JP6906812B2 - テバインが増加したポピーおよびおよびその生産方法 - Google Patents

テバインが増加したポピーおよびおよびその生産方法 Download PDF

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JP6906812B2
JP6906812B2 JP2019521398A JP2019521398A JP6906812B2 JP 6906812 B2 JP6906812 B2 JP 6906812B2 JP 2019521398 A JP2019521398 A JP 2019521398A JP 2019521398 A JP2019521398 A JP 2019521398A JP 6906812 B2 JP6906812 B2 JP 6906812B2
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plant
t6odm
endogenous gene
expression
gene encoding
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JP2019528084A (ja
JP2019528084A5 (enExample
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コワルチュク，イゴール
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Api Labs Inc
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Api Labs Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
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    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11031—Thebaine 6-O-demethylase (1.14.11.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11032—Codeine 3-O-demethylase (1.14.11.32)

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  • General Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019521398A 2016-08-12 2017-08-11 テバインが増加したポピーおよびおよびその生産方法 Active JP6906812B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662374682P 2016-08-12 2016-08-12
US62/374,682 2016-08-12
CA2941315A CA2941315C (en) 2016-08-12 2016-09-07 High thebaine poppy and methods of producing the same
CA2,941,315 2016-09-07
PCT/CA2017/050951 WO2018027324A1 (en) 2016-08-12 2017-08-11 High thebaine poppy and methods of producing the same

Related Child Applications (1)

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JP2020140406A Division JP2021000097A (ja) 2016-08-12 2020-08-21 テバインが増加したポピーおよびその生産方法

Publications (3)

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JP2019528084A JP2019528084A (ja) 2019-10-10
JP2019528084A5 JP2019528084A5 (enExample) 2019-11-21
JP6906812B2 true JP6906812B2 (ja) 2021-07-21

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JP2019521398A Active JP6906812B2 (ja) 2016-08-12 2017-08-11 テバインが増加したポピーおよびおよびその生産方法
JP2020140406A Pending JP2021000097A (ja) 2016-08-12 2020-08-21 テバインが増加したポピーおよびその生産方法

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US (2) US10808258B2 (enExample)
EP (1) EP3334826B1 (enExample)
JP (2) JP6906812B2 (enExample)
CN (1) CN110088284A (enExample)
AU (3) AU2017310339B2 (enExample)
CA (1) CA2941315C (enExample)
DK (1) DK3334826T5 (enExample)
ES (1) ES2970324T3 (enExample)
HU (1) HUE065349T2 (enExample)
PT (1) PT3334826T (enExample)
WO (1) WO2018027324A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3553177T1 (sl) 2013-03-15 2021-03-31 The Board Of Trustees Of The Leland Stanford Junior University Mikrobi, ki proizvajajo benzilizokinolinske alkaloide (BIA), in postopka za pripravo in uporabo le-teh
EP3066207A1 (en) 2013-11-04 2016-09-14 The Board Of Trustees Of The University Of the Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
WO2016179296A1 (en) 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
CA2983445A1 (en) 2015-05-08 2016-11-17 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
CN110114457A (zh) 2016-10-18 2019-08-09 安思雅公司 产生去甲阿片类和nal-阿片类苄基异喹啉生物碱的方法
ES2996607T3 (en) * 2017-05-02 2025-02-12 Sun Pharmaceutical Industries Australia Pty Ltd Modified poppy plants having elevated levels of thebaine
WO2019028390A1 (en) 2017-08-03 2019-02-07 Antheia, Inc. ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
WO2019165512A1 (en) * 2018-03-02 2019-09-06 Tasmanian Alkaloids Pty Ltd A plant of papaver somniferum with an altered alkaloid profile
MX2021010797A (es) 2019-03-08 2021-12-10 Univ Leland Stanford Junior Células hospederas no vegetales productoras de alcaloides del tropano (ta), y métodos de preparacion y uso de los mismos.
JP7555091B2 (ja) * 2020-02-29 2024-09-24 国立大学法人千葉大学 代謝物センサ及び酵素活性のスクリーニング方法

Family Cites Families (20)

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US6067749A (en) * 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
WO1999034663A1 (en) 1998-01-08 1999-07-15 Johnson & Johnson Research Pty. Limited Methods for plant transformation and regeneration
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6730838B1 (en) 1999-02-12 2004-05-04 Council Of Scientific And Industrial Research Opiumless and alkaloid-free non-narcotic opium poppy (Papaver somniferum) variety “Sujata”
AUPP946399A0 (en) 1999-03-26 1999-04-22 Johnson & Johnson Research Pty. Limited Codeinone reductase from alkaloid poppy
EP1270727A1 (en) 2001-06-11 2003-01-02 Institut für Pflanzenbiochemie Salutaridinol 7-O-acetyltransferase and derivatives thereof
CH695417A5 (de) * 2001-11-15 2006-05-15 Ddr Wassyl Nowicky Dipl Ing Verfahren zur Umsetzung von Alkaloiden.
US6790959B1 (en) 2003-06-05 2004-09-14 Halsey Drug Company, Inc. Process for manufacturing thebaine
US6864370B1 (en) 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
EP1512748A1 (en) 2003-09-03 2005-03-09 Johnson & Johnson Research Pty Limited O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in papaver somniferum
EP1632565A1 (en) 2004-08-12 2006-03-08 Johnson & Johnson Research Pty Limited Modulation of alkaloid biosynthesis in plants and plants having altered alkaloid biosynthesis
DE102005005449A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US7795503B2 (en) 2005-02-22 2010-09-14 Ceres, Inc. Modulating plant alkaloids
US7312376B2 (en) 2005-04-20 2007-12-25 Ceres, Inc. Regulatory regions from Papaveraceae
US9131649B2 (en) 2008-03-07 2015-09-15 Tasmanian Alkaloids Pty. Ltd Papaver somniferum strain with high concentration of thebaine
US8541647B2 (en) 2008-05-29 2013-09-24 Tasmania Alkaloids Pty, Ltd. Papaver somniferum with high concentration of codeine
WO2011058446A2 (en) 2009-11-12 2011-05-19 Uti Limited Partnership Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum
AU2011256838B2 (en) 2010-05-17 2014-10-09 Sangamo Therapeutics, Inc. Novel DNA-binding proteins and uses thereof
CA2872079A1 (en) * 2012-04-30 2013-11-07 Tpi Enterprises Ltd Papaver bracteatum with modified alkaloid content

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EP3334826B1 (en) 2023-10-11
US10808258B2 (en) 2020-10-20
CA2941315C (en) 2018-03-06
JP2019528084A (ja) 2019-10-10
EP3334826A4 (en) 2018-08-08
HUE065349T2 (hu) 2024-05-28
US20190169625A1 (en) 2019-06-06
CA2941315A1 (en) 2016-11-08
AU2019201771A1 (en) 2019-04-04
US20210246460A1 (en) 2021-08-12
CN110088284A (zh) 2019-08-02
JP2021000097A (ja) 2021-01-07
WO2018027324A1 (en) 2018-02-15
DK3334826T5 (da) 2024-10-07
DK3334826T3 (da) 2024-01-15
AU2017310339A1 (en) 2018-04-12
AU2021232757A1 (en) 2021-10-21
AU2017310339B2 (en) 2019-01-17
ES2970324T3 (es) 2024-05-28
WO2018027324A9 (en) 2019-07-18
EP3334826A1 (en) 2018-06-20
PT3334826T (pt) 2024-02-07

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