JP2010508019A5 - - Google Patents
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- Publication number
- JP2010508019A5 JP2010508019A5 JP2009534568A JP2009534568A JP2010508019A5 JP 2010508019 A5 JP2010508019 A5 JP 2010508019A5 JP 2009534568 A JP2009534568 A JP 2009534568A JP 2009534568 A JP2009534568 A JP 2009534568A JP 2010508019 A5 JP2010508019 A5 JP 2010508019A5
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- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- acid
- group
- encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- 238000006243 chemical reaction Methods 0.000 claims 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- 150000004665 fatty acids Chemical class 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 claims 2
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims 2
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims 2
- 235000021297 Eicosadienoic acid Nutrition 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 230000001588 bifunctional effect Effects 0.000 claims 2
- 108010011713 delta-15 desaturase Proteins 0.000 claims 2
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- BBWMTEYXFFWPIF-CJBMEHDJSA-N (2e,4e,6e)-icosa-2,4,6-trienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C=C\C(O)=O BBWMTEYXFFWPIF-CJBMEHDJSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 1
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85517706P | 2006-10-30 | 2006-10-30 | |
| US60/855,177 | 2006-10-30 | ||
| PCT/US2007/016490 WO2008054565A1 (en) | 2006-10-30 | 2007-07-19 | Δ17 desaturase and its use in making polyunsaturated fatty acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010508019A JP2010508019A (ja) | 2010-03-18 |
| JP2010508019A5 true JP2010508019A5 (enExample) | 2010-09-02 |
| JP5193216B2 JP5193216B2 (ja) | 2013-05-08 |
Family
ID=39167662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534568A Expired - Fee Related JP5193216B2 (ja) | 2006-10-30 | 2007-07-19 | Δ１７デサチュラーゼおよび多価不飽和脂肪酸の製造におけるその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7556949B2 (enExample) |
| EP (1) | EP2087105B1 (enExample) |
| JP (1) | JP5193216B2 (enExample) |
| CN (1) | CN101617040B (enExample) |
| AU (1) | AU2007314481B2 (enExample) |
| CA (1) | CA2663807C (enExample) |
| DK (1) | DK2087105T3 (enExample) |
| WO (1) | WO2008054565A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10538793B2 (en) | 2014-12-25 | 2020-01-21 | Kyoto University | ω3 fatty-acid desaturase and method for producing eicosapentaenoic acid |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110059496A1 (en) * | 2003-06-25 | 2011-03-10 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| CA2744716C (en) | 2008-12-18 | 2017-05-23 | E.I. Du Pont De Nemours And Company | Reducing byproduction of malonates in a fermentation process |
| CN102803289B (zh) | 2009-06-16 | 2015-07-22 | 纳幕尔杜邦公司 | 用于高水平生产二十碳五烯酸的改善的优化的解脂耶氏酵母菌株 |
| BRPI1009690A2 (pt) | 2009-06-16 | 2015-08-25 | Du Pont | "célula hospedeira microbiana oleaginosa, óleo, método de elaboração de um óleo, método de aumento da eficiência de conversão de alongamento de c18 para c20 em uma célula hospedeira recombinante microbiana oleaginosa e método de aumento da eficiência de conversão de dessaturação (delta) 4 em uma célula hospedeira recombinante microbiana oleaginosa produtora de ácidos graxos póli-insaturados de cadeia longa" |
| WO2010147907A1 (en) | 2009-06-16 | 2010-12-23 | E. I. Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica |
| WO2011087981A2 (en) | 2010-01-15 | 2011-07-21 | E. I. Du Pont De Nemours And Company | Clinical benefits of eicosapentaenoic acid in humans |
| CA2993690C (en) | 2010-01-19 | 2022-03-22 | Dsm Ip Assets B.V. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| CN103282474A (zh) | 2010-04-22 | 2013-09-04 | 纳幕尔杜邦公司 | 从微生物生物质中获得包含多不饱和脂肪酸的组合物的方法 |
| WO2012021686A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | Improved aquaculture meat products |
| EP2603094A1 (en) | 2010-08-11 | 2013-06-19 | E.I. Du Pont De Nemours And Company | A sustainable aquaculture feeding strategy |
| US20120040076A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | Aquaculture feed compositions |
| WO2012027676A1 (en) | 2010-08-26 | 2012-03-01 | E. I. Du Pont De Nemours And Company | Mutant delta-9 elongases and their use in making polyunsaturated fatty acids |
| US8703473B2 (en) | 2010-08-26 | 2014-04-22 | E I Du Pont De Nemours And Company | Recombinant microbial host cells for high eicosapentaenoic acid production |
| AU2011293189B2 (en) | 2010-08-26 | 2017-02-16 | E. I. Du Pont De Nemours And Company | Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
| CN106434392A (zh) | 2010-10-01 | 2017-02-22 | 国立大学法人九州大学 | 原生藻菌的转化方法 |
| BR112013016769A2 (pt) | 2010-12-30 | 2016-10-11 | Du Pont | yarrowia lipolytica transformada e método para produzir pelo menos um produto não nativo de interesse |
| US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| JP6061866B2 (ja) | 2011-02-11 | 2017-01-18 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 微生物バイオマスから脂質含有組成物を得る方法 |
| US20120247066A1 (en) | 2011-04-01 | 2012-10-04 | Ice House America, Llc | Ice bagging apparatus and methods |
| EA035287B1 (ru) | 2011-07-21 | 2020-05-25 | ДСМ АйПи АССЕТС Б.В. | Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции, содержащие жирные кислоты, и способы их получения и применения |
| CA2892516A1 (en) | 2012-12-21 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells |
| JP2016165226A (ja) * | 2013-07-12 | 2016-09-15 | 国立大学法人京都大学 | エイコサペンタエン酸を高含有する脂質の生産方法 |
| US20160208297A1 (en) * | 2013-08-27 | 2016-07-21 | Kyoto University | Omega3 unsaturated fatty acid enzyme and method for producing eicosapentaenoic acid |
| JP2017195777A (ja) * | 2014-08-29 | 2017-11-02 | 国立大学法人京都大学 | エイコサペンタエン酸を高含有する脂質の生産方法 |
| CN106010993B (zh) * | 2016-06-12 | 2019-07-05 | 福建师范大学 | 生产亚麻酸的圆红冬孢酵母及其制备方法 |
| US11913046B2 (en) | 2018-04-23 | 2024-02-27 | Inbiose N.V. | Increasing export of 2'fucosyllactose from microbial cells through the expression of a heterologous nucleic acid |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69917668T2 (de) * | 1998-10-23 | 2005-05-19 | Sosei Co., Ltd. | Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung |
| CA2415055A1 (en) * | 2000-08-03 | 2002-02-14 | Caliper Technologies Corporation | Methods and devices for high throughput fluid delivery |
| US6635451B2 (en) | 2001-01-25 | 2003-10-21 | Abbott Laboratories | Desaturase genes and uses thereof |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7238482B2 (en) * | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7202356B2 (en) | 2003-11-14 | 2007-04-10 | E. I. Du Pont De Nemours And Company | Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast |
| EP4219670A3 (de) | 2004-02-27 | 2023-08-09 | BASF Plant Science GmbH | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen pflanzen |
| CA2558726C (en) | 2004-02-27 | 2017-11-07 | Basf Plant Science Gmbh | Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms |
| US7189559B2 (en) | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7198937B2 (en) | 2004-11-04 | 2007-04-03 | E. I. Du Pont De Nemours And Company | Mortierella alpina diacylglycerol acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7192762B2 (en) | 2004-11-04 | 2007-03-20 | E. I. Du Pont De Nemours And Company | Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| DE102005013779A1 (de) * | 2005-03-22 | 2006-09-28 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen |
| TWI258780B (en) * | 2005-04-29 | 2006-07-21 | Asustek Comp Inc | Button structure |
| US7465793B2 (en) * | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
| CA2659993C (en) | 2006-08-24 | 2016-01-05 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
-
2007
- 2007-07-19 WO PCT/US2007/016490 patent/WO2008054565A1/en not_active Ceased
- 2007-07-19 JP JP2009534568A patent/JP5193216B2/ja not_active Expired - Fee Related
- 2007-07-19 AU AU2007314481A patent/AU2007314481B2/en not_active Ceased
- 2007-07-19 US US11/779,915 patent/US7556949B2/en active Active
- 2007-07-19 CA CA2663807A patent/CA2663807C/en not_active Expired - Fee Related
- 2007-07-19 CN CN2007800394209A patent/CN101617040B/zh not_active Expired - Fee Related
- 2007-07-19 EP EP07836170.6A patent/EP2087105B1/en not_active Not-in-force
- 2007-07-19 DK DK07836170.6T patent/DK2087105T3/da active
-
2009
- 2009-05-20 US US12/469,208 patent/US8241884B2/en active Active
-
2012
- 2012-06-28 US US13/535,775 patent/US20130011846A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10538793B2 (en) | 2014-12-25 | 2020-01-21 | Kyoto University | ω3 fatty-acid desaturase and method for producing eicosapentaenoic acid |