HRP20210699T1 - Izmijenjeni kolagen - Google Patents
Izmijenjeni kolagen Download PDFInfo
- Publication number
- HRP20210699T1 HRP20210699T1 HRP20210699TT HRP20210699T HRP20210699T1 HR P20210699 T1 HRP20210699 T1 HR P20210699T1 HR P20210699T T HRP20210699T T HR P20210699TT HR P20210699 T HRP20210699 T HR P20210699T HR P20210699 T1 HRP20210699 T1 HR P20210699T1
- Authority
- HR
- Croatia
- Prior art keywords
- collagen
- drug
- dehydrated
- maturation
- temperature
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title claims 22
- 108010035532 Collagen Proteins 0.000 title claims 22
- 229920001436 collagen Polymers 0.000 title claims 22
- 238000000034 method Methods 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- 230000035800 maturation Effects 0.000 claims 6
- 230000008014 freezing Effects 0.000 claims 4
- 238000007710 freezing Methods 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 230000018044 dehydration Effects 0.000 claims 3
- 238000006297 dehydration reaction Methods 0.000 claims 3
- 238000012377 drug delivery Methods 0.000 claims 3
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 1
- 229930182566 Gentamicin Natural products 0.000 claims 1
- 208000031737 Tissue Adhesions Diseases 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 229960002518 gentamicin Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (14)
1. Postupak za pripremu izmijenjenog kolagena, postupak obuhvaća korake:
a. pružanje izoliranog kolagena;
b. zamrzavanje izoliranog kolagena;
c. dehidriranje smrznutog kolagena; i
d. sazrijevanje dehidriranog kolagena,
pri čemu korak sazrijevanja obuhvaća čuvanje dehidriranog kolagena na temperaturi od 2-8 °C tijekom 1-3 godine.
2. Postupak u skladu s patentnim zahtjevom 1, naznačen time što korak sazrijevanja obuhvaća čuvanje dehidriranog kolagena na temperaturi od 2-8 °C tijekom 3 godine.
3. Postupak u skladu s patentnim zahtjevima 1 do 2, naznačen time što korak pružanja obuhvaća osiguravanje izolirane disperzije kolagena koja ima koncentraciju 3-30% (m/m) čestica kolaža.
4. Postupak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što korak smrzavanja obuhvaća zamrzavanje na temperaturu od -33 °C do -42 °C.
5. Postupak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što korak dehidracije obuhvaća uklanjanje vodene faze smanjenjem tlaka na 0.05 do 0.5 mbar.
6. Postupak u skladu s patentnim zahtjevom 1, naznačen time što je kolagen mljeven prije koraka sazrijevanja.
7. Postupak za pripremu pripravka za davanje lijeka za produženo oslobađanje lijeka, koji obuhvaća korake:
a. pružanje izoliranog kolagena;
b. zamrzavanje izoliranog kolagena;
c. dehidriranje smrznutog kolagena; i
d. sazrijevanje dehidriranog kolagena
pri čemu postupak nadalje obuhvaća korak davanja lijeka kojem je dodan sazreli kolagen, ili koji je dodan sazrelom kolagenu pri čemu se korak sazrijevanja sastoji od čuvanja dehidriranog kolagena na temperaturi od 2-8 °C tijekom 1-3 godine .
8. Postupak u skladu s patentnim zahtjevom 7, naznačen time što korak sazrijevanja obuhvaća čuvanje dehidriranog kolagena na temperaturi od 2-8 °C tijekom 3 godine.
9. Postupak u skladu s patentnim zahtjevima 7 do 8, naznačen time što je lijek vodena otopina lijeka.
10. Postupak u skladu s patentnim zahtjevima 7 do 9, naznačen time što je lijek gentamicin, bupivakain ili njihova sol ili predlijek.
11. Izmijenjeni kolagen koji se može dobiti postupkom u skladu s bilo kojim od patentnih zahtjeva 1 do 6.
12. Pripravak za isporuku lijeka koji se može dobiti postupkom u skladu s bilo kojim od patentnih zahtjeva 7 do 10.
13. Izmijenjeni kolagen u skladu s patentnim zahtjevom 11 ili pripravak za dostavu lijeka u skladu s patentnim zahtjevom 12 za uporabu kao lijek.
14. Izmijenjeni kolagen u skladu s patentnim zahtjevom 11 ili pripravak za isporuku lijeka u skladu s patentnim zahtjevom 12 za uporabu u liječenju ili prevenciji kirurških adhezija.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20120150527 EP2612888A1 (en) | 2012-01-09 | 2012-01-09 | A modified collagen |
| GBGB1220868.2A GB201220868D0 (en) | 2012-11-20 | 2012-11-20 | A modified collagen |
| EP19165538.0A EP3536748B1 (en) | 2012-01-09 | 2013-01-09 | A modified collagen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20210699T1 true HRP20210699T1 (hr) | 2021-09-17 |
Family
ID=47559477
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171635TT HRP20171635T1 (hr) | 2012-01-09 | 2017-10-25 | Modificirani kolagen |
| HRP20190861TT HRP20190861T1 (hr) | 2012-01-09 | 2019-05-09 | Modificirani kolagen |
| HRP20210699TT HRP20210699T1 (hr) | 2012-01-09 | 2021-05-05 | Izmijenjeni kolagen |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171635TT HRP20171635T1 (hr) | 2012-01-09 | 2017-10-25 | Modificirani kolagen |
| HRP20190861TT HRP20190861T1 (hr) | 2012-01-09 | 2019-05-09 | Modificirani kolagen |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10487134B2 (hr) |
| EP (4) | EP3255106B1 (hr) |
| JP (3) | JP6494285B2 (hr) |
| AU (1) | AU2013208952B2 (hr) |
| CA (1) | CA2860552C (hr) |
| CY (3) | CY1119524T1 (hr) |
| DK (3) | DK3536748T3 (hr) |
| EA (2) | EA027745B1 (hr) |
| ES (3) | ES2645445T3 (hr) |
| HK (1) | HK1244296B (hr) |
| HR (3) | HRP20171635T1 (hr) |
| HU (3) | HUE037043T2 (hr) |
| LT (3) | LT3536748T (hr) |
| MX (1) | MX368037B (hr) |
| NO (1) | NO2802624T3 (hr) |
| PL (3) | PL3536748T3 (hr) |
| PT (2) | PT2802624T (hr) |
| RS (3) | RS58935B1 (hr) |
| SI (3) | SI3536748T1 (hr) |
| TR (1) | TR201907156T4 (hr) |
| WO (1) | WO2013104687A2 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10487134B2 (en) | 2012-01-09 | 2019-11-26 | Innocoll Pharmaceuticals Limited | Modified collagen |
| US20180237259A1 (en) * | 2017-02-22 | 2018-08-23 | Otis Elevator Company | Method for detecting trapped passengers in elevator car |
| RU2704248C1 (ru) * | 2018-10-02 | 2019-10-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВО "ВГУИТ") | Способ получения пористого коллагенового материала |
| RU2760326C1 (ru) * | 2021-03-04 | 2021-11-24 | Общество с ограниченной ответственностью научно-производственное объединение «Велис» | Способ получения пористого влагоемкого материала на коллагеновой основе |
| WO2022219009A1 (en) | 2021-04-12 | 2022-10-20 | Innocoll Pharmaceuticals Limited | Drug-release implant for laparoscopic surgery |
| CN113201569B (zh) * | 2021-06-21 | 2022-08-30 | 江南大学 | 一种牛ⅰ型胶原蛋白的纯化方法 |
| IL310517A (en) * | 2021-07-28 | 2024-03-01 | Innocoll Pharm Ltd | Bupivacaine-collagen drug delivery implant and methods for its preparation and use |
| WO2023084005A1 (en) * | 2021-11-12 | 2023-05-19 | Innocoll Pharmaceuticals Limited | Resorbable collagen scaffold for dural repair |
| WO2024079289A1 (en) | 2022-10-12 | 2024-04-18 | Innocoll Pharmaceuticals Limited | A kit for implanting a drug-release implant for laparoscopic surgery |
Family Cites Families (27)
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| JPS5246282B2 (hr) * | 1972-11-15 | 1977-11-24 | ||
| US4097234A (en) * | 1976-12-10 | 1978-06-27 | Nippi, Incorporated | Method for preparing dispersion of collagen fiber |
| US4279812A (en) * | 1979-09-12 | 1981-07-21 | Seton Company | Process for preparing macromolecular biologically active collagen |
| US5206028A (en) * | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
| FR2720945B1 (fr) | 1994-06-08 | 1996-08-30 | Coletica | Membrane collagénique anti-adhérence post-opératoire. |
| US5945125A (en) | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| CA2277814A1 (en) * | 1997-01-16 | 1998-07-23 | Cohesion Corporation | Lyophilized collagen-based biomaterials, process of preparation and uses thereof |
| US20010014667A1 (en) * | 1998-01-05 | 2001-08-16 | Chen Charles C. | Compositions with enhanced osteogenic potential, methods for making the same and therapeutic uses thereof |
| US20050208114A1 (en) * | 1998-03-24 | 2005-09-22 | Petito George D | Composition and method for healing tissues |
| GB2345638A (en) * | 1998-09-11 | 2000-07-19 | Tissue Science Lab Limited | Injectable collagen compositions |
| US6682760B2 (en) * | 2000-04-18 | 2004-01-27 | Colbar R&D Ltd. | Cross-linked collagen matrices and methods for their preparation |
| BR0206464A (pt) | 2001-01-16 | 2005-01-18 | Vascular Therapies Llc | Aparelho e processos para impedir ou tratar insuficiência de acesso vascular para hemodiálise e outros enxertos vasculares |
| US7098315B2 (en) * | 2001-01-25 | 2006-08-29 | Nycomed Pharma As | Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
| JP2004099513A (ja) * | 2002-09-09 | 2004-04-02 | Toshiba Corp | クラゲのコラーゲン回収方法及びクラゲのコラーゲン回収システム |
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| EP2139457B1 (en) * | 2007-03-28 | 2016-05-04 | Innocoll Pharmaceuticals Limited | A drug delivery device for providing local analgesia, local anesthesia or nerve blockade |
| USRE47826E1 (en) * | 2007-03-28 | 2020-01-28 | Innocoll Pharmaceuticals Limited | Drug delivery device for providing local analgesia, local anesthesia or nerve blockage |
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| WO2011014155A1 (en) * | 2009-07-27 | 2011-02-03 | National Cheng Kung University | Preparation of high purity collagen |
| JP2011225462A (ja) * | 2010-04-16 | 2011-11-10 | Ihara Suisan Kk | 多孔質コラーゲン、その製造方法およびその用途 |
| US8951598B2 (en) | 2010-05-07 | 2015-02-10 | Empire Technology Development Llc | Nanoscale collagen particles and membranes |
| EP2510929A1 (en) * | 2011-04-11 | 2012-10-17 | Innocoll Technologies Limited | Methods for treating bacterial infection |
| US10487134B2 (en) * | 2012-01-09 | 2019-11-26 | Innocoll Pharmaceuticals Limited | Modified collagen |
| US11623947B2 (en) * | 2013-04-08 | 2023-04-11 | Innocoll Pharmaceuticals Limited | Collagen powder |
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