JP2018532693A5 - - Google Patents
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- Publication number
- JP2018532693A5 JP2018532693A5 JP2018506110A JP2018506110A JP2018532693A5 JP 2018532693 A5 JP2018532693 A5 JP 2018532693A5 JP 2018506110 A JP2018506110 A JP 2018506110A JP 2018506110 A JP2018506110 A JP 2018506110A JP 2018532693 A5 JP2018532693 A5 JP 2018532693A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- fragment
- insulin
- hypoglycemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 42
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 40
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 40
- 208000013016 Hypoglycemia Diseases 0.000 claims description 21
- 102000004877 Insulin Human genes 0.000 claims description 21
- 108090001061 Insulin Proteins 0.000 claims description 21
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 21
- 229940125396 insulin Drugs 0.000 claims description 21
- 102000003746 Insulin Receptor Human genes 0.000 claims description 20
- 108010001127 Insulin Receptor Proteins 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 12
- 239000012634 fragment Substances 0.000 claims description 11
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000000422 nocturnal effect Effects 0.000 claims description 4
- 102000051325 Glucagon Human genes 0.000 claims description 3
- 108060003199 Glucagon Proteins 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims description 3
- 229960004666 glucagon Drugs 0.000 claims description 3
- 206010022489 Insulin Resistance Diseases 0.000 claims description 2
- 229940100389 Sulfonylurea Drugs 0.000 claims description 2
- 238000007681 bariatric surgery Methods 0.000 claims description 2
- 235000020805 dietary restrictions Nutrition 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 230000002503 metabolic effect Effects 0.000 claims description 2
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims description 2
- 150000001413 amino acids Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 description 30
- 125000003275 alpha amino acid group Chemical group 0.000 description 18
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 210000004153 islets of langerhan Anatomy 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000007781 signaling event Effects 0.000 description 2
- 206010060378 Hyperinsulinaemia Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000009766 cell sprouting Effects 0.000 description 1
- 230000006999 cognitive decline Effects 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
- 208000033066 hyperinsulinemic hypoglycemia Diseases 0.000 description 1
- 201000008980 hyperinsulinism Diseases 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562202143P | 2015-08-06 | 2015-08-06 | |
| US62/202,143 | 2015-08-06 | ||
| US201662280675P | 2016-01-19 | 2016-01-19 | |
| US62/280,675 | 2016-01-19 | ||
| PCT/US2016/045917 WO2017024285A2 (en) | 2015-08-06 | 2016-08-05 | Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018532693A JP2018532693A (ja) | 2018-11-08 |
| JP2018532693A5 true JP2018532693A5 (cg-RX-API-DMAC7.html) | 2019-09-12 |
Family
ID=56684310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506110A Pending JP2018532693A (ja) | 2015-08-06 | 2016-08-05 | インスリン受容体に対する抗体断片及び低血糖を治療するためのその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10253101B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3331562A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018532693A (cg-RX-API-DMAC7.html) |
| CN (1) | CN108136006A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016304588A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2994841A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1255271A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017024285A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3265491A1 (en) * | 2015-03-03 | 2018-01-10 | Xoma (Us) Llc | Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery |
| KR20200134213A (ko) * | 2018-01-23 | 2020-12-01 | 엑스에리스 파머수티클스, 인크. | 소 용량의 안정한 글루카곤을 사용한 베리아트릭 후 저혈당증의 치료 |
| JP2025517443A (ja) * | 2022-05-20 | 2025-06-05 | レゾリュート インコーポレイテッド | 抗インスリン受容体抗体のための製剤及びそれらの使用 |
| WO2024014953A1 (en) * | 2022-07-12 | 2024-01-18 | Resiliun B.V. | Treating conditions with hypoglycemia associated with hyperinsulinemia. |
| TW202508633A (zh) | 2023-08-24 | 2025-03-01 | 美商瑞澤路特有限公司 | 用於抗胰島素受體抗體之高濃度調配物及其用途 |
| WO2025171378A1 (en) | 2024-02-09 | 2025-08-14 | Rezolute, Inc. | Insulin receptor modulation for tumor associated hyperinsulinism |
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| EP3265491A1 (en) * | 2015-03-03 | 2018-01-10 | Xoma (Us) Llc | Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery |
-
2016
- 2016-08-05 CN CN201680049563.7A patent/CN108136006A/zh active Pending
- 2016-08-05 CA CA2994841A patent/CA2994841A1/en not_active Abandoned
- 2016-08-05 HK HK18114431.8A patent/HK1255271A1/zh unknown
- 2016-08-05 JP JP2018506110A patent/JP2018532693A/ja active Pending
- 2016-08-05 AU AU2016304588A patent/AU2016304588A1/en not_active Abandoned
- 2016-08-05 EP EP16751135.1A patent/EP3331562A2/en not_active Withdrawn
- 2016-08-05 US US15/230,340 patent/US10253101B2/en active Active
- 2016-08-05 WO PCT/US2016/045917 patent/WO2017024285A2/en not_active Ceased
-
2018
- 2018-02-15 US US15/897,852 patent/US20180251562A1/en not_active Abandoned
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