JP2005512564A5 - - Google Patents
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- JP2005512564A5 JP2005512564A5 JP2003554878A JP2003554878A JP2005512564A5 JP 2005512564 A5 JP2005512564 A5 JP 2005512564A5 JP 2003554878 A JP2003554878 A JP 2003554878A JP 2003554878 A JP2003554878 A JP 2003554878A JP 2005512564 A5 JP2005512564 A5 JP 2005512564A5
- Authority
- JP
- Japan
- Prior art keywords
- cell density
- infected
- culture
- microcarrier
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002028 Biomass Substances 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/006,881 US6951752B2 (en) | 2001-12-10 | 2001-12-10 | Method for large scale production of virus antigen |
| PCT/EP2002/014011 WO2003054174A1 (en) | 2001-12-10 | 2002-12-10 | Method for large scale production of virus antigen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009157882A Division JP5021000B2 (ja) | 2001-12-10 | 2009-07-02 | ウイルス抗原の大規模生成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005512564A JP2005512564A (ja) | 2005-05-12 |
| JP2005512564A5 true JP2005512564A5 (https=) | 2009-08-20 |
| JP4370511B2 JP4370511B2 (ja) | 2009-11-25 |
Family
ID=21723079
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003554878A Expired - Lifetime JP4370511B2 (ja) | 2001-12-10 | 2002-12-10 | ウイルス抗原の大規模生成方法 |
| JP2009157882A Expired - Lifetime JP5021000B2 (ja) | 2001-12-10 | 2009-07-02 | ウイルス抗原の大規模生成方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009157882A Expired - Lifetime JP5021000B2 (ja) | 2001-12-10 | 2009-07-02 | ウイルス抗原の大規模生成方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6951752B2 (https=) |
| EP (3) | EP1453956B2 (https=) |
| JP (2) | JP4370511B2 (https=) |
| CN (2) | CN101100657B (https=) |
| AT (1) | ATE447010T2 (https=) |
| AU (1) | AU2002358662B2 (https=) |
| CA (1) | CA2469644C (https=) |
| DE (2) | DE122010000025I1 (https=) |
| DK (2) | DK1453956T3 (https=) |
| ES (2) | ES2335395T5 (https=) |
| FR (1) | FR10C0026I1 (https=) |
| HU (1) | HU225791B1 (https=) |
| MX (1) | MXPA04005644A (https=) |
| NO (1) | NO20042910L (https=) |
| PL (1) | PL208232B1 (https=) |
| RU (1) | RU2314344C2 (https=) |
| WO (1) | WO2003054174A1 (https=) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| JP5322252B2 (ja) * | 2001-12-20 | 2013-10-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | 感染細胞からのポックスウイルスの採取および精製法 |
| JP2005537793A (ja) | 2002-09-05 | 2005-12-15 | バヴァリアン・ノルディック・アクティーゼルスカブ | 無血清条件下で初代細胞を培養する方法及びウイルスを増幅させる方法 |
| CN101857851A (zh) * | 2002-12-23 | 2010-10-13 | 布里斯托尔-迈尔斯斯奎布公司 | 用于蛋白质生产的哺乳动物细胞培养方法 |
| EP1697505A1 (en) * | 2003-12-23 | 2006-09-06 | Schering Corporation | Methods for producing a549 cell lines stable in serum-free medium suspension culture |
| NZ548495A (en) | 2004-02-23 | 2009-05-31 | Crucell Holland Bv | Virus purification methods |
| JP4650798B2 (ja) * | 2004-04-19 | 2011-03-16 | デンカ生研株式会社 | ウイルスの生産方法 |
| NZ551640A (en) * | 2004-05-20 | 2010-05-28 | Id Biomedical Corp | Process for the production of an influenza vaccine |
| US7344839B2 (en) * | 2004-12-23 | 2008-03-18 | Aurx, Inc. | Virus preparations and methods |
| ATE547511T1 (de) | 2004-12-23 | 2012-03-15 | Medimmune Llc | Nichttumorbildende mdck-zellinie zur vermehrung von viren |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| WO2008105931A2 (en) | 2006-09-15 | 2008-09-04 | Medimmune Vaccines, Inc. | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
| JP5084214B2 (ja) * | 2006-09-29 | 2012-11-28 | 一般財団法人日本ポリオ研究所 | Ｉｐｖワクチン |
| JP5352578B2 (ja) * | 2007-05-04 | 2013-11-27 | バクスター・インターナショナル・インコーポレイテッド | ウイルスの増殖のための二段階温度プロフィール |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| EP2257634A1 (en) * | 2008-03-12 | 2010-12-08 | Wyeth LLC | Method for identifying cells suitable for large-scale production of recombinant proteins |
| MY172788A (en) | 2008-08-01 | 2019-12-12 | Gamma Vaccines Pty Ltd | Influenza vaccines |
| CN102215865B (zh) | 2008-09-24 | 2013-10-30 | 米迪缪尼有限公司 | 病毒纯化方法 |
| RU2547587C2 (ru) * | 2008-09-24 | 2015-04-10 | Медиммун, Ллк | Способы культивирования клеток, размножения и очистки вирусов |
| CA3150430A1 (en) | 2009-07-31 | 2011-02-03 | Pnuvax Inc. | High yield yellow fever virus strain with increased propagation in cells |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| RU2612154C2 (ru) * | 2009-12-23 | 2017-03-02 | Санофи Пастер | Способ культивирования адгезионных клеток |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| US9644187B2 (en) | 2010-04-14 | 2017-05-09 | Emd Millipore Corporation | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| CN101979517B (zh) * | 2010-10-15 | 2011-12-28 | 普莱柯生物工程股份有限公司 | 一种利用生物反应器大规模生产流感病毒的方法 |
| US20140079732A1 (en) | 2011-01-27 | 2014-03-20 | Gamma Vaccines Pty Limited | Combination vaccines |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| CN102492659A (zh) * | 2011-11-14 | 2012-06-13 | 成都康华生物制品有限公司 | 一种疫苗生产用甲肝病毒的生产方法 |
| US9950057B2 (en) | 2013-07-15 | 2018-04-24 | Wisconsin Alumni Research Foundation (Warf) | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| CN103387958B (zh) * | 2013-08-16 | 2016-04-06 | 北京科兴中维生物技术有限公司 | 人胚肺成纤维细胞sv-7在病毒培养中的应用 |
| JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
| WO2016121773A1 (ja) | 2015-01-26 | 2016-08-04 | 宇部興産株式会社 | ポリイミド多孔質膜を用いる細胞の大量培養方法、装置及びキット |
| JP6288311B2 (ja) | 2015-01-26 | 2018-03-07 | 宇部興産株式会社 | 物質の産生方法 |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| CA3014435C (en) | 2016-02-19 | 2023-04-18 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza b virus replication for vaccine development |
| JP7034949B2 (ja) | 2016-05-25 | 2022-03-14 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| SG11201900674XA (en) | 2016-07-25 | 2019-02-27 | Ube Industries | Cell culture module |
| EP3489342B1 (en) | 2016-07-25 | 2022-01-26 | UBE Industries, Ltd. | Siphon type cultivation method |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| EP3740234A1 (en) * | 2018-01-18 | 2020-11-25 | Yisheng Biopharma (Singapore) Pte. Ltd. | Method for adapting influenza viruses to vero cells |
| EP3749757A4 (en) * | 2018-02-07 | 2021-11-24 | Bharat Biotech International Limited | PROCESS FOR PURIFICATION AND INACTIVATION OF ENTERVIRUSES AND VACCINE COMPOSITIONS OBTAINED THEREOF |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| US11241492B2 (en) | 2019-01-23 | 2022-02-08 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to genes in influenza viruses |
| KR102228267B1 (ko) * | 2019-01-25 | 2021-03-17 | 바이로큐어 주식회사 | Bhk-21 세포를 이용한 바이러스 생산방법 |
| WO2020153619A1 (ko) * | 2019-01-25 | 2020-07-30 | 바이로큐어 주식회사 | Bhk-21 세포를 이용한 바이러스 생산방법 |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| EP3924469A4 (en) * | 2019-02-15 | 2022-12-14 | Ology Bioservices, Inc. | METHODS OF VIRUS PRODUCTION |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| KR20220042117A (ko) | 2019-08-09 | 2022-04-04 | 우베 고산 가부시키가이샤 | 엑소좀의 생성 방법 |
| TW202122569A (zh) | 2019-08-09 | 2021-06-16 | 日商宇部興產股份有限公司 | 應用小片多孔膜的細胞培養法 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN111850169B (zh) * | 2020-07-16 | 2022-09-27 | 华农（肇庆）生物产业技术研究院有限公司 | 一种计算AIV在MDCK-sus细胞中细胞单位均产毒量的方法 |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4525349A (en) | 1981-12-29 | 1985-06-25 | Societe Anonyme Dite: Institut Merueux | Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine |
| AT393356B (de) | 1989-12-22 | 1991-10-10 | Immuno Ag | Verfahren zur herstellung von fsme-virus-antigen |
| US5719051A (en) * | 1989-12-22 | 1998-02-17 | Immuno Aktiengesellschaft | Perfusion system and a method for the large scale production of virus or virus antigen |
| FR2723740B1 (fr) | 1994-08-16 | 1996-11-08 | Pasteur Merieux Serums Vacc | Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications |
| US5824536A (en) * | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| ES2378409T3 (es) | 1994-11-10 | 2012-04-12 | Baxter Healthcare S.A. | Método para producir sustancias biológicas en cultivo sin proteínas |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| GB2319413B (en) * | 1996-11-12 | 2001-06-06 | Lsi Logic Corp | Driver circuits |
| CA2278808C (en) * | 1997-01-31 | 2006-04-04 | Schering Corporation | Methods for cultivating cells and propagating viruses |
| US6168944B1 (en) * | 1997-01-31 | 2001-01-02 | Schering Corporation | Methods for cultivating cells and propagating viruses |
| AT407255B (de) | 1997-06-20 | 2001-02-26 | Immuno Ag | Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons |
| US5994134A (en) * | 1998-05-04 | 1999-11-30 | Canji, Inc. | Viral production process |
| US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| US6855535B2 (en) * | 2001-12-10 | 2005-02-15 | Baxter Healthcare S.A. | Method of large scale production of Hepatitis A virus |
-
2001
- 2001-12-10 US US10/006,881 patent/US6951752B2/en not_active Expired - Lifetime
-
2002
- 2002-12-10 DE DE122010000025C patent/DE122010000025I1/de active Pending
- 2002-12-10 MX MXPA04005644A patent/MXPA04005644A/es active IP Right Grant
- 2002-12-10 CN CN2007101271424A patent/CN101100657B/zh not_active Expired - Lifetime
- 2002-12-10 AT AT02792957T patent/ATE447010T2/de active
- 2002-12-10 CN CNB028279778A patent/CN100335619C/zh not_active Expired - Lifetime
- 2002-12-10 PL PL373487A patent/PL208232B1/pl unknown
- 2002-12-10 EP EP02792957.9A patent/EP1453956B2/en not_active Expired - Lifetime
- 2002-12-10 DE DE60234211T patent/DE60234211D1/de not_active Expired - Lifetime
- 2002-12-10 JP JP2003554878A patent/JP4370511B2/ja not_active Expired - Lifetime
- 2002-12-10 DK DK02792957T patent/DK1453956T3/da active
- 2002-12-10 RU RU2004121178/13A patent/RU2314344C2/ru not_active IP Right Cessation
- 2002-12-10 WO PCT/EP2002/014011 patent/WO2003054174A1/en not_active Ceased
- 2002-12-10 ES ES02792957.9T patent/ES2335395T5/es not_active Expired - Lifetime
- 2002-12-10 CA CA2469644A patent/CA2469644C/en not_active Expired - Lifetime
- 2002-12-10 AU AU2002358662A patent/AU2002358662B2/en not_active Expired
- 2002-12-10 EP EP07021348A patent/EP1894998A1/en not_active Withdrawn
- 2002-12-10 DK DK10011842.1T patent/DK2330189T3/da active
- 2002-12-10 EP EP10011842.1A patent/EP2330189B1/en not_active Expired - Lifetime
- 2002-12-10 ES ES10011842.1T patent/ES2488818T3/es not_active Expired - Lifetime
- 2002-12-10 HU HU0402415A patent/HU225791B1/hu not_active IP Right Cessation
-
2004
- 2004-07-09 NO NO20042910A patent/NO20042910L/no not_active Application Discontinuation
-
2005
- 2005-03-17 US US11/084,485 patent/US7524676B2/en not_active Expired - Lifetime
-
2009
- 2009-07-02 JP JP2009157882A patent/JP5021000B2/ja not_active Expired - Lifetime
-
2010
- 2010-04-16 FR FR10C0026C patent/FR10C0026I1/fr active Active
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