JP2008507543A5 - - Google Patents

Info

Publication number

JP2008507543A5

JP2008507543A5 JP2007522737A JP2007522737A JP2008507543A5 JP 2008507543 A5 JP2008507543 A5 JP 2008507543A5 JP 2007522737 A JP2007522737 A JP 2007522737A JP 2007522737 A JP2007522737 A JP 2007522737A JP 2008507543 A5 JP2008507543 A5 JP 2008507543A5

Authority

JP

Japan

Prior art keywords

alkyl

independently

hydrogen

hydroxy

aryl

Prior art date

2005-07-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 35
• 229910052739 hydrogen Inorganic materials 0.000 claims 30
• 239000001257 hydrogen Substances 0.000 claims 30
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 25
• 125000003118 aryl group Chemical group 0.000 claims 18
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 16
• 150000001875 compounds Chemical class 0.000 claims 15
• 229910052736 halogen Inorganic materials 0.000 claims 14
• 150000002367 halogens Chemical class 0.000 claims 14
• 125000001072 heteroaryl group Chemical group 0.000 claims 12
• 125000003710 aryl alkyl group Chemical group 0.000 claims 11
• -1 hydroxy, amino, piperidyl Chemical group 0.000 claims 11
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 9
• 125000004414 alkyl thio group Chemical group 0.000 claims 8
• 125000000623 heterocyclic group Chemical group 0.000 claims 7
• 125000006574 non-aromatic ring group Chemical group 0.000 claims 7
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 6
• 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 6
• 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 5
• 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 5
• 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 5
• 125000004423 acyloxy group Chemical group 0.000 claims 5
• 125000003277 amino group Chemical group 0.000 claims 5
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 5
• 125000003396 thiol group Chemical class [H]S* 0.000 claims 5
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
• 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 4
• 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 4
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 4
• 125000004429 atom Chemical group 0.000 claims 4
• 125000004093 cyano group Chemical group *C#N 0.000 claims 4
• 150000002431 hydrogen Chemical class 0.000 claims 4
• 229910052757 nitrogen Inorganic materials 0.000 claims 4
• 125000002252 acyl group Chemical group 0.000 claims 3
• 150000001540 azides Chemical class 0.000 claims 3
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
• 229910052760 oxygen Inorganic materials 0.000 claims 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
• 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
• NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 2
• 208000035143 Bacterial infection Diseases 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• 125000005035 acylthio group Chemical group 0.000 claims 2
• ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims 2
• HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 2
• 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
• 208000022362 bacterial infectious disease Diseases 0.000 claims 2
• 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 2
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 125000000753 cycloalkyl group Chemical group 0.000 claims 2
• 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 claims 2
• 125000005843 halogen group Chemical group 0.000 claims 2
• 125000004475 heteroaralkyl group Chemical group 0.000 claims 2
• 125000005647 linker group Chemical group 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 2
• JLAKYLMHGGAUDW-IYBDPMFKSA-N 6-[[(3ar,6as)-2-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CN3C[C@@H]4CN(C[C@@H]4C3)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 JLAKYLMHGGAUDW-IYBDPMFKSA-N 0.000 claims 1
• LNAGSKGSIOIECD-MOXGXCLJSA-N 6-[[[(3ar,4r,6as)-2-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-4-yl]amino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CN[C@@H]3CC[C@@H]4CN(C[C@@H]43)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 LNAGSKGSIOIECD-MOXGXCLJSA-N 0.000 claims 1
• LNAGSKGSIOIECD-BPAFIMBUSA-N 6-[[[(3ar,4s,6as)-2-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-4-yl]amino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CN[C@H]3CC[C@@H]4CN(C[C@@H]43)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 LNAGSKGSIOIECD-BPAFIMBUSA-N 0.000 claims 1
• WEDQDHFIUXWYDE-BYICEURKSA-N 6-[[[(3ar,6as)-2-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-5-yl]amino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC3C[C@H]4CN(C[C@H]4C3)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 WEDQDHFIUXWYDE-BYICEURKSA-N 0.000 claims 1
• SRAVTNUCBHQYLG-SOKVYYICSA-N 6-[[[(3as,6ar)-2-[2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]methylamino]methyl]-4h-pyrido[3,2-b][1,4]thiazin-3-one Chemical compound S1CC(=O)NC2=NC(CNC[C@]34CCC[C@H]3CN(C4)CCC3=C(F)C=NC4=CC=C(N=C43)OC)=CC=C21 SRAVTNUCBHQYLG-SOKVYYICSA-N 0.000 claims 1
• 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
• 125000005360 alkyl sulfoxide group Chemical group 0.000 claims 1
• 125000004391 aryl sulfonyl group Chemical group 0.000 claims 1
• 125000005361 aryl sulfoxide group Chemical group 0.000 claims 1
• 125000005110 aryl thio group Chemical group 0.000 claims 1
• 125000004104 aryloxy group Chemical group 0.000 claims 1
• 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 1
• 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 125000004468 heterocyclylthio group Chemical group 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1