CN101100657B - 大规模生产病毒抗原的方法 - Google Patents
大规模生产病毒抗原的方法 Download PDFInfo
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- CN101100657B CN101100657B CN2007101271424A CN200710127142A CN101100657B CN 101100657 B CN101100657 B CN 101100657B CN 2007101271424 A CN2007101271424 A CN 2007101271424A CN 200710127142 A CN200710127142 A CN 200710127142A CN 101100657 B CN101100657 B CN 101100657B
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/006,881 US6951752B2 (en) | 2001-12-10 | 2001-12-10 | Method for large scale production of virus antigen |
| US10/006881 | 2001-12-10 | ||
| US10/006,881 | 2001-12-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028279778A Division CN100335619C (zh) | 2001-12-10 | 2002-12-10 | 大规模生产病毒抗原的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101100657A CN101100657A (zh) | 2008-01-09 |
| CN101100657B true CN101100657B (zh) | 2012-05-30 |
Family
ID=21723079
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101271424A Expired - Lifetime CN101100657B (zh) | 2001-12-10 | 2002-12-10 | 大规模生产病毒抗原的方法 |
| CNB028279778A Expired - Lifetime CN100335619C (zh) | 2001-12-10 | 2002-12-10 | 大规模生产病毒抗原的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB028279778A Expired - Lifetime CN100335619C (zh) | 2001-12-10 | 2002-12-10 | 大规模生产病毒抗原的方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6951752B2 (https=) |
| EP (3) | EP1453956B2 (https=) |
| JP (2) | JP4370511B2 (https=) |
| CN (2) | CN101100657B (https=) |
| AT (1) | ATE447010T2 (https=) |
| AU (1) | AU2002358662B2 (https=) |
| CA (1) | CA2469644C (https=) |
| DE (2) | DE122010000025I1 (https=) |
| DK (2) | DK1453956T3 (https=) |
| ES (2) | ES2335395T5 (https=) |
| FR (1) | FR10C0026I1 (https=) |
| HU (1) | HU225791B1 (https=) |
| MX (1) | MXPA04005644A (https=) |
| NO (1) | NO20042910L (https=) |
| PL (1) | PL208232B1 (https=) |
| RU (1) | RU2314344C2 (https=) |
| WO (1) | WO2003054174A1 (https=) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7445924B2 (en) | 2000-11-23 | 2008-11-04 | Bavarian Nordic A/S | Modified Vaccinia Ankara virus variant and cultivation method |
| US6951752B2 (en) * | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| JP5322252B2 (ja) * | 2001-12-20 | 2013-10-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | 感染細胞からのポックスウイルスの採取および精製法 |
| JP2005537793A (ja) | 2002-09-05 | 2005-12-15 | バヴァリアン・ノルディック・アクティーゼルスカブ | 無血清条件下で初代細胞を培養する方法及びウイルスを増幅させる方法 |
| CN101857851A (zh) * | 2002-12-23 | 2010-10-13 | 布里斯托尔-迈尔斯斯奎布公司 | 用于蛋白质生产的哺乳动物细胞培养方法 |
| EP1697505A1 (en) * | 2003-12-23 | 2006-09-06 | Schering Corporation | Methods for producing a549 cell lines stable in serum-free medium suspension culture |
| NZ548495A (en) | 2004-02-23 | 2009-05-31 | Crucell Holland Bv | Virus purification methods |
| JP4650798B2 (ja) * | 2004-04-19 | 2011-03-16 | デンカ生研株式会社 | ウイルスの生産方法 |
| NZ551640A (en) * | 2004-05-20 | 2010-05-28 | Id Biomedical Corp | Process for the production of an influenza vaccine |
| US7344839B2 (en) * | 2004-12-23 | 2008-03-18 | Aurx, Inc. | Virus preparations and methods |
| ATE547511T1 (de) | 2004-12-23 | 2012-03-15 | Medimmune Llc | Nichttumorbildende mdck-zellinie zur vermehrung von viren |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| WO2008105931A2 (en) | 2006-09-15 | 2008-09-04 | Medimmune Vaccines, Inc. | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
| JP5084214B2 (ja) * | 2006-09-29 | 2012-11-28 | 一般財団法人日本ポリオ研究所 | Ｉｐｖワクチン |
| JP5352578B2 (ja) * | 2007-05-04 | 2013-11-27 | バクスター・インターナショナル・インコーポレイテッド | ウイルスの増殖のための二段階温度プロフィール |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| EP2257634A1 (en) * | 2008-03-12 | 2010-12-08 | Wyeth LLC | Method for identifying cells suitable for large-scale production of recombinant proteins |
| MY172788A (en) | 2008-08-01 | 2019-12-12 | Gamma Vaccines Pty Ltd | Influenza vaccines |
| CN102215865B (zh) | 2008-09-24 | 2013-10-30 | 米迪缪尼有限公司 | 病毒纯化方法 |
| RU2547587C2 (ru) * | 2008-09-24 | 2015-04-10 | Медиммун, Ллк | Способы культивирования клеток, размножения и очистки вирусов |
| CA3150430A1 (en) | 2009-07-31 | 2011-02-03 | Pnuvax Inc. | High yield yellow fever virus strain with increased propagation in cells |
| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| RU2612154C2 (ru) * | 2009-12-23 | 2017-03-02 | Санофи Пастер | Способ культивирования адгезионных клеток |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| US9644187B2 (en) | 2010-04-14 | 2017-05-09 | Emd Millipore Corporation | Methods of producing high titer, high purity virus stocks and methods of use thereof |
| EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| CN101979517B (zh) * | 2010-10-15 | 2011-12-28 | 普莱柯生物工程股份有限公司 | 一种利用生物反应器大规模生产流感病毒的方法 |
| US20140079732A1 (en) | 2011-01-27 | 2014-03-20 | Gamma Vaccines Pty Limited | Combination vaccines |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| CN102492659A (zh) * | 2011-11-14 | 2012-06-13 | 成都康华生物制品有限公司 | 一种疫苗生产用甲肝病毒的生产方法 |
| US9950057B2 (en) | 2013-07-15 | 2018-04-24 | Wisconsin Alumni Research Foundation (Warf) | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| CN103387958B (zh) * | 2013-08-16 | 2016-04-06 | 北京科兴中维生物技术有限公司 | 人胚肺成纤维细胞sv-7在病毒培养中的应用 |
| JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
| WO2016121773A1 (ja) | 2015-01-26 | 2016-08-04 | 宇部興産株式会社 | ポリイミド多孔質膜を用いる細胞の大量培養方法、装置及びキット |
| JP6288311B2 (ja) | 2015-01-26 | 2018-03-07 | 宇部興産株式会社 | 物質の産生方法 |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| CA3014435C (en) | 2016-02-19 | 2023-04-18 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza b virus replication for vaccine development |
| JP7034949B2 (ja) | 2016-05-25 | 2022-03-14 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| SG11201900674XA (en) | 2016-07-25 | 2019-02-27 | Ube Industries | Cell culture module |
| EP3489342B1 (en) | 2016-07-25 | 2022-01-26 | UBE Industries, Ltd. | Siphon type cultivation method |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
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