JP2005500363A5 - - Google Patents
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- JP2005500363A5 JP2005500363A5 JP2003518483A JP2003518483A JP2005500363A5 JP 2005500363 A5 JP2005500363 A5 JP 2005500363A5 JP 2003518483 A JP2003518483 A JP 2003518483A JP 2003518483 A JP2003518483 A JP 2003518483A JP 2005500363 A5 JP2005500363 A5 JP 2005500363A5
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- JP
- Japan
- Prior art keywords
- group
- composition
- ring
- thixotropic
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 delacoxib Chemical compound 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims 10
- 239000000194 fatty acid Substances 0.000 claims 10
- 229930195729 fatty acid Natural products 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 230000009974 thixotropic effect Effects 0.000 claims 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 239000000375 suspending agent Substances 0.000 claims 6
- 239000000080 wetting agent Substances 0.000 claims 6
- 239000002562 thickening agent Substances 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 2
- ZFKBWSREWJOSSJ-VIFPVBQESA-N (2s)-6,8-dichloro-2-(trifluoromethyl)-2h-chromene-3-carboxylic acid Chemical compound ClC1=CC(Cl)=C2O[C@H](C(F)(F)F)C(C(=O)O)=CC2=C1 ZFKBWSREWJOSSJ-VIFPVBQESA-N 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- ULFYMTMZNITFSB-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-3-(4-methylsulfonylphenyl)cyclopent-2-en-1-one Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=C(F)C=C(F)C=2)C(=O)CC1 ULFYMTMZNITFSB-UHFFFAOYSA-N 0.000 claims 2
- XKVUYEYANWFIJX-UHFFFAOYSA-N 5-methyl-1h-pyrazole Chemical group CC1=CC=NN1 XKVUYEYANWFIJX-UHFFFAOYSA-N 0.000 claims 2
- 244000215068 Acacia senegal Species 0.000 claims 2
- 239000005995 Aluminium silicate Substances 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 claims 2
- BZKFMUIJRXWWQK-UHFFFAOYSA-N Cyclopentenone Chemical group O=C1CCC=C1 BZKFMUIJRXWWQK-UHFFFAOYSA-N 0.000 claims 2
- 229920002907 Guar gum Polymers 0.000 claims 2
- 229920000084 Gum arabic Polymers 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 2
- 229920001615 Tragacanth Polymers 0.000 claims 2
- 235000010489 acacia gum Nutrition 0.000 claims 2
- 239000000205 acacia gum Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 150000005215 alkyl ethers Chemical class 0.000 claims 2
- 235000012211 aluminium silicate Nutrition 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 239000000305 astragalus gummifer gum Substances 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 239000000440 bentonite Substances 0.000 claims 2
- 229910000278 bentonite Inorganic materials 0.000 claims 2
- 235000012216 bentonite Nutrition 0.000 claims 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229960000590 celecoxib Drugs 0.000 claims 2
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims 2
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 125000003844 furanonyl group Chemical group 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 239000000665 guar gum Substances 0.000 claims 2
- 235000010417 guar gum Nutrition 0.000 claims 2
- 229960002154 guar gum Drugs 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004970 halomethyl group Chemical group 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 2
- 229920000609 methyl cellulose Polymers 0.000 claims 2
- 239000001923 methylcellulose Substances 0.000 claims 2
- 235000010981 methylcellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920001983 poloxamer Polymers 0.000 claims 2
- 229960000502 poloxamer Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 229920000136 polysorbate Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 150000003856 quaternary ammonium compounds Chemical group 0.000 claims 2
- 229960000371 rofecoxib Drugs 0.000 claims 2
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 235000002639 sodium chloride Nutrition 0.000 claims 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims 2
- 229960004224 tyloxapol Drugs 0.000 claims 2
- 229920001664 tyloxapol Polymers 0.000 claims 2
- 229960002004 valdecoxib Drugs 0.000 claims 2
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 1
- 239000013008 thixotropic agent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31037201P | 2001-08-06 | 2001-08-06 | |
| PCT/US2002/024746 WO2003013473A1 (en) | 2001-08-06 | 2002-08-05 | Stabilized oral suspension formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005500363A JP2005500363A (ja) | 2005-01-06 |
| JP2005500363A5 true JP2005500363A5 (enExample) | 2005-12-22 |
Family
ID=23202195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003518483A Pending JP2005500363A (ja) | 2001-08-06 | 2002-08-05 | 安定化経口懸濁液製剤 |
Country Status (33)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720061D0 (en) | 1997-09-19 | 1997-11-19 | Crosfield Joseph & Sons | Metal compounds as phosphate binders |
| US20040105889A1 (en) * | 2002-12-03 | 2004-06-03 | Elan Pharma International Limited | Low viscosity liquid dosage forms |
| US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
| US20050036956A1 (en) * | 2003-08-15 | 2005-02-17 | Lin Fei | Non-aqueous liquid tooth whitening composition |
| TR200301552A1 (tr) * | 2003-09-18 | 2005-10-21 | Nobel İlaç Sanayi̇ Ve Ti̇caret A. Ş. | Rofekoksib' in yeni oral farmakolojik formülasyonları. |
| US20050266031A1 (en) * | 2004-05-25 | 2005-12-01 | Jay Dickerson | Pharmaceutical suspension composition |
| US8318210B2 (en) * | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
| US8653145B2 (en) * | 2005-09-22 | 2014-02-18 | Eaton Scientific Systems, Ltd. | Method for alleviating climacteric symptoms |
| MY157620A (en) | 2006-01-31 | 2016-06-30 | Cytochroma Dev Inc | A granular material of a solid water-soluble mixed metal compound capable of binding phosphate |
| JP2009534459A (ja) * | 2006-04-26 | 2009-09-24 | ローズモント・フアーマシユーテイカルズ・リミテツド | 液体経口組成物 |
| CN100434072C (zh) * | 2006-06-19 | 2008-11-19 | 西安交通大学 | 具有抗炎性作用及改善血液流变性和抑制血栓形成的药物 |
| GB0714670D0 (en) | 2007-07-27 | 2007-09-05 | Ineos Healthcare Ltd | Use |
| GB0720220D0 (en) | 2007-10-16 | 2007-11-28 | Ineos Healthcare Ltd | Compound |
| US9119819B2 (en) | 2008-04-30 | 2015-09-01 | Wockhardt Ltd. | Oral liquid compositions of rhein or diacerein |
| GB0913525D0 (en) | 2009-08-03 | 2009-09-16 | Ineos Healthcare Ltd | Method |
| GB201001779D0 (en) | 2010-02-04 | 2010-03-24 | Ineos Healthcare Ltd | Composition |
| WO2011107855A2 (en) | 2010-03-04 | 2011-09-09 | Torrent Pharmaceuticals Limited | Sustained release oral liquid suspension dosage form |
| PL2544532T3 (pl) | 2010-03-12 | 2017-08-31 | Monsanto Technology Llc | Agrochemiczne kompozycje żelowe |
| EA031793B1 (ru) * | 2010-06-02 | 2019-02-28 | Астеллас Дойчланд Гмбх | Пероральные лекарственные формы бендамустина |
| EP2462922A1 (en) * | 2010-12-10 | 2012-06-13 | Bioprojet | New form of administration of enkephalinase inhibitor |
| BR112013018025A2 (pt) * | 2011-01-18 | 2020-10-27 | Senju Pharmaceutical Co., Ltd | composição de bromfenac líquida aquosa método para reforçar a eficácia conservante de uma solução aquosa |
| HK1216240A1 (zh) | 2012-11-14 | 2016-10-28 | W. R. Grace & Co.-Conn. | 含有生物活性材料与无序无机氧化物的组合物 |
| US20160346300A1 (en) * | 2015-05-29 | 2016-12-01 | Kiel Laboratories, Inc. | Liquid formulations of celecoxib for oral administration |
| US11083780B2 (en) | 2015-07-20 | 2021-08-10 | The Brigham And Women's Hospital, Inc. | Shear-thinning compositions as an intravascular embolic agent |
| CN105902409B (zh) * | 2016-05-13 | 2019-03-05 | 广东龙湖科技股份有限公司 | 一种温和且具有触变性的牙膏 |
| CN111481508A (zh) * | 2016-10-19 | 2020-08-04 | 萨恩帕斯药物有限公司 | 针对引起离子通道病的药物的保护性组合物和方法 |
| WO2019070818A2 (en) * | 2017-10-04 | 2019-04-11 | Panacea Biomatx, Inc. | SUSPENSION OF ENCAPSULATED PHARMACEUTICAL PRODUCTS AND METHODS OF MAKING AND USING SAME |
| CN112402376A (zh) * | 2019-08-22 | 2021-02-26 | 上海上药信谊药厂有限公司 | 一种结肠靶向的柳氮磺吡啶口服混悬剂及其制备方法 |
| CN114931552A (zh) * | 2021-02-12 | 2022-08-23 | 浙江贝灵生物医药有限公司 | 一种口服碱性溶媒组合物及其制备方法与应用 |
| WO2022185338A1 (en) * | 2021-03-05 | 2022-09-09 | Alkem Laboratories Limited | Stable oral suspension of celecoxib and method of preparation thereof |
| KR20240161261A (ko) | 2023-05-04 | 2024-11-12 | 주식회사 퍼슨 | 성상 안정성이 우수한 현탁액 조성물 |
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-
2002
- 2002-05-08 UA UA2004020879A patent/UA80682C2/uk unknown
- 2002-08-05 KR KR10-2004-7001860A patent/KR20040025740A/ko not_active Ceased
- 2002-08-05 ES ES02756952T patent/ES2280560T3/es not_active Expired - Lifetime
- 2002-08-05 JP JP2003518483A patent/JP2005500363A/ja active Pending
- 2002-08-05 PT PT02756952T patent/PT1414409E/pt unknown
- 2002-08-05 GE GE5420A patent/GEP20074027B/en unknown
- 2002-08-05 YU YU7404A patent/YU7404A/sh unknown
- 2002-08-05 US US10/212,308 patent/US20030108575A1/en not_active Abandoned
- 2002-08-05 SI SI200230516T patent/SI1414409T1/sl unknown
- 2002-08-05 EA EA200400148A patent/EA007901B1/ru not_active IP Right Cessation
- 2002-08-05 PL PL02366382A patent/PL366382A1/xx not_active Application Discontinuation
- 2002-08-05 AT AT02756952T patent/ATE353627T1/de not_active IP Right Cessation
- 2002-08-05 WO PCT/US2002/024746 patent/WO2003013473A1/en not_active Ceased
- 2002-08-05 CN CNB02815522XA patent/CN1287768C/zh not_active Expired - Fee Related
- 2002-08-05 DK DK02756952T patent/DK1414409T3/da active
- 2002-08-05 CA CA002454173A patent/CA2454173A1/en not_active Abandoned
- 2002-08-05 HR HR20040118A patent/HRP20040118A2/hr not_active Application Discontinuation
- 2002-08-05 NZ NZ530844A patent/NZ530844A/en unknown
- 2002-08-05 MX MXPA04001109A patent/MXPA04001109A/es active IP Right Grant
- 2002-08-05 BR BR0211736-3A patent/BR0211736A/pt not_active IP Right Cessation
- 2002-08-05 AP APAP/P/2004/002969A patent/AP1817A/en active
- 2002-08-05 EP EP02756952A patent/EP1414409B1/en not_active Expired - Lifetime
- 2002-08-05 OA OA1200400030A patent/OA12646A/en unknown
- 2002-08-05 IL IL15955102A patent/IL159551A0/xx unknown
- 2002-08-05 DE DE60218175T patent/DE60218175T2/de not_active Expired - Fee Related
- 2002-08-06 MY MYPI20022925A patent/MY135119A/en unknown
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2004
- 2004-01-26 IS IS7126A patent/IS7126A/is unknown
- 2004-01-27 ZA ZA200400639A patent/ZA200400639B/en unknown
- 2004-01-27 MA MA27503A patent/MA27054A1/fr unknown
- 2004-02-05 TN TNP2004000023A patent/TNSN04023A1/fr unknown
- 2004-02-06 CO CO04009302A patent/CO5560559A2/es not_active Application Discontinuation
- 2004-02-06 EC EC2004004974A patent/ECSP044974A/es unknown
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2007
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- 2007-12-21 US US11/962,903 patent/US20090081309A1/en not_active Abandoned
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