JP2005503125A5 - - Google Patents
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- JP2005503125A5 JP2005503125A5 JP2002582208A JP2002582208A JP2005503125A5 JP 2005503125 A5 JP2005503125 A5 JP 2005503125A5 JP 2002582208 A JP2002582208 A JP 2002582208A JP 2002582208 A JP2002582208 A JP 2002582208A JP 2005503125 A5 JP2005503125 A5 JP 2005503125A5
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- JP
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- Prior art keywords
- nucleic acid
- acid sequence
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- protein
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000007523 nucleic acids Chemical class 0.000 claims 53
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 35
- 108090000623 proteins and genes Proteins 0.000 claims 20
- 102000004169 proteins and genes Human genes 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 108010000700 Acetolactate synthase Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 108010030975 Polyketide Synthases Proteins 0.000 claims 7
- 244000005700 microbiome Species 0.000 claims 7
- 102000004243 Tubulin Human genes 0.000 claims 5
- 108090000704 Tubulin Proteins 0.000 claims 5
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- BCIHMWNOJJYBSJ-UHFFFAOYSA-N 2-pyrimidin-2-yloxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1OC1=NC=CC=N1 BCIHMWNOJJYBSJ-UHFFFAOYSA-N 0.000 claims 3
- CAAMSDWKXXPUJR-UHFFFAOYSA-N 3,5-dihydro-4H-imidazol-4-one Chemical compound O=C1CNC=N1 CAAMSDWKXXPUJR-UHFFFAOYSA-N 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims 3
- 230000002103 transcriptional effect Effects 0.000 claims 3
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 2
- 101710123462 Bleomycin resistance protein Proteins 0.000 claims 2
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 2
- 102000009114 Fatty acid desaturases Human genes 0.000 claims 2
- 108010087894 Fatty acid desaturases Proteins 0.000 claims 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- 230000006801 homologous recombination Effects 0.000 claims 2
- 238000002744 homologous recombination Methods 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 230000009466 transformation Effects 0.000 claims 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 1
- 241001467333 Thraustochytriaceae Species 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28411601P | 2001-04-16 | 2001-04-16 | |
| PCT/US2002/012040 WO2002083869A2 (en) | 2001-04-16 | 2002-04-16 | Product and process for transformation of thraustochytriales microorganisms |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010019881A Division JP5248536B2 (ja) | 2001-04-16 | 2010-02-01 | トラウストチトリアレス微生物の形質転換についての産物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503125A JP2005503125A (ja) | 2005-02-03 |
| JP2005503125A5 true JP2005503125A5 (enExample) | 2005-12-22 |
| JP4536324B2 JP4536324B2 (ja) | 2010-09-01 |
Family
ID=23088908
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002582208A Expired - Fee Related JP4536324B2 (ja) | 2001-04-16 | 2002-04-16 | トラウストチトリアレス微生物の形質転換についての産物および方法 |
| JP2010019881A Expired - Lifetime JP5248536B2 (ja) | 2001-04-16 | 2010-02-01 | トラウストチトリアレス微生物の形質転換についての産物および方法 |
| JP2012215905A Withdrawn JP2013005817A (ja) | 2001-04-16 | 2012-09-28 | トラウストチトリアレス微生物の形質転換についての産物および方法 |
| JP2015253726A Expired - Fee Related JP6211577B2 (ja) | 2001-04-16 | 2015-12-25 | トラウストチトリアレス微生物の形質転換についての産物および方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010019881A Expired - Lifetime JP5248536B2 (ja) | 2001-04-16 | 2010-02-01 | トラウストチトリアレス微生物の形質転換についての産物および方法 |
| JP2012215905A Withdrawn JP2013005817A (ja) | 2001-04-16 | 2012-09-28 | トラウストチトリアレス微生物の形質転換についての産物および方法 |
| JP2015253726A Expired - Fee Related JP6211577B2 (ja) | 2001-04-16 | 2015-12-25 | トラウストチトリアレス微生物の形質転換についての産物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US7001772B2 (enExample) |
| EP (3) | EP2314706B1 (enExample) |
| JP (4) | JP4536324B2 (enExample) |
| CN (3) | CN101760469A (enExample) |
| AT (1) | ATE533844T1 (enExample) |
| AU (1) | AU2002250592C1 (enExample) |
| CA (1) | CA2443908C (enExample) |
| ES (3) | ES2377557T3 (enExample) |
| TW (3) | TWI377253B (enExample) |
| WO (1) | WO2002083869A2 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| TWI377253B (en) * | 2001-04-16 | 2012-11-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| US7211656B2 (en) * | 2002-01-30 | 2007-05-01 | Abbott Laboratories | Desaturase genes, enzymes encoded thereby, and uses thereof |
| DK1572994T3 (da) * | 2002-12-20 | 2007-05-29 | Chromagenics Bv | Midler og fremgangsmåder til fremstilling af en protein gennem chromatinåbnere, som kan göre chromatin mere tilgængeligt for transkriptionsfaktorer |
| US7208590B2 (en) * | 2003-07-15 | 2007-04-24 | Abbott Laboratories | Genes involved in polyketide synthase pathways and uses thereof |
| CN103451246B (zh) | 2004-04-22 | 2018-02-16 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
| CA2563875C (en) | 2004-04-22 | 2015-06-30 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| US8999667B2 (en) * | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| ES2384391T3 (es) * | 2004-11-08 | 2012-07-04 | Chromagenics B.V. | Selección de células hospedantes que expresan proteína a altos niveles |
| CA2581422C (en) * | 2004-11-08 | 2012-05-22 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US20100136616A1 (en) * | 2004-11-08 | 2010-06-03 | Chromagenics B.V. | Selection of Host Cells Expressing Protein at High Levels |
| JP4796787B2 (ja) * | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | ラビリンチュラ類への遺伝子導入法 |
| JP4796786B2 (ja) | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | ラビリンチュラ類を形質転換可能なベクター |
| EP3467096B1 (en) | 2005-06-07 | 2022-01-12 | DSM Nutritional Products AG | Eukaryotic microorganisms for producing lipids and antioxidants |
| JP5123861B2 (ja) | 2005-11-23 | 2013-01-23 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | Δ９エロンガーゼおよびそれらの多価不飽和脂肪酸製造における使用 |
| EP1818411A1 (en) | 2006-02-13 | 2007-08-15 | Lonza AG | Process for the preparation of optically active chiral amines |
| EP2653557A1 (en) | 2006-03-15 | 2013-10-23 | DSM IP Assets B.V. | Plant seed oils containing polyunsaturated fatty acids |
| EP2007215A4 (en) * | 2006-04-11 | 2011-04-13 | Martek Biosciences Corp | FOODSTUFFS WITH LONG-CHAIN MULTIPLE-UNSATURATED FATTY ACIDS AND METHOD FOR THE PRODUCTION THEREOF |
| EP2034973B2 (en) | 2006-06-22 | 2022-01-19 | DSM IP Assets B.V. | Encapsulated labile compound compositions and methods of making the same |
| US9023616B2 (en) * | 2006-08-01 | 2015-05-05 | Dsm Nutritional Products Ag | Oil producing microbes and method of modification thereof |
| AU2007289233A1 (en) | 2006-08-29 | 2008-03-06 | Dsm Ip Assets B.V. | Use of DPA(n-6) oils in infant formula |
| BRPI0716075A2 (pt) | 2006-08-29 | 2013-08-06 | Commw Scient Ind Res Org | sÍntese de Ácidos graxos |
| KR100860111B1 (ko) * | 2006-10-02 | 2008-09-25 | 인제대학교 산학협력단 | 신규 미생물 트라우스토카이트리움 에스피.케이제이에스-1, 바실러스 폴리퍼멘티쿠스 케이제이에스-2 및 이들과 바실러스 리케니포르미스를 포함하고 있는 사료첨가제 및 사료 |
| PL2390339T3 (pl) | 2006-10-23 | 2013-12-31 | Du Pont | Delta-8 desaturazy i ich zastosowanie w wytwarzaniu polinienasyconych kwasów tłuszczowych |
| US7790156B2 (en) | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US8119860B2 (en) | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US8957280B2 (en) | 2007-05-03 | 2015-02-17 | E. I. Du Pont De Nemours And Company | Delta-5 desaturases and their use in making polyunsaturated fatty acids |
| US20090023808A1 (en) * | 2007-06-29 | 2009-01-22 | Martek Biosciences Corporation | Production and Purification of Esters of Polyunsaturated Fatty Acids |
| CA2699406C (en) | 2007-09-12 | 2019-09-03 | Martek Biosciences Corporation | Biological oils and production and uses thereof |
| US20110076379A1 (en) * | 2008-06-13 | 2011-03-31 | Means Michael M | High omega saturated fat free meat products |
| BR122021003836B1 (pt) | 2008-11-18 | 2022-02-01 | Commonwealth Scientific And Industrial Research Organisation | Polinucleotídeo isolado e/ou exógeno que não ocorre de forma natural, vetor e método para produzir óleo contendo ácidos graxos insaturados |
| EP2358862B1 (en) | 2008-12-18 | 2017-08-02 | E. I. du Pont de Nemours and Company | Reducing byproduction of malonates in a fermentation process |
| JP5415896B2 (ja) | 2009-01-29 | 2014-02-12 | Ｊｆｅスチール株式会社 | インダイレクトスポット溶接方法 |
| CN104263729B (zh) * | 2009-03-16 | 2020-09-15 | 帝斯曼知识产权资产有限公司 | 在网粘菌门微生物中产生蛋白质 |
| US8207363B2 (en) * | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| TWI600762B (zh) | 2009-03-19 | 2017-10-01 | Ｄｓｍ智慧財產有限公司 | 多不飽和脂肪酸合成酶核酸分子及多肽，組成物，以及其製造方法與用途 |
| DK2443248T3 (en) | 2009-06-16 | 2018-03-12 | Du Pont | IMPROVEMENT OF LONG-CHAIN POLYUM Saturated OMEGA-3 AND OMEGA-6 FATTY ACID BIOS SYNTHESIS BY EXPRESSION OF ACYL-CoA LYSOPHOSPHOLIPID ACYL TRANSFERASES |
| CA2807754C (en) * | 2009-09-24 | 2021-07-27 | Kyushu University, National University Corporation | Method for transforming stramenopiles |
| ES2701403T3 (es) * | 2009-12-28 | 2019-02-22 | Dsm Ip Assets Bv | Traustoquítridos recombinantes que crecen en sacarosa, y composiciones, métodos de preparación y usos de los mismos |
| US9012197B2 (en) * | 2009-12-28 | 2015-04-21 | Merial, Inc. | Production of hemagglutinin-neuraminidase protein in microalgae |
| CA3153553A1 (en) * | 2009-12-28 | 2011-07-28 | Sanofi Vaccine Technologies, S.A.S. | Methods of producing heterologous proteins comprising membrane domains in microalgal extracellular bodies |
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| CA2877279A1 (en) | 2012-06-19 | 2013-12-27 | E. I. Du Pont De Nemours And Company | Improved production of polyunsaturated fatty acids by coexpression of acyl-coa:lysophosphatidylcholine acyltransferases and phospholipid:diacylglycerol acyltransferases |
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| EA037817B1 (ru) | 2013-12-18 | 2021-05-25 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты |
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| JP6966040B2 (ja) | 2016-05-12 | 2021-11-10 | ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. | 微細藻類中でのオメガ−３多価不飽和脂肪酸産生を増加させる方法 |
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| JP2019520069A (ja) | 2016-07-13 | 2019-07-18 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | 藻類宿主細胞用のｃｒｉｓｐｒ−ｃａｓシステム |
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2002
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- 2002-04-15 TW TW091107634A patent/TWI324181B/zh not_active IP Right Cessation
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- 2002-04-16 CA CA2443908A patent/CA2443908C/en not_active Expired - Fee Related
- 2002-04-16 CN CN200910141898A patent/CN101760469A/zh active Pending
- 2002-04-16 EP EP10178911.3A patent/EP2314706B1/en not_active Expired - Lifetime
- 2002-04-16 WO PCT/US2002/012040 patent/WO2002083869A2/en not_active Ceased
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