HRP20171635T1 - Modificirani kolagen - Google Patents
Modificirani kolagen Download PDFInfo
- Publication number
- HRP20171635T1 HRP20171635T1 HRP20171635TT HRP20171635T HRP20171635T1 HR P20171635 T1 HRP20171635 T1 HR P20171635T1 HR P20171635T T HRP20171635T T HR P20171635TT HR P20171635 T HRP20171635 T HR P20171635T HR P20171635 T1 HRP20171635 T1 HR P20171635T1
- Authority
- HR
- Croatia
- Prior art keywords
- collagen
- temperature
- providing
- step consists
- modified
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title claims 19
- 108010035532 Collagen Proteins 0.000 title claims 19
- 229920001436 collagen Polymers 0.000 title claims 19
- 238000000034 method Methods 0.000 claims 16
- 230000018044 dehydration Effects 0.000 claims 5
- 238000006297 dehydration reaction Methods 0.000 claims 5
- 239000006185 dispersion Substances 0.000 claims 4
- 238000011067 equilibration Methods 0.000 claims 4
- 230000005070 ripening Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 230000008014 freezing Effects 0.000 claims 3
- 238000007710 freezing Methods 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000000354 decomposition reaction Methods 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (12)
1. Postupak priprave modificiranog kolagena, naznačen time što se postupak sastoji u koracima:
(a) osiguravanja izoliranog kolagena;
(b) smrzavanja izoliranog kolagena;
(c) dehidratiranja smrznutog kolagena; i
(d) zrenja dehidratiranog kolagena, gdje se korak zrenja sastoji u spremanju dehidratiranog kolagena na temperaturi od najmanje 40°C kroz najmanje šest tjedana, ili spremanju dehidratiranog kolagena na temperaturi od najmanje 65°C kroz najmanje tjedan dana, ili spremanju dehidratiranog kolagena na temperaturi od najmanje 30°C kroz najmanje dva mjeseca.
2. Postupak u skladu s patentnim zahtjevom 1, naznačen time što se korak osiguravanja sastoji u osiguravanju disperzije izoliranog kolagena s koncentracijom od 3-30 % (tež./tež.) čestica kolagena.
3. Postupak u skladu s patentnim zahtjevom 1 ili patentnim zahtjevom 2, naznačen time što se korak smrzavanja sastoji u smrzavanju na temperaturu od –33°C do –42°C.
4. Postupak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što se korak dehidratiranja sastoji u uklanjanju vodene faze smanjivanjem tlaka na 0,05 do 0,5 mbar.
5. Postupak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što se korak dehidratiranja sastoji u povećavanju temperature kolagena na +30°C.
6. Postupak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što korak dehidratiranja uključuje najmanje jedan korak uravnotežavanja, gdje se taj ili svaki korak uravnotežavanja sastoji u održavanju temperature na konstantnoj temperaturi kroz najmanje 10 minuta.
7. Postupak u skladu s patentnim zahtjevom 6, naznačen time što se korak dehidratiranja sastoji od šest koraka uravnotežavanja, gdje se svaki korak uravnotežavanja provodi kada temperatura poraste za 10°C.
8. Postupak u skladu s patentnim zahtjevom 1, naznačen time što se modificirani kolagen melje prije koraka zrenja.
9. Postupak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što se korak zrenja provodi uz relativnu vlažnost manju od 80%.
10. Postupak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što postupak dodatno uključuje korak osiguravanja lijeka kojem se dodaje zreli kolagen, ili koji se dodaje zrelom kolagenu, kako bi se osiguralo pripravak za unos lijeka s produljenim otpuštanjem.
11. Postupak u skladu s patentnim zahtjevom 10, naznačen time što je lijek vodena otopina lijeka.
12. Postupak proizvodnje pripravka koji sadrži modificirani kolagen, dobiven u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što se postupak sastoji u koracima:
(a) osiguravanja modificiranog kolagena postupcima u skladu s bilo kojim od prethodnih patentnih zahtjeva;
(b) priprave vodene disperzije modificiranog kolagena dodavanjem zagrijane vode modificiranom kolagenu;
(c) razgradnje vodene disperzije; i
(d) dehidratiranja vodene disperzije.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20120150527 EP2612888A1 (en) | 2012-01-09 | 2012-01-09 | A modified collagen |
| GBGB1220868.2A GB201220868D0 (en) | 2012-11-20 | 2012-11-20 | A modified collagen |
| EP13700286.1A EP2802624B1 (en) | 2012-01-09 | 2013-01-09 | A modified collagen |
| PCT/EP2013/050333 WO2013104687A2 (en) | 2012-01-09 | 2013-01-09 | A modified collagen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171635T1 true HRP20171635T1 (hr) | 2018-02-23 |
Family
ID=47559477
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171635TT HRP20171635T1 (hr) | 2012-01-09 | 2017-10-25 | Modificirani kolagen |
| HRP20190861TT HRP20190861T1 (hr) | 2012-01-09 | 2019-05-09 | Modificirani kolagen |
| HRP20210699TT HRP20210699T1 (hr) | 2012-01-09 | 2021-05-05 | Izmijenjeni kolagen |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190861TT HRP20190861T1 (hr) | 2012-01-09 | 2019-05-09 | Modificirani kolagen |
| HRP20210699TT HRP20210699T1 (hr) | 2012-01-09 | 2021-05-05 | Izmijenjeni kolagen |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10487134B2 (hr) |
| EP (4) | EP2802624B1 (hr) |
| JP (3) | JP6494285B2 (hr) |
| AU (1) | AU2013208952B2 (hr) |
| CA (1) | CA2860552C (hr) |
| CY (3) | CY1119524T1 (hr) |
| DK (3) | DK3536748T3 (hr) |
| EA (2) | EA037396B1 (hr) |
| ES (3) | ES2870137T3 (hr) |
| HK (1) | HK1244296B (hr) |
| HR (3) | HRP20171635T1 (hr) |
| HU (3) | HUE054838T2 (hr) |
| LT (3) | LT3536748T (hr) |
| MX (1) | MX368037B (hr) |
| NO (1) | NO2802624T3 (hr) |
| PL (3) | PL3536748T3 (hr) |
| PT (2) | PT2802624T (hr) |
| RS (3) | RS56564B1 (hr) |
| SI (3) | SI3255106T1 (hr) |
| TR (1) | TR201907156T4 (hr) |
| WO (1) | WO2013104687A2 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS56564B1 (sr) | 2012-01-09 | 2018-02-28 | Innocoll Pharm Ltd | Modifikovan kolagen |
| US20180237259A1 (en) * | 2017-02-22 | 2018-08-23 | Otis Elevator Company | Method for detecting trapped passengers in elevator car |
| RU2704248C1 (ru) * | 2018-10-02 | 2019-10-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВО "ВГУИТ") | Способ получения пористого коллагенового материала |
| RU2760326C1 (ru) * | 2021-03-04 | 2021-11-24 | Общество с ограниченной ответственностью научно-производственное объединение «Велис» | Способ получения пористого влагоемкого материала на коллагеновой основе |
| WO2022219009A1 (en) | 2021-04-12 | 2022-10-20 | Innocoll Pharmaceuticals Limited | Drug-release implant for laparoscopic surgery |
| CN113201569B (zh) * | 2021-06-21 | 2022-08-30 | 江南大学 | 一种牛ⅰ型胶原蛋白的纯化方法 |
| EP4376806A2 (en) * | 2021-07-28 | 2024-06-05 | Innocoll Pharmaceuticals Limited | Bupivacaine-collagen drug delivery implant and methods of making and using thereof |
| WO2023084005A1 (en) * | 2021-11-12 | 2023-05-19 | Innocoll Pharmaceuticals Limited | Resorbable collagen scaffold for dural repair |
| WO2024079289A1 (en) | 2022-10-12 | 2024-04-18 | Innocoll Pharmaceuticals Limited | A kit for implanting a drug-release implant for laparoscopic surgery |
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| JPS5246282B2 (hr) * | 1972-11-15 | 1977-11-24 | ||
| US4097234A (en) * | 1976-12-10 | 1978-06-27 | Nippi, Incorporated | Method for preparing dispersion of collagen fiber |
| US4279812A (en) * | 1979-09-12 | 1981-07-21 | Seton Company | Process for preparing macromolecular biologically active collagen |
| US5206028A (en) | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
| FR2720945B1 (fr) * | 1994-06-08 | 1996-08-30 | Coletica | Membrane collagénique anti-adhérence post-opératoire. |
| US5945125A (en) | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| CA2277814A1 (en) * | 1997-01-16 | 1998-07-23 | Cohesion Corporation | Lyophilized collagen-based biomaterials, process of preparation and uses thereof |
| US20010014667A1 (en) * | 1998-01-05 | 2001-08-16 | Chen Charles C. | Compositions with enhanced osteogenic potential, methods for making the same and therapeutic uses thereof |
| US20050208114A1 (en) * | 1998-03-24 | 2005-09-22 | Petito George D | Composition and method for healing tissues |
| GB2345638A (en) * | 1998-09-11 | 2000-07-19 | Tissue Science Lab Limited | Injectable collagen compositions |
| US6682760B2 (en) * | 2000-04-18 | 2004-01-27 | Colbar R&D Ltd. | Cross-linked collagen matrices and methods for their preparation |
| PT2314293T (pt) * | 2001-01-16 | 2017-04-11 | Vascular Therapies Llc | Dispositivo implantável que contém material de matriz reabsorvível e rapamicina para prevenir ou tratar doenças vasuloproliferativas |
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| RS56564B1 (sr) * | 2012-01-09 | 2018-02-28 | Innocoll Pharm Ltd | Modifikovan kolagen |
| US11623947B2 (en) * | 2013-04-08 | 2023-04-11 | Innocoll Pharmaceuticals Limited | Collagen powder |
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2013
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2016
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2022
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