JP2005514005A - 新規のlna組成物およびその使用 - Google Patents

新規のlna組成物およびその使用 Download PDF

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Publication number
JP2005514005A
JP2005514005A JP2003525009A JP2003525009A JP2005514005A JP 2005514005 A JP2005514005 A JP 2005514005A JP 2003525009 A JP2003525009 A JP 2003525009A JP 2003525009 A JP2003525009 A JP 2003525009A JP 2005514005 A JP2005514005 A JP 2005514005A
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nucleic acid
lna
target
oligonucleotide
acid according
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JP2005514005A5 (https=
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ジェスパー・ウェンゲル
サカリ・カウピネン
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Exiqon AS
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2003525009A 2001-09-04 2002-09-04 新規のlna組成物およびその使用 Pending JP2005514005A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31703401P 2001-09-04 2001-09-04
US32396701P 2001-09-22 2001-09-22
PCT/IB2002/003911 WO2003020739A2 (en) 2001-09-04 2002-09-04 Novel lna compositions and uses thereof

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JP2005514005A true JP2005514005A (ja) 2005-05-19
JP2005514005A5 JP2005514005A5 (https=) 2006-01-05

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JP2003525009A Pending JP2005514005A (ja) 2001-09-04 2002-09-04 新規のlna組成物およびその使用

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US (1) US7060809B2 (https=)
EP (1) EP1446412B1 (https=)
JP (1) JP2005514005A (https=)
AU (1) AU2002334307A1 (https=)
CA (1) CA2459347C (https=)
WO (1) WO2003020739A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
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JP2013078317A (ja) * 2006-04-03 2013-05-02 Santaris Pharma As antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物
JP2015502365A (ja) * 2011-12-12 2015-01-22 オンコイミューニン,インコーポレイティド オリゴヌクレオチドのイン−ビボ送達
JP2016521753A (ja) * 2013-06-12 2016-07-25 オンコイミューニン,インコーポレイティド オリゴヌクレオチドの全身性イン−ビボ送達
WO2019182037A1 (ja) * 2018-03-20 2019-09-26 国立大学法人東京工業大学 毒性が低減されたアンチセンスオリゴヌクレオチド
JP2024129413A (ja) * 2023-03-13 2024-09-27 Kmバイオロジクス株式会社 T細胞受容体遺伝子再構成断片(TREC)、Igκ鎖遺伝子再構成断片(KREC)およびSMN1遺伝子の量を定量PCRにより同時に測定する方法およびそのための新規プライマー

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