JP2018512402A5 - - Google Patents

Info

Publication number

JP2018512402A5

JP2018512402A5 JP2017548142A JP2017548142A JP2018512402A5 JP 2018512402 A5 JP2018512402 A5 JP 2018512402A5 JP 2017548142 A JP2017548142 A JP 2017548142A JP 2017548142 A JP2017548142 A JP 2017548142A JP 2018512402 A5 JP2018512402 A5 JP 2018512402A5

Authority

JP

Japan

Prior art keywords

immunoconjugate

immune complex

subject

seq

amino acid

Prior art date

2016-03-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 229940127121 immunoconjugate Drugs 0.000 claims 14
• 125000003275 alpha amino acid group Chemical group 0.000 claims 9
• 239000012634 fragment Substances 0.000 claims 5
• 206010005003 Bladder cancer Diseases 0.000 claims 4
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
• 102000023732 binding proteins Human genes 0.000 claims 3
• 108091008324 binding proteins Proteins 0.000 claims 3
• 239000003053 toxin Substances 0.000 claims 3
• 231100000765 toxin Toxicity 0.000 claims 3
• 108700012359 toxins Proteins 0.000 claims 3
• 201000005112 urinary bladder cancer Diseases 0.000 claims 3
• 208000009458 Carcinoma in Situ Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 201000004933 in situ carcinoma Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108010006654 Bleomycin Proteins 0.000 claims 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
• 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 102000014150 Interferons Human genes 0.000 claims 1
• 108010050904 Interferons Proteins 0.000 claims 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
• 238000002679 ablation Methods 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 229960001561 bleomycin Drugs 0.000 claims 1
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 1
• 229960004562 carboplatin Drugs 0.000 claims 1
• 190000008236 carboplatin Chemical compound 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
• 229960004316 cisplatin Drugs 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 229960002949 fluorouracil Drugs 0.000 claims 1
• 102000045551 human EPCAM Human genes 0.000 claims 1
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
• 229960001101 ifosfamide Drugs 0.000 claims 1
• 229940079322 interferon Drugs 0.000 claims 1
• 229960000485 methotrexate Drugs 0.000 claims 1
• 210000003205 muscle Anatomy 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000003439 radiotherapeutic effect Effects 0.000 claims 1
• 230000000717 retained effect Effects 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 230000003442 weekly effect Effects 0.000 claims 1