JP2004532263A5 - - Google Patents
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- Publication number
- JP2004532263A5 JP2004532263A5 JP2003500061A JP2003500061A JP2004532263A5 JP 2004532263 A5 JP2004532263 A5 JP 2004532263A5 JP 2003500061 A JP2003500061 A JP 2003500061A JP 2003500061 A JP2003500061 A JP 2003500061A JP 2004532263 A5 JP2004532263 A5 JP 2004532263A5
- Authority
- JP
- Japan
- Prior art keywords
- dibenz
- azepine
- dihydro
- carboxamide
- oxyleno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZFXVFMBOFIEPII-UHFFFAOYSA-N 1h-azepine-4-carboxamide Chemical compound NC(=O)C1=CC=CNC=C1 ZFXVFMBOFIEPII-UHFFFAOYSA-N 0.000 claims 4
- 239000003054 catalyst Substances 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- PGAKBXJPZAOAKB-UHFFFAOYSA-N 1h-azepine-3-carboxamide Chemical compound NC(=O)C1=CNC=CC=C1 PGAKBXJPZAOAKB-UHFFFAOYSA-N 0.000 claims 1
- MEJUSBCKLPAFRO-UHFFFAOYSA-N 2-(1h-azepin-3-yl)acetamide Chemical compound NC(=O)CC1=CNC=CC=C1 MEJUSBCKLPAFRO-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229960000623 carbamazepine Drugs 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000000852 hydrogen donor Substances 0.000 claims 1
- 238000007142 ring opening reaction Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0112812.3A GB0112812D0 (en) | 2001-05-25 | 2001-05-25 | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
| PCT/GB2002/002356 WO2002096881A1 (en) | 2001-05-25 | 2002-05-22 | Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-0x0-5h-dibenz/b,f/azepine-5-carboxamide |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008201613A Division JP2009057376A (ja) | 2001-05-25 | 2008-08-05 | １０，１１−ジヒドロ−１０−ヒドルオキシ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミド及び１０，１１−ジヒドロ−１０−オキソ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミドの製造方法 |
| JP2009054515A Division JP5280252B2 (ja) | 2001-05-25 | 2009-03-09 | １０，１１−ジヒドロ−１０−ヒドロキシ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミド及び１０，１１−ジヒドロ−１０−オキソ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミドの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532263A JP2004532263A (ja) | 2004-10-21 |
| JP2004532263A5 true JP2004532263A5 (enExample) | 2007-04-05 |
| JP4323309B2 JP4323309B2 (ja) | 2009-09-02 |
Family
ID=9915332
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003500061A Expired - Fee Related JP4323309B2 (ja) | 2001-05-25 | 2002-05-22 | １０，１１−ジヒドロ−１０−ヒドルオキシ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミド及び１０，１１−ジヒドロ−１０−オキソ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミドの製造方法 |
| JP2008201613A Pending JP2009057376A (ja) | 2001-05-25 | 2008-08-05 | １０，１１−ジヒドロ−１０−ヒドルオキシ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミド及び１０，１１−ジヒドロ−１０−オキソ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミドの製造方法 |
| JP2009054515A Expired - Fee Related JP5280252B2 (ja) | 2001-05-25 | 2009-03-09 | １０，１１−ジヒドロ−１０−ヒドロキシ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミド及び１０，１１−ジヒドロ−１０−オキソ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミドの製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008201613A Pending JP2009057376A (ja) | 2001-05-25 | 2008-08-05 | １０，１１−ジヒドロ−１０−ヒドルオキシ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミド及び１０，１１−ジヒドロ−１０−オキソ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミドの製造方法 |
| JP2009054515A Expired - Fee Related JP5280252B2 (ja) | 2001-05-25 | 2009-03-09 | １０，１１−ジヒドロ−１０−ヒドロキシ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミド及び１０，１１−ジヒドロ−１０−オキソ−５Ｈ−ジベンズ／ｂ，ｆ／アゼピン−５−カルボキシアミドの製造方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7241886B2 (enExample) |
| EP (2) | EP1399424B8 (enExample) |
| JP (3) | JP4323309B2 (enExample) |
| KR (1) | KR100931916B1 (enExample) |
| CN (2) | CN101172967A (enExample) |
| AR (1) | AR035460A1 (enExample) |
| AT (2) | ATE400560T1 (enExample) |
| AU (2) | AU2002307863B8 (enExample) |
| BR (1) | BR0210019A (enExample) |
| CA (2) | CA2750876C (enExample) |
| CY (3) | CY1108345T1 (enExample) |
| CZ (1) | CZ303130B6 (enExample) |
| DE (2) | DE60227517D1 (enExample) |
| DK (2) | DK1958938T3 (enExample) |
| ES (2) | ES2305299T3 (enExample) |
| GB (1) | GB0112812D0 (enExample) |
| HU (1) | HU230019B1 (enExample) |
| LU (1) | LU91603I2 (enExample) |
| MX (1) | MXPA03010793A (enExample) |
| PL (1) | PL215305B1 (enExample) |
| RU (2) | RU2311411C2 (enExample) |
| SI (1) | SI1399424T1 (enExample) |
| WO (1) | WO2002096881A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
| ITMI20042230A1 (it) | 2004-11-19 | 2005-02-19 | Farchemia Srl | Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide |
| ITMI20042291A1 (it) | 2004-11-26 | 2005-02-26 | Farchema S R L | Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide |
| GB2422149A (en) * | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
| GB0517740D0 (en) * | 2005-08-31 | 2005-10-12 | Novartis Ag | Organic compounds |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| US8372431B2 (en) * | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
| EP2459198A1 (en) | 2009-07-27 | 2012-06-06 | Bial-Portela & CA, S.A. | Use of 5h-dibenz / b, f/ azepine-5-carboxamide derivatives for treating fibromyalgia |
| US20150065704A1 (en) | 2011-07-13 | 2015-03-05 | Ketan Hirpara | Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof |
| IN2015DN02296A (enExample) | 2012-09-26 | 2015-08-21 | Ranbaxy Lab Ltd | |
| WO2017049213A1 (en) | 2015-09-16 | 2017-03-23 | PetaOmics, Inc. | Methods and compositions for genomic target enrichment and selective dna sequencing |
| US12492423B2 (en) | 2015-09-16 | 2025-12-09 | PetaOmics, Inc. | Methods and compositions for genomic target enrichment and selective DNA sequencing |
| CN111943347B (zh) * | 2020-07-16 | 2022-08-30 | 同济大学 | 一种铜离子活化过氧乙酸去除废水中卡马西平的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5439390B2 (enExample) * | 1971-09-30 | 1979-11-27 | ||
| BE789320A (fr) * | 1971-09-30 | 1973-03-27 | Takeda Chemical Industries Ltd | Derives de dibenzoxirenazepine |
| CH633271A5 (en) * | 1978-04-18 | 1982-11-30 | Ciba Geigy Ag | Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines |
| CH642950A5 (en) * | 1979-10-30 | 1984-05-15 | Ciba Geigy Ag | Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
| IT1272897B (it) * | 1995-01-13 | 1997-07-01 | I F C Iniziative Finanziaarie | Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide |
| PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| PT101876B (pt) * | 1996-05-27 | 1999-09-30 | Portela & Ca Sa | Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida |
| AT408224B (de) * | 1999-03-15 | 2001-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von oxcarbazepin |
-
2001
- 2001-05-25 GB GBGB0112812.3A patent/GB0112812D0/en not_active Ceased
-
2002
- 2002-05-22 DK DK08075527.5T patent/DK1958938T3/da active
- 2002-05-22 CA CA2750876A patent/CA2750876C/en not_active Expired - Fee Related
- 2002-05-22 AT AT02774050T patent/ATE400560T1/de active
- 2002-05-22 ES ES02774050T patent/ES2305299T3/es not_active Expired - Lifetime
- 2002-05-22 US US10/478,770 patent/US7241886B2/en not_active Expired - Lifetime
- 2002-05-22 DK DK02774050T patent/DK1399424T3/da active
- 2002-05-22 CN CNA2007101939981A patent/CN101172967A/zh active Pending
- 2002-05-22 WO PCT/GB2002/002356 patent/WO2002096881A1/en not_active Ceased
- 2002-05-22 CN CN028105915A patent/CN1511141B/zh not_active Expired - Fee Related
- 2002-05-22 AT AT08075527T patent/ATE506351T1/de active
- 2002-05-22 RU RU2003137224/04A patent/RU2311411C2/ru active
- 2002-05-22 ES ES08075527T patent/ES2362688T3/es not_active Expired - Lifetime
- 2002-05-22 DE DE60227517T patent/DE60227517D1/de not_active Expired - Lifetime
- 2002-05-22 KR KR1020037015323A patent/KR100931916B1/ko not_active Expired - Fee Related
- 2002-05-22 PL PL366993A patent/PL215305B1/pl unknown
- 2002-05-22 JP JP2003500061A patent/JP4323309B2/ja not_active Expired - Fee Related
- 2002-05-22 MX MXPA03010793A patent/MXPA03010793A/es active IP Right Grant
- 2002-05-22 EP EP02774050A patent/EP1399424B8/en not_active Expired - Lifetime
- 2002-05-22 DE DE60239842T patent/DE60239842D1/de not_active Expired - Lifetime
- 2002-05-22 EP EP08075527A patent/EP1958938B1/en not_active Expired - Lifetime
- 2002-05-22 CZ CZ20033203A patent/CZ303130B6/cs not_active IP Right Cessation
- 2002-05-22 HU HU0400296A patent/HU230019B1/hu unknown
- 2002-05-22 SI SI200230717T patent/SI1399424T1/sl unknown
- 2002-05-22 CA CA2448094A patent/CA2448094C/en not_active Expired - Lifetime
- 2002-05-22 AU AU2002307863A patent/AU2002307863B8/en not_active Ceased
- 2002-05-22 BR BR0210019-3A patent/BR0210019A/pt active Search and Examination
- 2002-05-24 AR ARP020101958A patent/AR035460A1/es not_active Application Discontinuation
-
2007
- 2007-06-01 RU RU2007120532/04A patent/RU2449992C2/ru not_active IP Right Cessation
- 2007-10-04 AU AU2007221834A patent/AU2007221834B2/en not_active Ceased
-
2008
- 2008-08-05 JP JP2008201613A patent/JP2009057376A/ja active Pending
- 2008-09-17 CY CY20081100998T patent/CY1108345T1/el unknown
-
2009
- 2009-03-09 JP JP2009054515A patent/JP5280252B2/ja not_active Expired - Fee Related
- 2009-08-28 LU LU91603C patent/LU91603I2/fr unknown
- 2009-10-19 CY CY2009017C patent/CY2009017I1/el unknown
-
2011
- 2011-05-27 CY CY20111100515T patent/CY1111492T1/el unknown
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