JP2013151573A - 治療のためのヒストンの使用方法 - Google Patents
治療のためのヒストンの使用方法 Download PDFInfo
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- JP2013151573A JP2013151573A JP2013102973A JP2013102973A JP2013151573A JP 2013151573 A JP2013151573 A JP 2013151573A JP 2013102973 A JP2013102973 A JP 2013102973A JP 2013102973 A JP2013102973 A JP 2013102973A JP 2013151573 A JP2013151573 A JP 2013151573A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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Abstract
【課題】血小板減少症の治療に使用できる活性物質を見出す。
【解決手段】本発明は、血小板減少症の処置のための基礎原料として、少なくとも一つのヒト組換えヒストン、特に、少なくとも一つのヒストンH1サブタイプ及び/又は治療上有効なヒストンセグメントを使用する方法に関する。
【選択図】図1
Description
Claims (7)
- 血小板減少症の治療処置のための基礎原料として、少なくとも一つのヒト組換えヒストン、特に少なくとも一つのH1サブタイプ及び/又はその治療上有効なセグメントを使用する方法。
- 血液疾患の付随的徴候としての血小板減少症の治療処置のために使用する、請求項1に記載のヒストン及び/又はその治療上有効なセグメント。
- 血液疾患の治療のため、特に薬物治療の後に、治療中又はその後の血小板減少症の治療処置のために使用する、請求項1に記載のヒストン及び/又はその治療上有効なセグメント。
- 血小板減少症の治療処置と同時に、白血病、特に急性脊髄性白血病の治療処置のために使用する、請求項1に記載のヒストン及び/又はその治療上有効なセグメント。
- 何らかの病因による疾患からもたらされる血小板減少症の場合の治療のために使用する、請求項1に記載のヒストン及び/又はその治療上有効なセグメント。
- 何らかの病因による疾患からもたらされる命にかかわる血小板減少症の場合に予防的治療に使用する、請求項5に記載のヒストン及び/又はその治療上有効なセグメント。
- ヒト組換えヒストンH1.3であることを特徴とする、請求項1に記載のヒストン及び/又はその治療上有効なセグメント。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005022319.2 | 2005-05-10 | ||
DE102005022319A DE102005022319A1 (de) | 2005-05-10 | 2005-05-10 | Verwendung von Histonen zu therapeutischen Zwecken |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008510461A Division JP2008540473A (ja) | 2005-05-10 | 2006-05-04 | 治療のためのヒストンの使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013151573A true JP2013151573A (ja) | 2013-08-08 |
JP5667238B2 JP5667238B2 (ja) | 2015-02-12 |
Family
ID=37310925
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008510461A Pending JP2008540473A (ja) | 2005-05-10 | 2006-05-04 | 治療のためのヒストンの使用方法 |
JP2013102973A Expired - Fee Related JP5667238B2 (ja) | 2005-05-10 | 2013-05-15 | 治療のためのヒストンの使用方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008510461A Pending JP2008540473A (ja) | 2005-05-10 | 2006-05-04 | 治療のためのヒストンの使用方法 |
Country Status (12)
Country | Link |
---|---|
US (3) | US20090305966A1 (ja) |
EP (1) | EP1879609B1 (ja) |
JP (2) | JP2008540473A (ja) |
KR (3) | KR20140137462A (ja) |
CN (1) | CN101171027A (ja) |
CA (2) | CA2811995A1 (ja) |
DE (1) | DE102005022319A1 (ja) |
ES (1) | ES2461564T3 (ja) |
HU (1) | HUE027070T2 (ja) |
PL (1) | PL1879609T3 (ja) |
PT (1) | PT1879609E (ja) |
WO (1) | WO2006119912A2 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005022319A1 (de) * | 2005-05-10 | 2006-11-23 | Symbiotec Gesellschaft Zur Forschung Und Entwicklung Auf Dem Gebiet Der Biotechnologie Mbh | Verwendung von Histonen zu therapeutischen Zwecken |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03502582A (ja) * | 1988-05-31 | 1991-06-13 | シェリング・バイオテック・コーポレーション | 骨髄性白血病の治療方法 |
JP2000512311A (ja) * | 1997-04-11 | 2000-09-19 | シンバイオテック・ゲゼルシャフト・ツーア・フォルシュング・ウント・エントヴィックルング・アウフ・デム・ゲビート・デア・ビオテヒノロギー・ミット・ベシュレンクテル・ハフツング | 個別性をもつ癌細胞を特徴づけるのに有用な、癌の治療的、予防的、診断的薬剤 |
JP2002355048A (ja) * | 2001-05-31 | 2002-12-10 | Communication Research Laboratory | リボヌクレオチド還元酵素r1とその阻害ペプチド |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4818763A (en) * | 1984-01-12 | 1989-04-04 | Volker Rusch | Biologically active substance with hormonal properties, production process thereof and utilization of histones for medical purposes |
DE4000154A1 (de) * | 1990-01-04 | 1991-07-11 | Symbiotec Gmbh | Chemotherapeutisches mittel, insbesondere zur behandlung von krebserkrankungen |
US5571686A (en) * | 1994-04-14 | 1996-11-05 | Massachusetts Institute Of Technology | Method of using megapoietin for prolonging the survival & viability of platlets |
US20030017987A1 (en) * | 1997-04-11 | 2003-01-23 | Michael Zeppezauer | Therapeutic, prophylactic, and diagnostic agent for cancer, useful for characterizing cancer cells with individual properties |
US6884423B1 (en) * | 1998-08-13 | 2005-04-26 | Symbiotec Gmbh | Antimicrobial histone H1 compositions, kits, and methods of use thereof |
AU4676500A (en) * | 1999-04-28 | 2000-11-10 | Northwestern University | Localization of major peptide autoepitopes for nucleosome specific t cells of systemic lupus erythematosus |
DE10001113A1 (de) * | 2000-01-13 | 2001-07-26 | Strathmann Ag & Co | Rekombinante Herstellung von humanen Histon 1-Subtypen sowie deren Verwendung für therapeutische Zwecke |
US7931897B2 (en) | 2001-02-07 | 2011-04-26 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for hematopoietic tumors |
JP2004519476A (ja) | 2001-02-22 | 2004-07-02 | シンビオテック・ゲゼルシャフト・ミット・ベシュレンクター・ハフツンク | 血小板凝集防止用組成物及び方法 |
DE10230223A1 (de) * | 2002-07-04 | 2004-01-22 | Tegenero Ag | Mikropartikel mit CD28-spezifischen monoklonalen Antikörpern |
US20040146585A1 (en) * | 2002-10-31 | 2004-07-29 | Oregon Health & Science University | Use of thiol-based compositions in treating chemotherapeutic agent-induced thrombocytopenia |
DE102005022319A1 (de) * | 2005-05-10 | 2006-11-23 | Symbiotec Gesellschaft Zur Forschung Und Entwicklung Auf Dem Gebiet Der Biotechnologie Mbh | Verwendung von Histonen zu therapeutischen Zwecken |
-
2005
- 2005-05-10 DE DE102005022319A patent/DE102005022319A1/de not_active Ceased
-
2006
- 2006-05-04 US US11/920,050 patent/US20090305966A1/en not_active Abandoned
- 2006-05-04 JP JP2008510461A patent/JP2008540473A/ja active Pending
- 2006-05-04 CN CNA2006800157213A patent/CN101171027A/zh active Pending
- 2006-05-04 KR KR1020147031207A patent/KR20140137462A/ko active Search and Examination
- 2006-05-04 CA CA2811995A patent/CA2811995A1/en not_active Abandoned
- 2006-05-04 ES ES06742792.2T patent/ES2461564T3/es active Active
- 2006-05-04 WO PCT/EP2006/004167 patent/WO2006119912A2/de active Application Filing
- 2006-05-04 KR KR1020077025805A patent/KR20080007351A/ko not_active Application Discontinuation
- 2006-05-04 CA CA2608019A patent/CA2608019C/en not_active Expired - Fee Related
- 2006-05-04 KR KR1020137019312A patent/KR20130099207A/ko active Application Filing
- 2006-05-04 PT PT67427922T patent/PT1879609E/pt unknown
- 2006-05-04 PL PL06742792T patent/PL1879609T3/pl unknown
- 2006-05-04 EP EP06742792.2A patent/EP1879609B1/de not_active Not-in-force
- 2006-05-04 HU HUE06742792A patent/HUE027070T2/en unknown
-
2013
- 2013-02-04 US US13/758,950 patent/US8962562B2/en not_active Expired - Fee Related
- 2013-05-15 JP JP2013102973A patent/JP5667238B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-02 US US14/588,836 patent/US20150119331A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03502582A (ja) * | 1988-05-31 | 1991-06-13 | シェリング・バイオテック・コーポレーション | 骨髄性白血病の治療方法 |
JP2000512311A (ja) * | 1997-04-11 | 2000-09-19 | シンバイオテック・ゲゼルシャフト・ツーア・フォルシュング・ウント・エントヴィックルング・アウフ・デム・ゲビート・デア・ビオテヒノロギー・ミット・ベシュレンクテル・ハフツング | 個別性をもつ癌細胞を特徴づけるのに有用な、癌の治療的、予防的、診断的薬剤 |
JP2002355048A (ja) * | 2001-05-31 | 2002-12-10 | Communication Research Laboratory | リボヌクレオチド還元酵素r1とその阻害ペプチド |
Non-Patent Citations (5)
Title |
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JPN6011059873; VALIRON,O. et al: 'Histone H1(0) expression is restricted to progenitor cells during human hematopoiesis' Eur J Cell Biol Vol.72, No.1, 1997, p.39-45 * |
JPN6011059874; GOODMAN,R. et al: 'Hematopoietic stem cells: effect of preirradiation, bleeding, and erythropoietin on thrombopoietic d' Blood Vol.49, No.2, 1977, p.253-61 * |
JPN6011059875; BUG,G. et al: 'Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells' Cancer Res Vol.65, No.7, 2005, p.2537-41 * |
JPN6011059876; Semina v: 'Effect of histone on hematopoietic stem cells (cfu-s) in normal and irradiated organism' Radiacionnaa biologia radioekologia 34(4-5), 1994, 544-9 * |
JPN6012029388; 徐瑞栄ら: '益気養陰清熱法を併用した急性骨髄性白血病の治療' 中医臨床 Vol.26, No.1, 2005, 32-5 * |
Also Published As
Publication number | Publication date |
---|---|
ES2461564T3 (es) | 2014-05-20 |
HUE027070T2 (en) | 2016-08-29 |
JP5667238B2 (ja) | 2015-02-12 |
PL1879609T3 (pl) | 2014-08-29 |
DE102005022319A1 (de) | 2006-11-23 |
KR20140137462A (ko) | 2014-12-02 |
US20150119331A1 (en) | 2015-04-30 |
CA2811995A1 (en) | 2006-11-16 |
CA2608019C (en) | 2013-07-02 |
WO2006119912A2 (de) | 2006-11-16 |
JP2008540473A (ja) | 2008-11-20 |
WO2006119912A3 (de) | 2007-04-12 |
US20140148391A1 (en) | 2014-05-29 |
KR20080007351A (ko) | 2008-01-18 |
KR20130099207A (ko) | 2013-09-05 |
PT1879609E (pt) | 2014-06-09 |
CN101171027A (zh) | 2008-04-30 |
CA2608019A1 (en) | 2006-11-16 |
US8962562B2 (en) | 2015-02-24 |
US20090305966A1 (en) | 2009-12-10 |
EP1879609A2 (de) | 2008-01-23 |
EP1879609B1 (de) | 2014-03-12 |
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