JP2005533493A5 - - Google Patents

Info

Publication number

JP2005533493A5

JP2005533493A5 JP2004513434A JP2004513434A JP2005533493A5 JP 2005533493 A5 JP2005533493 A5 JP 2005533493A5 JP 2004513434 A JP2004513434 A JP 2004513434A JP 2004513434 A JP2004513434 A JP 2004513434A JP 2005533493 A5 JP2005533493 A5 JP 2005533493A5

Authority

JP

Japan

Prior art keywords

antibody

seq

fragment

antibody fragment

chain variable

Prior art date

2003-06-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 65
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 65
• 125000003275 alpha amino acid group Chemical group 0.000 claims 27
• 102000038455 IGF Type 1 Receptor Human genes 0.000 claims 19
• 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 19
• 210000004027 cell Anatomy 0.000 claims 17
• 239000012634 fragment Substances 0.000 claims 16
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 13
• 206010028980 Neoplasm Diseases 0.000 claims 13
• 201000011510 cancer Diseases 0.000 claims 13
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 230000002401 inhibitory effect Effects 0.000 claims 7
• 238000000034 method Methods 0.000 claims 7
• 102000005962 receptors Human genes 0.000 claims 6
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 5
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 5
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• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
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