 LMJJOAJSFFEASA-UHFFFAOYSA-N 0.000 claims 1
- RIVPPGHNETZFKI-UHFFFAOYSA-N n-[[4-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methyl]-3-oxo-4h-1,4-benzothiazine-6-sulfonamide Chemical compound S1CC(=O)NC2=CC(S(=O)(=O)NCC3OCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 RIVPPGHNETZFKI-UHFFFAOYSA-N 0.000 claims 1
- JBYPDPRGTXGQGZ-UHFFFAOYSA-N n-[[4-[2-(6-methoxy-1,5-naphthyridin-4-yl)ethyl]morpholin-2-yl]methyl]-3-oxo-4h-pyrido[3,2-b][1,4]thiazine-6-carboxamide Chemical compound S1CC(=O)NC2=NC(C(=O)NCC3OCCN(C3)CCC3=CC=NC4=CC=C(N=C43)OC)=CC=C21 JBYPDPRGTXGQGZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58644604P | 2004-07-08 | 2004-07-08 | |
| PCT/US2005/024221 WO2006014580A1 (en) | 2004-07-08 | 2005-07-08 | Antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008505920A JP2008505920A (ja) | 2008-02-28 |
| JP2008505920A5 true JP2008505920A5 (enExample) | 2008-09-04 |
Family
ID=35787423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007520525A Pending JP2008505920A (ja) | 2004-07-08 | 2005-07-08 | 抗菌剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070254872A1 (enExample) |
| EP (1) | EP1773831A1 (enExample) |
| JP (1) | JP2008505920A (enExample) |
| WO (1) | WO2006014580A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1796466A4 (en) * | 2004-06-15 | 2009-09-02 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
| EP1845995A4 (en) * | 2005-01-25 | 2010-03-03 | Glaxo Group Ltd | ANTIBACTERIAL AGENTS |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| HRP20100194T8 (hr) * | 2005-10-21 | 2010-06-30 | Glaxo Group Limited | Perikondenzirani triciklički spojevi, korisni kao antibakterijska sredstva |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| ATE481406T1 (de) | 2006-04-06 | 2010-10-15 | Glaxo Group Ltd | Pyrrolochinoxalinonderivate als antibakterielle mittel |
| US7709496B2 (en) | 2006-04-06 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
| MX2008014908A (es) * | 2006-05-26 | 2009-05-13 | Toyama Chemical Co Ltd | Compuesto heterociclico nuevo o sal del mismo e intermedio del mismo. |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| US20090325956A1 (en) * | 2006-10-13 | 2009-12-31 | Takahiko Taniguchi | Aromatic amine derivative and use thereof |
| PT2137196E (pt) | 2007-04-20 | 2010-12-16 | Glaxo Group Ltd | Compostos tricíclicos contendo azoto como agentes antibacterianos |
| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| WO2009128019A1 (en) * | 2008-04-15 | 2009-10-22 | Actelion Pharmaceuticals Ltd | Tricyclic antibiotics |
| JP2012505866A (ja) | 2008-10-17 | 2012-03-08 | グラクソ グループ リミテッド | 抗菌剤として使用される三環式窒素化合物 |
| CN102232078B (zh) | 2008-12-12 | 2014-07-16 | 埃科特莱茵药品有限公司 | 5-氨基-2-(1-羟基-乙基)-四氢吡喃衍生物 |
| US8318940B2 (en) | 2009-01-15 | 2012-11-27 | Glaxo Group Limited | Naphthyridin-2 (1 H)-one compounds useful as antibacterials |
| US8716280B2 (en) | 2009-01-21 | 2014-05-06 | Basilea Pharmaceutica Ag | Bicyclic antibiotics |
| JP5697685B2 (ja) | 2009-12-18 | 2015-04-08 | バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ | 三環式抗生物質 |
| CN103635474B (zh) * | 2011-06-17 | 2016-04-27 | 巴斯利尔药物股份公司 | 三环抗生素 |
| AR101674A1 (es) | 2014-08-22 | 2017-01-04 | Glaxosmithkline Ip Dev Ltd | Uso de un compuesto tricíclico que contiene nitrógeno |
| MA41169A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
| UY36629A (es) | 2015-04-17 | 2016-11-30 | Abbvie Inc | Indazolonas como moduladores de la señalización de tnf |
| UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| US12590298B2 (en) | 2019-10-18 | 2026-03-31 | The Regents Of The University Of California | Ex vivo tumor angiogenesis model |
| US11884647B2 (en) | 2019-10-18 | 2024-01-30 | The Regents Of The University Of California | Compounds and methods for targeting pathogenic blood vessels |
| AR121715A1 (es) | 2020-04-03 | 2022-06-29 | Biocryst Pharm Inc | Pirrolopirimidinaminas como inhibidores del sistema del complemento |
| US20250214980A1 (en) | 2022-03-14 | 2025-07-03 | Slap Pharmaceuticals Llc | Multicyclic compounds |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194413B1 (en) * | 1995-11-13 | 2001-02-27 | Smithkline Beecham Corporation | Hemoregulatory compounds |
| GB9822440D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| GB9914486D0 (en) * | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
| GB9917408D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| GB9917406D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| US6403610B1 (en) * | 1999-09-17 | 2002-06-11 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them |
| US6803369B1 (en) * | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
| CN1452619A (zh) * | 2000-07-26 | 2003-10-29 | 史密斯克莱·比奇曼公司 | 具有抗细菌活性的氨基哌啶喹啉和它们的氮杂等排的类似物 |
| EP1719770A3 (en) * | 2000-09-21 | 2008-03-05 | Smithkline Beecham Plc | Quinoline derivatives as antibacterials |
| US6603005B2 (en) * | 2000-11-15 | 2003-08-05 | Aventis Pharma S.A. | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them |
| GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| US6602884B2 (en) * | 2001-03-13 | 2003-08-05 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them |
| US20030203917A1 (en) * | 2001-07-25 | 2003-10-30 | Smithkline Beecham Corporation And Smithkline Beecham P.L.C. | Compounds and methods for the treatment of neoplastic disease |
| US7109213B2 (en) * | 2002-01-29 | 2006-09-19 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| JP4445753B2 (ja) * | 2002-01-29 | 2010-04-07 | グラクソ グループ リミテッド | アミノピペリジン誘導体 |
| AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| FR2844270B1 (fr) * | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| JP4602903B2 (ja) * | 2002-10-10 | 2010-12-22 | モルフォケム アクチェンゲゼルシャフト フュア コンビナトリシェ ヘミー | 抗菌活性を有する新規化合物 |
| ES2350977T3 (es) * | 2002-11-05 | 2011-01-28 | Glaxo Group Limited | Agentes antibacterianos. |
| AU2003303956A1 (en) * | 2002-11-05 | 2004-11-23 | Smithkline Beecham Corporation | Antibacterial agents |
| DE60324179D1 (de) * | 2002-12-04 | 2008-11-27 | Glaxo Group Ltd | Chinoline und stickstoffhaltige derivatedavon und deren verwendung als antibakterielle mittel |
| AR042486A1 (es) * | 2002-12-18 | 2005-06-22 | Glaxo Group Ltd | Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . |
| TW200507841A (en) * | 2003-03-27 | 2005-03-01 | Glaxo Group Ltd | Antibacterial agents |
| US7232833B2 (en) * | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| DE10316081A1 (de) * | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| US7348434B2 (en) * | 2003-08-08 | 2008-03-25 | Antony Bigot | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
-
2005
- 2005-07-08 US US11/570,441 patent/US20070254872A1/en not_active Abandoned
- 2005-07-08 JP JP2007520525A patent/JP2008505920A/ja active Pending
- 2005-07-08 WO PCT/US2005/024221 patent/WO2006014580A1/en not_active Ceased
- 2005-07-08 EP EP05771319A patent/EP1773831A1/en not_active Withdrawn