JP2019528084A5 - - Google Patents
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- Publication number
- JP2019528084A5 JP2019528084A5 JP2019521398A JP2019521398A JP2019528084A5 JP 2019528084 A5 JP2019528084 A5 JP 2019528084A5 JP 2019521398 A JP2019521398 A JP 2019521398A JP 2019521398 A JP2019521398 A JP 2019521398A JP 2019528084 A5 JP2019528084 A5 JP 2019528084A5
- Authority
- JP
- Japan
- Prior art keywords
- plant
- gene encoding
- endogenous gene
- t6odm
- codm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000196324 Embryophyta Species 0.000 claims 179
- 108090000623 proteins and genes Proteins 0.000 claims 134
- 108030002839 Thebaine 6-O-demethylases Proteins 0.000 claims 95
- 108030002895 Codeine 3-O-demethylases Proteins 0.000 claims 88
- 238000000034 method Methods 0.000 claims 86
- 108020004707 nucleic acids Proteins 0.000 claims 56
- 102000039446 nucleic acids Human genes 0.000 claims 56
- 150000007523 nucleic acids Chemical class 0.000 claims 56
- 108700028369 Alleles Proteins 0.000 claims 34
- 240000001090 Papaver somniferum Species 0.000 claims 26
- FQXXSQDCDRQNQE-UHFFFAOYSA-N markiertes Thebain Natural products COC1=CC=C2C(N(CC3)C)CC4=CC=C(OC)C5=C4C23C1O5 FQXXSQDCDRQNQE-UHFFFAOYSA-N 0.000 claims 14
- 229930003945 thebaine Natural products 0.000 claims 14
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical compound C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 claims 14
- 108091027967 Small hairpin RNA Proteins 0.000 claims 13
- 238000004519 manufacturing process Methods 0.000 claims 12
- 238000012239 gene modification Methods 0.000 claims 11
- 230000005017 genetic modification Effects 0.000 claims 11
- 235000013617 genetically modified food Nutrition 0.000 claims 11
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 10
- 230000035772 mutation Effects 0.000 claims 10
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 8
- 230000037431 insertion Effects 0.000 claims 8
- 238000003780 insertion Methods 0.000 claims 8
- 238000012216 screening Methods 0.000 claims 6
- 238000009825 accumulation Methods 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 4
- 229960004126 codeine Drugs 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000009368 gene silencing by RNA Effects 0.000 claims 4
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 230000007423 decrease Effects 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 235000008753 Papaver somniferum Nutrition 0.000 claims 2
- 230000004777 loss-of-function mutation Effects 0.000 claims 2
- 230000013011 mating Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 238000012250 transgenic expression Methods 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 235000006502 papoula Nutrition 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 238000012225 targeting induced local lesions in genomes Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374682P | 2016-08-12 | 2016-08-12 | |
| US62/374,682 | 2016-08-12 | ||
| CA2941315A CA2941315C (en) | 2016-08-12 | 2016-09-07 | High thebaine poppy and methods of producing the same |
| CA2,941,315 | 2016-09-07 | ||
| PCT/CA2017/050951 WO2018027324A1 (en) | 2016-08-12 | 2017-08-11 | High thebaine poppy and methods of producing the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020140406A Division JP2021000097A (ja) | 2016-08-12 | 2020-08-21 | テバインが増加したポピーおよびその生産方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019528084A JP2019528084A (ja) | 2019-10-10 |
| JP2019528084A5 true JP2019528084A5 (enExample) | 2019-11-21 |
| JP6906812B2 JP6906812B2 (ja) | 2021-07-21 |
Family
ID=57243364
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521398A Active JP6906812B2 (ja) | 2016-08-12 | 2017-08-11 | テバインが増加したポピーおよびおよびその生産方法 |
| JP2020140406A Pending JP2021000097A (ja) | 2016-08-12 | 2020-08-21 | テバインが増加したポピーおよびその生産方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020140406A Pending JP2021000097A (ja) | 2016-08-12 | 2020-08-21 | テバインが増加したポピーおよびその生産方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10808258B2 (enExample) |
| EP (1) | EP3334826B1 (enExample) |
| JP (2) | JP6906812B2 (enExample) |
| CN (1) | CN110088284A (enExample) |
| AU (3) | AU2017310339B2 (enExample) |
| CA (1) | CA2941315C (enExample) |
| DK (1) | DK3334826T5 (enExample) |
| ES (1) | ES2970324T3 (enExample) |
| HU (1) | HUE065349T2 (enExample) |
| PT (1) | PT3334826T (enExample) |
| WO (1) | WO2018027324A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3553177T1 (sl) | 2013-03-15 | 2021-03-31 | The Board Of Trustees Of The Leland Stanford Junior University | Mikrobi, ki proizvajajo benzilizokinolinske alkaloide (BIA), in postopka za pripravo in uporabo le-teh |
| EP3066207A1 (en) | 2013-11-04 | 2016-09-14 | The Board Of Trustees Of The University Of the Leland Stanford Junior University | Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same |
| WO2016179296A1 (en) | 2015-05-04 | 2016-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same |
| CA2983445A1 (en) | 2015-05-08 | 2016-11-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of producing epimerases and benzylisoquinoline alkaloids |
| CN110114457A (zh) | 2016-10-18 | 2019-08-09 | 安思雅公司 | 产生去甲阿片类和nal-阿片类苄基异喹啉生物碱的方法 |
| ES2996607T3 (en) * | 2017-05-02 | 2025-02-12 | Sun Pharmaceutical Industries Australia Pty Ltd | Modified poppy plants having elevated levels of thebaine |
| WO2019028390A1 (en) | 2017-08-03 | 2019-02-07 | Antheia, Inc. | ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS |
| WO2019165512A1 (en) * | 2018-03-02 | 2019-09-06 | Tasmanian Alkaloids Pty Ltd | A plant of papaver somniferum with an altered alkaloid profile |
| MX2021010797A (es) | 2019-03-08 | 2021-12-10 | Univ Leland Stanford Junior | Células hospederas no vegetales productoras de alcaloides del tropano (ta), y métodos de preparacion y uso de los mismos. |
| JP7555091B2 (ja) * | 2020-02-29 | 2024-09-24 | 国立大学法人千葉大学 | 代謝物センサ及び酵素活性のスクリーニング方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6067749A (en) * | 1996-07-11 | 2000-05-30 | Tasmanian Alkaloids Pty. Ltd. | Papaver somniferum strain with high concentration of thebaine and oripavine |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| WO1999034663A1 (en) | 1998-01-08 | 1999-07-15 | Johnson & Johnson Research Pty. Limited | Methods for plant transformation and regeneration |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6730838B1 (en) | 1999-02-12 | 2004-05-04 | Council Of Scientific And Industrial Research | Opiumless and alkaloid-free non-narcotic opium poppy (Papaver somniferum) variety “Sujata” |
| AUPP946399A0 (en) | 1999-03-26 | 1999-04-22 | Johnson & Johnson Research Pty. Limited | Codeinone reductase from alkaloid poppy |
| EP1270727A1 (en) | 2001-06-11 | 2003-01-02 | Institut für Pflanzenbiochemie | Salutaridinol 7-O-acetyltransferase and derivatives thereof |
| CH695417A5 (de) * | 2001-11-15 | 2006-05-15 | Ddr Wassyl Nowicky Dipl Ing | Verfahren zur Umsetzung von Alkaloiden. |
| US6790959B1 (en) | 2003-06-05 | 2004-09-14 | Halsey Drug Company, Inc. | Process for manufacturing thebaine |
| US6864370B1 (en) | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
| EP1512748A1 (en) | 2003-09-03 | 2005-03-09 | Johnson & Johnson Research Pty Limited | O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in papaver somniferum |
| EP1632565A1 (en) | 2004-08-12 | 2006-03-08 | Johnson & Johnson Research Pty Limited | Modulation of alkaloid biosynthesis in plants and plants having altered alkaloid biosynthesis |
| DE102005005449A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US7795503B2 (en) | 2005-02-22 | 2010-09-14 | Ceres, Inc. | Modulating plant alkaloids |
| US7312376B2 (en) | 2005-04-20 | 2007-12-25 | Ceres, Inc. | Regulatory regions from Papaveraceae |
| US9131649B2 (en) | 2008-03-07 | 2015-09-15 | Tasmanian Alkaloids Pty. Ltd | Papaver somniferum strain with high concentration of thebaine |
| US8541647B2 (en) | 2008-05-29 | 2013-09-24 | Tasmania Alkaloids Pty, Ltd. | Papaver somniferum with high concentration of codeine |
| WO2011058446A2 (en) | 2009-11-12 | 2011-05-19 | Uti Limited Partnership | Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum |
| AU2011256838B2 (en) | 2010-05-17 | 2014-10-09 | Sangamo Therapeutics, Inc. | Novel DNA-binding proteins and uses thereof |
| CA2872079A1 (en) * | 2012-04-30 | 2013-11-07 | Tpi Enterprises Ltd | Papaver bracteatum with modified alkaloid content |
-
2016
- 2016-09-07 CA CA2941315A patent/CA2941315C/en active Active
-
2017
- 2017-08-11 EP EP17838267.7A patent/EP3334826B1/en active Active
- 2017-08-11 CN CN201780063464.9A patent/CN110088284A/zh active Pending
- 2017-08-11 PT PT178382677T patent/PT3334826T/pt unknown
- 2017-08-11 US US15/762,090 patent/US10808258B2/en active Active
- 2017-08-11 WO PCT/CA2017/050951 patent/WO2018027324A1/en not_active Ceased
- 2017-08-11 AU AU2017310339A patent/AU2017310339B2/en active Active
- 2017-08-11 ES ES17838267T patent/ES2970324T3/es active Active
- 2017-08-11 HU HUE17838267A patent/HUE065349T2/hu unknown
- 2017-08-11 DK DK17838267.7T patent/DK3334826T5/da active
- 2017-08-11 JP JP2019521398A patent/JP6906812B2/ja active Active
-
2019
- 2019-03-14 AU AU2019201771A patent/AU2019201771A1/en not_active Abandoned
-
2020
- 2020-08-21 JP JP2020140406A patent/JP2021000097A/ja active Pending
- 2020-09-17 US US17/023,569 patent/US20210246460A1/en not_active Abandoned
-
2021
- 2021-09-16 AU AU2021232757A patent/AU2021232757A1/en not_active Abandoned
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