JP2004536072A5 - - Google Patents
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- JP2004536072A5 JP2004536072A5 JP2002592967A JP2002592967A JP2004536072A5 JP 2004536072 A5 JP2004536072 A5 JP 2004536072A5 JP 2002592967 A JP2002592967 A JP 2002592967A JP 2002592967 A JP2002592967 A JP 2002592967A JP 2004536072 A5 JP2004536072 A5 JP 2004536072A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- agent
- pharmaceutical composition
- hngf
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003795 chemical substances by application Substances 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 230000004968 inflammatory condition Effects 0.000 claims 10
- 206010003246 arthritis Diseases 0.000 claims 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 6
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 6
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 6
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 201000004681 Psoriasis Diseases 0.000 claims 5
- 208000006673 asthma Diseases 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- 101100404651 Mus musculus Ngf gene Proteins 0.000 claims 2
- 101150111783 NTRK1 gene Proteins 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 102000057041 human TNF Human genes 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 1
- 108091008604 NGF receptors Proteins 0.000 claims 1
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000046917 human NGF Human genes 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29439201P | 2001-05-30 | 2001-05-30 | |
| PCT/US2002/015284 WO2002096458A1 (en) | 2001-05-30 | 2002-05-09 | Anti-ngf antibodies for the treatment of various disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009211917A Division JP5761902B2 (ja) | 2001-05-30 | 2009-09-14 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004536072A JP2004536072A (ja) | 2004-12-02 |
| JP2004536072A5 true JP2004536072A5 (cg-RX-API-DMAC7.html) | 2005-12-22 |
| JP4567944B2 JP4567944B2 (ja) | 2010-10-27 |
Family
ID=23133215
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592967A Expired - Lifetime JP4567944B2 (ja) | 2001-05-30 | 2002-05-09 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2009211917A Expired - Lifetime JP5761902B2 (ja) | 2001-05-30 | 2009-09-14 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2013025893A Withdrawn JP2013139453A (ja) | 2001-05-30 | 2013-02-13 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2014215231A Pending JP2015061840A (ja) | 2001-05-30 | 2014-10-22 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2016079748A Expired - Lifetime JP6271631B2 (ja) | 2001-05-30 | 2016-04-12 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009211917A Expired - Lifetime JP5761902B2 (ja) | 2001-05-30 | 2009-09-14 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2013025893A Withdrawn JP2013139453A (ja) | 2001-05-30 | 2013-02-13 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2014215231A Pending JP2015061840A (ja) | 2001-05-30 | 2014-10-22 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
| JP2016079748A Expired - Lifetime JP6271631B2 (ja) | 2001-05-30 | 2016-04-12 | 種々の疾患の治療のための抗−ｎｇｆ抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US7727527B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1401498B1 (cg-RX-API-DMAC7.html) |
| JP (5) | JP4567944B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR20040049829A (cg-RX-API-DMAC7.html) |
| CN (2) | CN1684708A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE522229T1 (cg-RX-API-DMAC7.html) |
| AU (7) | AU2002308722B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR0210231A (cg-RX-API-DMAC7.html) |
| CA (2) | CA2975521A1 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1112425T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK1401498T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2371748T3 (cg-RX-API-DMAC7.html) |
| IL (2) | IL158921A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA03010911A (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ544410A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1401498E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2002096458A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200308999B (cg-RX-API-DMAC7.html) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1684708A (zh) * | 2001-05-30 | 2005-10-19 | 基因技术股份有限公司 | 抗ngf抗体用于治疗各种疾病 |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
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| AU2003304238A1 (en) | 2002-10-08 | 2005-01-13 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| AU2011201157C1 (en) * | 2002-12-24 | 2017-09-07 | Rinat Neuroscience Corp. | Anti-NGF antibodies and methods using same |
| SI2263692T1 (sl) * | 2002-12-24 | 2020-10-30 | Rinat Neuroscience Corp. | Anti-NGF protitelesa in postopki, v katerih se le-ta uporabljajo |
| US7569364B2 (en) | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| KR20050111598A (ko) * | 2003-02-19 | 2005-11-25 | 리나트 뉴로사이언스 코퍼레이션 | 신경 성장 인자 길항제 및 ｎｓａｉｄ를 투여함으로써통증을 치료하는 방법 및 그것을 함유하는 조성물 |
| CN102358903B (zh) * | 2003-07-15 | 2017-04-26 | 安姆根有限公司 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
| KR100894191B1 (ko) | 2003-07-15 | 2009-04-22 | 암젠 인코포레이티드 | 선택적인 ｎｇｆ 경로 저해제로서의 인체 항-ｎｇｆ 중화 항체 및 이 항체를 포함하는 약학적 조성물 |
| ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| DK2206728T3 (en) * | 2004-04-07 | 2018-04-23 | Rinat Neuroscience Corp | METHODS OF TREATING BONE CANCER PAIN BY SUBMITTING A NERVOUS FACTOR-ANTAGONISTIC ANTIBODY |
| ME00226B (me) | 2004-07-15 | 2011-02-10 | Medarex Llc | Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade |
| RU2406728C2 (ru) * | 2005-01-24 | 2010-12-20 | Медиммун Лимитэд | Партнеры специфического связывания с ngf |
| ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| EP1857146A1 (en) * | 2006-05-16 | 2007-11-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Treatment of respiratory disorders |
| CA2678451A1 (en) | 2007-02-20 | 2008-08-28 | Robert A. Horlick | Somatic hypermutation systems |
| US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
| US7988967B2 (en) | 2007-08-10 | 2011-08-02 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human nerve growth factor |
| AU2008337100B2 (en) * | 2007-12-17 | 2013-02-28 | Pfizer Limited | Treatment of interstitial cystitis |
| SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| PE20100054A1 (es) | 2008-06-03 | 2010-03-03 | Abbott Lab | Inmunoglobulina con dominio variable dual |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
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| CN102224153B (zh) | 2008-09-22 | 2014-04-30 | 阵列生物制药公司 | 作为trk激酶抑制剂的取代的咪唑并[1，2-b]哒嗪化合物 |
| LT3106463T (lt) | 2008-10-22 | 2018-06-25 | Array Biopharma, Inc. | Pakeistieji pirazolo[1,5-]pirimidino junginiai kaip trk kinazės slopikliai |
| BRPI1012195A2 (pt) * | 2009-05-01 | 2018-04-24 | Abbott Lab | imunoglobulinas de domínio variável duplo e usos das mesmas |
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| NZ598929A (en) * | 2009-09-01 | 2014-05-30 | Abbvie Inc | Dual variable domain immunoglobulins and uses thereof |
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| PH12012501761A1 (en) | 2010-03-17 | 2012-11-12 | Abbott Res Bv | Anti-nerve growth factor (ngf) antibody compositions |
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| PT3333188T (pt) | 2010-08-19 | 2022-03-28 | Zoetis Belgium S A | Anticorpos de anti-ngf e a sua utilização |
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| BR112014015851A2 (pt) | 2011-12-30 | 2019-09-24 | Abbvie Inc | proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17 |
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| BR112015009961B1 (pt) | 2012-11-01 | 2020-10-20 | Abbvie Inc. | proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende |
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| CA2938066C (en) | 2014-02-02 | 2025-05-06 | Medimmune Limited | CHIMERIC PROTEIN COMPOSED OF NERVE GROWTH FACTOR ANTAGONIST DOMAIN AND TUMOR NECROSIS FACTOR-ANTAGONIST DOMAIN-A |
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| CN108743568B (zh) * | 2018-06-05 | 2021-09-07 | 桂林医学院附属医院 | 用于降低气道高反应性的抗ngf抗体缓释微球及制备方法 |
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| UA80447C2 (en) * | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| KR20050111598A (ko) * | 2003-02-19 | 2005-11-25 | 리나트 뉴로사이언스 코퍼레이션 | 신경 성장 인자 길항제 및 ｎｓａｉｄ를 투여함으로써통증을 치료하는 방법 및 그것을 함유하는 조성물 |
| DK2206728T3 (en) * | 2004-04-07 | 2018-04-23 | Rinat Neuroscience Corp | METHODS OF TREATING BONE CANCER PAIN BY SUBMITTING A NERVOUS FACTOR-ANTAGONISTIC ANTIBODY |
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2002
- 2002-05-09 CN CNA028149920A patent/CN1684708A/zh active Pending
- 2002-05-09 KR KR10-2003-7015659A patent/KR20040049829A/ko not_active Ceased
- 2002-05-09 IL IL15892102A patent/IL158921A0/xx unknown
- 2002-05-09 EP EP02774103A patent/EP1401498B1/en not_active Revoked
- 2002-05-09 ES ES02774103T patent/ES2371748T3/es not_active Expired - Lifetime
- 2002-05-09 KR KR1020087027819A patent/KR101004353B1/ko not_active Expired - Lifetime
- 2002-05-09 EP EP10010557A patent/EP2340849A1/en not_active Ceased
- 2002-05-09 PT PT02774103T patent/PT1401498E/pt unknown
- 2002-05-09 NZ NZ544410A patent/NZ544410A/en not_active IP Right Cessation
- 2002-05-09 CN CN200910171008A patent/CN101653604A/zh active Pending
- 2002-05-09 AU AU2002308722A patent/AU2002308722B2/en not_active Expired
- 2002-05-09 WO PCT/US2002/015284 patent/WO2002096458A1/en not_active Ceased
- 2002-05-09 BR BR0210231-5A patent/BR0210231A/pt not_active Application Discontinuation
- 2002-05-09 CA CA2975521A patent/CA2975521A1/en not_active Abandoned
- 2002-05-09 KR KR1020107027004A patent/KR20100132559A/ko not_active Withdrawn
- 2002-05-09 JP JP2002592967A patent/JP4567944B2/ja not_active Expired - Lifetime
- 2002-05-09 CA CA2448956A patent/CA2448956C/en not_active Expired - Lifetime
- 2002-05-09 MX MXPA03010911A patent/MXPA03010911A/es not_active Application Discontinuation
- 2002-05-09 US US10/479,872 patent/US7727527B2/en not_active Expired - Lifetime
- 2002-05-09 DK DK02774103.2T patent/DK1401498T3/da active
- 2002-05-09 AT AT02774103T patent/ATE522229T1/de active
- 2002-05-09 NZ NZ529612A patent/NZ529612A/xx not_active IP Right Cessation
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2003
- 2003-11-18 IL IL158921A patent/IL158921A/en active IP Right Grant
- 2003-11-19 ZA ZA2003/08999A patent/ZA200308999B/en unknown
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2007
- 2007-08-16 AU AU2007207881A patent/AU2007207881B2/en not_active Expired
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2009
- 2009-09-14 JP JP2009211917A patent/JP5761902B2/ja not_active Expired - Lifetime
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2010
- 2010-01-15 AU AU2010200170A patent/AU2010200170B2/en not_active Expired
- 2010-04-06 US US12/755,279 patent/US20100254990A1/en not_active Abandoned
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2011
- 2011-04-19 US US13/090,048 patent/US20110268725A1/en not_active Abandoned
- 2011-11-28 CY CY20111101167T patent/CY1112425T1/el unknown
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2012
- 2012-09-06 US US13/605,722 patent/US20130004495A1/en not_active Abandoned
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2013
- 2013-02-13 JP JP2013025893A patent/JP2013139453A/ja not_active Withdrawn
- 2013-10-10 AU AU2013242812A patent/AU2013242812A1/en not_active Abandoned
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2014
- 2014-03-24 US US14/223,881 patent/US20140294829A1/en not_active Abandoned
- 2014-10-22 JP JP2014215231A patent/JP2015061840A/ja active Pending
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2016
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- 2016-11-03 AU AU2016253605A patent/AU2016253605A1/en not_active Abandoned
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2018
- 2018-06-04 AU AU2018203920A patent/AU2018203920A1/en not_active Abandoned
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2020
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- 2020-05-12 AU AU2020203115A patent/AU2020203115A1/en not_active Abandoned
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