JP2004535414A5

JP2004535414A5 -

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Publication number: JP2004535414A5
Authority: JP; Japan
Prior art keywords: ylamino; pyrimidin; bromo; benzenesulfonamide; methyl
Prior art date: 2002-05-23
Legal status : Granted

Application number

JP2003500067A

Other languages

English (en)

Japanese (ja)

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JP2004535414A (ja

JP4291135B2 (ja

Filing date

2002-05-23

Publication date

2009-03-26

2001-05-29 Priority claimed from DE10127581A external-priority patent/DE10127581A1/de

2002-03-11 Priority claimed from DE10212098A external-priority patent/DE10212098A1/de

2002-05-23 Application filed filed Critical

2002-05-23 Priority claimed from PCT/EP2002/005669 external-priority patent/WO2002096888A1/de

2004-11-25 Publication of JP2004535414A publication Critical patent/JP2004535414A/ja

2009-03-26 Publication of JP2004535414A5 publication Critical patent/JP2004535414A5/ja

2009-07-08 Application granted granted Critical

2009-07-08 Publication of JP4291135B2 publication Critical patent/JP4291135B2/ja

2022-05-23 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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-1 hydroxy, hydroxy Chemical group 0.000 claims 24
150000001408 amides Chemical class 0.000 claims 7
125000000753 cycloalkyl group Chemical group 0.000 claims 6
239000000825 pharmaceutical preparation Substances 0.000 claims 5
206010028980 Neoplasm Diseases 0.000 claims 4
201000010099 disease Diseases 0.000 claims 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
230000004770 neurodegeneration Effects 0.000 claims 4
208000015122 neurodegenerative disease Diseases 0.000 claims 4
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
208000023275 Autoimmune disease Diseases 0.000 claims 3
208000024172 Cardiovascular disease Diseases 0.000 claims 3
208000036142 Viral infection Diseases 0.000 claims 3
230000001154 acute effect Effects 0.000 claims 3
125000000217 alkyl group Chemical group 0.000 claims 3
201000011510 cancer Diseases 0.000 claims 3
230000001684 chronic effect Effects 0.000 claims 3
150000001875 compounds Chemical class 0.000 claims 3
229910052736 halogen Inorganic materials 0.000 claims 3
150000002367 halogens Chemical class 0.000 claims 3
229910052739 hydrogen Inorganic materials 0.000 claims 3
150000002431 hydrogen Chemical group 0.000 claims 3
239000001257 hydrogen Substances 0.000 claims 3
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
208000015181 infectious disease Diseases 0.000 claims 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
230000009385 viral infection Effects 0.000 claims 3
XSPDIJHMXIOAAM-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2s)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonyl fluoride Chemical compound C1=C(Br)C(N[C@H](CO)C(C)C)=NC(NC=2C=C(C=CC=2)S(F)(=O)=O)=N1 XSPDIJHMXIOAAM-CYBMUJFWSA-N 0.000 claims 2
XGXLQYXQHKKNBW-UHFFFAOYSA-N 4-[[5-bromo-4-(cyclohexylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCCCC2)=N1 XGXLQYXQHKKNBW-UHFFFAOYSA-N 0.000 claims 2
SEKKALNTFPTFSU-UHFFFAOYSA-N 4-[[5-bromo-4-[(4-morpholin-4-ylcyclohexyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(CC2)N2CCOCC2)=N1 SEKKALNTFPTFSU-UHFFFAOYSA-N 0.000 claims 2
FGHMZQKPPMDGPL-HNNXBMFYSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-hydroxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCO)=N1 FGHMZQKPPMDGPL-HNNXBMFYSA-N 0.000 claims 2
CAEOUNLFYKBMQK-UHFFFAOYSA-N 4-[[5-bromo-4-[[4-(1,3-dihydroxypropan-2-ylamino)cyclohexyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(CC2)NC(CO)CO)=N1 CAEOUNLFYKBMQK-UHFFFAOYSA-N 0.000 claims 2
OBAVLVDITDFXPY-UHFFFAOYSA-N 4-[[5-bromo-4-[[4-(3-hydroxypyrrolidin-1-yl)cyclohexyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(CC2)N2CC(O)CC2)=N1 OBAVLVDITDFXPY-UHFFFAOYSA-N 0.000 claims 2
BWOHFZMMQXOIOB-UHFFFAOYSA-N 4-[[5-bromo-4-[[4-(cyclopropylamino)cyclohexyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(CC2)NC2CC2)=N1 BWOHFZMMQXOIOB-UHFFFAOYSA-N 0.000 claims 2
201000004384 Alopecia Diseases 0.000 claims 2
108091000080 Phosphotransferase Proteins 0.000 claims 2
231100000360 alopecia Toxicity 0.000 claims 2
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
125000004093 cyano group Chemical group *C#N 0.000 claims 2
238000009472 formulation Methods 0.000 claims 2
125000001072 heteroaryl group Chemical group 0.000 claims 2
239000003112 inhibitor Substances 0.000 claims 2
FKWGXFQRNHMIPY-UHFFFAOYSA-N methyl 6-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]hexanoate Chemical compound C1=C(Br)C(NCCCCCC(=O)OC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 FKWGXFQRNHMIPY-UHFFFAOYSA-N 0.000 claims 2
239000000203 mixture Substances 0.000 claims 2
102000020233 phosphotransferase Human genes 0.000 claims 2
125000001424 substituent group Chemical group 0.000 claims 2
NENICYIQLCYNII-AWEZNQCLSA-N (2r)-2-[[5-bromo-2-(3-methylsulfonylanilino)pyrimidin-4-yl]amino]-3-methylbutan-1-ol Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=C(C=CC=2)S(C)(=O)=O)=N1 NENICYIQLCYNII-AWEZNQCLSA-N 0.000 claims 1
OAOMNZDRBMUIIJ-AWEZNQCLSA-N (2r)-2-[[5-bromo-2-(4-methylsulfonylanilino)pyrimidin-4-yl]amino]-3-methylbutan-1-ol Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(C)(=O)=O)=N1 OAOMNZDRBMUIIJ-AWEZNQCLSA-N 0.000 claims 1
AFQIRVPDWCOXNF-GFCCVEGCSA-N (2r)-2-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]-3-methylbutanoic acid Chemical compound C1=C(Br)C(N[C@H](C(C)C)C(O)=O)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 AFQIRVPDWCOXNF-GFCCVEGCSA-N 0.000 claims 1
DMPLZVOZGQRKFY-HNNXBMFYSA-N (2r)-2-[[5-bromo-2-[3-(2-hydroxyethylsulfonyl)anilino]pyrimidin-4-yl]amino]-3-methylbutan-1-ol Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)CCO)=N1 DMPLZVOZGQRKFY-HNNXBMFYSA-N 0.000 claims 1
BNJGHFMCPWJPNT-CQSZACIVSA-N (2r)-2-[[5-bromo-2-[4-(2-hydroxyethylsulfamoyl)anilino]pyrimidin-4-yl]amino]-3-methylbutanoic acid Chemical compound C1=C(Br)C(N[C@H](C(C)C)C(O)=O)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCO)=N1 BNJGHFMCPWJPNT-CQSZACIVSA-N 0.000 claims 1
WDAQHQPSZNIQMH-ZDUSSCGKSA-N (2r)-2-[[5-bromo-2-[4-(trifluoromethylsulfonyl)anilino]pyrimidin-4-yl]amino]-3-methylbutan-1-ol Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)C(F)(F)F)=N1 WDAQHQPSZNIQMH-ZDUSSCGKSA-N 0.000 claims 1
XGLICGVXAPVYBI-ZETCQYMHSA-N (2s)-2-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]propanamide Chemical compound C1=C(Br)C(N[C@@H](C)C(N)=O)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 XGLICGVXAPVYBI-ZETCQYMHSA-N 0.000 claims 1
125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 1
125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
HFISRXLKZTXXKP-AUEPDCJTSA-N 2-[(e)-3-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]butan-2-ylideneamino]oxyacetic acid Chemical compound C1=C(Br)C(NC(C)C(\C)=N\OCC(O)=O)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 HFISRXLKZTXXKP-AUEPDCJTSA-N 0.000 claims 1
GUUYSULIBQOZIQ-UHFFFAOYSA-N 2-[3-[[5-bromo-4-(2-morpholin-4-ylethylamino)pyrimidin-2-yl]amino]phenyl]sulfonylethanol Chemical compound OCCS(=O)(=O)C1=CC=CC(NC=2N=C(NCCN3CCOCC3)C(Br)=CN=2)=C1 GUUYSULIBQOZIQ-UHFFFAOYSA-N 0.000 claims 1
RJVHJGWKLQVDCX-UHFFFAOYSA-N 2-[3-[[5-bromo-4-(prop-2-ynylamino)pyrimidin-2-yl]amino]phenyl]sulfonylethanol Chemical compound OCCS(=O)(=O)C1=CC=CC(NC=2N=C(NCC#C)C(Br)=CN=2)=C1 RJVHJGWKLQVDCX-UHFFFAOYSA-N 0.000 claims 1
CITDQBCZOBOFHG-NSHDSACASA-N 2-[3-[[5-bromo-4-[[(2s)-1-methoxypropan-2-yl]amino]pyrimidin-2-yl]amino]phenyl]sulfonylethanol Chemical compound C1=C(Br)C(N[C@@H](C)COC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)CCO)=N1 CITDQBCZOBOFHG-NSHDSACASA-N 0.000 claims 1
MGLNAHDYUZYRJP-UHFFFAOYSA-N 2-[[5-bromo-2-[3-(2-hydroxyethylsulfonyl)anilino]pyrimidin-4-yl]amino]propane-1,3-diol Chemical compound OCCS(=O)(=O)C1=CC=CC(NC=2N=C(NC(CO)CO)C(Br)=CN=2)=C1 MGLNAHDYUZYRJP-UHFFFAOYSA-N 0.000 claims 1
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
YCMLQMDWSXFTIF-UHFFFAOYSA-N 2-methylbenzenesulfonimidic acid Chemical compound CC1=CC=CC=C1S(N)(=O)=O YCMLQMDWSXFTIF-UHFFFAOYSA-N 0.000 claims 1
SAERAINFZWAKGQ-UHFFFAOYSA-N 2-methylbenzenesulfonyl fluoride Chemical compound CC1=CC=CC=C1S(F)(=O)=O SAERAINFZWAKGQ-UHFFFAOYSA-N 0.000 claims 1
FETWCXOAWZUZBR-UHFFFAOYSA-N 2-n-[3-(benzenesulfonyl)phenyl]-5-bromo-4-n-prop-2-ynylpyrimidine-2,4-diamine Chemical compound N1=C(NCC#C)C(Br)=CN=C1NC1=CC=CC(S(=O)(=O)C=2C=CC=CC=2)=C1 FETWCXOAWZUZBR-UHFFFAOYSA-N 0.000 claims 1
KTJVQPLZQWUAQY-UHFFFAOYSA-N 3-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]propanoic acid Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCC(O)=O)=N1 KTJVQPLZQWUAQY-UHFFFAOYSA-N 0.000 claims 1
AFKUTJOFCAOYQP-UHFFFAOYSA-N 3-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]propylphosphonic acid Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCCP(O)(O)=O)=N1 AFKUTJOFCAOYQP-UHFFFAOYSA-N 0.000 claims 1
DOEGEYSAKWHDSP-UHFFFAOYSA-N 3-[[5-bromo-4-(prop-2-ynylamino)pyrimidin-2-yl]amino]-n-butylbenzenesulfonamide Chemical compound CCCCNS(=O)(=O)C1=CC=CC(NC=2N=C(NCC#C)C(Br)=CN=2)=C1 DOEGEYSAKWHDSP-UHFFFAOYSA-N 0.000 claims 1
AHTSLHIJXZTEIU-UHFFFAOYSA-N 3-[[5-bromo-4-(prop-2-ynylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC(NC=2N=C(NCC#C)C(Br)=CN=2)=C1 AHTSLHIJXZTEIU-UHFFFAOYSA-N 0.000 claims 1
XQMKRPIZJHEKSG-INIZCTEOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(1,3-dihydroxypropan-2-yl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NC(CO)CO)=N1 XQMKRPIZJHEKSG-INIZCTEOSA-N 0.000 claims 1
ALOBCOOXNZFQRZ-SFHVURJKSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(5-hydroxypentyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCCCCO)=N1 ALOBCOOXNZFQRZ-SFHVURJKSA-N 0.000 claims 1
FCNGRYGECNKENN-HNNXBMFYSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-ethoxybenzenesulfonamide Chemical compound CCONS(=O)(=O)C1=CC=CC(NC=2N=C(N[C@@H](CO)C(C)C)C(Br)=CN=2)=C1 FCNGRYGECNKENN-HNNXBMFYSA-N 0.000 claims 1
WMVKSRVLBYMNNR-GFCCVEGCSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-methoxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCOC)=N1 WMVKSRVLBYMNNR-GFCCVEGCSA-N 0.000 claims 1
ZHRIYMCBQBKDHN-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-morpholin-4-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCN2CCOCC2)=N1 ZHRIYMCBQBKDHN-OAHLLOKOSA-N 0.000 claims 1
DQOCEAXNGWJYOV-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-phenoxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCOC=2C=CC=CC=2)=N1 DQOCEAXNGWJYOV-MRXNPFEDSA-N 0.000 claims 1
WEFXZBPQJHRJGU-QGZVFWFLSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-phenylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCC=2C=CC=CC=2)=N1 WEFXZBPQJHRJGU-QGZVFWFLSA-N 0.000 claims 1
CVNAOWSLMKCPDR-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-piperidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCN2CCCCC2)=N1 CVNAOWSLMKCPDR-MRXNPFEDSA-N 0.000 claims 1
FQDMZEONIQIPCD-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-pyrrolidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCN2CCCC2)=N1 FQDMZEONIQIPCD-OAHLLOKOSA-N 0.000 claims 1
PYJUMANJGQJYCC-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-methylbutyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCC(C)C)=N1 PYJUMANJGQJYCC-CQSZACIVSA-N 0.000 claims 1
QBMQJPSFFULETH-SNVBAGLBSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-methylsulfanyl-1h-1,2,4-triazol-5-yl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NC=2NN=C(SC)N=2)=N1 QBMQJPSFFULETH-SNVBAGLBSA-N 0.000 claims 1
DSXTVCKGNOCFHH-GOSISDBHSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-phenylpropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCCC=2C=CC=CC=2)=N1 DSXTVCKGNOCFHH-GOSISDBHSA-N 0.000 claims 1
NTTYBZPCDJEMGL-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(cyclohexylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC2CCCCC2)=N1 NTTYBZPCDJEMGL-MRXNPFEDSA-N 0.000 claims 1
XNCPLDQMRCGQLJ-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(furan-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2OC=CC=2)=N1 XNCPLDQMRCGQLJ-CYBMUJFWSA-N 0.000 claims 1
KZAIMJMQCPUPST-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(pyridin-3-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=NC=CC=2)=N1 KZAIMJMQCPUPST-OAHLLOKOSA-N 0.000 claims 1
RWMLEQMESBSDMD-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(pyridin-4-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=CN=CC=2)=N1 RWMLEQMESBSDMD-OAHLLOKOSA-N 0.000 claims 1
SLAQTACRMFNDIX-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(thiophen-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2SC=CC=2)=N1 SLAQTACRMFNDIX-CYBMUJFWSA-N 0.000 claims 1
IBIBVRHCWCQJNH-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(2-methoxyphenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C(=CC=CC=2)OC)=N1 IBIBVRHCWCQJNH-MRXNPFEDSA-N 0.000 claims 1
AGKAZHMKZRTJOQ-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(3-fluorophenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=C(F)C=CC=2)=N1 AGKAZHMKZRTJOQ-MRXNPFEDSA-N 0.000 claims 1
SNTLJCJGTVYKFQ-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-fluorophenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=CC(F)=CC=2)=N1 SNTLJCJGTVYKFQ-MRXNPFEDSA-N 0.000 claims 1
SVAIQKVFEZHILC-QGZVFWFLSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-methylphenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=CC(C)=CC=2)=N1 SVAIQKVFEZHILC-QGZVFWFLSA-N 0.000 claims 1
OMQITYLLWBUKKU-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(5-methylfuran-2-yl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2OC(C)=CC=2)=N1 OMQITYLLWBUKKU-CQSZACIVSA-N 0.000 claims 1
RKVDLZVPSHAYPI-LDCVWXEPSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(1-methylpyrrolidin-2-yl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCC2N(CCC2)C)=N1 RKVDLZVPSHAYPI-LDCVWXEPSA-N 0.000 claims 1
FTNVAOSKGMGKSL-QGZVFWFLSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-chlorophenyl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCC=2C=CC(Cl)=CC=2)=N1 FTNVAOSKGMGKSL-QGZVFWFLSA-N 0.000 claims 1
PPKBRPTUSPUDQR-QGZVFWFLSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-[di(propan-2-yl)amino]ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCN(C(C)C)C(C)C)=N1 PPKBRPTUSPUDQR-QGZVFWFLSA-N 0.000 claims 1
ORBIQXHHKZROQS-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[3-(2-oxopyrrolidin-1-yl)propyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCCN2C(CCC2)=O)=N1 ORBIQXHHKZROQS-OAHLLOKOSA-N 0.000 claims 1
OYPQNXKADMGHLP-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[3-(dimethylamino)propyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCCN(C)C)=N1 OYPQNXKADMGHLP-CQSZACIVSA-N 0.000 claims 1
JNLSCERXOUBHGD-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[[3-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=C(C=CC=2)C(F)(F)F)=N1 JNLSCERXOUBHGD-MRXNPFEDSA-N 0.000 claims 1
UAKAXDMMFAGEHM-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[[4-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=CC(=CC=2)C(F)(F)F)=N1 UAKAXDMMFAGEHM-MRXNPFEDSA-N 0.000 claims 1
ADGWKXKIHZBHAX-SECBINFHSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonyl fluoride Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C=CC=2)S(F)(=O)=O)=N1 ADGWKXKIHZBHAX-SECBINFHSA-N 0.000 claims 1
XLBCJSGIMQHZEH-LLVKDONJSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-methoxyethyl)benzenesulfonamide Chemical compound COCCNS(=O)(=O)C1=CC=CC(NC=2N=C(N[C@H](C)CO)C(Br)=CN=2)=C1 XLBCJSGIMQHZEH-LLVKDONJSA-N 0.000 claims 1
UFHQGGDEMRSHDQ-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-morpholin-4-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCN2CCOCC2)=N1 UFHQGGDEMRSHDQ-CQSZACIVSA-N 0.000 claims 1
WPOHQHLIZSRXQU-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-phenoxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCOC=2C=CC=CC=2)=N1 WPOHQHLIZSRXQU-OAHLLOKOSA-N 0.000 claims 1
RVGJRAWSYHAMFA-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-phenylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCC=2C=CC=CC=2)=N1 RVGJRAWSYHAMFA-OAHLLOKOSA-N 0.000 claims 1
WVRXIMVPTKLEPX-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-piperidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCN2CCCCC2)=N1 WVRXIMVPTKLEPX-OAHLLOKOSA-N 0.000 claims 1
KHHGKANJWHUIAX-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-pyrrolidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCN2CCCC2)=N1 KHHGKANJWHUIAX-CQSZACIVSA-N 0.000 claims 1
MTBKYKFYNKWNGJ-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-imidazol-1-ylpropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCCN2C=NC=C2)=N1 MTBKYKFYNKWNGJ-CQSZACIVSA-N 0.000 claims 1
PJBORUXSXCOIQM-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-methylbutyl)benzenesulfonamide Chemical compound CC(C)CCNS(=O)(=O)C1=CC=CC(NC=2N=C(N[C@H](C)CO)C(Br)=CN=2)=C1 PJBORUXSXCOIQM-CYBMUJFWSA-N 0.000 claims 1
XPXZIODJTRYGEE-SECBINFHSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-methylsulfanyl-1h-1,2,4-triazol-5-yl)benzenesulfonamide Chemical compound CSC1=NNC(NS(=O)(=O)C=2C=C(NC=3N=C(N[C@H](C)CO)C(Br)=CN=3)C=CC=2)=N1 XPXZIODJTRYGEE-SECBINFHSA-N 0.000 claims 1
KIWXNRCTXOKRJR-GFCCVEGCSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(furan-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2OC=CC=2)=N1 KIWXNRCTXOKRJR-GFCCVEGCSA-N 0.000 claims 1
AULKUOWQTVHRKB-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(pyridin-3-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=NC=CC=2)=N1 AULKUOWQTVHRKB-CYBMUJFWSA-N 0.000 claims 1
NLYBAGOFTTYOKJ-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(pyridin-4-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=CN=CC=2)=N1 NLYBAGOFTTYOKJ-CYBMUJFWSA-N 0.000 claims 1
SAJCHQYDWJCRSK-GFCCVEGCSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(thiophen-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2SC=CC=2)=N1 SAJCHQYDWJCRSK-GFCCVEGCSA-N 0.000 claims 1
MNKUNFVGHBROAO-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(2-methoxyphenyl)methyl]benzenesulfonamide Chemical compound COC1=CC=CC=C1CNS(=O)(=O)C1=CC=CC(NC=2N=C(N[C@H](C)CO)C(Br)=CN=2)=C1 MNKUNFVGHBROAO-CQSZACIVSA-N 0.000 claims 1
NNYSAPFTRZPKQP-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(3-fluorophenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=C(F)C=CC=2)=N1 NNYSAPFTRZPKQP-CYBMUJFWSA-N 0.000 claims 1
YVQWALIASCAKJZ-QQFBHYJXSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-cyanocyclohexyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC2CCC(CC2)C#N)=N1 YVQWALIASCAKJZ-QQFBHYJXSA-N 0.000 claims 1
VUVPZBWLWVJAAQ-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-fluorophenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=CC(F)=CC=2)=N1 VUVPZBWLWVJAAQ-CYBMUJFWSA-N 0.000 claims 1
QQKJAUQFSDWVDD-OAHLLOKOSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-methylphenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2C=CC(C)=CC=2)=N1 QQKJAUQFSDWVDD-OAHLLOKOSA-N 0.000 claims 1
NSDKWIAIQYRORA-GFCCVEGCSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(5-methylfuran-2-yl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCC=2OC(C)=CC=2)=N1 NSDKWIAIQYRORA-GFCCVEGCSA-N 0.000 claims 1
WBAQCFNNCJEJOD-IURRXHLWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(1-methylpyrrolidin-2-yl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCC2N(CCC2)C)=N1 WBAQCFNNCJEJOD-IURRXHLWSA-N 0.000 claims 1
YAVSDGHOUMLLGF-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-chlorophenyl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCC=2C=CC(Cl)=CC=2)=N1 YAVSDGHOUMLLGF-CQSZACIVSA-N 0.000 claims 1
AYWKQVYUIOQCJD-GFCCVEGCSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(dimethylamino)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCN(C)C)=N1 AYWKQVYUIOQCJD-GFCCVEGCSA-N 0.000 claims 1
AUSPUCCQZAVOPM-MRXNPFEDSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-[di(propan-2-yl)amino]ethyl]benzenesulfonamide Chemical compound CC(C)N(C(C)C)CCNS(=O)(=O)C1=CC=CC(NC=2N=C(N[C@H](C)CO)C(Br)=CN=2)=C1 AUSPUCCQZAVOPM-MRXNPFEDSA-N 0.000 claims 1
XNEVTOKXOOQLRB-CQSZACIVSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[3-(2-oxopyrrolidin-1-yl)propyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCCN2C(CCC2)=O)=N1 XNEVTOKXOOQLRB-CQSZACIVSA-N 0.000 claims 1
SUSZGWOOWBEOCO-CYBMUJFWSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[3-(dimethylamino)propyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(=O)(=O)NCCCN(C)C)=N1 SUSZGWOOWBEOCO-CYBMUJFWSA-N 0.000 claims 1
YYUAOKYOMBAEIV-MRVPVSSYSA-N 3-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonyl fluoride Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C=CC=2)S(F)(=O)=O)=N1 YYUAOKYOMBAEIV-MRVPVSSYSA-N 0.000 claims 1
QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 claims 1
YNVRKQALFIIIRZ-UHFFFAOYSA-N 4-[(4-morpholin-4-ylpyrimidin-2-yl)amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=CC(N2CCOCC2)=N1 YNVRKQALFIIIRZ-UHFFFAOYSA-N 0.000 claims 1
ZJBFNXOTWBYPTB-UHFFFAOYSA-N 4-[(5-bromo-4-morpholin-4-ylpyrimidin-2-yl)amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(N2CCOCC2)=N1 ZJBFNXOTWBYPTB-UHFFFAOYSA-N 0.000 claims 1
OROWGIVHKDNXBO-UHFFFAOYSA-N 4-[(5-bromo-4-piperidin-4-yloxypyrimidin-2-yl)amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(OC2CCNCC2)=N1 OROWGIVHKDNXBO-UHFFFAOYSA-N 0.000 claims 1
VDBWWJBJRVAGQB-UHFFFAOYSA-N 4-[[4-(1-adamantylmethylamino)-5-bromopyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC23CC4CC(CC(C4)C2)C3)=N1 VDBWWJBJRVAGQB-UHFFFAOYSA-N 0.000 claims 1
GCGSXQZTUFHHCZ-UHFFFAOYSA-N 4-[[4-(3-bicyclo[2.2.1]heptanylamino)-5-bromopyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2C3CCC(C3)C2)=N1 GCGSXQZTUFHHCZ-UHFFFAOYSA-N 0.000 claims 1
JTRVZRICDWQIPA-ZDUSSCGKSA-N 4-[[4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]-5-iodopyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(I)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 JTRVZRICDWQIPA-ZDUSSCGKSA-N 0.000 claims 1
JYUVZGOTLRBBIS-UHFFFAOYSA-N 4-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]butanoic acid Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCCC(O)=O)=N1 JYUVZGOTLRBBIS-UHFFFAOYSA-N 0.000 claims 1
NPOBEUCLSYVDCY-UHFFFAOYSA-N 4-[[5-bromo-4-(1,3-diethoxypropan-2-yloxy)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(OC(COCC)COCC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 NPOBEUCLSYVDCY-UHFFFAOYSA-N 0.000 claims 1
RSSOAJYESBJIOK-UHFFFAOYSA-N 4-[[5-bromo-4-(1,3-dihydroxypropan-2-ylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC(CO)CO)=N1 RSSOAJYESBJIOK-UHFFFAOYSA-N 0.000 claims 1
LCSODXGZHNCVHW-UHFFFAOYSA-N 4-[[5-bromo-4-(1,3-dihydroxypropan-2-yloxy)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(OC(CO)CO)=N1 LCSODXGZHNCVHW-UHFFFAOYSA-N 0.000 claims 1
QPEQBYJEVPXQJZ-UHFFFAOYSA-N 4-[[5-bromo-4-(1-phenylethylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C=1C=CC=CC=1C(C)NC(C(=CN=1)Br)=NC=1NC1=CC=C(S(N)(=O)=O)C=C1 QPEQBYJEVPXQJZ-UHFFFAOYSA-N 0.000 claims 1
WELQEQDZCUWKQM-UHFFFAOYSA-N 4-[[5-bromo-4-(2,2,3,3,3-pentafluoropropoxy)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(OCC(F)(F)C(F)(F)F)=N1 WELQEQDZCUWKQM-UHFFFAOYSA-N 0.000 claims 1
VMFCDYLTPGHBNJ-UHFFFAOYSA-N 4-[[5-bromo-4-(2,2,3,3,3-pentafluoropropylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC(F)(F)C(F)(F)F)=N1 VMFCDYLTPGHBNJ-UHFFFAOYSA-N 0.000 claims 1
CJGXSBQAYYVPRL-UHFFFAOYSA-N 4-[[5-bromo-4-(2-hydroxybutylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NCC(O)CC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 CJGXSBQAYYVPRL-UHFFFAOYSA-N 0.000 claims 1
XZHUQRVSRNNCNT-UHFFFAOYSA-N 4-[[5-bromo-4-(2-hydroxyethylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCO)=N1 XZHUQRVSRNNCNT-UHFFFAOYSA-N 0.000 claims 1
STGDSBMMLJUBLC-UHFFFAOYSA-N 4-[[5-bromo-4-(2-hydroxypropylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NCC(O)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 STGDSBMMLJUBLC-UHFFFAOYSA-N 0.000 claims 1
XSDPUAAWRKOPAY-UHFFFAOYSA-N 4-[[5-bromo-4-(2-morpholin-4-ylethylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCN2CCOCC2)=N1 XSDPUAAWRKOPAY-UHFFFAOYSA-N 0.000 claims 1
KTTXFMUXETXSAW-UHFFFAOYSA-N 4-[[5-bromo-4-(3-diethoxyphosphorylpropylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NCCCP(=O)(OCC)OCC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 KTTXFMUXETXSAW-UHFFFAOYSA-N 0.000 claims 1
ZOBMWTCOGJLMCJ-UHFFFAOYSA-N 4-[[5-bromo-4-(3-hydroxyhexan-2-ylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)C(O)CCC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 ZOBMWTCOGJLMCJ-UHFFFAOYSA-N 0.000 claims 1
YTTHJGBSJSAALC-UHFFFAOYSA-N 4-[[5-bromo-4-(3-hydroxyiminobutan-2-ylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)C(C)=NO)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 YTTHJGBSJSAALC-UHFFFAOYSA-N 0.000 claims 1
XJOGWEVFKQFVRV-UHFFFAOYSA-N 4-[[5-bromo-4-(3-hydroxypentan-2-ylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)C(O)CC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 XJOGWEVFKQFVRV-UHFFFAOYSA-N 0.000 claims 1
DEUNZRZNKLIPOL-UHFFFAOYSA-N 4-[[5-bromo-4-(3-oxobutan-2-ylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)C(C)=O)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 DEUNZRZNKLIPOL-UHFFFAOYSA-N 0.000 claims 1
GYQQYCSCAZNEIH-UHFFFAOYSA-N 4-[[5-bromo-4-(4,4,4-trifluorobutoxy)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(OCCCC(F)(F)F)=N1 GYQQYCSCAZNEIH-UHFFFAOYSA-N 0.000 claims 1
UTWKYJCAWVQKLQ-UHFFFAOYSA-N 4-[[5-bromo-4-(4-hydroxybutylamino)pyrimidin-2-yl]amino]-n-methylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NC)=CC=C1NC1=NC=C(Br)C(NCCCCO)=N1 UTWKYJCAWVQKLQ-UHFFFAOYSA-N 0.000 claims 1
XCGNELJEIMQENC-UHFFFAOYSA-N 4-[[5-bromo-4-(4-hydroxybutylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCCCO)=N1 XCGNELJEIMQENC-UHFFFAOYSA-N 0.000 claims 1
BBVZCQPITGEOJG-UHFFFAOYSA-N 4-[[5-bromo-4-(4-hydroxyhexan-3-ylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(CC)C(O)CC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 BBVZCQPITGEOJG-UHFFFAOYSA-N 0.000 claims 1
ZKORCOAXYCRUCN-UHFFFAOYSA-N 4-[[5-bromo-4-(butan-2-ylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)CC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 ZKORCOAXYCRUCN-UHFFFAOYSA-N 0.000 claims 1
BKNFOZHRQQKWNM-UHFFFAOYSA-N 4-[[5-bromo-4-(cycloheptylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCCCCC2)=N1 BKNFOZHRQQKWNM-UHFFFAOYSA-N 0.000 claims 1
VPWWFLLPZUCGAG-UHFFFAOYSA-N 4-[[5-bromo-4-(cyclohexylamino)pyrimidin-2-yl]amino]-n-(2-hydroxyethyl)benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NCCO)=CC=C1NC1=NC=C(Br)C(NC2CCCCC2)=N1 VPWWFLLPZUCGAG-UHFFFAOYSA-N 0.000 claims 1
HVLFLNWNVOHNGC-UHFFFAOYSA-N 4-[[5-bromo-4-(cyclopropylmethylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC2CC2)=N1 HVLFLNWNVOHNGC-UHFFFAOYSA-N 0.000 claims 1
BKQWRIPYUSWLIX-UHFFFAOYSA-N 4-[[5-bromo-4-(dimethoxyphosphorylmethylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NCP(=O)(OC)OC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 BKQWRIPYUSWLIX-UHFFFAOYSA-N 0.000 claims 1
WOKLXKLQILMIOI-UHFFFAOYSA-N 4-[[5-bromo-4-(oxan-4-yloxy)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(OC2CCOCC2)=N1 WOKLXKLQILMIOI-UHFFFAOYSA-N 0.000 claims 1
HVGPOHZHMRGTBL-UHFFFAOYSA-N 4-[[5-bromo-4-(phenacylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC(=O)C=2C=CC=CC=2)=N1 HVGPOHZHMRGTBL-UHFFFAOYSA-N 0.000 claims 1
HBITXFFJRLBCBB-UHFFFAOYSA-N 4-[[5-bromo-4-(prop-2-ynylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC#C)=N1 HBITXFFJRLBCBB-UHFFFAOYSA-N 0.000 claims 1
MXYTWRWCLAIKPZ-UHFFFAOYSA-N 4-[[5-bromo-4-(pyridin-2-ylmethylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC=2N=CC=CC=2)=N1 MXYTWRWCLAIKPZ-UHFFFAOYSA-N 0.000 claims 1
SVHRGOHQMWLVJZ-UHFFFAOYSA-N 4-[[5-bromo-4-(pyridin-4-ylmethylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC=2C=CN=CC=2)=N1 SVHRGOHQMWLVJZ-UHFFFAOYSA-N 0.000 claims 1
HEVZYWBHZIVJCG-UHFFFAOYSA-N 4-[[5-bromo-4-(thiolan-3-ylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CSCC2)=N1 HEVZYWBHZIVJCG-UHFFFAOYSA-N 0.000 claims 1
IBTCCVNYIPUVRC-UHFFFAOYSA-N 4-[[5-bromo-4-(thiophen-2-ylmethylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC=2SC=CC=2)=N1 IBTCCVNYIPUVRC-UHFFFAOYSA-N 0.000 claims 1
MAKPVOMTPFBUDR-UHFFFAOYSA-N 4-[[5-bromo-4-[(1-ethynylcyclohexyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2(CCCCC2)C#C)=N1 MAKPVOMTPFBUDR-UHFFFAOYSA-N 0.000 claims 1
UFOQEUPOIVSAKO-UHFFFAOYSA-N 4-[[5-bromo-4-[(1-hydroxy-2,3-dimethylbutan-2-yl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)(CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 UFOQEUPOIVSAKO-UHFFFAOYSA-N 0.000 claims 1
TVHFYTNZZQSQQP-UHFFFAOYSA-N 4-[[5-bromo-4-[(1-hydroxy-2-methylpropan-2-yl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)(CO)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 TVHFYTNZZQSQQP-UHFFFAOYSA-N 0.000 claims 1
MQOXDWNBNCQLAV-UHFFFAOYSA-N 4-[[5-bromo-4-[(1-hydroxy-3-methoxypropan-2-yl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(CO)COC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 MQOXDWNBNCQLAV-UHFFFAOYSA-N 0.000 claims 1
QUSJIZGWTJJURZ-UHFFFAOYSA-N 4-[[5-bromo-4-[(2-hydroxy-2-phenylpropyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C=1C=CC=CC=1C(O)(C)CNC(C(=CN=1)Br)=NC=1NC1=CC=C(S(N)(=O)=O)C=C1 QUSJIZGWTJJURZ-UHFFFAOYSA-N 0.000 claims 1
AUGYGCJBVAWRFY-UHFFFAOYSA-N 4-[[5-bromo-4-[(2-hydroxy-3,3-dimethylbutyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NCC(O)C(C)(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 AUGYGCJBVAWRFY-UHFFFAOYSA-N 0.000 claims 1
BUWBYOIMHIIOAZ-UHFFFAOYSA-N 4-[[5-bromo-4-[(2-methylcyclohexyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound CC1CCCCC1NC1=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=NC=C1Br BUWBYOIMHIIOAZ-UHFFFAOYSA-N 0.000 claims 1
OZTBYNUUGKQRDE-UHFFFAOYSA-N 4-[[5-bromo-4-[(3,3-dimethyl-2-oxobutyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NCC(=O)C(C)(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 OZTBYNUUGKQRDE-UHFFFAOYSA-N 0.000 claims 1
QCVJAROPMVVQQM-UHFFFAOYSA-N 4-[[5-bromo-4-[(3-hydroxy-1-methoxybutan-2-yl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(COC)C(C)O)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 QCVJAROPMVVQQM-UHFFFAOYSA-N 0.000 claims 1
ISUNAZHSSOIYRS-UHFFFAOYSA-N 4-[[5-bromo-4-[(3-hydroxy-1-phenylpropyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC(CCO)C=2C=CC=CC=2)=N1 ISUNAZHSSOIYRS-UHFFFAOYSA-N 0.000 claims 1
VPYOPYDJTQEJRA-UHFFFAOYSA-N 4-[[5-bromo-4-[(3-hydroxy-3-methylbutan-2-yl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)C(C)(C)O)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 VPYOPYDJTQEJRA-UHFFFAOYSA-N 0.000 claims 1
GCKYLPIHRIXFNW-UHFFFAOYSA-N 4-[[5-bromo-4-[(3-hydroxy-3-methylpentan-2-yl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)C(C)(O)CC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 GCKYLPIHRIXFNW-UHFFFAOYSA-N 0.000 claims 1
ZNDGZGFDXHELDB-UHFFFAOYSA-N 4-[[5-bromo-4-[(3-hydroxy-4-phenylbutan-2-yl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C=1C=CC=CC=1CC(O)C(C)NC(C(=CN=1)Br)=NC=1NC1=CC=C(S(N)(=O)=O)C=C1 ZNDGZGFDXHELDB-UHFFFAOYSA-N 0.000 claims 1
VDDHXEFQMMPYFB-UHFFFAOYSA-N 4-[[5-bromo-4-[(3-pyridin-3-yl-1,2-oxazol-4-yl)methylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC=2C(=NOC=2)C=2C=NC=CC=2)=N1 VDDHXEFQMMPYFB-UHFFFAOYSA-N 0.000 claims 1
ACZDAHXHLOAGRC-UHFFFAOYSA-N 4-[[5-bromo-4-[(4-fluorophenyl)methylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCC=2C=CC(F)=CC=2)=N1 ACZDAHXHLOAGRC-UHFFFAOYSA-N 0.000 claims 1
RWMBSHSFSDPDNN-UHFFFAOYSA-N 4-[[5-bromo-4-[(4-hydroxycyclohexyl)amino]pyrimidin-2-yl]amino]-n-(2-hydroxyethyl)benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NCCO)=CC=C1NC1=NC=C(Br)C(NC2CCC(O)CC2)=N1 RWMBSHSFSDPDNN-UHFFFAOYSA-N 0.000 claims 1
PADQQENOHOLKJI-UHFFFAOYSA-N 4-[[5-bromo-4-[(4-hydroxycyclohexyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(O)CC2)=N1 PADQQENOHOLKJI-UHFFFAOYSA-N 0.000 claims 1
YZNKBOPXCBPXQL-UHFFFAOYSA-N 4-[[5-bromo-4-[(4-methoxyphenyl)methylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CNC1=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=NC=C1Br YZNKBOPXCBPXQL-UHFFFAOYSA-N 0.000 claims 1
PJPWWTSDKINYAU-UHFFFAOYSA-N 4-[[5-bromo-4-[(4-methylcyclohexyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1CC(C)CCC1NC1=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=NC=C1Br PJPWWTSDKINYAU-UHFFFAOYSA-N 0.000 claims 1
QQNKPKIIVDTBII-UHFFFAOYSA-N 4-[[5-bromo-4-[(4-oxocyclohexyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(=O)CC2)=N1 QQNKPKIIVDTBII-UHFFFAOYSA-N 0.000 claims 1
ZWCNPJSGCZIBRJ-UHFFFAOYSA-N 4-[[5-bromo-4-[(4-piperidin-1-ylcyclohexyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(CC2)N2CCCCC2)=N1 ZWCNPJSGCZIBRJ-UHFFFAOYSA-N 0.000 claims 1
XVBYOJUJGBQWPE-UHFFFAOYSA-N 4-[[5-bromo-4-[2-(1-methylpyrrolidin-2-yl)ethylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound CN1CCCC1CCNC1=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=NC=C1Br XVBYOJUJGBQWPE-UHFFFAOYSA-N 0.000 claims 1
KNLYXFXSEDFZHB-UHFFFAOYSA-N 4-[[5-bromo-4-[2-(1h-imidazol-5-yl)ethylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCC=2NC=NC=2)=N1 KNLYXFXSEDFZHB-UHFFFAOYSA-N 0.000 claims 1
PMJHAXGVXBMMHX-UHFFFAOYSA-N 4-[[5-bromo-4-[2-(2-ethoxyethoxy)ethoxy]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(OCCOCCOCC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 PMJHAXGVXBMMHX-UHFFFAOYSA-N 0.000 claims 1
WVCXHMNXASLWIV-UHFFFAOYSA-N 4-[[5-bromo-4-[2-(2-oxo-1h-imidazol-3-yl)ethylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCN2C(NC=C2)=O)=N1 WVCXHMNXASLWIV-UHFFFAOYSA-N 0.000 claims 1
PFXMRXGKDQGXSN-UHFFFAOYSA-N 4-[[5-bromo-4-[3-(cyclopropylamino)butan-2-ylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound N=1C(NC=2C=CC(=CC=2)S(N)(=O)=O)=NC=C(Br)C=1NC(C)C(C)NC1CC1 PFXMRXGKDQGXSN-UHFFFAOYSA-N 0.000 claims 1
WCKYTBXMLZSLSM-UHFFFAOYSA-N 4-[[5-bromo-4-[3-(dimethylamino)propylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NCCCN(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 WCKYTBXMLZSLSM-UHFFFAOYSA-N 0.000 claims 1
WRXMGEYGNHUEPI-UHFFFAOYSA-N 4-[[5-bromo-4-[3-(hydroxymethyl)pentan-3-ylamino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(CC)(CO)CC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 WRXMGEYGNHUEPI-UHFFFAOYSA-N 0.000 claims 1
UKLQIRIXWVHJCZ-IRXDYDNUSA-N 4-[[5-bromo-4-[[(1s,2s)-1,3-dihydroxy-1-phenylpropan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(N[C@@H](CO)[C@@H](O)C=2C=CC=CC=2)=N1 UKLQIRIXWVHJCZ-IRXDYDNUSA-N 0.000 claims 1
KCTZDKZTFSBZEX-KBPBESRZSA-N 4-[[5-bromo-4-[[(1s,2s)-2-hydroxycyclohexyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(N[C@@H]2[C@H](CCCC2)O)=N1 KCTZDKZTFSBZEX-KBPBESRZSA-N 0.000 claims 1
SBACLTGMCWRKCJ-PMACEKPBSA-N 4-[[5-bromo-4-[[(1s,2s)-2-phenylmethoxycyclopentyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(N[C@@H]2[C@H](CCC2)OCC=2C=CC=CC=2)=N1 SBACLTGMCWRKCJ-PMACEKPBSA-N 0.000 claims 1
REFWQLGSUZABCN-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-cyclohexyl-3-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(N[C@@H](CO)CC2CCCCC2)=N1 REFWQLGSUZABCN-OAHLLOKOSA-N 0.000 claims 1
CQLAJLGSSXZYMT-ZDUSSCGKSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3,3-dimethylbutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 CQLAJLGSSXZYMT-ZDUSSCGKSA-N 0.000 claims 1
WJPZGCKNPYXRFI-LBPRGKRZSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-3-hydroxybenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C(=CC(=CC=2)S(N)(=O)=O)O)=N1 WJPZGCKNPYXRFI-LBPRGKRZSA-N 0.000 claims 1
GOKHZGQBLPFGPX-INIZCTEOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(1,3-dihydroxypropan-2-yl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NC(CO)CO)=N1 GOKHZGQBLPFGPX-INIZCTEOSA-N 0.000 claims 1
SQEBTISVTWEPAY-HNNXBMFYSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(1,3-thiazol-2-yl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NC=2SC=CN=2)=N1 SQEBTISVTWEPAY-HNNXBMFYSA-N 0.000 claims 1
NWRRAJNEOKIKSV-JRZJBTRGSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-hydroxybutyl)benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NCC(O)CC)=CC=C1NC1=NC=C(Br)C(N[C@@H](CO)C(C)C)=N1 NWRRAJNEOKIKSV-JRZJBTRGSA-N 0.000 claims 1
QNTPIUDNXRXINQ-INIZCTEOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-hydroxypropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCO)=N1 QNTPIUDNXRXINQ-INIZCTEOSA-N 0.000 claims 1
QYTFTGGLPZXRQR-SFHVURJKSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(5-hydroxypentyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCCCO)=N1 QYTFTGGLPZXRQR-SFHVURJKSA-N 0.000 claims 1
MSWSAELIPUGNJB-KRWDZBQOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(cyclopropylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC2CC2)=N1 MSWSAELIPUGNJB-KRWDZBQOSA-N 0.000 claims 1
UCAZDSIXDRHHKJ-PKHIMPSTSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(oxolan-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC2OCCC2)=N1 UCAZDSIXDRHHKJ-PKHIMPSTSA-N 0.000 claims 1
HEOQKVPIQAJIAD-BPZDKFOGSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-cyanocyclohexyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC2CCC(CC2)C#N)=N1 HEOQKVPIQAJIAD-BPZDKFOGSA-N 0.000 claims 1
GITZPQVLXGQOFC-ZDUSSCGKSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-hydroxybenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NO)=N1 GITZPQVLXGQOFC-ZDUSSCGKSA-N 0.000 claims 1
JRCIPBPLMCNNAZ-AWEZNQCLSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-methylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NC)=CC=C1NC1=NC=C(Br)C(N[C@@H](CO)C(C)C)=N1 JRCIPBPLMCNNAZ-AWEZNQCLSA-N 0.000 claims 1
SURDDRPIORWROJ-FQEVSTJZSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-phenylmethoxybenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NOCC=2C=CC=CC=2)=N1 SURDDRPIORWROJ-FQEVSTJZSA-N 0.000 claims 1
DBRARTVFVQICAR-INIZCTEOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-pyrimidin-2-ylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CN=2)=N1 DBRARTVFVQICAR-INIZCTEOSA-N 0.000 claims 1
HKKPMWUXYNOAMH-ZDUSSCGKSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 HKKPMWUXYNOAMH-ZDUSSCGKSA-N 0.000 claims 1
XXRVXBGHUKJSIE-GFCCVEGCSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxy-4-methylpentan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 XXRVXBGHUKJSIE-GFCCVEGCSA-N 0.000 claims 1
JYHIAVNXXAOMOP-GFCCVEGCSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-methoxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCOC)=N1 JYHIAVNXXAOMOP-GFCCVEGCSA-N 0.000 claims 1
MOQOQWYFSLCRAF-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-morpholin-4-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCN2CCOCC2)=N1 MOQOQWYFSLCRAF-OAHLLOKOSA-N 0.000 claims 1
CGGQTGLIIRJICO-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-phenoxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCOC=2C=CC=CC=2)=N1 CGGQTGLIIRJICO-MRXNPFEDSA-N 0.000 claims 1
CJCFZRXZAIMSEF-QGZVFWFLSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-phenylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCC=2C=CC=CC=2)=N1 CJCFZRXZAIMSEF-QGZVFWFLSA-N 0.000 claims 1
NBYSQJLMKWONFD-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-piperidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCN2CCCCC2)=N1 NBYSQJLMKWONFD-MRXNPFEDSA-N 0.000 claims 1
OIDQEZVDBXFHIZ-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-imidazol-1-ylpropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCN2C=NC=C2)=N1 OIDQEZVDBXFHIZ-OAHLLOKOSA-N 0.000 claims 1
TYLJSCDFQRNRPP-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-methylbutyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCC(C)C)=N1 TYLJSCDFQRNRPP-CQSZACIVSA-N 0.000 claims 1
JBYAKKJCFOWWBR-SNVBAGLBSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-methylsulfanyl-1h-1,2,4-triazol-5-yl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NC=2NN=C(SC)N=2)=N1 JBYAKKJCFOWWBR-SNVBAGLBSA-N 0.000 claims 1
RPCBQIYZEZPTPF-GOSISDBHSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-phenylpropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCC=2C=CC=CC=2)=N1 RPCBQIYZEZPTPF-GOSISDBHSA-N 0.000 claims 1
CPNHYHNOBMDVOF-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(cyclohexylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC2CCCCC2)=N1 CPNHYHNOBMDVOF-MRXNPFEDSA-N 0.000 claims 1
JNOAGNVWSYXSPQ-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(furan-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2OC=CC=2)=N1 JNOAGNVWSYXSPQ-CYBMUJFWSA-N 0.000 claims 1
CYCCZYUADXNPOZ-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(pyridin-3-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=NC=CC=2)=N1 CYCCZYUADXNPOZ-OAHLLOKOSA-N 0.000 claims 1
OXYBJLCZAKJBLV-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(pyridin-4-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=CN=CC=2)=N1 OXYBJLCZAKJBLV-OAHLLOKOSA-N 0.000 claims 1
CTSAAFVAKMBXOE-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(thiophen-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2SC=CC=2)=N1 CTSAAFVAKMBXOE-CYBMUJFWSA-N 0.000 claims 1
ZREICNPHXIRKFS-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(2-methoxyphenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C(=CC=CC=2)OC)=N1 ZREICNPHXIRKFS-MRXNPFEDSA-N 0.000 claims 1
XKQPZMWHAHLRFF-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(3,4-dimethoxyphenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=C(OC)C(OC)=CC=2)=N1 XKQPZMWHAHLRFF-MRXNPFEDSA-N 0.000 claims 1
JALQCMUJHPYDDR-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(3-fluorophenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=C(F)C=CC=2)=N1 JALQCMUJHPYDDR-MRXNPFEDSA-N 0.000 claims 1
CONRSYAAHSEZNE-OFLPRAFFSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-cyanocyclohexyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC2CCC(CC2)C#N)=N1 CONRSYAAHSEZNE-OFLPRAFFSA-N 0.000 claims 1
HWXKWOWZXBIKQE-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-fluorophenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=CC(F)=CC=2)=N1 HWXKWOWZXBIKQE-MRXNPFEDSA-N 0.000 claims 1
OTXZJRWIKYDAFG-QGZVFWFLSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-methylphenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=CC(C)=CC=2)=N1 OTXZJRWIKYDAFG-QGZVFWFLSA-N 0.000 claims 1
DUGZLAZIQIAHNA-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(5-methylfuran-2-yl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2OC(C)=CC=2)=N1 DUGZLAZIQIAHNA-CQSZACIVSA-N 0.000 claims 1
PVCLSBRNZFMIIL-LDCVWXEPSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(1-methylpyrrolidin-2-yl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCC2N(CCC2)C)=N1 PVCLSBRNZFMIIL-LDCVWXEPSA-N 0.000 claims 1
LLRIYDPKZNCKIW-QGZVFWFLSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-chlorophenyl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCC=2C=CC(Cl)=CC=2)=N1 LLRIYDPKZNCKIW-QGZVFWFLSA-N 0.000 claims 1
BZZHQAZRENPBLF-QGZVFWFLSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCC=2C=CC(OC)=CC=2)=N1 BZZHQAZRENPBLF-QGZVFWFLSA-N 0.000 claims 1
NXMZNKRQBUGKFU-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(dimethylamino)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCN(C)C)=N1 NXMZNKRQBUGKFU-CYBMUJFWSA-N 0.000 claims 1
FADZTHFNEKILEE-QGZVFWFLSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-[di(propan-2-yl)amino]ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCN(C(C)C)C(C)C)=N1 FADZTHFNEKILEE-QGZVFWFLSA-N 0.000 claims 1
ZCNLIKVHFSZRMA-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[3-(2-oxopyrrolidin-1-yl)propyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCN2C(CCC2)=O)=N1 ZCNLIKVHFSZRMA-OAHLLOKOSA-N 0.000 claims 1
IQZPISAYENKKPK-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[3-(dimethylamino)propyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCN(C)C)=N1 IQZPISAYENKKPK-CQSZACIVSA-N 0.000 claims 1
QOXHCBQLRMGDND-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[[3-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=C(C=CC=2)C(F)(F)F)=N1 QOXHCBQLRMGDND-MRXNPFEDSA-N 0.000 claims 1
NGKJZKMAMLIWOF-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[[4-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=CC(=CC=2)C(F)(F)F)=N1 NGKJZKMAMLIWOF-MRXNPFEDSA-N 0.000 claims 1
JKAGJQIISTWTSJ-LLVKDONJSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-cyclopropylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NC2CC2)=N1 JKAGJQIISTWTSJ-LLVKDONJSA-N 0.000 claims 1
XRGNODWUWZWICO-SECBINFHSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 XRGNODWUWZWICO-SECBINFHSA-N 0.000 claims 1
SOIDQVUTNSQPIE-SECBINFHSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonyl fluoride Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(F)(=O)=O)=N1 SOIDQVUTNSQPIE-SECBINFHSA-N 0.000 claims 1
OPOIKZSKCNYCGG-LLVKDONJSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-methoxyethyl)benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NCCOC)=CC=C1NC1=NC=C(Br)C(N[C@H](C)CO)=N1 OPOIKZSKCNYCGG-LLVKDONJSA-N 0.000 claims 1
AXGKHKXXCZWGDR-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-morpholin-4-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCN2CCOCC2)=N1 AXGKHKXXCZWGDR-CQSZACIVSA-N 0.000 claims 1
GRLTVHLTFXVCDS-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-phenoxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCOC=2C=CC=CC=2)=N1 GRLTVHLTFXVCDS-OAHLLOKOSA-N 0.000 claims 1
KYKYMCDWQJIZJJ-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-phenylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCC=2C=CC=CC=2)=N1 KYKYMCDWQJIZJJ-OAHLLOKOSA-N 0.000 claims 1
OUXRNUPTKPCVAM-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-piperidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCN2CCCCC2)=N1 OUXRNUPTKPCVAM-OAHLLOKOSA-N 0.000 claims 1
LXIXVTKNXULCQQ-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-pyrrolidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCN2CCCC2)=N1 LXIXVTKNXULCQQ-CQSZACIVSA-N 0.000 claims 1
CZFUEQDFLHSZDI-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-imidazol-1-ylpropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCN2C=NC=C2)=N1 CZFUEQDFLHSZDI-CQSZACIVSA-N 0.000 claims 1
PJUUERIEVHJDSL-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-methylbutyl)benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NCCC(C)C)=CC=C1NC1=NC=C(Br)C(N[C@H](C)CO)=N1 PJUUERIEVHJDSL-CYBMUJFWSA-N 0.000 claims 1
SNKRUHDRJOWIGC-SECBINFHSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-methylsulfanyl-1h-1,2,4-triazol-5-yl)benzenesulfonamide Chemical compound CSC1=NNC(NS(=O)(=O)C=2C=CC(NC=3N=C(N[C@H](C)CO)C(Br)=CN=3)=CC=2)=N1 SNKRUHDRJOWIGC-SECBINFHSA-N 0.000 claims 1
BEBSFANBTSGFFQ-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-phenylpropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCC=2C=CC=CC=2)=N1 BEBSFANBTSGFFQ-MRXNPFEDSA-N 0.000 claims 1
JIQCPHSHJJKNLU-QGZVFWFLSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(4-phenylbutyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCCC=2C=CC=CC=2)=N1 JIQCPHSHJJKNLU-QGZVFWFLSA-N 0.000 claims 1
NVZSOJQMXPPCHS-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(cyclohexylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC2CCCCC2)=N1 NVZSOJQMXPPCHS-CQSZACIVSA-N 0.000 claims 1
CQISQCHYUDUYKD-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(pyridin-4-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=CN=CC=2)=N1 CQISQCHYUDUYKD-CYBMUJFWSA-N 0.000 claims 1
GSQRVWWDZPUURH-GFCCVEGCSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(thiophen-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2SC=CC=2)=N1 GSQRVWWDZPUURH-GFCCVEGCSA-N 0.000 claims 1
CVVPAUWBCXQHIB-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(2-methoxyphenyl)methyl]benzenesulfonamide Chemical compound COC1=CC=CC=C1CNS(=O)(=O)C(C=C1)=CC=C1NC1=NC=C(Br)C(N[C@H](C)CO)=N1 CVVPAUWBCXQHIB-CQSZACIVSA-N 0.000 claims 1
VBPYEQIXWPOOCU-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(3-fluorophenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=C(F)C=CC=2)=N1 VBPYEQIXWPOOCU-CYBMUJFWSA-N 0.000 claims 1
GKWZVHMMHGRNCC-QQFBHYJXSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-cyanocyclohexyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC2CCC(CC2)C#N)=N1 GKWZVHMMHGRNCC-QQFBHYJXSA-N 0.000 claims 1
RKOXJQRKXRDDLL-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-fluorophenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=CC(F)=CC=2)=N1 RKOXJQRKXRDDLL-CYBMUJFWSA-N 0.000 claims 1
GVZCJBSKTSUYNK-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-methylphenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=CC(C)=CC=2)=N1 GVZCJBSKTSUYNK-OAHLLOKOSA-N 0.000 claims 1
VAXNDIJVKXZTEP-GFCCVEGCSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(5-methylfuran-2-yl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2OC(C)=CC=2)=N1 VAXNDIJVKXZTEP-GFCCVEGCSA-N 0.000 claims 1
YGVSYUFPVBDBIX-IURRXHLWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(1-methylpyrrolidin-2-yl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCC2N(CCC2)C)=N1 YGVSYUFPVBDBIX-IURRXHLWSA-N 0.000 claims 1
NJMQSCXETRCMLD-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-chlorophenyl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCC=2C=CC(Cl)=CC=2)=N1 NJMQSCXETRCMLD-CQSZACIVSA-N 0.000 claims 1
ZTGMVKFRZXONFQ-OAHLLOKOSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CCNS(=O)(=O)C(C=C1)=CC=C1NC1=NC=C(Br)C(N[C@H](C)CO)=N1 ZTGMVKFRZXONFQ-OAHLLOKOSA-N 0.000 claims 1
AWZKKEKCRDKYIN-GFCCVEGCSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(dimethylamino)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCN(C)C)=N1 AWZKKEKCRDKYIN-GFCCVEGCSA-N 0.000 claims 1
AEXPTWWTZXNJTN-MRXNPFEDSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-[di(propan-2-yl)amino]ethyl]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NCCN(C(C)C)C(C)C)=CC=C1NC1=NC=C(Br)C(N[C@H](C)CO)=N1 AEXPTWWTZXNJTN-MRXNPFEDSA-N 0.000 claims 1
CKAJKOCHOVOSEQ-CQSZACIVSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[3-(2-oxopyrrolidin-1-yl)propyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCCN2C(CCC2)=O)=N1 CKAJKOCHOVOSEQ-CQSZACIVSA-N 0.000 claims 1
AULZJRFGVAEASE-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[[3-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=C(C=CC=2)C(F)(F)F)=N1 AULZJRFGVAEASE-CYBMUJFWSA-N 0.000 claims 1
NOTZBHHJZRWHNU-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[[4-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCC=2C=CC(=CC=2)C(F)(F)F)=N1 NOTZBHHJZRWHNU-CYBMUJFWSA-N 0.000 claims 1
YJSHWXLAAXZPHF-SNVBAGLBSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-cyclopropylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NC2CC2)=N1 YJSHWXLAAXZPHF-SNVBAGLBSA-N 0.000 claims 1
MJIALGDLOLWBRQ-MRVPVSSYSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 MJIALGDLOLWBRQ-MRVPVSSYSA-N 0.000 claims 1
VQASKXHBWAXJBZ-MRVPVSSYSA-N 4-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonyl fluoride Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=CC(=CC=2)S(F)(=O)=O)=N1 VQASKXHBWAXJBZ-MRVPVSSYSA-N 0.000 claims 1
NAKHVYGRJPQMKS-VXGBXAGGSA-N 4-[[5-bromo-4-[[(2r,3s)-1,3,4-trihydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(N[C@H](CO)[C@H](O)CO)=N1 NAKHVYGRJPQMKS-VXGBXAGGSA-N 0.000 claims 1
CQLAJLGSSXZYMT-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2s)-1-hydroxy-3,3-dimethylbutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@H](CO)C(C)(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 CQLAJLGSSXZYMT-CYBMUJFWSA-N 0.000 claims 1
GITZPQVLXGQOFC-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2s)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-n-hydroxybenzenesulfonamide Chemical compound C1=C(Br)C(N[C@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NO)=N1 GITZPQVLXGQOFC-CYBMUJFWSA-N 0.000 claims 1
HKKPMWUXYNOAMH-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2s)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 HKKPMWUXYNOAMH-CYBMUJFWSA-N 0.000 claims 1
LYKOLNKZXOWCFK-CYBMUJFWSA-N 4-[[5-bromo-4-[[(2s)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonyl fluoride Chemical compound C1=C(Br)C(N[C@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(F)(=O)=O)=N1 LYKOLNKZXOWCFK-CYBMUJFWSA-N 0.000 claims 1
XXRVXBGHUKJSIE-LBPRGKRZSA-N 4-[[5-bromo-4-[[(2s)-1-hydroxy-4-methylpentan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@H](CO)CC(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 XXRVXBGHUKJSIE-LBPRGKRZSA-N 0.000 claims 1
NLLQUEKHQAIVQU-NSHDSACASA-N 4-[[5-bromo-4-[[(2s)-1-hydroxy-4-methylsulfanylbutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@H](CO)CCSC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 NLLQUEKHQAIVQU-NSHDSACASA-N 0.000 claims 1
XRGNODWUWZWICO-VIFPVBQESA-N 4-[[5-bromo-4-[[(2s)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@H](CO)CC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 XRGNODWUWZWICO-VIFPVBQESA-N 0.000 claims 1
MJIALGDLOLWBRQ-QMMMGPOBSA-N 4-[[5-bromo-4-[[(2s)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@H](CO)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 MJIALGDLOLWBRQ-QMMMGPOBSA-N 0.000 claims 1
YWHGNLJQAAZUSQ-NSHDSACASA-N 4-[[5-bromo-4-[[(2s)-1-methoxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n,n-dimethylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](C)COC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)N(C)C)=N1 YWHGNLJQAAZUSQ-NSHDSACASA-N 0.000 claims 1
XAYLGTIEKZYYHR-NSHDSACASA-N 4-[[5-bromo-4-[[(2s)-1-methoxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-hydroxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](C)COC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCO)=N1 XAYLGTIEKZYYHR-NSHDSACASA-N 0.000 claims 1
YRDQBAKMPBVDID-JTQLQIEISA-N 4-[[5-bromo-4-[[(2s)-1-methoxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-methylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NC)=CC=C1NC1=NC=C(Br)C(N[C@@H](C)COC)=N1 YRDQBAKMPBVDID-JTQLQIEISA-N 0.000 claims 1
NMCCJSJOKZFDIW-VIFPVBQESA-N 4-[[5-bromo-4-[[(2s)-1-methoxypropan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](C)COC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 NMCCJSJOKZFDIW-VIFPVBQESA-N 0.000 claims 1
HQGQQBSYKPJVMW-BRJLIKDPSA-N 4-[[5-bromo-4-[[(3e)-3-[(2-methylpropan-2-yl)oxyimino]butan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)C(\C)=N\OC(C)(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 HQGQQBSYKPJVMW-BRJLIKDPSA-N 0.000 claims 1
GROTZQKRUBGFKS-LSHDLFTRSA-N 4-[[5-bromo-4-[[(3e)-3-methoxyiminobutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(Br)C(NC(C)C(/C)=N/OC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 GROTZQKRUBGFKS-LSHDLFTRSA-N 0.000 claims 1
PNZLCZKYHUQWKQ-LLVKDONJSA-N 4-[[5-bromo-4-[[(3r)-2-oxooxolan-3-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(N[C@H]2C(OCC2)=O)=N1 PNZLCZKYHUQWKQ-LLVKDONJSA-N 0.000 claims 1
BVQPZAIXEHOTTK-JTQLQIEISA-N 4-[[5-bromo-4-[[(3s)-oxolan-3-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(N[C@@H]2COCC2)=N1 BVQPZAIXEHOTTK-JTQLQIEISA-N 0.000 claims 1
VJSXBIHTEMQPKF-UHFFFAOYSA-N 4-[[5-bromo-4-[[1-(hydroxymethyl)cyclopentyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2(CO)CCCC2)=N1 VJSXBIHTEMQPKF-UHFFFAOYSA-N 0.000 claims 1
ZLNJYIARGUQBMB-UHFFFAOYSA-N 4-[[5-bromo-4-[[4-(2-pyrrolidin-1-ylethylamino)cyclohexyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(CC2)NCCN2CCCC2)=N1 ZLNJYIARGUQBMB-UHFFFAOYSA-N 0.000 claims 1
KXFBOVVIXHEMBB-UHFFFAOYSA-N 4-[[5-bromo-4-[[4-(4-hydroxypiperidin-1-yl)cyclohexyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NC2CCC(CC2)N2CCC(O)CC2)=N1 KXFBOVVIXHEMBB-UHFFFAOYSA-N 0.000 claims 1
YQCBGLUENDIFKW-UHFFFAOYSA-N 4-[[5-bromo-4-[[4-(dimethylamino)cyclohexyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1CC(N(C)C)CCC1NC1=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=NC=C1Br YQCBGLUENDIFKW-UHFFFAOYSA-N 0.000 claims 1
UUEUZISITWLJBZ-UHFFFAOYSA-N 4-[[5-bromo-4-[[4-[2-(dimethylamino)ethylamino]cyclohexyl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1CC(NCCN(C)C)CCC1NC1=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=NC=C1Br UUEUZISITWLJBZ-UHFFFAOYSA-N 0.000 claims 1
OQLMHCXDDKLEGP-UHFFFAOYSA-N 4-[[5-chloro-4-(prop-2-ynylamino)pyrimidin-2-yl]amino]-n-(2-hydroxyethyl)benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NCCO)=CC=C1NC1=NC=C(Cl)C(NCC#C)=N1 OQLMHCXDDKLEGP-UHFFFAOYSA-N 0.000 claims 1
YHVZUEKIFDIKTE-UHFFFAOYSA-N 4-[[5-chloro-4-(prop-2-ynylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Cl)C(NCC#C)=N1 YHVZUEKIFDIKTE-UHFFFAOYSA-N 0.000 claims 1
GGWXJVRSLQRCJA-UHFFFAOYSA-N 4-[[5-fluoro-4-(prop-2-ynylamino)pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(F)C(NCC#C)=N1 GGWXJVRSLQRCJA-UHFFFAOYSA-N 0.000 claims 1
TWMVRLBMEKNBNI-ZDUSSCGKSA-N 4-[[5-fluoro-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]benzenesulfonamide Chemical compound C1=C(F)C(N[C@@H](CO)C(C)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 TWMVRLBMEKNBNI-ZDUSSCGKSA-N 0.000 claims 1
JEBBDHYFCKGZOA-ZDUSSCGKSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxy-3-methylbutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C(C)C)=NC(NC=2C=C(C(C)=CC=2)S(N)(=O)=O)=N1 JEBBDHYFCKGZOA-ZDUSSCGKSA-N 0.000 claims 1
KAWBBMVMSIXVFC-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(2-phenoxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCOC=2C=CC=CC=2)=N1 KAWBBMVMSIXVFC-QGZVFWFLSA-N 0.000 claims 1
VOKDBHSMDJNRSR-GOSISDBHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(2-phenylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC=2C=CC=CC=2)=N1 VOKDBHSMDJNRSR-GOSISDBHSA-N 0.000 claims 1
LEBSANLCLDTCKV-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(3-methylbutyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC(C)C)=N1 LEBSANLCLDTCKV-OAHLLOKOSA-N 0.000 claims 1
OVDBVSIILYEALU-LJQANCHMSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(3-phenylpropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCCC=2C=CC=CC=2)=N1 OVDBVSIILYEALU-LJQANCHMSA-N 0.000 claims 1
CSHPZBZXTBWTLG-HXUWFJFHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(4-phenylbutyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCCCC=2C=CC=CC=2)=N1 CSHPZBZXTBWTLG-HXUWFJFHSA-N 0.000 claims 1
BICIEPIKVJHMTI-MRXNPFEDSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(pyridin-3-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=NC=CC=2)=N1 BICIEPIKVJHMTI-MRXNPFEDSA-N 0.000 claims 1
NTGXPHPQEZHKLB-MRXNPFEDSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(pyridin-4-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=CN=CC=2)=N1 NTGXPHPQEZHKLB-MRXNPFEDSA-N 0.000 claims 1
XTVVIPBRJVOUNT-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(thiophen-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2SC=CC=2)=N1 XTVVIPBRJVOUNT-CQSZACIVSA-N 0.000 claims 1
KFFUNORGDJUGDY-GOSISDBHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[(4-methylphenyl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=CC(C)=CC=2)=N1 KFFUNORGDJUGDY-GOSISDBHSA-N 0.000 claims 1
ZAUMXNJFGFSWBY-PYUWXLGESA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[2-(1-methylpyrrolidin-2-yl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC2N(CCC2)C)=N1 ZAUMXNJFGFSWBY-PYUWXLGESA-N 0.000 claims 1
PSBFJCJIKCXCMO-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC=2C=CC(=CC=2)S(N)(=O)=O)=N1 PSBFJCJIKCXCMO-QGZVFWFLSA-N 0.000 claims 1
DAJCMVOMEZYTHT-MRXNPFEDSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[3-(2-oxopyrrolidin-1-yl)propyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCCN2C(CCC2)=O)=N1 DAJCMVOMEZYTHT-MRXNPFEDSA-N 0.000 claims 1
PZUBCNYUFQIMFT-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[[3-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=C(C=CC=2)C(F)(F)F)=N1 PZUBCNYUFQIMFT-QGZVFWFLSA-N 0.000 claims 1
IUZOEOJVUFMQQK-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[[4-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=CC(=CC=2)C(F)(F)F)=N1 IUZOEOJVUFMQQK-QGZVFWFLSA-N 0.000 claims 1
HRYZMGIHWGHZFY-LJQANCHMSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-nonylbenzenesulfonamide Chemical compound C1=C(C)C(S(=O)(=O)NCCCCCCCCC)=CC(NC=2N=C(N[C@H](CC)CO)C(Br)=CN=2)=C1 HRYZMGIHWGHZFY-LJQANCHMSA-N 0.000 claims 1
CUYPKHHYFHWVGZ-GOSISDBHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-octylbenzenesulfonamide Chemical compound C1=C(C)C(S(=O)(=O)NCCCCCCCC)=CC(NC=2N=C(N[C@H](CC)CO)C(Br)=CN=2)=C1 CUYPKHHYFHWVGZ-GOSISDBHSA-N 0.000 claims 1
GNMPHDLJXUNMST-SNVBAGLBSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonyl fluoride Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(F)(=O)=O)=N1 GNMPHDLJXUNMST-SNVBAGLBSA-N 0.000 claims 1
ZWRAIRQTWVNPEU-CYBMUJFWSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-methoxyethyl)-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCOC)=N1 ZWRAIRQTWVNPEU-CYBMUJFWSA-N 0.000 claims 1
ADKORQSOLXNILO-XMMPIXPASA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3,3-diphenylpropyl)-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC(C=2C=CC=CC=2)C=2C=CC=CC=2)=N1 ADKORQSOLXNILO-XMMPIXPASA-N 0.000 claims 1
XWIQIMJNKSRVIY-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-(cyclohexylmethyl)-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC2CCCCC2)=N1 XWIQIMJNKSRVIY-QGZVFWFLSA-N 0.000 claims 1
ASODTPRJACMKOC-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(2-methoxyphenyl)methyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C(=CC=CC=2)OC)=N1 ASODTPRJACMKOC-QGZVFWFLSA-N 0.000 claims 1
UCPPHFPDYPTIGC-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(3-fluorophenyl)methyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=C(F)C=CC=2)=N1 UCPPHFPDYPTIGC-QGZVFWFLSA-N 0.000 claims 1
CUHRYIWKILBNEK-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-fluorophenyl)methyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=CC(F)=CC=2)=N1 CUHRYIWKILBNEK-QGZVFWFLSA-N 0.000 claims 1
HEEXRWNVOCHSKJ-GOSISDBHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-chlorophenyl)ethyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC=2C=CC(Cl)=CC=2)=N1 HEEXRWNVOCHSKJ-GOSISDBHSA-N 0.000 claims 1
JBRACZXUTCMBGG-GOSISDBHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-methoxyphenyl)ethyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC=2C=CC(OC)=CC=2)=N1 JBRACZXUTCMBGG-GOSISDBHSA-N 0.000 claims 1
ZSSOAXOUKRUDLQ-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(dimethylamino)ethyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCN(C)C)=N1 ZSSOAXOUKRUDLQ-CQSZACIVSA-N 0.000 claims 1
NMEMOQCDOKTFDX-GOSISDBHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-[di(propan-2-yl)amino]ethyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCN(C(C)C)C(C)C)=N1 NMEMOQCDOKTFDX-GOSISDBHSA-N 0.000 claims 1
KGEVWSPBOZNJDG-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-[3-(dimethylamino)propyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCCN(C)C)=N1 KGEVWSPBOZNJDG-OAHLLOKOSA-N 0.000 claims 1
VXDVNQWKMOMECD-GFCCVEGCSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-cyclopropyl-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)CC)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NC2CC2)=N1 VXDVNQWKMOMECD-GFCCVEGCSA-N 0.000 claims 1
JHNAAZGCISYTLS-HXUWFJFHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-decyl-2-methylbenzenesulfonamide Chemical compound C1=C(C)C(S(=O)(=O)NCCCCCCCCCC)=CC(NC=2N=C(N[C@H](CC)CO)C(Br)=CN=2)=C1 JHNAAZGCISYTLS-HXUWFJFHSA-N 0.000 claims 1
QBNCIMDBZKJYJY-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-heptyl-2-methylbenzenesulfonamide Chemical compound C1=C(C)C(S(=O)(=O)NCCCCCCC)=CC(NC=2N=C(N[C@H](CC)CO)C(Br)=CN=2)=C1 QBNCIMDBZKJYJY-QGZVFWFLSA-N 0.000 claims 1
MDLCRTCAGLJYTQ-MRXNPFEDSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxybutan-2-yl]amino]pyrimidin-2-yl]amino]-n-hexyl-2-methylbenzenesulfonamide Chemical compound C1=C(C)C(S(=O)(=O)NCCCCCC)=CC(NC=2N=C(N[C@H](CC)CO)C(Br)=CN=2)=C1 MDLCRTCAGLJYTQ-MRXNPFEDSA-N 0.000 claims 1
UZACHZKCPVCRPX-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(2-morpholin-4-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCN2CCOCC2)=N1 UZACHZKCPVCRPX-OAHLLOKOSA-N 0.000 claims 1
CGPSZEURQFOQBR-MRXNPFEDSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(2-phenoxyethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCOC=2C=CC=CC=2)=N1 CGPSZEURQFOQBR-MRXNPFEDSA-N 0.000 claims 1
MMXKUKKKEBEZME-MRXNPFEDSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(2-phenylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC=2C=CC=CC=2)=N1 MMXKUKKKEBEZME-MRXNPFEDSA-N 0.000 claims 1
RCTNOCAWAHEDSN-MRXNPFEDSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(2-piperidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCN2CCCCC2)=N1 RCTNOCAWAHEDSN-MRXNPFEDSA-N 0.000 claims 1
QBBLKECBLORKCL-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(2-pyrrolidin-1-ylethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCN2CCCC2)=N1 QBBLKECBLORKCL-OAHLLOKOSA-N 0.000 claims 1
RAMVJNHDITVKPQ-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(3-methylbutyl)benzenesulfonamide Chemical compound C1=C(C)C(S(=O)(=O)NCCC(C)C)=CC(NC=2N=C(N[C@H](C)CO)C(Br)=CN=2)=C1 RAMVJNHDITVKPQ-CQSZACIVSA-N 0.000 claims 1
NTVISAJIAZPDTC-QGZVFWFLSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(3-phenylpropyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCCC=2C=CC=CC=2)=N1 NTVISAJIAZPDTC-QGZVFWFLSA-N 0.000 claims 1
MGGGDGAPYCYHCK-GOSISDBHSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(4-phenylbutyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCCCC=2C=CC=CC=2)=N1 MGGGDGAPYCYHCK-GOSISDBHSA-N 0.000 claims 1
ZWDNLJHYDZKZSO-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(pyridin-3-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=NC=CC=2)=N1 ZWDNLJHYDZKZSO-CQSZACIVSA-N 0.000 claims 1
MIQUAKWQUBUMRP-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(pyridin-4-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=CN=CC=2)=N1 MIQUAKWQUBUMRP-CQSZACIVSA-N 0.000 claims 1
WSRQHUQCQMQOAO-CYBMUJFWSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-(thiophen-2-ylmethyl)benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2SC=CC=2)=N1 WSRQHUQCQMQOAO-CYBMUJFWSA-N 0.000 claims 1
KUJVLMIOVUPWLQ-CYBMUJFWSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[(5-methylfuran-2-yl)methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2OC(C)=CC=2)=N1 KUJVLMIOVUPWLQ-CYBMUJFWSA-N 0.000 claims 1
SZXMCRLJQZBFGY-LDCVWXEPSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[2-(1-methylpyrrolidin-2-yl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC2N(CCC2)C)=N1 SZXMCRLJQZBFGY-LDCVWXEPSA-N 0.000 claims 1
UFXONPNVMBXORI-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC=2C=CC(=CC=2)S(N)(=O)=O)=N1 UFXONPNVMBXORI-OAHLLOKOSA-N 0.000 claims 1
TYKYVNGEZLPOIP-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[[3-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=C(C=CC=2)C(F)(F)F)=N1 TYKYVNGEZLPOIP-CQSZACIVSA-N 0.000 claims 1
NWYSHTULYODZLP-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-2-methyl-n-[[4-(trifluoromethyl)phenyl]methyl]benzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=CC(=CC=2)C(F)(F)F)=N1 NWYSHTULYODZLP-CQSZACIVSA-N 0.000 claims 1
LQWGKFRWBCQQNL-GFCCVEGCSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(2-methoxyethyl)-2-methylbenzenesulfonamide Chemical compound C1=C(C)C(S(=O)(=O)NCCOC)=CC(NC=2N=C(N[C@H](C)CO)C(Br)=CN=2)=C1 LQWGKFRWBCQQNL-GFCCVEGCSA-N 0.000 claims 1
GTSDKLCPGKWKNV-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(3-imidazol-1-ylpropyl)-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCCN2C=NC=C2)=N1 GTSDKLCPGKWKNV-OAHLLOKOSA-N 0.000 claims 1
PUBMJHHLKSAMDQ-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(cyclohexylmethyl)-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC2CCCCC2)=N1 PUBMJHHLKSAMDQ-OAHLLOKOSA-N 0.000 claims 1
QAJITLOKYBDAKN-CYBMUJFWSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-(furan-2-ylmethyl)-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2OC=CC=2)=N1 QAJITLOKYBDAKN-CYBMUJFWSA-N 0.000 claims 1
UTPQOVOJOJHIQS-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(2-methoxyphenyl)methyl]-2-methylbenzenesulfonamide Chemical compound COC1=CC=CC=C1CNS(=O)(=O)C1=CC(NC=2N=C(N[C@H](C)CO)C(Br)=CN=2)=CC=C1C UTPQOVOJOJHIQS-OAHLLOKOSA-N 0.000 claims 1
PRAWLWNFIZPWMT-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(3-fluorophenyl)methyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=C(F)C=CC=2)=N1 PRAWLWNFIZPWMT-CQSZACIVSA-N 0.000 claims 1
ROIXALYMOQIAKO-CQSZACIVSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[(4-fluorophenyl)methyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCC=2C=CC(F)=CC=2)=N1 ROIXALYMOQIAKO-CQSZACIVSA-N 0.000 claims 1
FZDLEUQBKRLLMJ-OAHLLOKOSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-chlorophenyl)ethyl]-2-methylbenzenesulfonamide Chemical compound C1=C(Br)C(N[C@@H](CO)C)=NC(NC=2C=C(C(C)=CC=2)S(=O)(=O)NCCC=2C=CC(Cl)=CC=2)=N1 FZDLEUQBKRLLMJ-OAHLLOKOSA-N 0.000 claims 1
LEKDCGCGHXTBFQ-MRXNPFEDSA-N 5-[[5-bromo-4-[[(2r)-1-hydroxypropan-2-yl]amino]pyrimidin-2-yl]amino]-n-[2-(4-methoxyphenyl)ethyl]-2-methylbenzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CCNS(=O)(=O)C1=CC(NC=2N=C(N[C@H](C)CO)C(Br)=CN=2)=CC=C1C LEKDCGCGHXTBFQ-MRXNPFEDSA-N 0.000 claims 1
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JOIORRUUZNTGDY-UHFFFAOYSA-N 6-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]-n-(1,3-dihydroxypropan-2-yl)hexanamide Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCCCCC(=O)NC(CO)CO)=N1 JOIORRUUZNTGDY-UHFFFAOYSA-N 0.000 claims 1
JGDHGKUWDDZRII-UHFFFAOYSA-N 6-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]hexanoic acid Chemical compound C1=CC(S(=O)(=O)N)=CC=C1NC1=NC=C(Br)C(NCCCCCC(O)=O)=N1 JGDHGKUWDDZRII-UHFFFAOYSA-N 0.000 claims 1
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102100036329 Cyclin-dependent kinase 3 Human genes 0.000 claims 1
102100036252 Cyclin-dependent kinase 4 Human genes 0.000 claims 1
102100026804 Cyclin-dependent kinase 6 Human genes 0.000 claims 1
102100026810 Cyclin-dependent kinase 7 Human genes 0.000 claims 1
102100024456 Cyclin-dependent kinase 8 Human genes 0.000 claims 1
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NQLLJCWSEDXJGP-IBGZPJMESA-N [(2r)-2-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]-3-methylbutyl] n-(3,4,5-trimethoxyphenyl)carbamate Chemical compound COC1=C(OC)C(OC)=CC(NC(=O)OC[C@H](NC=2C(=CN=C(NC=3C=CC(=CC=3)S(N)(=O)=O)N=2)Br)C(C)C)=C1 NQLLJCWSEDXJGP-IBGZPJMESA-N 0.000 claims 1
DVEMUNMMHWICPE-IBGZPJMESA-N [(2r)-2-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]-3-methylbutyl] n-phenylcarbamate Chemical compound C([C@@H](C(C)C)NC=1C(=CN=C(NC=2C=CC(=CC=2)S(N)(=O)=O)N=1)Br)OC(=O)NC1=CC=CC=C1 DVEMUNMMHWICPE-IBGZPJMESA-N 0.000 claims 1
MEPFFDPMFNUOSD-UHFFFAOYSA-N [3-acetyloxy-2-[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]oxypropyl] acetate Chemical compound C1=C(Br)C(OC(COC(C)=O)COC(=O)C)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 MEPFFDPMFNUOSD-UHFFFAOYSA-N 0.000 claims 1
XXBTYXOWBDMMQN-UHFFFAOYSA-N [4-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]cyclohexyl] n-butylcarbamate Chemical compound C1CC(OC(=O)NCCCC)CCC1NC1=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=NC=C1Br XXBTYXOWBDMMQN-UHFFFAOYSA-N 0.000 claims 1
FJZDVAQIQBWNJC-UHFFFAOYSA-N [[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]methyl-methoxyphosphinic acid Chemical compound C1=C(Br)C(NCP(O)(=O)OC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 FJZDVAQIQBWNJC-UHFFFAOYSA-N 0.000 claims 1
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ZZBCEDDMQQHNLP-UHFFFAOYSA-N ethyl 4-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]butanoate Chemical compound C1=C(Br)C(NCCCC(=O)OCC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 ZZBCEDDMQQHNLP-UHFFFAOYSA-N 0.000 claims 1
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SJWFPJZXWGKMEU-UHFFFAOYSA-N methyl 2-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]-3-hydroxypropanoate Chemical compound C1=C(Br)C(NC(CO)C(=O)OC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 SJWFPJZXWGKMEU-UHFFFAOYSA-N 0.000 claims 1
SDOJPUMBQBDAQS-UHFFFAOYSA-N methyl 2-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]butanoate Chemical compound C1=C(Br)C(NC(CC)C(=O)OC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 SDOJPUMBQBDAQS-UHFFFAOYSA-N 0.000 claims 1
CVWHZCDRMJQOBC-UHFFFAOYSA-N methyl 4-[3-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]propanoylamino]butanoate Chemical compound C1=C(Br)C(NCCC(=O)NCCCC(=O)OC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 CVWHZCDRMJQOBC-UHFFFAOYSA-N 0.000 claims 1
BPDQTICFFSLEBY-UHFFFAOYSA-N methyl 4-[6-[[5-bromo-2-(4-sulfamoylanilino)pyrimidin-4-yl]amino]hexanoylamino]butanoate Chemical compound C1=C(Br)C(NCCCCCC(=O)NCCCC(=O)OC)=NC(NC=2C=CC(=CC=2)S(N)(=O)=O)=N1 BPDQTICFFSLEBY-UHFFFAOYSA-N 0.000 claims 1
QRVBZWQEQOXGKP-UHFFFAOYSA-N methyl 4-[[5-bromo-2-[4-(2-hydroxyethylsulfamoyl)anilino]pyrimidin-4-yl]amino]butanoate Chemical compound C1=C(Br)C(NCCCC(=O)OC)=NC(NC=2C=CC(=CC=2)S(=O)(=O)NCCO)=N1 QRVBZWQEQOXGKP-UHFFFAOYSA-N 0.000 claims 1
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JP2003500067A 2001-05-29 2002-05-23 Ｃｄｋ阻害性ピリミジン、それらの製造および薬剤としての使用 Expired - Fee Related JP4291135B2 (ja)