CY1108345T1 - Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου - Google Patents

Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου

Info

Publication number
CY1108345T1
CY1108345T1 CY20081100998T CY081100998T CY1108345T1 CY 1108345 T1 CY1108345 T1 CY 1108345T1 CY 20081100998 T CY20081100998 T CY 20081100998T CY 081100998 T CY081100998 T CY 081100998T CY 1108345 T1 CY1108345 T1 CY 1108345T1
Authority
CY
Cyprus
Prior art keywords
dibenzo
carboxamide
dihydro
azepino
oxo
Prior art date
Application number
CY20081100998T
Other languages
English (en)
Inventor
David Alexander Learmonth
Original Assignee
Bial - Portela & Ca., S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial - Portela & Ca., S.A. filed Critical Bial - Portela & Ca., S.A.
Publication of CY1108345T1 publication Critical patent/CY1108345T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Abstract

Μία μέθοδος για την παρασκευή 10,11-διυδρο-10-υδροξυ-5Η-διβενζο/b, f/αζεπινο-5-καρβοξαμίδιου και 10,11-διυδρο-10-οξο-5Η-διβενζο/b, f/αζεπινο-5-καρβοξαμίδιου από καρβαμαζεπίνη μέσω μιας μεθόδου τριών σταδίων που περιλαμβάνει (i) την εποξείδωση της καρβαμαζεπίνης˙ (ii) το άνοιγμα του δακτυλίου του εποξείδιου που προκύπτει και (iii) την οξείδωση της αλκοόλης που προκύπτει.
CY20081100998T 2001-05-25 2008-09-17 Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου CY1108345T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0112812.3A GB0112812D0 (en) 2001-05-25 2001-05-25 Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom
PCT/GB2002/002356 WO2002096881A1 (en) 2001-05-25 2002-05-22 Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-0x0-5h-dibenz/b,f/azepine-5-carboxamide

Publications (1)

Publication Number Publication Date
CY1108345T1 true CY1108345T1 (el) 2012-01-25

Family

ID=9915332

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20081100998T CY1108345T1 (el) 2001-05-25 2008-09-17 Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου
CY2009017C CY2009017I2 (el) 2001-05-25 2009-10-19 Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου
CY20111100515T CY1111492T1 (el) 2001-05-25 2011-05-27 ΜΙΑ ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ 10,11-ΔΙΥΔΡΟ-10-ΟΞΟ-5Η-ΔΙΒΕΝΖΟ[b,f]ΑΖΕΠΙΝΟ-5-ΚΑΡΒΟΞΑΜΙΔΙΟΥ

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY2009017C CY2009017I2 (el) 2001-05-25 2009-10-19 Μεθοδος για την παρασκευη 10, 11-διυδρο-10-υδροξυ-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου και 10,11-διυδρο-10-οξο-5η-διβενζο/β,f/αζεπινο-5-καρβοξαμιδιου
CY20111100515T CY1111492T1 (el) 2001-05-25 2011-05-27 ΜΙΑ ΜΕΘΟΔΟΣ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ 10,11-ΔΙΥΔΡΟ-10-ΟΞΟ-5Η-ΔΙΒΕΝΖΟ[b,f]ΑΖΕΠΙΝΟ-5-ΚΑΡΒΟΞΑΜΙΔΙΟΥ

Country Status (23)

Country Link
US (1) US7241886B2 (el)
EP (2) EP1399424B8 (el)
JP (3) JP4323309B2 (el)
KR (1) KR100931916B1 (el)
CN (2) CN1511141B (el)
AR (1) AR035460A1 (el)
AT (2) ATE506351T1 (el)
AU (2) AU2002307863B8 (el)
BR (1) BR0210019A (el)
CA (2) CA2750876C (el)
CY (3) CY1108345T1 (el)
CZ (1) CZ303130B6 (el)
DE (2) DE60239842D1 (el)
DK (2) DK1399424T3 (el)
ES (2) ES2362688T3 (el)
GB (1) GB0112812D0 (el)
HU (1) HU230019B1 (el)
LU (1) LU91603I2 (el)
MX (1) MXPA03010793A (el)
PL (1) PL215305B1 (el)
RU (2) RU2311411C2 (el)
SI (1) SI1399424T1 (el)
WO (1) WO2002096881A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0303615D0 (en) * 2003-02-17 2003-03-19 Novartis Ag Use of organic compounds
ITMI20042230A1 (it) 2004-11-19 2005-02-19 Farchemia Srl Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide
ITMI20042291A1 (it) 2004-11-26 2005-02-26 Farchema S R L Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide
GB2422149A (en) * 2005-01-14 2006-07-19 Portela & Ca Sa Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB0517740D0 (en) * 2005-08-31 2005-10-12 Novartis Ag Organic compounds
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
RU2012106827A (ru) 2009-07-27 2013-09-10 БИАЛ-ПОРТЕЛА энд КА., С.А. Применение производных 5н-дибенз/в, f/азепин-5-карбоксамида для лечения фибромиалгии
US20150065704A1 (en) 2011-07-13 2015-03-05 Ketan Hirpara Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
IN2015DN02296A (el) 2012-09-26 2015-08-21 Ranbaxy Lab Ltd
US11046999B2 (en) 2015-09-16 2021-06-29 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective DNA sequencing
CN111943347B (zh) * 2020-07-16 2022-08-30 同济大学 一种铜离子活化过氧乙酸去除废水中卡马西平的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5439390B2 (el) * 1971-09-30 1979-11-27
BE789320A (fr) * 1971-09-30 1973-03-27 Takeda Chemical Industries Ltd Derives de dibenzoxirenazepine
CH633271A5 (en) 1978-04-18 1982-11-30 Ciba Geigy Ag Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines
CH642950A5 (en) * 1979-10-30 1984-05-15 Ciba Geigy Ag Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
PT101876B (pt) * 1996-05-27 1999-09-30 Portela & Ca Sa Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida
AT408224B (de) 1999-03-15 2001-09-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von oxcarbazepin

Also Published As

Publication number Publication date
CA2448094A1 (en) 2002-12-05
AR035460A1 (es) 2004-05-26
CN1511141B (zh) 2011-06-08
EP1958938B1 (en) 2011-04-20
CA2750876A1 (en) 2002-12-05
HUP0400296A2 (hu) 2004-08-30
DE60239842D1 (de) 2011-06-01
AU2007221834B2 (en) 2009-02-05
MXPA03010793A (es) 2004-07-01
AU2002307863B2 (en) 2007-09-27
DK1958938T3 (da) 2011-07-25
RU2007120532A (ru) 2008-12-10
SI1399424T1 (sl) 2008-10-31
KR100931916B1 (ko) 2009-12-15
HUP0400296A3 (en) 2008-03-28
JP4323309B2 (ja) 2009-09-02
EP1399424B1 (en) 2008-07-09
US20040158060A1 (en) 2004-08-12
BR0210019A (pt) 2004-08-10
JP5280252B2 (ja) 2013-09-04
LU91603I2 (fr) 2009-10-28
RU2003137224A (ru) 2005-05-27
PL215305B1 (pl) 2013-11-29
CN101172967A (zh) 2008-05-07
JP2009167194A (ja) 2009-07-30
ATE506351T1 (de) 2011-05-15
GB0112812D0 (en) 2001-07-18
EP1399424A1 (en) 2004-03-24
ES2305299T3 (es) 2008-11-01
CA2750876C (en) 2014-10-28
US7241886B2 (en) 2007-07-10
CY2009017I1 (el) 2012-01-25
JP2009057376A (ja) 2009-03-19
ATE400560T1 (de) 2008-07-15
RU2449992C2 (ru) 2012-05-10
DK1399424T3 (da) 2008-09-08
RU2311411C2 (ru) 2007-11-27
WO2002096881A8 (en) 2003-02-27
CN1511141A (zh) 2004-07-07
KR20040030626A (ko) 2004-04-09
WO2002096881A1 (en) 2002-12-05
CZ303130B6 (cs) 2012-04-18
ES2362688T3 (es) 2011-07-11
CY2009017I2 (el) 2012-01-25
AU2002307863B8 (en) 2007-10-18
CA2448094C (en) 2011-11-01
DE60227517D1 (de) 2008-08-21
EP1958938A2 (en) 2008-08-20
EP1958938A3 (en) 2008-09-03
HU230019B1 (hu) 2015-05-28
CZ20033203A3 (cs) 2004-06-16
CY1111492T1 (el) 2015-08-05
AU2007221834A1 (en) 2007-10-25
EP1399424B8 (en) 2008-10-01
PL366993A1 (en) 2005-02-07
JP2004532263A (ja) 2004-10-21

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