JP2004536873A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004536873A5 JP2004536873A5 JP2003516067A JP2003516067A JP2004536873A5 JP 2004536873 A5 JP2004536873 A5 JP 2004536873A5 JP 2003516067 A JP2003516067 A JP 2003516067A JP 2003516067 A JP2003516067 A JP 2003516067A JP 2004536873 A5 JP2004536873 A5 JP 2004536873A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- dioxan
- dioxolan
- phenethyl
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29752101P | 2001-06-11 | 2001-06-11 | |
| US29851401P | 2001-06-14 | 2001-06-14 | |
| US36609002P | 2002-03-19 | 2002-03-19 | |
| PCT/US2002/018689 WO2002100347A2 (en) | 2001-06-11 | 2002-06-11 | Prodrugs of gaba analogs, compositions and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008171589A Division JP5001227B2 (ja) | 2001-06-11 | 2008-06-30 | Gaba類似体のプロドラッグ、組成物およびその使用 |
| JP2008171250A Division JP2009051822A (ja) | 2001-06-11 | 2008-06-30 | Gaba類似体のプロドラッグ、組成物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536873A JP2004536873A (ja) | 2004-12-09 |
| JP2004536873A5 true JP2004536873A5 (https=) | 2005-12-15 |
| JP4216713B2 JP4216713B2 (ja) | 2009-01-28 |
Family
ID=27404495
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503214A Pending JP2004534057A (ja) | 2001-06-11 | 2002-06-11 | 低毒性を示す経口投与剤形のgaba類似体プロドラッグ |
| JP2003516067A Expired - Lifetime JP4216713B2 (ja) | 2001-06-11 | 2002-06-11 | Gaba類似体のプロドラッグ、組成物およびその使用 |
| JP2008171250A Withdrawn JP2009051822A (ja) | 2001-06-11 | 2008-06-30 | Gaba類似体のプロドラッグ、組成物およびその使用 |
| JP2008171589A Expired - Lifetime JP5001227B2 (ja) | 2001-06-11 | 2008-06-30 | Gaba類似体のプロドラッグ、組成物およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503214A Pending JP2004534057A (ja) | 2001-06-11 | 2002-06-11 | 低毒性を示す経口投与剤形のgaba類似体プロドラッグ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008171250A Withdrawn JP2009051822A (ja) | 2001-06-11 | 2008-06-30 | Gaba類似体のプロドラッグ、組成物およびその使用 |
| JP2008171589A Expired - Lifetime JP5001227B2 (ja) | 2001-06-11 | 2008-06-30 | Gaba類似体のプロドラッグ、組成物およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6833140B2 (https=) |
| EP (4) | EP1404310A4 (https=) |
| JP (4) | JP2004534057A (https=) |
| KR (5) | KR20040016882A (https=) |
| CN (1) | CN1533270A (https=) |
| AT (2) | ATE540678T1 (https=) |
| AU (4) | AU2002345664C1 (https=) |
| CA (2) | CA2449729C (https=) |
| CY (1) | CY1107894T1 (https=) |
| DE (1) | DE60223923T3 (https=) |
| DK (1) | DK1404324T4 (https=) |
| ES (2) | ES2380287T3 (https=) |
| HU (2) | HUP0400183A2 (https=) |
| IL (5) | IL159299A0 (https=) |
| MX (2) | MXPA03011565A (https=) |
| NO (4) | NO20035473D0 (https=) |
| NZ (1) | NZ567711A (https=) |
| PT (1) | PT1404324E (https=) |
| WO (2) | WO2002100347A2 (https=) |
| ZA (1) | ZA200309679B (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2327285C (en) * | 1998-05-15 | 2005-06-14 | Warner-Lambert Company | Stabilized pharmaceutical preparations of gamma-aminobutyric acid derivatives and process for preparing the same |
| WO2002044324A2 (en) | 2000-10-06 | 2002-06-06 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| AU2002211863A1 (en) * | 2000-10-06 | 2002-04-15 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| EP1343515A4 (en) * | 2000-10-06 | 2005-08-03 | Xenoport Inc | COMPOUNDS FOR PROLONGED RELEASE OF ORAL DRUGS |
| AU2002230398A1 (en) | 2000-10-06 | 2002-04-29 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| CA2449729C (en) | 2001-06-11 | 2009-11-03 | Xenoport, Inc. | Prodrugs of gaba analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) * | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| AU2002345638A1 (en) * | 2001-06-11 | 2002-12-23 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| US6818787B2 (en) * | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US20040137052A1 (en) * | 2001-12-25 | 2004-07-15 | Yoshihiro Uchiyama | Acid-containing preparations |
| AU2002316231A1 (en) | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| US7025745B2 (en) * | 2002-10-07 | 2006-04-11 | Advanced Cardiovascular Systems, Inc. | Method of making a catheter balloon using a tapered mandrel |
| US20040162351A1 (en) * | 2002-12-11 | 2004-08-19 | Gallop Mark A. | Orally administered dosage forms of fused GABA analog prodrugs having reduced toxicity |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| AU2003303041B2 (en) | 2002-12-13 | 2008-07-24 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
| EP1572187A1 (en) * | 2002-12-13 | 2005-09-14 | Warner-Lambert Company LLC | Pregabalin and derivatives thereof for the treatment of fibromyalgia and other related disorders |
| US8641987B2 (en) | 2003-01-24 | 2014-02-04 | Applied Biosystems, Llc | Sample chamber array and method for processing a biological sample |
| KR20050119676A (ko) * | 2003-03-31 | 2005-12-21 | 제노포트 인코포레이티드 | 가바 유사체의 프로드러그를 사용한 열성 홍조의 치료 또는예방 |
| US7169812B2 (en) | 2003-07-01 | 2007-01-30 | Medtronic, Inc. | Process for producing injectable gabapentin compositions |
| US7662987B2 (en) * | 2003-07-15 | 2010-02-16 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl compounds |
| ATE546427T1 (de) * | 2003-08-20 | 2012-03-15 | Xenoport Inc | Acyloxyalkylcarbamat-prodrugs, syntheseverfahren und anwendung |
| BRPI0413756A (pt) | 2003-08-20 | 2006-10-31 | Xenoport Inc | composto, métodos para tratar ou evitar espasticidade ou um sintoma de espasticidade, doença de refluxo gastro-esofágico, vìcio em droga, vìcio em ou abuso de álcool, ou vìcio em ou abuso de nicotina, e tosse ou êmese em um paciente, e, composição farmacêutica |
| EP2354120A1 (en) * | 2003-08-20 | 2011-08-10 | XenoPort, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
| KR20060119971A (ko) * | 2003-09-11 | 2006-11-24 | 제노포트 인코포레이티드 | Gaba 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방 |
| AU2004271800A1 (en) | 2003-09-12 | 2005-03-24 | Pfizer Inc. | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| NZ579515A (en) * | 2003-09-17 | 2011-09-30 | Xenoport Inc | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
| RU2458049C2 (ru) * | 2003-09-17 | 2012-08-10 | Ксенопорт, Инк. | Лечение или предупреждение синдрома беспокойных ног с использованием пролекарств аналогов гамк |
| SG147437A1 (en) | 2003-10-14 | 2008-11-28 | Xenoport Inc | Crystalline form of gamma-aminobutyric acid analog |
| WO2005041976A2 (en) * | 2003-10-23 | 2005-05-12 | Medtronic, Inc. | Injectable gabapentin compositions |
| CN1902175B (zh) * | 2003-12-30 | 2012-08-22 | 什诺波特有限公司 | 酰氧基烃基氨基甲酸酯前药及其中间体的合成 |
| CN102702065A (zh) * | 2003-12-30 | 2012-10-03 | 什诺波特有限公司 | 酰氧基烃基氨基甲酸酯前药及其中间体的合成 |
| EP2172445A1 (en) * | 2004-03-17 | 2010-04-07 | Hikal Limited | Cis (z) 4-t-butylgabapentin and its synthesis |
| WO2005102389A2 (en) * | 2004-04-20 | 2005-11-03 | Pfizer Products Inc. | Combinations comprising alpha-2-delta ligands and ep4 receptor antagonists |
| US7566738B2 (en) | 2004-11-03 | 2009-07-28 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
| US7494985B2 (en) | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| MX2007005306A (es) | 2004-11-04 | 2007-06-11 | Xenoport Inc | Formas de dosis oral de liberacion sostenida de la prodroga gabapentina. |
| AU2006214454B2 (en) * | 2005-02-15 | 2011-05-19 | Jazz Pharmaceuticals, Inc. | Dosage form and method for sustained release of a substituted pyrazine compound |
| US7351740B2 (en) * | 2005-06-20 | 2008-04-01 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use |
| WO2007027477A2 (en) * | 2005-08-23 | 2007-03-08 | Xenoport, Inc. | Treating vulvodynia using prodrugs of gaba analogs |
| WO2007027476A2 (en) * | 2005-08-26 | 2007-03-08 | Xenoport, Inc. | Treating premature ejaculation using gabapentin and pregabalin prodrugs |
| JP2009507793A (ja) * | 2005-08-31 | 2009-02-26 | ワイス | グリシルサイクリンの9−アミノカルボニル置換誘導体 |
| US7727978B2 (en) * | 2006-08-24 | 2010-06-01 | Bristol-Myers Squibb Company | Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| US7585996B2 (en) | 2006-09-15 | 2009-09-08 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7879906B2 (en) | 2006-11-24 | 2011-02-01 | Anchen Laboratories, Inc. | GABA analogs, compositions and methods for manufacturing thereof |
| AR064001A1 (es) * | 2006-11-30 | 2009-03-04 | Cenerx Bio Pharma Inc | Esteres de dialquilaminoalquilo de pivagabina como medicamentos para el tratamiento de trastornos del sistema nervioso central, metodos para su preparacion y composiciones farmaceuticas que los comprenden. |
| US20080161393A1 (en) * | 2006-12-08 | 2008-07-03 | Barrett Ronald W | Use of prodrugs of GABA analogs for treating disease |
| CA2673545A1 (en) | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids |
| TW200908957A (en) * | 2007-06-15 | 2009-03-01 | Xenoport Inc | Use of prodrugs of GABA analogs, antispasticity agents, and prodrugs of GABAB receptor agonists for treating spasticity |
| EP2173837A2 (en) | 2007-07-20 | 2010-04-14 | Amyris Biotechnologies, Inc. | Fuel compositions comprising tetramethylcyclohexane |
| US20090118365A1 (en) * | 2007-11-06 | 2009-05-07 | Xenoport, Inc | Use of Prodrugs of GABA B Agonists for Treating Neuropathic and Musculoskeletal Pain |
| EP2250148B1 (en) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use |
| ES2601852T3 (es) | 2008-01-25 | 2017-02-16 | Xenoport, Inc. | Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| US8299291B2 (en) | 2008-08-07 | 2012-10-30 | Xenoport, Inc. | Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs |
| US7989641B2 (en) * | 2008-08-07 | 2011-08-02 | Xenoport, Inc. | Methods of synthesizing N-hydroxysuccinimidyl carbonates |
| US8283487B2 (en) | 2008-11-26 | 2012-10-09 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation and purification of gabapentin enacarbil |
| WO2010101115A1 (ja) | 2009-03-02 | 2010-09-10 | アステラス製薬株式会社 | 固形製剤の包装体 |
| JP5580345B2 (ja) | 2009-03-06 | 2014-08-27 | ゼノポート,インコーポレイティド | 高充填量のガバペンチンプロドラッグを有する経口剤形 |
| WO2011101245A1 (en) | 2010-02-18 | 2011-08-25 | Nicox S.A. | Nitric oxide releasing compounds for the treatment of neuropathic pain |
| CA2805371C (en) | 2010-07-30 | 2017-10-31 | Toray Industries, Inc. | Therapeutic agent or prophylactic agent for neuropathic pain |
| CN104271549B (zh) * | 2012-05-03 | 2017-07-04 | 帝斯曼知识产权资产管理有限公司 | 一种新的制备维生素b6的中间体化合物 |
| EP2961730A2 (en) | 2013-02-26 | 2016-01-06 | XenoPort, Inc. | Method of making 1-(acyloxy)-alkyl carbamate compounds |
| RS58991B1 (sr) * | 2013-11-05 | 2019-08-30 | Astrazeneca Ab | Prolekovi nmda antagonista |
| US10213394B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság | Composition and method for treating neurological disease |
| US10213393B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Feleõsségû Társaság | Composition and method for treating neurological disease |
| US20190247331A1 (en) | 2018-02-15 | 2019-08-15 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság | Composition and method for treating neurological disease |
| WO2020074160A1 (en) * | 2018-10-10 | 2020-04-16 | Curovir Ab | Condensed pyrimidine or pyridazine derivatives as antiviral agents |
| CN114306234A (zh) * | 2021-12-23 | 2022-04-12 | 江苏百奥信康医药科技有限公司 | 一种含有加巴喷丁复合物的tpgs胶束口服液及其制备方法 |
Family Cites Families (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
| US2003A (en) * | 1841-03-12 | Improvement in horizontal windivhlls | ||
| US2996431A (en) * | 1953-12-16 | 1961-08-15 | Barry Richard Henry | Friable tablet and process for manufacturing same |
| US3402240A (en) * | 1957-06-25 | 1968-09-17 | Pfizer & Co C | Medicinal tablet and process of making same |
| US3139383A (en) * | 1961-06-26 | 1964-06-30 | Norton Co | Encapsulated time release pellets and method for encapsulating the same |
| GB1364672A (en) | 1971-06-09 | 1974-08-29 | Beecham Group Ltd | Penicillins |
| US3962414A (en) * | 1972-04-27 | 1976-06-08 | Alza Corporation | Structured bioerodible drug delivery device |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3811444A (en) * | 1972-12-27 | 1974-05-21 | Alza Corp | Bioerodible ocular device |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| DE2336218C3 (de) * | 1973-07-17 | 1985-11-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Orale Arzneiform |
| US3992414A (en) * | 1973-12-20 | 1976-11-16 | Lever Brothers Company | Process for the preparation of selectively halogenated ketals |
| US3992518A (en) * | 1974-10-24 | 1976-11-16 | G. D. Searle & Co. | Method for making a microsealed delivery device |
| GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4093709A (en) * | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| US4036064A (en) * | 1975-09-11 | 1977-07-19 | Gilford Instrument Laboratories, Inc. | Pipette device |
| US4093571A (en) * | 1976-01-14 | 1978-06-06 | Celanese Corporation | Process for making porous metal containing powder coating compositions |
| US4063064A (en) * | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
| US4079038A (en) * | 1976-03-05 | 1978-03-14 | Alza Corporation | Poly(carbonates) |
| US4066747A (en) * | 1976-04-08 | 1978-01-03 | Alza Corporation | Polymeric orthoesters housing beneficial drug for controlled release therefrom |
| US4070347A (en) * | 1976-08-16 | 1978-01-24 | Alza Corporation | Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality |
| US4189571A (en) * | 1978-02-07 | 1980-02-19 | Fisons Limited | Esters of cromoglycates |
| US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
| US4285987A (en) * | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
| FR2476087A1 (fr) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
| JPS57193489A (en) * | 1981-05-21 | 1982-11-27 | Fujisawa Pharmaceut Co Ltd | Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation |
| US4434153A (en) * | 1982-03-22 | 1984-02-28 | Alza Corporation | Drug delivery system comprising a reservoir containing a plurality of tiny pills |
| US4421736A (en) * | 1982-05-20 | 1983-12-20 | Merrel Dow Pharmaceuticals Inc. | Sustained release diethylpropion compositions |
| US4721613A (en) * | 1982-12-13 | 1988-01-26 | Alza Corporation | Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use |
| US4760057A (en) | 1983-06-23 | 1988-07-26 | Merck & Co., Inc. | (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
| DE3475065D1 (en) * | 1983-06-23 | 1988-12-15 | Merck & Co Inc | (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives |
| EP0136893B1 (en) * | 1983-10-05 | 1989-08-16 | Merck Frosst Canada Inc. | Benzo[a]phenothiazines and hydro-derivatives and pharmaceutical compositions containing them |
| DE3484745D1 (de) * | 1983-10-05 | 1991-08-01 | Merck Frosst Canada Inc | Inhibitoren fuer die leukotrien-biosynthese. |
| US4611056A (en) * | 1983-10-05 | 1986-09-09 | Merck Frosst Canada, Inc. | Benzo[A]phenothiazines and hydro-derivatives |
| US4916230A (en) * | 1984-07-02 | 1990-04-10 | Merck & Co., Inc. | Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs |
| US5051448A (en) * | 1984-07-24 | 1991-09-24 | The Mclean Hospital Corporation | GABA esters and GABA analog esters |
| US4820523A (en) * | 1986-04-15 | 1989-04-11 | Warner-Lambert Company | Pharmaceutical composition |
| US4752470A (en) * | 1986-11-24 | 1988-06-21 | Mehta Atul M | Controlled release indomethacin |
| IL87710A (en) * | 1987-09-18 | 1992-06-21 | Ciba Geigy Ag | Covered floating retard form for controlled release in gastric juice |
| US4816263A (en) * | 1987-10-02 | 1989-03-28 | Alza Corporation | Dosage form for treating cardiovascular diseases comprising isradipine |
| US4853229A (en) * | 1987-10-26 | 1989-08-01 | Alza Corporation | Method for adminstering tiny pills |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| PH26730A (en) * | 1988-12-30 | 1992-09-28 | Ciba Geigy Ag | Coated adhesive tablets |
| DE3928183A1 (de) | 1989-08-25 | 1991-02-28 | Goedecke Ag | Lactamfreie cyclische aminosaeuren |
| US5084169A (en) * | 1989-09-19 | 1992-01-28 | The University Of Colorado Foundation, Inc. | Stationary magnetically stabilized fluidized bed for protein separation and purification |
| US5084479A (en) * | 1990-01-02 | 1992-01-28 | Warner-Lambert Company | Novel methods for treating neurodegenerative diseases |
| GB9001405D0 (en) * | 1990-01-22 | 1990-03-21 | Leo Pharm Prod Ltd | New intermediates,their production and use |
| EP0458751A1 (en) * | 1990-05-25 | 1991-11-27 | Warner-Lambert Company | Delivery system for cyclic amino acids with improved taste, texture and compressibility |
| JPH04103574A (ja) * | 1990-08-22 | 1992-04-06 | Kumiai Chem Ind Co Ltd | ピリミジン誘導体及び除草剤 |
| US5827819A (en) * | 1990-11-01 | 1998-10-27 | Oregon Health Sciences University | Covalent polar lipid conjugates with neurologically active compounds for targeting |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| AU9137091A (en) | 1990-11-27 | 1992-06-25 | Northwestern University | Gaba and l-glutamic acid analogs for antiseizure treatment |
| TW209174B (https=) * | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| GB9204918D0 (en) | 1992-03-06 | 1992-04-22 | Nycomed As | Chemical compounds |
| HU222776B1 (hu) | 1992-05-20 | 2003-10-28 | Northwestern University | (S)-(+)-4-amino-3-(2-metil-propil)-butánsav előállításának új hexánsav- és butándisav-származék köztitermékei és ezek előállítása |
| EP0647133A4 (en) | 1992-06-12 | 1997-10-29 | Affymax Tech Nv | COMPOSITIONS AND METHODS FOR IMPROVED DRUG DELIVERY. |
| EP0723545B1 (en) | 1993-10-14 | 2002-05-08 | Abbott Laboratories | Quinolizinone type compounds |
| ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| US5466811A (en) | 1994-07-18 | 1995-11-14 | Merck & Co., Inc. | Dioxolenylmethyl carbamates pro moieties for amine drugs |
| US5684018A (en) * | 1994-12-13 | 1997-11-04 | Merck & Co., Inc. | Acyloxyisopropyl carbamates as prodrugs for amine drugs |
| US5672584A (en) * | 1995-04-25 | 1997-09-30 | The University Of Kansas | Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability |
| WO1996038435A1 (en) | 1995-05-30 | 1996-12-05 | Abbott Laboratories | Dopamine agonists |
| US5929088A (en) | 1996-02-07 | 1999-07-27 | Warner-Lambert Company | Cyclic amino acids as pharmaceutical agents |
| UA49011C2 (uk) * | 1996-03-14 | 2002-09-16 | Варнер-Ламберт Компані | Похідні циклічної амінокислоти, фармацевтична композиція та спосіб лікування |
| US6020370A (en) * | 1996-03-14 | 2000-02-01 | Warner-Lambert Company | Bridged cyclic amino acids as pharmaceutical agents |
| PL189872B1 (pl) * | 1996-07-24 | 2005-10-31 | Warner Lambert Co | Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu |
| EE9900036A (et) | 1996-07-30 | 1999-08-16 | Arris Pharmaceutical Corporation | Uued ühendid ja kompositsioonid trüptaasi aktiivsusega seotud haiguste raviks |
| US5962473A (en) | 1996-08-16 | 1999-10-05 | Eli Lilly And Company | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F |
| US6375987B1 (en) * | 1996-10-01 | 2002-04-23 | Gattefossé, S.A. | Process for the manufacture of pharmaceutical composition with modified release of active principle comprising the matrix |
| WO1998017627A1 (en) | 1996-10-23 | 1998-04-30 | Warner-Lambert Company | Substituted gamma aminobutyric acids as pharmaceutical agents |
| EP1007037A4 (en) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | ANTITHROMBOTIC AGENTS |
| WO1999008670A1 (en) | 1997-08-20 | 1999-02-25 | Guglietta, Antonio | Gaba analogs to prevent and treat gastrointestinal damage |
| US6127418A (en) * | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
| US6740682B2 (en) * | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| HUP0004310A3 (en) | 1997-10-27 | 2001-11-28 | Warner Lambert Co | Cyclic amino acids, and derivatives thereof and pharmaceutical compositions comprising the said compounds as active agents |
| DK1045839T3 (da) | 1997-12-16 | 2004-07-05 | Warner Lambert Co | Hidtil ukendte aminer som farmaceutiske midler |
| NZ503980A (en) | 1997-12-16 | 2002-09-27 | Warner Lambert Co | 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (= gabapentin analogues), pharmaceuticals thereof, and their use in the treatment of neurological disorders |
| US6518289B1 (en) | 1997-12-16 | 2003-02-11 | Pfizer, Inc. | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
| AU2463099A (en) | 1998-01-23 | 1999-08-09 | Warner-Lambert Company | Gabapentin and its derivatives for the treatment of muscular and skeletal pain |
| EP1082306A1 (en) | 1998-05-26 | 2001-03-14 | Warner-Lambert Company | Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel |
| FR2779651B1 (fr) * | 1998-06-16 | 2001-04-20 | Gattefosse Ets Sa | Procede pour la fabrication de comprimes a liberation prolongee de principe(s) actif(s) presentant une cinetique de dissolution d'ordre zero |
| US6171615B1 (en) * | 1998-07-06 | 2001-01-09 | Gattefoss{acute over (e)} | Sustained release theophylline formulations, excipient systems and methods of production |
| WO2000015611A1 (en) | 1998-09-14 | 2000-03-23 | Warner-Lambert Company | Branched alkyl pyrrolidine-3-carboxylic acids |
| EP1121114B1 (en) | 1998-10-16 | 2007-01-10 | Warner-Lambert Company Llc | Use of gaba analogs for the manufacture of a medicament for the treatment of mania and bipolar disorders |
| CO5210925A1 (es) * | 1998-11-17 | 2002-10-30 | Novartis Ag | Derivados de diamino nitroguanidina tetrasustituidos |
| AU1602100A (en) | 1998-11-25 | 2000-06-13 | Warner-Lambert Company | Improved gamma amino butyric acid analogs |
| EP1031350A1 (en) | 1999-02-23 | 2000-08-30 | Warner-Lambert Company | Use of a gabapentin-analog for the manufacture of a medicament for preventing and treating visceral pain |
| EP1180102B9 (en) | 1999-05-27 | 2005-03-02 | Pfizer Products Inc. | Mutual prodrugs of amlodipine and atorvastatin |
| RS50352B (sr) * | 1999-06-10 | 2009-11-10 | Warner-Lambert Company Llc., | Monosupstituisane 3-propil gama-aminobuterne kiseline |
| HN2000000224A (es) * | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| ATE308510T1 (de) | 1999-12-08 | 2005-11-15 | Warner Lambert Co | Inhibitore der verzweigte-aminosäure-abhängigen aminotransferase und deren verwendung in der behandlung der zuckerkranke retinopathie |
| MXPA02007252A (es) | 2000-01-28 | 2003-01-29 | Rohm & Haas | Compuestos farmaceuticos con propiedades mejoradas. |
| AU2001243253A1 (en) | 2000-02-24 | 2001-09-03 | Biocryst Pharmaceuticals, Inc. | Prodrugs of substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
| IL152701A0 (en) | 2000-05-25 | 2003-06-24 | Hoffmann La Roche | Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists |
| GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
| PL359872A1 (en) | 2000-06-26 | 2004-09-06 | Warner-Lambert Company | Gabapentin analogues for sleep disorders |
| AU2001268951A1 (en) | 2000-07-07 | 2002-01-21 | Novo-Nordisk A/S | Modulators of protein tyrosine phosphatases (ptpases) |
| ATE321052T1 (de) | 2000-07-07 | 2006-04-15 | Novo Nordisk As | Modulatoren von protein tyrosin phosphatasen (ptpasen) |
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| GB2365425A (en) * | 2000-08-01 | 2002-02-20 | Parke Davis & Co Ltd | Alkyl amino acid derivatives useful as pharmaceutical agents |
| DZ3415A1 (fr) | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
| WO2002044324A2 (en) | 2000-10-06 | 2002-06-06 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| AU2002211863A1 (en) * | 2000-10-06 | 2002-04-15 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| AU2002230398A1 (en) | 2000-10-06 | 2002-04-29 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| CA2426430C (en) | 2000-10-20 | 2014-10-07 | Biocryst Pharmaceuticals, Inc. | Biaryl compounds as serine protease inhibitors |
| US6683112B2 (en) * | 2000-10-24 | 2004-01-27 | Andrx Corporation | Gabapentin prodrugs and formulations |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| WO2002042414A2 (en) * | 2000-11-17 | 2002-05-30 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| WO2002062766A2 (en) * | 2001-02-07 | 2002-08-15 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| MXPA03011096A (es) | 2001-05-29 | 2004-12-06 | Depomed Dev Ltd | Metodo para el tratamiento de la enfermedad de reflujo gastroesofagico y la saturacion acida nocturna. |
| CA2449729C (en) | 2001-06-11 | 2009-11-03 | Xenoport, Inc. | Prodrugs of gaba analogs, compositions and uses thereof |
| US6818787B2 (en) * | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| GB0115517D0 (en) | 2001-06-25 | 2001-08-15 | Ferring Bv | Novel antidiabetic agents |
| RU2325152C2 (ru) | 2001-07-04 | 2008-05-27 | Сан Фармасьютикл Индастриз Лимитид | Удерживаемая в желудке система регулируемой доставки лекарственного средства |
| EP2329826A1 (en) | 2001-07-13 | 2011-06-08 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of multiple sclerosis |
| US7053076B2 (en) * | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| US6723340B2 (en) * | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
| US20030158254A1 (en) * | 2002-01-24 | 2003-08-21 | Xenoport, Inc. | Engineering absorption of therapeutic compounds via colonic transporters |
| AU2002316231A1 (en) * | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| WO2005098444A2 (en) * | 2003-07-03 | 2005-10-20 | Xenoport, Inc. | Monocarboxylate transporters expressed in cancer cells |
| WO2005121787A2 (en) * | 2004-06-04 | 2005-12-22 | Xenoport, Inc. | Lat1 transporters expressed in cancer cells |
| TW200616604A (en) * | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
-
2002
- 2002-06-11 CA CA002449729A patent/CA2449729C/en not_active Expired - Lifetime
- 2002-06-11 JP JP2003503214A patent/JP2004534057A/ja active Pending
- 2002-06-11 EP EP02737485A patent/EP1404310A4/en not_active Withdrawn
- 2002-06-11 DE DE60223923T patent/DE60223923T3/de not_active Expired - Lifetime
- 2002-06-11 KR KR10-2003-7016204A patent/KR20040016882A/ko not_active Ceased
- 2002-06-11 HU HU0400183A patent/HUP0400183A2/hu unknown
- 2002-06-11 WO PCT/US2002/018689 patent/WO2002100347A2/en not_active Ceased
- 2002-06-11 EP EP07020763A patent/EP1902714B1/en not_active Expired - Lifetime
- 2002-06-11 AU AU2002345664A patent/AU2002345664C1/en not_active Ceased
- 2002-06-11 JP JP2003516067A patent/JP4216713B2/ja not_active Expired - Lifetime
- 2002-06-11 CN CNA028145836A patent/CN1533270A/zh active Pending
- 2002-06-11 MX MXPA03011565A patent/MXPA03011565A/es active IP Right Grant
- 2002-06-11 KR KR1020037016230A patent/KR100926921B1/ko not_active Expired - Lifetime
- 2002-06-11 MX MXPA03011566A patent/MXPA03011566A/es active IP Right Grant
- 2002-06-11 IL IL15929902A patent/IL159299A0/xx unknown
- 2002-06-11 AT AT07020763T patent/ATE540678T1/de active
- 2002-06-11 HU HU0400167A patent/HUP0400167A3/hu not_active Application Discontinuation
- 2002-06-11 IL IL15930002A patent/IL159300A0/xx unknown
- 2002-06-11 KR KR1020097022012A patent/KR20090121404A/ko not_active Ceased
- 2002-06-11 US US10/170,127 patent/US6833140B2/en not_active Expired - Lifetime
- 2002-06-11 EP EP09003173A patent/EP2085087A1/en not_active Withdrawn
- 2002-06-11 NZ NZ567711A patent/NZ567711A/en unknown
- 2002-06-11 CA CA002449673A patent/CA2449673A1/en not_active Abandoned
- 2002-06-11 ES ES07020763T patent/ES2380287T3/es not_active Expired - Lifetime
- 2002-06-11 ES ES02744314T patent/ES2296956T5/es not_active Expired - Lifetime
- 2002-06-11 KR KR1020097001793A patent/KR100958552B1/ko not_active Expired - Lifetime
- 2002-06-11 WO PCT/US2002/018701 patent/WO2002100392A1/en not_active Ceased
- 2002-06-11 PT PT02744314T patent/PT1404324E/pt unknown
- 2002-06-11 KR KR1020077024007A patent/KR20070108282A/ko not_active Ceased
- 2002-06-11 DK DK02744314.2T patent/DK1404324T4/da active
- 2002-06-11 AU AU2002310409A patent/AU2002310409C1/en not_active Ceased
- 2002-06-11 EP EP02744314A patent/EP1404324B2/en not_active Expired - Lifetime
- 2002-06-11 AT AT02744314T patent/ATE380029T1/de active
-
2003
- 2003-12-09 NO NO20035473A patent/NO20035473D0/no not_active Application Discontinuation
- 2003-12-09 NO NO20035474A patent/NO333756B1/no not_active IP Right Cessation
- 2003-12-10 IL IL159300A patent/IL159300A/en active IP Right Grant
- 2003-12-12 ZA ZA2003/09679A patent/ZA200309679B/en unknown
-
2004
- 2004-04-21 US US10/829,896 patent/US20040198820A1/en not_active Abandoned
-
2007
- 2007-07-19 AU AU2007203364A patent/AU2007203364B2/en not_active Ceased
-
2008
- 2008-02-25 CY CY20081100218T patent/CY1107894T1/el unknown
- 2008-06-30 JP JP2008171250A patent/JP2009051822A/ja not_active Withdrawn
- 2008-06-30 JP JP2008171589A patent/JP5001227B2/ja not_active Expired - Lifetime
- 2008-09-16 NO NO20083958A patent/NO20083958L/no not_active Application Discontinuation
- 2008-09-16 NO NO20083956A patent/NO20083956L/no not_active Application Discontinuation
- 2008-09-17 AU AU2008221505A patent/AU2008221505C1/en not_active Ceased
-
2009
- 2009-03-26 IL IL197843A patent/IL197843A/en active IP Right Grant
-
2011
- 2011-06-19 IL IL213649A patent/IL213649A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004536873A5 (https=) | ||
| CN102498112B (zh) | 制备氮杂二环化合物的方法 | |
| RU2315772C2 (ru) | Производные пептидов, содержащие тиазепиновую группу, для лечения гиперлипемических состояний | |
| US20240043421A1 (en) | Amino acid compounds and methods of use | |
| WO1995019961A1 (en) | Metalloproteinase inhibitors | |
| JPH05501864A (ja) | 化合物 | |
| WO2000015603A1 (en) | Benzene derivatives and medicinal use thereof | |
| PT749418E (pt) | Derivados de l-n6-(1-iminoetil)lisina uteis como inibidores de oxido nitrico sintetase | |
| KR20090118994A (ko) | 하부요로증상을 치료하기 위한 알파-2-델타 리간드 | |
| US9403793B2 (en) | Compositions and methods for the treatment of moderate to severe pain | |
| SK285994B6 (sk) | Substituované aminoderiváty 3-amino-1-fenyl-1H-1,2,4-triazolu, spôsob ich prípravy a farmaceutické prostriedky, ktoré ich obsahujú | |
| JPH0676377B2 (ja) | 脳保護剤 | |
| JP2015527309A (ja) | 中等度から重度の疼痛の治療のための組成物及び方法 | |
| CA3043445C (en) | Compositions and methods for the treatment of gastrointestinal polyps | |
| CA3129677C (en) | Compounds and compositions comprising the same for treating hypertension or heart failure | |
| US20060094664A1 (en) | Deoxycholic acid derivatives for the treatment of acute dysfunctions of portal and hepatic venous circulation | |
| JPH0692948A (ja) | 新規なアセタミド誘導体及びその用途 | |
| JP2010241835A (ja) | 内臓の機能的運動障害におけるアシルアミノアルケニレン−アミド誘導体の使用 | |
| JP2589245B2 (ja) | N−(3−アルキル(またはアルケニル)−4−ヒドロキシベンゾイル)グリシン亜鉛錯体 | |
| HUT61573A (en) | Process for producing n-phenyl-n-alkoxycarbonyl alkyl glycineamides and pharmaceutical compositions comprising same | |
| JP2006516588A5 (https=) | ||
| CN101316599A (zh) | 抑制nkt细胞的机能的糖脂衍生物作为有效成分的治疗剂 | |
| JP2007530594A (ja) | 炎症及び免疫に関連する用途に用いられるアクリロニトリル誘導体 | |
| JP2758041B2 (ja) | シクロヘキサジエノン誘導体 | |
| EP3256459A1 (en) | Compositions and methods for the treatment of mucositis |