JP2009534032A5 - - Google Patents
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- Publication number
- JP2009534032A5 JP2009534032A5 JP2009506580A JP2009506580A JP2009534032A5 JP 2009534032 A5 JP2009534032 A5 JP 2009534032A5 JP 2009506580 A JP2009506580 A JP 2009506580A JP 2009506580 A JP2009506580 A JP 2009506580A JP 2009534032 A5 JP2009534032 A5 JP 2009534032A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- encoding
- desaturase
- set forth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 229920001184 polypeptide Polymers 0.000 claims description 45
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 45
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 25
- 239000002773 nucleotide Substances 0.000 claims description 22
- 125000003729 nucleotide group Chemical group 0.000 claims description 22
- 150000007523 nucleic acids Chemical class 0.000 claims description 21
- 108020004707 nucleic acids Proteins 0.000 claims description 20
- 102000039446 nucleic acids Human genes 0.000 claims description 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 12
- 241000235013 Yarrowia Species 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 8
- 108020004705 Codon Proteins 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 8
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 7
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 6
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 6
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 6
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 6
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims description 6
- 229960004488 linolenic acid Drugs 0.000 claims description 6
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims description 4
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims description 4
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims description 4
- 235000021342 arachidonic acid Nutrition 0.000 claims description 4
- 229940114079 arachidonic acid Drugs 0.000 claims description 4
- 230000001588 bifunctional effect Effects 0.000 claims description 4
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims description 4
- 238000002955 isolation Methods 0.000 claims description 4
- 235000020778 linoleic acid Nutrition 0.000 claims description 4
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 241000235015 Yarrowia lipolytica Species 0.000 description 11
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 241000233866 Fungi Species 0.000 description 2
- 241000223252 Rhodotorula Species 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241001149698 Lipomyces Species 0.000 description 1
- 241000235575 Mortierella Species 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 241000233671 Schizochytrium Species 0.000 description 1
- 241000233675 Thraustochytrium Species 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79357506P | 2006-04-20 | 2006-04-20 | |
| PCT/US2007/009572 WO2007123999A2 (en) | 2006-04-20 | 2007-04-19 | Δ17 desaturases and their use in making polyunsaturated fatty acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009534032A JP2009534032A (ja) | 2009-09-24 |
| JP2009534032A5 true JP2009534032A5 (enExample) | 2010-05-20 |
Family
ID=38625589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506580A Ceased JP2009534032A (ja) | 2006-04-20 | 2007-04-19 | Δ１７デサチュラーゼおよび多価不飽和脂肪酸の製造におけるそれらの使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7465793B2 (enExample) |
| EP (1) | EP2010648B1 (enExample) |
| JP (1) | JP2009534032A (enExample) |
| CN (1) | CN101646766B (enExample) |
| AT (1) | ATE542892T1 (enExample) |
| AU (1) | AU2007240741B2 (enExample) |
| DK (1) | DK2010648T3 (enExample) |
| MX (1) | MX2008013306A (enExample) |
| WO (1) | WO2007123999A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10538793B2 (en) | 2014-12-25 | 2020-01-21 | Kyoto University | ω3 fatty-acid desaturase and method for producing eicosapentaenoic acid |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2659993C (en) * | 2006-08-24 | 2016-01-05 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
| WO2008054565A1 (en) * | 2006-10-30 | 2008-05-08 | E. I. Du Pont De Nemours And Company | Δ17 desaturase and its use in making polyunsaturated fatty acids |
| US7709239B2 (en) * | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8119860B2 (en) * | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| EP2337791B1 (en) * | 2008-10-14 | 2013-07-24 | Monsanto Technology LLC | Utilization of fatty acid desaturases from hemiselmis spp |
| DE112009003708T5 (de) * | 2008-12-12 | 2012-09-13 | Basf Plant Science Gmbh | Desaturasen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenenOrganismen |
| WO2012027676A1 (en) * | 2010-08-26 | 2012-03-01 | E. I. Du Pont De Nemours And Company | Mutant delta-9 elongases and their use in making polyunsaturated fatty acids |
| US20160208297A1 (en) | 2013-08-27 | 2016-07-21 | Kyoto University | Omega3 unsaturated fatty acid enzyme and method for producing eicosapentaenoic acid |
| WO2017097218A1 (zh) * | 2015-12-09 | 2017-06-15 | 江南大学 | 来源于寄生疫霉的用于合成多不饱和脂肪酸的ω-3脂肪酸脱饱和酶、含所述脂肪酸脱饱和酶的载体、重组微生物及其应用 |
| CN105368851B (zh) * | 2015-12-09 | 2019-05-07 | 江南大学 | 一种来源于寄生疫霉的ω-3脱饱和酶、含所述脱饱和酶的载体、重组微生物及其应用 |
| CN106916796B (zh) * | 2015-12-28 | 2021-06-29 | 丰益(上海)生物技术研发中心有限公司 | 裂殖壶菌delta-12脂肪酸脱饱和酶相关序列及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US7008664B1 (en) * | 1998-06-11 | 2006-03-07 | E. I. Du Pont De Nemours And Company | Method for improving the carcass quality of an animal |
| US6635451B2 (en) | 2001-01-25 | 2003-10-21 | Abbott Laboratories | Desaturase genes and uses thereof |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| PT2172536T (pt) | 2003-08-01 | 2016-08-17 | Basf Plant Science Gmbh | Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos |
| US20050132441A1 (en) | 2003-11-12 | 2005-06-16 | Damude Howard G. | Delta15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| EP4219670A3 (de) | 2004-02-27 | 2023-08-09 | BASF Plant Science GmbH | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen pflanzen |
| CA2558726C (en) | 2004-02-27 | 2017-11-07 | Basf Plant Science Gmbh | Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms |
| US7192762B2 (en) | 2004-11-04 | 2007-03-20 | E. I. Du Pont De Nemours And Company | Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US7189559B2 (en) | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| DE102005013779A1 (de) | 2005-03-22 | 2006-09-28 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen |
-
2007
- 2007-04-18 US US11/787,772 patent/US7465793B2/en not_active Expired - Fee Related
- 2007-04-19 AT AT07775772T patent/ATE542892T1/de active
- 2007-04-19 DK DK07775772.2T patent/DK2010648T3/da active
- 2007-04-19 JP JP2009506580A patent/JP2009534032A/ja not_active Ceased
- 2007-04-19 AU AU2007240741A patent/AU2007240741B2/en not_active Ceased
- 2007-04-19 MX MX2008013306A patent/MX2008013306A/es not_active Application Discontinuation
- 2007-04-19 CN CN2007800139991A patent/CN101646766B/zh not_active Expired - Fee Related
- 2007-04-19 WO PCT/US2007/009572 patent/WO2007123999A2/en not_active Ceased
- 2007-04-19 EP EP07775772A patent/EP2010648B1/en not_active Not-in-force
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10538793B2 (en) | 2014-12-25 | 2020-01-21 | Kyoto University | ω3 fatty-acid desaturase and method for producing eicosapentaenoic acid |
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