JP2005514441A5 - - Google Patents
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- Publication number
- JP2005514441A5 JP2005514441A5 JP2003559507A JP2003559507A JP2005514441A5 JP 2005514441 A5 JP2005514441 A5 JP 2005514441A5 JP 2003559507 A JP2003559507 A JP 2003559507A JP 2003559507 A JP2003559507 A JP 2003559507A JP 2005514441 A5 JP2005514441 A5 JP 2005514441A5
- Authority
- JP
- Japan
- Prior art keywords
- phenylphenylmethyl
- oxopropyl
- carboxy
- amino
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 125000004494 ethyl ester group Chemical group 0.000 claims description 3
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims description 3
- 229960004699 valsartan Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- -1 3- carboxy-1-oxopropyl Chemical group 0.000 claims 4
- ZBSFEPOXERUZFE-SFHVURJKSA-N (2R)-4-amino-2-methyl-2-[(4-phenylphenyl)methyl]butanoic acid Chemical compound C1(=CC=CC=C1)C1=CC=C(C=C1)C[C@@](C(=O)O)(CCN)C ZBSFEPOXERUZFE-SFHVURJKSA-N 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- UEBQNXUHSKFIIR-FQEVSTJZSA-N ethyl (2R)-4-amino-2-methyl-2-[(4-phenylphenyl)methyl]butanoate Chemical compound C(C)OC([C@](CCN)(C)CC1=CC=C(C=C1)C1=CC=CC=C1)=O UEBQNXUHSKFIIR-FQEVSTJZSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002552 dosage form Substances 0.000 description 3
- 241000700159 Rattus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XAIFNLJOYACUNR-IBGZPJMESA-N CC(C)[C@@H](C(O)=O)N(Cc(cc1)ccc1-c(cccc1)c1-c1nnn[nH]1)C(C)=O Chemical compound CC(C)[C@@H](C(O)=O)N(Cc(cc1)ccc1-c(cccc1)c1-c1nnn[nH]1)C(C)=O XAIFNLJOYACUNR-IBGZPJMESA-N 0.000 description 1
- VPGRYOFKCNULNK-ACXQXYJUSA-N Deoxycorticosterone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)COC(=O)C)[C@@]1(C)CC2 VPGRYOFKCNULNK-ACXQXYJUSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 229960004486 desoxycorticosterone acetate Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34966002P | 2002-01-17 | 2002-01-17 | |
| US60/349,660 | 2002-01-17 | ||
| PCT/EP2003/000415 WO2003059345A1 (en) | 2002-01-17 | 2003-01-16 | Pharmaceutical compositions comprising valsartan and nep inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011116928A Division JP2011207898A (ja) | 2002-01-17 | 2011-05-25 | バルサルタンおよびｎｅｐ阻害剤を含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005514441A JP2005514441A (ja) | 2005-05-19 |
| JP2005514441A5 true JP2005514441A5 (OSRAM) | 2011-08-04 |
| JP4820056B2 JP4820056B2 (ja) | 2011-11-24 |
Family
ID=23373410
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003559507A Expired - Lifetime JP4820056B2 (ja) | 2002-01-17 | 2003-01-16 | バルサルタンおよびｎｅｐ阻害剤を含む医薬組成物 |
| JP2011116928A Withdrawn JP2011207898A (ja) | 2002-01-17 | 2011-05-25 | バルサルタンおよびｎｅｐ阻害剤を含む医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011116928A Withdrawn JP2011207898A (ja) | 2002-01-17 | 2011-05-25 | バルサルタンおよびｎｅｐ阻害剤を含む医薬組成物 |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1467728B1 (OSRAM) |
| JP (2) | JP4820056B2 (OSRAM) |
| KR (2) | KR20100057704A (OSRAM) |
| CN (2) | CN102091330B (OSRAM) |
| AT (1) | ATE370732T1 (OSRAM) |
| AU (1) | AU2003206738C1 (OSRAM) |
| BE (1) | BE2016C025I2 (OSRAM) |
| BR (2) | BRPI0306907B8 (OSRAM) |
| CA (1) | CA2472399C (OSRAM) |
| CO (1) | CO5600999A2 (OSRAM) |
| CY (2) | CY1106959T1 (OSRAM) |
| DE (1) | DE60315795T2 (OSRAM) |
| DK (1) | DK1467728T3 (OSRAM) |
| EC (1) | ECSP045190A (OSRAM) |
| ES (1) | ES2290429T3 (OSRAM) |
| FR (1) | FR16C0019I2 (OSRAM) |
| HU (1) | HUS1600024I1 (OSRAM) |
| IL (2) | IL162661A0 (OSRAM) |
| LU (1) | LU93074I2 (OSRAM) |
| MX (1) | MXPA04006917A (OSRAM) |
| NL (1) | NL300811I2 (OSRAM) |
| NO (2) | NO333191B1 (OSRAM) |
| NZ (1) | NZ533968A (OSRAM) |
| PL (1) | PL212318B1 (OSRAM) |
| PT (1) | PT1467728E (OSRAM) |
| RU (1) | RU2334513C3 (OSRAM) |
| SI (1) | SI1467728T1 (OSRAM) |
| WO (1) | WO2003059345A1 (OSRAM) |
| ZA (1) | ZA200405117B (OSRAM) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1776095A1 (en) * | 2004-06-23 | 2007-04-25 | Solvay Pharmaceuticals GmbH | Pharmaceutical compositions comprising nep-inhibitors, inhibitors of the endogenous endothelin producing system and at1-receptor antagonists |
| EA015108B1 (ru) | 2004-12-24 | 2011-06-30 | КРКА, д.д., НОВО МЕСТО | Способ получения твердой фармацевтической композиции, содержащей валсартан |
| MY146830A (en) * | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
| WO2007045663A2 (en) * | 2005-10-19 | 2007-04-26 | Novartis Ag | Combination of an ati receptor antagonist and a np inhibitor fro treating ia hypertension and heartfailure |
| WO2007051007A2 (en) * | 2005-10-28 | 2007-05-03 | Novartis Ag | Combination of antihypertensives with cholesterol-lowering agent |
| AR057882A1 (es) * | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| WO2007106708A2 (en) * | 2006-03-10 | 2007-09-20 | Novartis Ag | Combinations of the angiotensin ii antagonist valsartan and the nep inhibitor daglutril |
| CZ300801B6 (cs) * | 2006-06-07 | 2009-08-12 | Helvetia Pharma A.S. | Kompozice s valsartanem v pevných lékových formách |
| RU2530900C2 (ru) | 2007-01-12 | 2014-10-20 | Новартис Аг | Способ получения 5-бифенил-4-амино-2-метилпентановой кислоты |
| GB0708507D0 (en) | 2007-05-02 | 2007-06-13 | Queen Mary & Westfield College | Substituted phosphonates and their use |
| CN101848700A (zh) | 2007-11-06 | 2010-09-29 | 诺瓦提斯公司 | 基于血管紧张素受体拮抗剂/阻断剂(arb)和中性内肽酶(nep)抑制剂的超结构的双重作用的药物组合物 |
| CN101774941A (zh) | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
| JP5420761B2 (ja) | 2009-05-28 | 2014-02-19 | ノバルティス アーゲー | ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体 |
| SG176010A1 (en) | 2009-05-28 | 2011-12-29 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| BR112013004164A2 (pt) | 2010-08-23 | 2016-05-10 | Novartis Ag | processo para a preparação de intermediários para a produção de inibidores da nep |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| SI2887961T1 (sl) * | 2012-08-24 | 2021-08-31 | Novartis Ag | Zaviralci NEP za zdravljenje bolezni, značilnih po atrialni širitvi ali preoblikovanju |
| WO2014126972A1 (en) | 2013-02-14 | 2014-08-21 | Novartis Ag | Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy |
| NZ710574A (en) | 2013-02-14 | 2017-11-24 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors |
| CN104230865B (zh) * | 2013-06-13 | 2018-01-09 | 上海翰森生物医药科技有限公司 | 联芳基取代的4‑氨基丁酸衍生物及其制备方法和用途 |
| EP3038653A1 (en) | 2013-08-26 | 2016-07-06 | Novartis AG | New use |
| RS65037B1 (sr) | 2013-08-26 | 2024-02-29 | Novartis Ag | Lečenje kardiovaskularnih oboljenja |
| CN106458857A (zh) * | 2014-08-27 | 2017-02-22 | 上海翰森生物医药科技有限公司 | AHU‑377结晶型游离酸、半钙盐、α﹣苯乙胺盐及其制备方法和应用 |
| WO2016037098A1 (en) * | 2014-09-04 | 2016-03-10 | Concert Pharmaceuticals, Inc. | Deuterated sacubitril |
| CN106414416B (zh) * | 2014-09-09 | 2020-03-27 | 上海翰森生物医药科技有限公司 | 结晶型ARB-NEPi复合物及其制备方法和应用 |
| CN105503760A (zh) * | 2014-10-10 | 2016-04-20 | 上海翰森生物医药科技有限公司 | 结晶型ARB-NEPi双阳离子复合物及其制备方法和应用 |
| PL3218351T3 (pl) | 2014-11-14 | 2019-12-31 | Zentiva K.S. | Sposób wytwarzania, wyodrębniania i oczyszczania farmaceutycznie dopuszczalnych postaci AHU-377 |
| WO2016086798A1 (zh) * | 2014-12-03 | 2016-06-09 | 上海翰森生物医药科技有限公司 | Nep抑制剂结晶型游离酸、钙盐多晶型及其制备方法和应用 |
| PL3229799T3 (pl) * | 2014-12-08 | 2019-05-31 | Crystal Pharmatech Co Ltd | Krystaliczne postacie supramolekularnego kompleksu trisodowego zawierającego walsartan i AHU-377 i ich sposoby |
| CN105693543B (zh) * | 2014-12-15 | 2018-08-10 | 四川海思科制药有限公司 | 沙库比曲类衍生物、其药物组合物、制备方法及用途 |
| CN104826115A (zh) * | 2015-04-19 | 2015-08-12 | 浙江巨泰药业有限公司 | 一种抗心衰药物组合物及其制备方法 |
| CN106138069A (zh) * | 2015-04-21 | 2016-11-23 | 刘春丽 | 作为治疗来自非角化复层上皮组织的不适的局部药剂的1-二仲丁基膦酰基戊烷 |
| HUE071910T2 (hu) | 2015-05-11 | 2025-10-28 | Novartis Ag | Szakubitril-valzartán adagolási rend krónikus szisztolés szívelégtelenség kezelésére |
| EP3302460A1 (en) | 2015-05-29 | 2018-04-11 | Novartis AG | Sacubitril and valsartan for treating metabolic disease |
| WO2017006254A1 (en) | 2015-07-08 | 2017-01-12 | Novartis Ag | Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist |
| WO2017012600A1 (en) | 2015-07-20 | 2017-01-26 | Zentiva, K.S. | A pharmaceutical composition containing valsartan and sacubitril and methods for preparation and stabilization thereof |
| CN106397249A (zh) * | 2015-08-03 | 2017-02-15 | 深圳信立泰药业股份有限公司 | 一种高稳定性lcz696结晶粉末及其制备方法 |
| JP6598985B2 (ja) | 2015-08-28 | 2019-10-30 | ノバルティス アーゲー | 新規の使用 |
| WO2017036420A1 (zh) * | 2015-09-06 | 2017-03-09 | 常州方楠医药技术有限公司 | 含沙库比曲和缬沙坦的药用组合物及其制备方法 |
| CN105348209B (zh) * | 2015-12-09 | 2017-12-26 | 浙江天宇药业股份有限公司 | 一种抗心衰药lcz696的制备方法 |
| EP3386945A1 (en) | 2015-12-11 | 2018-10-17 | Zentiva, K.S. | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method |
| US10722471B2 (en) | 2016-02-03 | 2020-07-28 | Novartis Ag | Galenic formulations of organic compounds |
| HRP20250913T1 (hr) | 2016-02-03 | 2025-09-26 | Novartis Ag | Nova upotreba kombinacije sakubitrila i valsartana |
| EP3524250B1 (en) | 2016-10-08 | 2025-07-16 | Wuhan LL Science And Technology Development Co., Ltd. | Pharmaceutical composition comprising a neutral endopeptidase (nep) inhibitor and an azilsartan ester derivative and use thereof for treating cardiovascular diseases |
| WO2018211479A1 (en) | 2017-05-19 | 2018-11-22 | Lupin Limited | Stabilized compositions of angiotensin ii inhibitors and neutral endopeptidase inhibitors and process for preparation thereof |
| US11382866B2 (en) | 2017-07-06 | 2022-07-12 | Mankind Pharma Ltd. | Fixed dose pharmaceutical composition of valsartan and sacubitril |
| WO2019020706A1 (en) | 2017-07-28 | 2019-01-31 | Synthon B.V. | PHARMACEUTICAL COMPOSITION COMPRISING SACUBITRIL AND VALSARTAN |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
| CN110237071B (zh) | 2018-03-09 | 2022-03-22 | 武汉朗来科技发展有限公司 | 药物制剂及其应用 |
| US20210177803A1 (en) | 2018-08-23 | 2021-06-17 | Novartis Ag | New pharmaceutical use for the treatment of heart failure |
| WO2020039394A1 (en) | 2018-08-24 | 2020-02-27 | Novartis Ag | New drug combinations |
| KR20200020746A (ko) | 2020-02-07 | 2020-02-26 | 보령제약 주식회사 | 하이브리드 화합물 및 그 제조방법 |
| WO2021158084A1 (ko) * | 2020-02-07 | 2021-08-12 | 보령제약 주식회사 | 하이브리드 화합물 및 그 제조방법 |
| KR20210101164A (ko) | 2020-02-07 | 2021-08-18 | 보령제약 주식회사 | 하이브리드 화합물 및 그 제조방법 |
| KR20210120560A (ko) | 2020-03-27 | 2021-10-07 | 주식회사 유영제약 | 고함량의 주성분을 포함하는 정제 및 그 제조방법 |
| KR20220091767A (ko) | 2020-12-24 | 2022-07-01 | 주식회사 보령 | 사쿠비트릴 발사르탄 하이브리드 화합물 또는 그 약제학적으로 허용되는 염을 유효성분으로 포함하는 약제학적 조성물 |
| EP4640223A1 (en) | 2022-12-20 | 2025-10-29 | THPharm Corp. | Pharmaceutical composition for prevention or treatment of cardiovascular disease, comprising sodium-glucose cotransporter-2 inhibitor and angiotensin ii receptor blocker |
| JP2026501945A (ja) | 2022-12-20 | 2026-01-19 | ティーエイチファーム コーポレーション | ナトリウム－グルコース共輸送体－２阻害剤およびアンジオテンシンｉｉ受容体遮断剤を含む経口用薬学製剤 |
| CN116687921A (zh) * | 2023-06-14 | 2023-09-05 | 宁波大学 | 沙库巴曲缬沙坦类物质在制备神经毒性和认知障碍类药物的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1256692A (en) * | 1991-02-06 | 1992-09-07 | Schering Corporation | Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor |
| US5217996A (en) * | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| CA2168066A1 (en) * | 1995-02-08 | 1996-08-09 | James R. Powell | Treatment of hypertension and congestive heart failure |
| EP1267855A2 (en) * | 2000-04-03 | 2003-01-02 | Bristol-Myers Squibb Company | Vasopeptidase inhibitors to treat isolated systolic hypertension |
| CZ20024180A3 (cs) * | 2000-06-22 | 2003-04-16 | Novartis Ag | Pevné orální farmaceutické kompozice obsahující valsartan |
| BR0112665A (pt) * | 2000-07-19 | 2003-06-24 | Novartis Ag | Sais |
| US6777443B2 (en) * | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
-
2003
- 2003-01-16 PT PT03704413T patent/PT1467728E/pt unknown
- 2003-01-16 CN CN201110029600.7A patent/CN102091330B/zh not_active Expired - Lifetime
- 2003-01-16 NZ NZ533968A patent/NZ533968A/en not_active IP Right Cessation
- 2003-01-16 IL IL16266103A patent/IL162661A0/xx unknown
- 2003-01-16 BR BRPI0306907A patent/BRPI0306907B8/pt active IP Right Grant
- 2003-01-16 DK DK03704413T patent/DK1467728T3/da active
- 2003-01-16 EP EP03704413A patent/EP1467728B1/en not_active Expired - Lifetime
- 2003-01-16 CN CNA038022680A patent/CN1615134A/zh active Pending
- 2003-01-16 WO PCT/EP2003/000415 patent/WO2003059345A1/en not_active Ceased
- 2003-01-16 BR BR122018015003A patent/BR122018015003B8/pt not_active IP Right Cessation
- 2003-01-16 ES ES03704413T patent/ES2290429T3/es not_active Expired - Lifetime
- 2003-01-16 CA CA2472399A patent/CA2472399C/en not_active Expired - Lifetime
- 2003-01-16 AT AT03704413T patent/ATE370732T1/de active
- 2003-01-16 KR KR1020107010521A patent/KR20100057704A/ko not_active Ceased
- 2003-01-16 PL PL369773A patent/PL212318B1/pl unknown
- 2003-01-16 KR KR1020047011124A patent/KR100984939B1/ko not_active Ceased
- 2003-01-16 AU AU2003206738A patent/AU2003206738C1/en active Active
- 2003-01-16 MX MXPA04006917A patent/MXPA04006917A/es active IP Right Grant
- 2003-01-16 RU RU2004125178A patent/RU2334513C3/ru active
- 2003-01-16 SI SI200331029T patent/SI1467728T1/sl unknown
- 2003-01-16 DE DE60315795T patent/DE60315795T2/de not_active Expired - Lifetime
- 2003-01-16 JP JP2003559507A patent/JP4820056B2/ja not_active Expired - Lifetime
-
2004
- 2004-06-21 IL IL162661A patent/IL162661A/en active Protection Beyond IP Right Term
- 2004-06-28 ZA ZA2004/05117A patent/ZA200405117B/en unknown
- 2004-07-14 EC EC2004005190A patent/ECSP045190A/es unknown
- 2004-08-06 CO CO04076723A patent/CO5600999A2/es active IP Right Grant
- 2004-08-13 NO NO20043380A patent/NO333191B1/no not_active IP Right Cessation
-
2007
- 2007-10-25 CY CY20071101386T patent/CY1106959T1/el unknown
-
2011
- 2011-05-25 JP JP2011116928A patent/JP2011207898A/ja not_active Withdrawn
-
2016
- 2016-05-17 FR FR16C0019C patent/FR16C0019I2/fr active Active
- 2016-05-18 NO NO2016009C patent/NO2016009I1/no unknown
- 2016-05-18 CY CY2016013C patent/CY2016013I1/el unknown
- 2016-05-18 HU HUS1600024C patent/HUS1600024I1/hu unknown
- 2016-05-18 LU LU93074C patent/LU93074I2/fr unknown
- 2016-05-18 BE BE2016C025C patent/BE2016C025I2/nl unknown
- 2016-05-18 NL NL300811C patent/NL300811I2/nl unknown
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