JP2005506331A5 - - Google Patents
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- Publication number
- JP2005506331A5 JP2005506331A5 JP2003530327A JP2003530327A JP2005506331A5 JP 2005506331 A5 JP2005506331 A5 JP 2005506331A5 JP 2003530327 A JP2003530327 A JP 2003530327A JP 2003530327 A JP2003530327 A JP 2003530327A JP 2005506331 A5 JP2005506331 A5 JP 2005506331A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- use according
- aglycosylated
- origin
- rat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 11
- 206010003246 arthritis Diseases 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 231100000673 dose–response relationship Toxicity 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000009885 systemic effect Effects 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 125000002345 steroid group Chemical group 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 201000004595 synovitis Diseases 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0123156A GB2380127A (en) | 2001-09-26 | 2001-09-26 | Treatment of chronic joint inflammation |
| GB0123156.2 | 2001-09-26 | ||
| PCT/GB2002/004358 WO2003026692A2 (en) | 2001-09-26 | 2002-09-26 | Treatment of chronic joint inflammation using an antibody against the cd3 antigen complex |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005506331A JP2005506331A (ja) | 2005-03-03 |
| JP2005506331A5 true JP2005506331A5 (cg-RX-API-DMAC7.html) | 2007-08-02 |
| JP4694784B2 JP4694784B2 (ja) | 2011-06-08 |
Family
ID=9922741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530327A Expired - Fee Related JP4694784B2 (ja) | 2001-09-26 | 2002-09-26 | 慢性関節炎の処置 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050037004A1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2199307B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4694784B2 (cg-RX-API-DMAC7.html) |
| AU (2) | AU2002329423B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2461714C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60217698T2 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2279884T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2380127A (cg-RX-API-DMAC7.html) |
| PT (1) | PT1432445E (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003026692A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
| US6660948B2 (en) * | 2001-02-28 | 2003-12-09 | Vip Investments Ltd. | Switch matrix |
| BRPI0308585B8 (pt) | 2002-03-13 | 2021-05-25 | Biogen Idec Inc | anticorpo isolado ou fragmento de ligação a antígeno do mesmo que se liga à alfavbeta6, composição, método de detecção in vitro de alfavbeta6 e construção de dna |
| CN1871259A (zh) * | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
| US7883703B2 (en) * | 2003-11-14 | 2011-02-08 | The Brigham And Women's Hospital, Inc. | Methods of modulating immunity |
| CN1972714B (zh) * | 2004-04-06 | 2012-10-03 | 诺夫免疫股份有限公司 | 治疗自身免疫疾病和炎性疾病的方法 |
| BRPI0511782B8 (pt) | 2004-06-03 | 2021-05-25 | Novimmune Sa | anticorpos anti-cd3, uso e método de produção dos mesmos, composição farmacêutica, molécula de ácido nucleico isolada e vetor |
| RU2271816C1 (ru) * | 2004-07-08 | 2006-03-20 | Григорий Менделевич Дубровин | Способ профилактики посттравматического остеоартроза |
| BRPI0513798A (pt) | 2004-07-26 | 2008-05-13 | Biogen Idec Inc | anticorpos anti-cd154 |
| US7740856B2 (en) | 2005-12-20 | 2010-06-22 | Isu Abxis Co., Ltd. | Effect of BST2 on inflammation |
| US8329186B2 (en) | 2004-12-20 | 2012-12-11 | Isu Abxis Co., Ltd | Treatment of inflammation using BST2 inhibitor |
| CN102875681A (zh) * | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| AU2006267090B2 (en) | 2005-07-11 | 2013-03-07 | Provention Bio, Inc. | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| WO2007117600A2 (en) * | 2006-04-07 | 2007-10-18 | Macrogenics, Inc. | Combination therapy for treating autoimmune diseases |
| JP2009544761A (ja) * | 2006-06-14 | 2009-12-17 | マクロジェニクス，インコーポレーテッド | 低毒性免疫抑制モノクローナル抗体を用いて自己免疫疾患を治療する方法 |
| US7927590B2 (en) | 2006-07-10 | 2011-04-19 | Biogen Idec Ma Inc. | Compositions and methods for inhibiting growth of smad4-deficient cancers |
| EP2170951A2 (en) * | 2007-05-31 | 2010-04-07 | Genmab A/S | Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering |
| WO2010132872A1 (en) * | 2009-05-15 | 2010-11-18 | Novimmune S.A | Combination therapies and methods using anti-cd3 modulating agents and anti-tnf antagonists |
| US20120269826A1 (en) * | 2009-10-20 | 2012-10-25 | Mckee Charlotte | Anti-cd3 antibody dosing in autoimmune disease |
| WO2014143739A2 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| US10035859B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
| TWI809286B (zh) | 2019-07-05 | 2023-07-21 | 日商小野藥品工業股份有限公司 | 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療 |
| JP2025509702A (ja) | 2022-03-14 | 2025-04-11 | ラムキャップ バイオ ガンマ エージー | ＧＰＣ３陽性悪性細胞を標的殺傷するための二重特異性ＧＰＣ３ｘＣＤ２８抗体およびＧＰＣ３ｘＣＤ３抗体ならびにそれらの組み合わせ |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5183657A (en) * | 1988-03-11 | 1993-02-02 | Celltech Limited | Antibodies for use in antilymphocyte antibody therapy |
| US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| DK0610447T3 (da) | 1991-10-15 | 1999-08-23 | Btg Int Ltd | CDw52-specifikt antistof til behandling af T-cellemedieret inflammation af leddene |
| GB9206422D0 (en) * | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
| US5834597A (en) * | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| SE510197C2 (sv) | 1997-02-06 | 1999-04-26 | Asea Brown Boveri | Förfarande och anordning för styrning av ett kondensatordon för en shuntkopplad statisk kompensatorenhet med deblockeringssignaler för indikering av icke strömförande tillstånd hos ingående ventiler |
| US5843597A (en) * | 1997-12-01 | 1998-12-01 | Eveready Battery Company, Inc. | Ribbed gasket for miniature galvanic cell |
| CA2224256C (en) * | 1997-12-09 | 2013-04-30 | I.N.S.E.R.M. | Method for treating established spontaneous auto-immune diseases in mammals |
| GB9815909D0 (en) * | 1998-07-21 | 1998-09-16 | Btg Int Ltd | Antibody preparation |
| US6939545B2 (en) * | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
| AUPQ431299A0 (en) * | 1999-11-26 | 1999-12-23 | Unisearch Limited | Method of inducing immune tolerance |
-
2001
- 2001-09-26 GB GB0123156A patent/GB2380127A/en not_active Withdrawn
-
2002
- 2002-09-26 JP JP2003530327A patent/JP4694784B2/ja not_active Expired - Fee Related
- 2002-09-26 EP EP10156934.1A patent/EP2199307B1/en not_active Expired - Lifetime
- 2002-09-26 CA CA2461714A patent/CA2461714C/en not_active Expired - Fee Related
- 2002-09-26 ES ES02765050T patent/ES2279884T3/es not_active Expired - Lifetime
- 2002-09-26 US US10/491,112 patent/US20050037004A1/en not_active Abandoned
- 2002-09-26 PT PT02765050T patent/PT1432445E/pt unknown
- 2002-09-26 DE DE60217698T patent/DE60217698T2/de not_active Expired - Lifetime
- 2002-09-26 AU AU2002329423A patent/AU2002329423B2/en not_active Ceased
- 2002-09-26 EP EP07000627A patent/EP1803466B1/en not_active Expired - Lifetime
- 2002-09-26 ES ES07000627T patent/ES2389781T3/es not_active Expired - Lifetime
- 2002-09-26 EP EP02765050A patent/EP1432445B1/en not_active Revoked
- 2002-09-26 WO PCT/GB2002/004358 patent/WO2003026692A2/en not_active Ceased
-
2008
- 2008-08-15 AU AU2008207338A patent/AU2008207338B2/en not_active Ceased
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