JP2005500294A - ホスホジエステラーゼ7に対するピリミジン阻害剤 - Google Patents
ホスホジエステラーゼ7に対するピリミジン阻害剤 Download PDFInfo
- Publication number
- JP2005500294A JP2005500294A JP2003504902A JP2003504902A JP2005500294A JP 2005500294 A JP2005500294 A JP 2005500294A JP 2003504902 A JP2003504902 A JP 2003504902A JP 2003504902 A JP2003504902 A JP 2003504902A JP 2005500294 A JP2005500294 A JP 2005500294A
- Authority
- JP
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- Prior art keywords
- alkyl
- heterocyclo
- substituted
- heteroaryl
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CCCC*(CCC1)C1=O Chemical compound CCCC*(CCC1)C1=O 0.000 description 7
- LIUOLFOJUPDQMX-UHFFFAOYSA-N CCOC(C(N=C(N)N1)=CC1=O)=O Chemical compound CCOC(C(N=C(N)N1)=CC1=O)=O LIUOLFOJUPDQMX-UHFFFAOYSA-N 0.000 description 1
- LYUCMVHKWPMQPM-UHFFFAOYSA-N CCOC(Cc1cc(Cl)nc(Nc2nc(C)c(C(OCC)=O)[s]2)n1)=O Chemical compound CCOC(Cc1cc(Cl)nc(Nc2nc(C)c(C(OCC)=O)[s]2)n1)=O LYUCMVHKWPMQPM-UHFFFAOYSA-N 0.000 description 1
- KEEBMBYBJRRQCO-UHFFFAOYSA-N CCOC(c(cc1)ccc1-c1nc(N)nc(Cl)c1)=O Chemical compound CCOC(c(cc1)ccc1-c1nc(N)nc(Cl)c1)=O KEEBMBYBJRRQCO-UHFFFAOYSA-N 0.000 description 1
- ASGAHMHUTURAES-UHFFFAOYSA-N CCOC(c1c(C)nc(Nc2nc(-c(cc3)ccc3C(O)=O)cc(N(CCC3)CCN3C(C)=O)n2)[s]1)=O Chemical compound CCOC(c1c(C)nc(Nc2nc(-c(cc3)ccc3C(O)=O)cc(N(CCC3)CCN3C(C)=O)n2)[s]1)=O ASGAHMHUTURAES-UHFFFAOYSA-N 0.000 description 1
- WDVRXKMQWKAXDR-UHFFFAOYSA-N CCOC(c1c(C)nc(Nc2nc(-c3cnc[o]3)cc(NCc(cc3)ccc3Cl)n2)[s]1)=O Chemical compound CCOC(c1c(C)nc(Nc2nc(-c3cnc[o]3)cc(NCc(cc3)ccc3Cl)n2)[s]1)=O WDVRXKMQWKAXDR-UHFFFAOYSA-N 0.000 description 1
- KYQQZPBANPSWSM-UHFFFAOYSA-N CCOC(c1c(C)nc(Nc2nc(C3=CN=C[U]3)cc(Cl)n2)[s]1)=O Chemical compound CCOC(c1c(C)nc(Nc2nc(C3=CN=C[U]3)cc(Cl)n2)[s]1)=O KYQQZPBANPSWSM-UHFFFAOYSA-N 0.000 description 1
- VHFCLRHNFQHRPN-UHFFFAOYSA-N CCOC(c1c(C)nc(Nc2nc(Cc(cc3)ccc3SC)cc(Cl)n2)[s]1)=O Chemical compound CCOC(c1c(C)nc(Nc2nc(Cc(cc3)ccc3SC)cc(Cl)n2)[s]1)=O VHFCLRHNFQHRPN-UHFFFAOYSA-N 0.000 description 1
- PRCILUVFSDOAMJ-UHFFFAOYSA-N CCc1c(C(OCC)=O)[s]c(Nc2nc(N(CC3)CCC3C=O)cc(-c(cc3)ccc3-c3nnn[nH]3)n2)n1 Chemical compound CCc1c(C(OCC)=O)[s]c(Nc2nc(N(CC3)CCC3C=O)cc(-c(cc3)ccc3-c3nnn[nH]3)n2)n1 PRCILUVFSDOAMJ-UHFFFAOYSA-N 0.000 description 1
- JREZTZJRSLDXOU-UHFFFAOYSA-N CN(Cc(cc1OC)cc(OC)c1OC)c1cc(N2CCN(C)CC2)nc(NC(N)=S)n1 Chemical compound CN(Cc(cc1OC)cc(OC)c1OC)c1cc(N2CCN(C)CC2)nc(NC(N)=S)n1 JREZTZJRSLDXOU-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29928701P | 2001-06-19 | 2001-06-19 | |
US35514102P | 2002-02-08 | 2002-02-08 | |
US36875202P | 2002-03-29 | 2002-03-29 | |
PCT/US2002/019097 WO2002102313A2 (en) | 2001-06-19 | 2002-06-17 | Pyrimidine inhibitors of phosphodiesterase (pde) 7 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2005500294A true JP2005500294A (ja) | 2005-01-06 |
Family
ID=27404644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003504902A Pending JP2005500294A (ja) | 2001-06-19 | 2002-06-17 | ホスホジエステラーゼ7に対するピリミジン阻害剤 |
Country Status (6)
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009515992A (ja) * | 2005-11-16 | 2009-04-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤として有用なアミノピリミジン |
JP2013501034A (ja) * | 2009-08-05 | 2013-01-10 | カトリック・ユニベルシティト・ルーヴァン | 新規ウイルス複製阻害剤 |
JP2016523976A (ja) * | 2013-07-11 | 2016-08-12 | アジオス ファーマシューティカルズ, インコーポレイテッド | 癌の処置のためのidh2突然変異体阻害剤としての2,4−または4,6−ジアミノピリミジン化合物 |
JP2017502940A (ja) * | 2013-12-11 | 2017-01-26 | セルジーン クオンティセル リサーチ,インク. | リジン特異的デメチラーゼ−1の阻害剤 |
JP2017514830A (ja) * | 2014-05-01 | 2017-06-08 | セルジーン クオンティセル リサーチ,インク. | リジン特異的なデメチラーゼ−1の阻害剤 |
JP2017527561A (ja) * | 2014-09-05 | 2017-09-21 | セルジーン クオンティセル リサーチ,インク. | リジン特異的なデメチラーゼ−1の阻害剤 |
Families Citing this family (137)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100850812B1 (ko) * | 2000-10-23 | 2008-08-06 | 스미스클라인 비참 코포레이션 | 신규 화합물 |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
DK1534286T3 (da) | 2002-07-29 | 2010-04-26 | Rigel Pharmaceuticals Inc | Fremgangsmåder til behandling eller forebyggelse af autoimmune sygdomme med 2,4-pyrimidindiamin-forbindelser |
MXPA05005477A (es) | 2002-11-21 | 2005-07-25 | Chiron Corp | Pirimidinas 2,4,6-trisustituidas como inhibidores de fosfotidilinositol (pi) 3-cinasa y su uso en el tratamiento del cancer. |
NZ539823A (en) * | 2002-11-28 | 2008-04-30 | Schering Aktiengessellschaft | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
PL379330A1 (pl) * | 2002-12-20 | 2006-08-21 | Pfizer Products Inc. | Pochodne pirymidyny dla leczenia nienormalnego wzrostu komórek |
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AU2457201A (en) | 1999-12-28 | 2001-07-09 | Bristol-Myers Squibb Company | Cytokine, especially tnf-alpha, inhibitors |
CZ20022521A3 (cs) | 2000-01-27 | 2003-02-12 | Warner-Lambert Company | Pyridopyrimidinonové deriváty pro léčení neurodegenerativních onemocnění |
-
2002
- 2002-06-17 CA CA002450934A patent/CA2450934A1/en not_active Abandoned
- 2002-06-17 US US10/173,442 patent/US7087614B2/en not_active Expired - Lifetime
- 2002-06-17 EP EP02744381A patent/EP1397142A4/en not_active Withdrawn
- 2002-06-17 WO PCT/US2002/019097 patent/WO2002102313A2/en not_active Application Discontinuation
- 2002-06-17 HU HU0402352A patent/HUP0402352A2/hu unknown
- 2002-06-17 JP JP2003504902A patent/JP2005500294A/ja active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009515992A (ja) * | 2005-11-16 | 2009-04-16 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤として有用なアミノピリミジン |
JP2013501034A (ja) * | 2009-08-05 | 2013-01-10 | カトリック・ユニベルシティト・ルーヴァン | 新規ウイルス複製阻害剤 |
JP2016523976A (ja) * | 2013-07-11 | 2016-08-12 | アジオス ファーマシューティカルズ, インコーポレイテッド | 癌の処置のためのidh2突然変異体阻害剤としての2,4−または4,6−ジアミノピリミジン化合物 |
JP2017502940A (ja) * | 2013-12-11 | 2017-01-26 | セルジーン クオンティセル リサーチ,インク. | リジン特異的デメチラーゼ−1の阻害剤 |
JP2017514830A (ja) * | 2014-05-01 | 2017-06-08 | セルジーン クオンティセル リサーチ,インク. | リジン特異的なデメチラーゼ−1の阻害剤 |
JP2017527561A (ja) * | 2014-09-05 | 2017-09-21 | セルジーン クオンティセル リサーチ,インク. | リジン特異的なデメチラーゼ−1の阻害剤 |
JP2020125321A (ja) * | 2014-09-05 | 2020-08-20 | セルジーン クオンティセル リサーチ,インク. | リジン特異的なデメチラーゼ−1の阻害剤 |
Also Published As
Publication number | Publication date |
---|---|
HUP0402352A2 (hu) | 2005-02-28 |
EP1397142A2 (en) | 2004-03-17 |
WO2002102313A3 (en) | 2003-04-03 |
US7087614B2 (en) | 2006-08-08 |
WO2002102313A2 (en) | 2002-12-27 |
EP1397142A4 (en) | 2004-11-03 |
CA2450934A1 (en) | 2002-12-27 |
US20030162802A1 (en) | 2003-08-28 |
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