JP2004532263A5 - - Google Patents
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- Publication number
- JP2004532263A5 JP2004532263A5 JP2003500061A JP2003500061A JP2004532263A5 JP 2004532263 A5 JP2004532263 A5 JP 2004532263A5 JP 2003500061 A JP2003500061 A JP 2003500061A JP 2003500061 A JP2003500061 A JP 2003500061A JP 2004532263 A5 JP2004532263 A5 JP 2004532263A5
- Authority
- JP
- Japan
- Prior art keywords
- dibenz
- azepine
- dihydro
- carboxamide
- oxyleno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZFXVFMBOFIEPII-UHFFFAOYSA-N 1H-azepine-4-carboxamide Chemical compound NC(=O)C1=CC=CNC=C1 ZFXVFMBOFIEPII-UHFFFAOYSA-N 0.000 claims 4
- MEJUSBCKLPAFRO-UHFFFAOYSA-N 2-(1H-azepin-3-yl)acetamide Chemical compound NC(=O)CC1=CNC=CC=C1 MEJUSBCKLPAFRO-UHFFFAOYSA-N 0.000 claims 3
- 239000003054 catalyst Substances 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- FFGPTBGBLSHEPO-UHFFFAOYSA-N Carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims 2
- PGAKBXJPZAOAKB-UHFFFAOYSA-N 1H-azepine-3-carboxamide Chemical compound NC(=O)C1=CNC=CC=C1 PGAKBXJPZAOAKB-UHFFFAOYSA-N 0.000 claims 1
- 229960000623 carbamazepine Drugs 0.000 claims 1
- 230000003197 catalytic Effects 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000000852 hydrogen donor Substances 0.000 claims 1
- 238000007142 ring opening reaction Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 claims 1
Claims (1)
10,11-ジヒドロ-10-ヒドルオキシ-5H-ジベンズ/b,f/アゼピン-5-カルボキシアミド(1)の製造方法であって、下記工程を含む;カルバマゼピン(3)を実質的に不活性な溶媒においてペルオキシ酢酸及び金属触媒と反応させ、11a,10b-ジヒドロ-6H-ジベンズ/b,f/オキシレノ[d]アゼピン-6-カルボキシアミド(5)を製造し、続いて、水素供与体及び金属触媒の存在下において、触媒的転移水素化により、又はそれにかわり金属触媒の存在下においてガス状水素による触媒的水素化により、11a,10b-ジヒドロ-6H-ジベンズ/b,f/オキシレノ[d]アゼピン-6-カルボキシアミド(5)の開環を行うことにより、10,11-ジヒドロ-10-ヒドルオキシ-5H-ジベンズ/b,f/アゼピン-5-カルボキシアミド(1)を製造する、前記方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0112812.3A GB0112812D0 (en) | 2001-05-25 | 2001-05-25 | Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom |
PCT/GB2002/002356 WO2002096881A1 (en) | 2001-05-25 | 2002-05-22 | Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-0x0-5h-dibenz/b,f/azepine-5-carboxamide |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008201613A Division JP2009057376A (ja) | 2001-05-25 | 2008-08-05 | 10,11−ジヒドロ−10−ヒドルオキシ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミド及び10,11−ジヒドロ−10−オキソ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミドの製造方法 |
JP2009054515A Division JP5280252B2 (ja) | 2001-05-25 | 2009-03-09 | 10,11−ジヒドロ−10−ヒドロキシ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミド及び10,11−ジヒドロ−10−オキソ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミドの製造方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004532263A JP2004532263A (ja) | 2004-10-21 |
JP2004532263A5 true JP2004532263A5 (ja) | 2007-04-05 |
JP4323309B2 JP4323309B2 (ja) | 2009-09-02 |
Family
ID=9915332
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003500061A Expired - Fee Related JP4323309B2 (ja) | 2001-05-25 | 2002-05-22 | 10,11−ジヒドロ−10−ヒドルオキシ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミド及び10,11−ジヒドロ−10−オキソ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミドの製造方法 |
JP2008201613A Pending JP2009057376A (ja) | 2001-05-25 | 2008-08-05 | 10,11−ジヒドロ−10−ヒドルオキシ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミド及び10,11−ジヒドロ−10−オキソ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミドの製造方法 |
JP2009054515A Expired - Fee Related JP5280252B2 (ja) | 2001-05-25 | 2009-03-09 | 10,11−ジヒドロ−10−ヒドロキシ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミド及び10,11−ジヒドロ−10−オキソ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミドの製造方法 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008201613A Pending JP2009057376A (ja) | 2001-05-25 | 2008-08-05 | 10,11−ジヒドロ−10−ヒドルオキシ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミド及び10,11−ジヒドロ−10−オキソ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミドの製造方法 |
JP2009054515A Expired - Fee Related JP5280252B2 (ja) | 2001-05-25 | 2009-03-09 | 10,11−ジヒドロ−10−ヒドロキシ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミド及び10,11−ジヒドロ−10−オキソ−5H−ジベンズ/b,f/アゼピン−5−カルボキシアミドの製造方法 |
Country Status (23)
Country | Link |
---|---|
US (1) | US7241886B2 (ja) |
EP (2) | EP1958938B1 (ja) |
JP (3) | JP4323309B2 (ja) |
KR (1) | KR100931916B1 (ja) |
CN (2) | CN1511141B (ja) |
AR (1) | AR035460A1 (ja) |
AT (2) | ATE506351T1 (ja) |
AU (2) | AU2002307863B8 (ja) |
BR (1) | BR0210019A (ja) |
CA (2) | CA2750876C (ja) |
CY (3) | CY1108345T1 (ja) |
CZ (1) | CZ303130B6 (ja) |
DE (2) | DE60227517D1 (ja) |
DK (2) | DK1399424T3 (ja) |
ES (2) | ES2362688T3 (ja) |
GB (1) | GB0112812D0 (ja) |
HU (1) | HU230019B1 (ja) |
LU (1) | LU91603I2 (ja) |
MX (1) | MXPA03010793A (ja) |
PL (1) | PL215305B1 (ja) |
RU (2) | RU2311411C2 (ja) |
SI (1) | SI1399424T1 (ja) |
WO (1) | WO2002096881A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
ITMI20042230A1 (it) | 2004-11-19 | 2005-02-19 | Farchemia Srl | Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide |
ITMI20042291A1 (it) | 2004-11-26 | 2005-02-26 | Farchema S R L | Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide |
GB2422149A (en) | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
US20060252745A1 (en) * | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
GB0517740D0 (en) * | 2005-08-31 | 2005-10-12 | Novartis Ag | Organic compounds |
GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
US8372431B2 (en) | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
CA2769181C (en) | 2009-07-27 | 2017-11-28 | Bial-Portela & Ca., S.A. | Use of 5h-dibenz / b, f/ azepine-5-carboxamide derivatives for treating fibromyalgia |
WO2013008194A2 (en) | 2011-07-13 | 2013-01-17 | Ranbaxy Laboratories Limited | Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof |
US20150232426A1 (en) | 2012-09-26 | 2015-08-20 | Ranbaxy Laboratories Limited | Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate |
JP6937294B2 (ja) | 2015-09-16 | 2021-09-22 | ぺタオミクス, インコーポレイテッド | ゲノムターゲットエンリッチメント及び選択的dnaシーケンシングのための方法及び組成物 |
CN111943347B (zh) * | 2020-07-16 | 2022-08-30 | 同济大学 | 一种铜离子活化过氧乙酸去除废水中卡马西平的方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5439390B2 (ja) * | 1971-09-30 | 1979-11-27 | ||
BE789320A (fr) * | 1971-09-30 | 1973-03-27 | Takeda Chemical Industries Ltd | Derives de dibenzoxirenazepine |
CH633271A5 (en) | 1978-04-18 | 1982-11-30 | Ciba Geigy Ag | Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines |
CH642950A5 (en) | 1979-10-30 | 1984-05-15 | Ciba Geigy Ag | Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide |
IT1272897B (it) * | 1995-01-13 | 1997-07-01 | I F C Iniziative Finanziaarie | Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide |
PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
PT101876B (pt) * | 1996-05-27 | 1999-09-30 | Portela & Ca Sa | Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida |
AT408224B (de) | 1999-03-15 | 2001-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von oxcarbazepin |
-
2001
- 2001-05-25 GB GBGB0112812.3A patent/GB0112812D0/en not_active Ceased
-
2002
- 2002-05-22 EP EP08075527A patent/EP1958938B1/en not_active Expired - Lifetime
- 2002-05-22 US US10/478,770 patent/US7241886B2/en not_active Expired - Lifetime
- 2002-05-22 JP JP2003500061A patent/JP4323309B2/ja not_active Expired - Fee Related
- 2002-05-22 AU AU2002307863A patent/AU2002307863B8/en not_active Ceased
- 2002-05-22 DK DK02774050T patent/DK1399424T3/da active
- 2002-05-22 DK DK08075527.5T patent/DK1958938T3/da active
- 2002-05-22 PL PL366993A patent/PL215305B1/pl unknown
- 2002-05-22 DE DE60227517T patent/DE60227517D1/de not_active Expired - Lifetime
- 2002-05-22 CN CN028105915A patent/CN1511141B/zh not_active Expired - Fee Related
- 2002-05-22 SI SI200230717T patent/SI1399424T1/sl unknown
- 2002-05-22 AT AT08075527T patent/ATE506351T1/de active
- 2002-05-22 WO PCT/GB2002/002356 patent/WO2002096881A1/en active IP Right Grant
- 2002-05-22 MX MXPA03010793A patent/MXPA03010793A/es active IP Right Grant
- 2002-05-22 HU HU0400296A patent/HU230019B1/hu unknown
- 2002-05-22 KR KR1020037015323A patent/KR100931916B1/ko not_active IP Right Cessation
- 2002-05-22 ES ES08075527T patent/ES2362688T3/es not_active Expired - Lifetime
- 2002-05-22 EP EP02774050A patent/EP1399424B8/en not_active Expired - Lifetime
- 2002-05-22 DE DE60239842T patent/DE60239842D1/de not_active Expired - Lifetime
- 2002-05-22 ES ES02774050T patent/ES2305299T3/es not_active Expired - Lifetime
- 2002-05-22 CA CA2750876A patent/CA2750876C/en not_active Expired - Fee Related
- 2002-05-22 RU RU2003137224/04A patent/RU2311411C2/ru active
- 2002-05-22 CZ CZ20033203A patent/CZ303130B6/cs not_active IP Right Cessation
- 2002-05-22 CA CA2448094A patent/CA2448094C/en not_active Expired - Lifetime
- 2002-05-22 BR BR0210019-3A patent/BR0210019A/pt active Search and Examination
- 2002-05-22 AT AT02774050T patent/ATE400560T1/de active
- 2002-05-22 CN CNA2007101939981A patent/CN101172967A/zh active Pending
- 2002-05-24 AR ARP020101958A patent/AR035460A1/es not_active Application Discontinuation
-
2007
- 2007-06-01 RU RU2007120532/04A patent/RU2449992C2/ru not_active IP Right Cessation
- 2007-10-04 AU AU2007221834A patent/AU2007221834B2/en not_active Ceased
-
2008
- 2008-08-05 JP JP2008201613A patent/JP2009057376A/ja active Pending
- 2008-09-17 CY CY20081100998T patent/CY1108345T1/el unknown
-
2009
- 2009-03-09 JP JP2009054515A patent/JP5280252B2/ja not_active Expired - Fee Related
- 2009-08-28 LU LU91603C patent/LU91603I2/fr unknown
- 2009-10-19 CY CY2009017C patent/CY2009017I1/el unknown
-
2011
- 2011-05-27 CY CY20111100515T patent/CY1111492T1/el unknown
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