RU2311411C2 - СПОСОБ ПОЛУЧЕНИЯ 10,11-ДИГИДРО-10-ГИДРОКСИ-5H-ДИБЕНЗ/b,f/АЗЕПИН-5-КАРБОКСАМИДА И 10,11-ДИГИДРО-10-ОКСО-5H-ДИБЕНЗ/b,f/АЗЕПИН-5-КАРБОКСАМИДА - Google Patents

СПОСОБ ПОЛУЧЕНИЯ 10,11-ДИГИДРО-10-ГИДРОКСИ-5H-ДИБЕНЗ/b,f/АЗЕПИН-5-КАРБОКСАМИДА И 10,11-ДИГИДРО-10-ОКСО-5H-ДИБЕНЗ/b,f/АЗЕПИН-5-КАРБОКСАМИДА Download PDF

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Publication number
RU2311411C2
RU2311411C2 RU2003137224/04A RU2003137224A RU2311411C2 RU 2311411 C2 RU2311411 C2 RU 2311411C2 RU 2003137224/04 A RU2003137224/04 A RU 2003137224/04A RU 2003137224 A RU2003137224 A RU 2003137224A RU 2311411 C2 RU2311411 C2 RU 2311411C2
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RU
Russia
Prior art keywords
dibenz
carboxamide
dihydro
azepine
reaction
Prior art date
Application number
RU2003137224/04A
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English (en)
Russian (ru)
Other versions
RU2003137224A (ru
Inventor
Дэвид Александер ЛЕРМОНТ (PT)
Дэвид Александер ЛЕРМОНТ
Original Assignee
Портела Энд Ка Са
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Publication date
Application filed by Портела Энд Ка Са filed Critical Портела Энд Ка Са
Publication of RU2003137224A publication Critical patent/RU2003137224A/ru
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Publication of RU2311411C2 publication Critical patent/RU2311411C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Catalysts (AREA)
RU2003137224/04A 2001-05-25 2002-05-22 СПОСОБ ПОЛУЧЕНИЯ 10,11-ДИГИДРО-10-ГИДРОКСИ-5H-ДИБЕНЗ/b,f/АЗЕПИН-5-КАРБОКСАМИДА И 10,11-ДИГИДРО-10-ОКСО-5H-ДИБЕНЗ/b,f/АЗЕПИН-5-КАРБОКСАМИДА RU2311411C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0112812.3 2001-05-25
GBGB0112812.3A GB0112812D0 (en) 2001-05-25 2001-05-25 Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2007120532/04A Division RU2449992C2 (ru) 2001-05-25 2007-06-01 СПОСОБ ПОЛУЧЕНИЯ 10,11-ДИГИДРО-10-ОКСО-5Н-ДИБЕНЗ(b,f)АЗЕПИН-5-КАРБОКСАМИДА

Publications (2)

Publication Number Publication Date
RU2003137224A RU2003137224A (ru) 2005-05-27
RU2311411C2 true RU2311411C2 (ru) 2007-11-27

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ID=9915332

Family Applications (2)

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RU2003137224/04A RU2311411C2 (ru) 2001-05-25 2002-05-22 СПОСОБ ПОЛУЧЕНИЯ 10,11-ДИГИДРО-10-ГИДРОКСИ-5H-ДИБЕНЗ/b,f/АЗЕПИН-5-КАРБОКСАМИДА И 10,11-ДИГИДРО-10-ОКСО-5H-ДИБЕНЗ/b,f/АЗЕПИН-5-КАРБОКСАМИДА
RU2007120532/04A RU2449992C2 (ru) 2001-05-25 2007-06-01 СПОСОБ ПОЛУЧЕНИЯ 10,11-ДИГИДРО-10-ОКСО-5Н-ДИБЕНЗ(b,f)АЗЕПИН-5-КАРБОКСАМИДА

Family Applications After (1)

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Country Status (23)

Country Link
US (1) US7241886B2 (enExample)
EP (2) EP1958938B1 (enExample)
JP (3) JP4323309B2 (enExample)
KR (1) KR100931916B1 (enExample)
CN (2) CN101172967A (enExample)
AR (1) AR035460A1 (enExample)
AT (2) ATE400560T1 (enExample)
AU (2) AU2002307863B8 (enExample)
BR (1) BR0210019A (enExample)
CA (2) CA2750876C (enExample)
CY (3) CY1108345T1 (enExample)
CZ (1) CZ303130B6 (enExample)
DE (2) DE60227517D1 (enExample)
DK (2) DK1399424T3 (enExample)
ES (2) ES2362688T3 (enExample)
GB (1) GB0112812D0 (enExample)
HU (1) HU230019B1 (enExample)
LU (1) LU91603I2 (enExample)
MX (1) MXPA03010793A (enExample)
PL (1) PL215305B1 (enExample)
RU (2) RU2311411C2 (enExample)
SI (1) SI1399424T1 (enExample)
WO (1) WO2002096881A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0303615D0 (en) * 2003-02-17 2003-03-19 Novartis Ag Use of organic compounds
ITMI20042230A1 (it) 2004-11-19 2005-02-19 Farchemia Srl Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide
ITMI20042291A1 (it) 2004-11-26 2005-02-26 Farchema S R L Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide
GB2422149A (en) * 2005-01-14 2006-07-19 Portela & Ca Sa Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
US20060252745A1 (en) * 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB0517740D0 (en) * 2005-08-31 2005-10-12 Novartis Ag Organic compounds
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
CA2769181C (en) 2009-07-27 2017-11-28 Bial-Portela & Ca., S.A. Use of 5h-dibenz / b, f/ azepine-5-carboxamide derivatives for treating fibromyalgia
WO2013008194A2 (en) 2011-07-13 2013-01-17 Ranbaxy Laboratories Limited Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
IN2015DN02296A (enExample) 2012-09-26 2015-08-21 Ranbaxy Lab Ltd
DK3350343T3 (da) 2015-09-16 2020-07-20 Petaomics Inc Fremgangsmåder og sammensætninger til genommålberigelse og selektiv dna-sekventering
US12492423B2 (en) 2015-09-16 2025-12-09 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective DNA sequencing
CN111943347B (zh) * 2020-07-16 2022-08-30 同济大学 一种铜离子活化过氧乙酸去除废水中卡马西平的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753646A (en) * 1995-06-30 1998-05-19 Portela & Ca., S.A. Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them

Family Cites Families (7)

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JPS5439390B2 (enExample) * 1971-09-30 1979-11-27
BE789320A (fr) * 1971-09-30 1973-03-27 Takeda Chemical Industries Ltd Derives de dibenzoxirenazepine
CH633271A5 (en) 1978-04-18 1982-11-30 Ciba Geigy Ag Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines
CH642950A5 (en) * 1979-10-30 1984-05-15 Ciba Geigy Ag Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
PT101876B (pt) * 1996-05-27 1999-09-30 Portela & Ca Sa Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida
AT408224B (de) 1999-03-15 2001-09-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von oxcarbazepin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753646A (en) * 1995-06-30 1998-05-19 Portela & Ca., S.A. Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
G.BELUCCI et al. The Metabolism of Carbamazepine in Humans: steric course of the Enzymatic Hydrolysis of the 10,11-Epoxide. J. Med. Chem., 1987, 30, p.768-773. *
К.М.BAKER et al. 10,11-Dihydro-10,11-dihydroxy-5H-dibenz[b,f]azepine-5-carboxamide, a Metabolite of Carbamazepine Isolated from Human and Rat Urine. J. of Med. Chem., 1973, v.16, n.6, p.703-705. SENANAYAKE C.H. et al. The Role of 4-(3-Phenylpropyl)pyridine N-Oxide(P 3 NO) in the Manganese-Salen-Catalyzed Asymmetric Epoxidation of Indene. TETRAHEDRON LETTERS, v.37, n.19, 1996, p.3271-3274. *

Also Published As

Publication number Publication date
GB0112812D0 (en) 2001-07-18
ATE400560T1 (de) 2008-07-15
CN101172967A (zh) 2008-05-07
DK1399424T3 (da) 2008-09-08
RU2449992C2 (ru) 2012-05-10
US20040158060A1 (en) 2004-08-12
KR100931916B1 (ko) 2009-12-15
JP2009167194A (ja) 2009-07-30
HUP0400296A3 (en) 2008-03-28
PL366993A1 (en) 2005-02-07
BR0210019A (pt) 2004-08-10
JP2009057376A (ja) 2009-03-19
DE60227517D1 (de) 2008-08-21
CA2750876A1 (en) 2002-12-05
CY1108345T1 (el) 2012-01-25
EP1958938A3 (en) 2008-09-03
RU2007120532A (ru) 2008-12-10
EP1958938A2 (en) 2008-08-20
CZ303130B6 (cs) 2012-04-18
CN1511141B (zh) 2011-06-08
AU2002307863B2 (en) 2007-09-27
ES2305299T3 (es) 2008-11-01
AR035460A1 (es) 2004-05-26
CY1111492T1 (el) 2015-08-05
CY2009017I1 (el) 2012-01-25
AU2002307863B8 (en) 2007-10-18
DE60239842D1 (de) 2011-06-01
CY2009017I2 (el) 2012-01-25
EP1399424B8 (en) 2008-10-01
CN1511141A (zh) 2004-07-07
WO2002096881A1 (en) 2002-12-05
JP2004532263A (ja) 2004-10-21
ATE506351T1 (de) 2011-05-15
HU230019B1 (hu) 2015-05-28
ES2362688T3 (es) 2011-07-11
JP5280252B2 (ja) 2013-09-04
SI1399424T1 (sl) 2008-10-31
AU2007221834A1 (en) 2007-10-25
CA2448094C (en) 2011-11-01
LU91603I2 (fr) 2009-10-28
RU2003137224A (ru) 2005-05-27
DK1958938T3 (da) 2011-07-25
CZ20033203A3 (cs) 2004-06-16
JP4323309B2 (ja) 2009-09-02
WO2002096881A8 (en) 2003-02-27
EP1399424B1 (en) 2008-07-09
US7241886B2 (en) 2007-07-10
EP1958938B1 (en) 2011-04-20
PL215305B1 (pl) 2013-11-29
MXPA03010793A (es) 2004-07-01
CA2750876C (en) 2014-10-28
CA2448094A1 (en) 2002-12-05
KR20040030626A (ko) 2004-04-09
AU2007221834B2 (en) 2009-02-05
EP1399424A1 (en) 2004-03-24
HUP0400296A2 (hu) 2004-08-30

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