JP2004523537A5 - - Google Patents

Info

Publication number

JP2004523537A5

JP2004523537A5 JP2002562342A JP2002562342A JP2004523537A5 JP 2004523537 A5 JP2004523537 A5 JP 2004523537A5 JP 2002562342 A JP2002562342 A JP 2002562342A JP 2002562342 A JP2002562342 A JP 2002562342A JP 2004523537 A5 JP2004523537 A5 JP 2004523537A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

vascular

composition according

sleeve

agent

Prior art date

2002-01-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 230000002792 vascular Effects 0.000 claims 20
• 239000008194 pharmaceutical composition Substances 0.000 claims 18
• 239000003795 chemical substances by application Substances 0.000 claims 10
• 230000001028 anti-proliverative effect Effects 0.000 claims 7
• 239000011159 matrix material Substances 0.000 claims 6
• 238000000502 dialysis Methods 0.000 claims 4
• 101000933603 Rattus norvegicus Protein BTG1 Proteins 0.000 claims 3
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 3
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
• 208000012868 Overgrowth Diseases 0.000 claims 2
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims 2
• 230000003872 anastomosis Effects 0.000 claims 2
• 210000004204 blood vessel Anatomy 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229920000669 heparin Polymers 0.000 claims 2
• 239000000463 material Substances 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 230000009696 proliferative response Effects 0.000 claims 2
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
• 229960002930 sirolimus Drugs 0.000 claims 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• 102000012422 Collagen Type I Human genes 0.000 claims 1
• 108010022452 Collagen Type I Proteins 0.000 claims 1
• 108010092160 Dactinomycin Proteins 0.000 claims 1
• 101710170181 Metalloproteinase inhibitor Proteins 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 229940123237 Taxane Drugs 0.000 claims 1
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims 1
• 230000000735 allogeneic effect Effects 0.000 claims 1
• BIIVYFLTOXDAOV-YVEFUNNKSA-N alvocidib Chemical compound O[C@@H]1CN(C)CC[C@@H]1C1=C(O)C=C(O)C2=C1OC(C=1C(=CC=CC=1)Cl)=CC2=O BIIVYFLTOXDAOV-YVEFUNNKSA-N 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 210000002798 bone marrow cell Anatomy 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• 229960000640 dactinomycin Drugs 0.000 claims 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
• 229960003957 dexamethasone Drugs 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 238000012377 drug delivery Methods 0.000 claims 1
• 230000004064 dysfunction Effects 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 210000005260 human cell Anatomy 0.000 claims 1
• 230000003463 hyperproliferative effect Effects 0.000 claims 1
• 229940126170 metalloproteinase inhibitor Drugs 0.000 claims 1
• 239000003475 metalloproteinase inhibitor Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 210000000663 muscle cell Anatomy 0.000 claims 1
• -1 other taxanes Chemical compound 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 210000000130 stem cell Anatomy 0.000 claims 1
• 150000003431 steroids Chemical class 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 229960001967 tacrolimus Drugs 0.000 claims 1
• QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
• 208000019553 vascular disease Diseases 0.000 claims 1
• 210000003462 vein Anatomy 0.000 claims 1